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김범철,최광순,김철구,이유희,김동섭,박제철 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-
Seasonal and vertical distributions of dissolved and particulate organic carbon were investigated from May 1995 to March 1997 in n deep mesotrophic reservoir, Lake Soyang, POC contentrations at the dam site ranged from 0.1 to 1.8 mgC/L and DOC concentrations ranged from 1.4 to 4.9 mgC/L. POC concentrations in the surface layer were higher in the season of cyanobacterial bloom, July to September. High POC was observed at the depth of 30 to 60m after storm runoff in summer monsoon season. Turbid storm runoff formed intermediate current laden with much particulate materials from terrestrial sources. The vertical and seasonal variation of DOC was smaller than POC. Higher DOC was observed near the lake bottom which implies sedimentation and degradation of much organic detritus at the bottom. The ratio of DOC : POC varied from 2 to 60, and the ratio was lowest in September 1995 when algal density was highest. DOC : POC ratio of the main inflowing river, the Soyang River, varied from 1 to 10, and the ratio was low in storm runoff when the POC concentration was high.
정위상 및 탈위상 경사에코영상과 생체 수소 자기공명분광법을 이용한 담낭 담즙내 지질성분의 측정$^1$
신석환,조순구,김영수,우제홍,김형진,서창해,Sin, Seok-Hwan,Jo, Sun-Gu,Kim, Yeong-Su,U, Je-Hong,Kim, Hyeong-Jin,Seo, Chang-Hae 대한영상의학회 2002 대한영상의학회지 Vol.46 No.2
목적: 지질 억제 자기공명영상 기법과 수소 자기공명분광에서 측정한 지질 피크의 상대적 비율을 비교 분석하여,이 두 방법에 의한 담낭내 담즙 지질의 정량적 분석이 가능한 지를 알아보고자 하였다. 대상과 방법: 간기능 검사 및 콜레스테롤 수치가 정상이며, 초음파검사에서 담낭벽의 비후가 없고 담낭이 잘 팽창되어 있는 정상자원자 26명을 대상으로 하였다.담낭의 정위상 및 탈위상 경사에 코영상에서 담낭의 신호강도 차이를 계산하였으며, 담낭 자기공명분광 스펙트럼의 지질피크(0.8-1.6 ppm)와,2.0-2.4 ppm,3.2-3.4 ppm,3.9-4.1 ppm,5.2-5.4 ppm에서 관찰되는 피크의 넓이를 측정하였다. 전체 피크의 합에 대한 지질피크의 비율를 계산하였고, 신호강도 비율과 지질피크 비율를 비교하였다. 결과: 정위상 및 탈위상 자기공명영상에서의 신호강도비율은11.3-43.4%(평균 26 $\pm$8.9%)였고, 생체 수소 자기공명분광의 가장 현저한 피크는 지질피크(21명,92%)였으며, [ 피크0.8-1.6 ppm의 면적/모든 피크의 면적의 합] 은 0.10-0.97(평균 0.66 $\pm$0.21)였다. 신호강도 비율과 지질피크 비율의 상관성은 통계적으로 의미있는 상관성을 보였다(r=0.478,p=0.014). 결론: 지질 억제 자기공명영상 기법과 수소 자기공명분광법이 담낭내 담즙 지질성분을 측정하는 방법으로 이용될 가능성이 있다. Purpose: To evaluate the utility of signal intensity differences between in- and opposed-phase MRI and the lipid peak ratio in in-vivo proton MR spectroscopy of the gallbladder as diagnostic tools for measuring the lipidcontent of gallbladder bile. Materials and Methods: Twenty-six normal volunteers underwent MR imaging (FMPSPGR) and in-vivo proton MR spectroscopy of the gallbladder. In all cases the results of liver function tests were normal, as were cholesterol levels,and ultrasonography of the gaubladder revealed nothing unusual. For MRI and MRS a 1.5T unit (Signa Horizon; GE Medical Systems, Milwaukee, U.S.A.) was used. In-phase and opposed-phase coronal-section MR images(FMPSPGR; TR=125 msec, TE=1.8, 4.2 msec) of the gallbladder were obtained, and differences in signal intensity thus determined. For proton MR spectroscopy of the gallbladder, a localized proton STEAM sequence was employed. A single voxel of 1-8 cm3 was placed at the center of the gallbladder cavity, peak areas at 0.8-1.6 ppm (lipid), 2.0-2.4 ppm, 3.2-3.4 ppm, 3.9-4.1 ppm, and 5.2-5.4 ppm were measured by proton MRS and the relative peak area ratios of peak 0.8-1.6 ppm/other peaks were calculated. The degree of correlation between signal intensity differences at MRI and the relative peak area ratio of lipid in proton MRS was estimated using the p-value and Pearson's correlation coefficient. Results: Signal intensity differences ranged from 11.3 to 43.4% (mean,26$\pm$8.9%), and the range of lipid peak area ratio at MRS was 0.10-0.97 (mean, 0.66$\pm$0.21). There was significant correlation between the two measured values (P=0.014, Pearson’s correlation coefficient=0.478). Conclusion: In normal cystic bile, signal intensity differences at in- and opposed-phase MRI and relative lipid peak area ratios at MRS varied, though both methods could be used diagnostically for measuring the lipid contents of body tissue.
Je, U.,Kim, J.,Cho, H.,Lim, H.,Park, C.,Kim, G.,Park, S.,Park, Y.,Kim, K.,Woo, T.,Chung, N.,Kim, J.,Kim, J. Published for IMEKO by the Institute of Measuremen 2016 MEASUREMENT -LONDON- Vol.91 No.-
We have recently developed very precise carbon-interspaced antiscatter grids having a wide range of grid strip densities (i.e., 85-234lines/in.) by adopting the sawing process, depending on the demands of specific imaging modalities. However, because grid strips of the recently developed grids are mostly invisible through X-ray nondestructive testing due to their high strip densities, quality assurance in the manufacturing has not yet satisfactorily made. In this work, we proposed a pragmatic method to measure actual grid strip densities over the Nyquist sampling rate based on the moire pattern analysis. We prepared several samples of the carbon-interspaced grids having nominal grid strip densities of 85, 103, 130, 150, 178, 203, 215, and 234lines/in. and measured their strip densities by using the proposed method to demonstrate its viability assessment. The differences between the nominal and the measured grid strip densities were less than about 1.8%, indicating the proposed method is useful for the quality assurance in grid manufacturing.
Je, U.K.,Park, C.K.,Lim, H.W.,Cho, H.S.,Lee, D.Y.,Lee, H.W.,Kim, K.S.,Park, S.Y.,Kim, G.A.,Kang, S.Y.,Park, J.E.,Kim, W.S.,Jeon, D.H.,Woo, T.H. Elsevier BV * North-Holland 2017 Nuclear Instruments & Methods in Physics Research. Vol. No.
<P><B>Abstract</B></P> <P>We have recently developed precise x-ray grids having strip densities in the range of 100 – 250 lines/inch by adopting the precision sawing process and carbon interspace material for the demands of specific x-ray imaging techniques. However, quality assurance in the grid manufacturing has not yet satisfactorily conducted because grid strips of a high strip density are often invisible through an x-ray nondestructive testing with a flat-panel detector of an ordinary pixel resolution (>100 μ m). In this work, we propose a useful method to evaluate actual grid strip densities over the Nyquist sampling rate based on the moiré artifact analysis. We performed a systematic simulation and experiment with several sample grids and a detector having a 143- μ m pixel resolution to verify the proposed quality assurance method. According to our results, the relative differences between the nominal and the evaluated grid strip densities were within 0.2% and 1.8% in the simulation and experiment, respectively, which demonstrates that the proposed method is viable with an ordinary detector having a moderate pixel resolution for quality assurance in grid manufacturing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The precise carbon-interspaced antiscatter grids have been studied. </LI> <LI> It is proposed for a useful method to evaluate actual grid strip densities over the Nyquist sampling rate based on the moiré artifact analysis. </LI> <LI> The simulation and experimental results demonstrate that the proposed method is viable with an ordinary detector having a moderate pixel resolution (>100 μ m) for quality assurance in grid manufacturing. </LI> </UL> </P>
Je, U.K.,Cho, H.M.,Cho, H.S.,Park, Y.O.,Park, C.K.,Lim, H.W.,Kim, K.S.,Kim, G.A.,Park, S.Y.,Woo, T.H.,Choi, S.I. Pergamon 2016 Radiation physics and chemistry Vol.119 No.-
<P>In this paper, we propose a new/next-generation type of CT examinations, the so-called Interior Computed Tomography (ICT), which may presumably lead to dose reduction to the patient outside the target region-of-interest (ROI), in dental x-ray imaging. Here an x-ray beam from each projection position covers only a relatively small ROI containing a target of diagnosis from the examined structure, leading to imaging benefits such as decreasing scatters and system cost as well as reducing imaging dose. We considered the compressed-sensing (CS) framework, rather than common filtered-backprojection (FBP)-based algorithms, for more accurate ICT reconstruction. We implemented a CS-based ICT algorithm and performed a systematic simulation to investigate the imaging characteristics. Simulation conditions of two ROI ratios of 0.28 and 0.14 between the target and the whole phantom sizes and four projection numbers of 360, 180, 90, and 45 were tested. We successfully reconstructed ICT images of substantially high image quality by using the CS framework even with few-view projection data, still preserving sharp edges in the images. (C) 2015 Elsevier Ltd. All rights reserved.</P>
Kim, K.S.,Kang, S.Y.,Kim, W.S.,Cho, H.S.,Park, C.K.,Lee, D.Y.,Kim, G.A.,Park, S.Y.,Lim, H.W.,Lee, H.W.,Park, J.E.,Jeon, D.H.,Lim, Y.H.,Je, U.K.,Woo, T.H. BUTTERWORTH-HEINEMANN 2018 NDT AND E INTERNATIONAL Vol.98 No.-
<P><B>Abstract</B></P> <P>In conventional radiography, image visibility is often limited mainly due to the superimposition of the object’s structure under investigation and scattered x-rays. Several methods, including the antiscatter grid technique, the air-gap technique, and scatter correction methods using measurements, mathematical-physical modeling, or a combination of both, have been extensively investigated in an attempt to overcome these difficulties. However, these methods require special equipment, geometry, and extra work to measure the scatter characteristics. In this study, we propose a new image restoration method based on a simple radiographic scattering model in which the intensity of the scattered x-rays and the direct transmission function of a given object are estimated from a single x-ray image by using the dark-channel prior. We implemented the proposed algorithm and performed a systematic experiment by using a 450-kV industrial x-ray inspection system to demonstrate its viability for nondestructive testing. Our results indicated that the structure of the examined object was much more clearly visible in the restored image, considerably improving the radiographic visibility.</P>
자궁경부암 유전자 치료를 위한 p53 종양 억제 유전자를 포함한 아데노 연관 바이러스벡터 (AAVCMVp53)의 제조
김용욱 ( Kim Yong Ug ),서민제 ( Seo Min Je ),배수미 ( Bae Su Mi ),전진근 ( Jeon Jin Geun ),김태형 ( Kim Tae Hyeong ),진태영 ( Jin Tae Yeong ),이석우 ( Lee Seog U ),김용완 ( Kim Yong Wan ),김종국 ( Kim Jong Gug ),이준모 ( Lee Jun M 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
목적: 재조합 아데노 연관 바이러스 rAAVCMVp53를 생산하기 위해서 3가지 플라스미드 pAAVp53, pAAVLacZ 벡터 플라스미드, packaging 플라스미드, helper 플라스미드를 사용하여 cotransfection 방법을 통해 아데노바이러스 오염이 없는 순수 rAAVCMVp53을 생산하고자 하였다. 연구 방법: 벡터 플라스미드 (pAAVp53, pAAVLacZ), AAV를 암호한 부분에 2개의 p5 promoter를 가지는 플라스미드 Objective: To eliminate the potential problem of adenovirus contamination during recombinant adeno-associated virus (rAAV) vector production, we investigated new rAAV production method by a triple transfection of vector plasmid, packaging plasmid, and ade
Ho-166 부착풍선도자를 이용한 방사선 조사의 돼지 관상동맥 스텐트 재협착 예방 효과
김원 ( Kim Won ),정명호 ( Jeong Myeong Ho ),박옥영 ( Park Og Yeong ),정우곤 ( Jeong U Gon ),박우석 ( Park U Seog ),김주한 ( Kim Ju Han ),안영근 ( An Yeong Geun ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Je 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
배경 : 국내에서 개발된 방사선 동위원소 Holmium-166 (166Ho)은 주로 베타선을 방출하며, 166Ho을 부착한 풍선도자를 이용하여 돼지 관상동맥 재협착 모형에서 풍선확장술 후 신생내막 증식을 전신적 부작용 없이 안전하고 효과적으로 억제하였음을 보고한 바 있다. 본 연구에서는 돼지 관상동맥 스텐트 재협착 모형에서 스텐트 시술 후 신생내막 증식에 의한 재협착 병변을 166Ho 부착 풍선도자를 이용하여 치료하여 그 효과를 관찰하고자 하였다. 방법
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간세포암 수술 후 조기 합병증 및 수술 사망률에 영향을 미치는 위험인자
김완욱 ( Kim Wan Ug ),이광웅 ( Lee Gwang Ung ),최성호 ( Choe Seong Ho ),허진석 ( Heo Jin Seog ),김용일 ( Kim Yong Il ),김성주 ( Kim Seong Ju ),박제훈 ( Park Je Hun ),우돈희 ( U Don Hui ),조재원 ( Jo Jae Won ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)