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김한샘(Kim, Han-saem) 우리말글학회 2015 우리말 글 Vol.65 No.-
초등학교 교과서 어휘 분석 말뭉치를 대상으로 고유어 명사 파생 접두사의 생산성을 측정해 보았다. Baayen(1989)의 방법론을 한국어에 적용하기 위해 기존 공식을 검토하여 생산성 측정식을 ‘P = (n1+U+1)?T/N’로 제안하였다. n1은 단발어의 수, U는 미등재어의 수, T는 해당 접사 형성 파생어 종수, N은 빈도가 평균 빈도 이하인 해당 접사 형성 파생어 빈도의 총합을 의미한다. 측정 결과 ‘수- > 한- > 참- > 통- > 암- > 실-, 헛-> 맞-, 덧- > 쇠- > 맨- > 개-, 햇- > 알-, 줄-, 쪽-, 풋-, 날- > 돌- >잔- > 들-, 막-, 찰- > 먹- > 맏- > 늦-, 민-, 외- > 군- , 말-, 웃- >홀- > 메- > 겹- > 떡-’의 순으로 생산성이 측정되었다. 접사의 생산성에 대한 논의는 어종, 세부 범주의 측면에서 확대되어야 하며 그간의 이론적인 연구를 어떻게 어휘 교육에 적용할 것인가로 발전해 나가야 할 것이다. Elementary school textbooks looked vocabulary corpus in this study to measure the productivity of native language noun derived prefix. Baayen(1989) review the existing formula to apply the methodology was proposed in Korean productivity measuring expression as "P = (n1 + U + 1) .T / N". n1 is the number of Sudan I, U is the number of tail lamp Measure, T is the total sum of the macro means forming species derivatives, N is the frequency of the average frequency of less than or equal to the frequency of the macro forming derivatives. Measurement "Su- > Han- > Cham- > Tong- > Am- > Si-, Heot- > Mat-, Deot- > Soe- > Maen- > Gae-, Haet- > Al-, Jul-, Jjok-, Put-, Nal- > Dol- > Jan- > Deuls -, Mak-, Chal- > Meok- > Mat- > Neut-, Min-, Oe- > Gun-, Mal-, Ut- > Hol- > Me- > Gyeop- > Ddeok" was measured in the order. Discussion on the productivity of the macro is to be expanded in terms of species, will get developed into detailed categories and how to apply the theoretical study of vocabulary teaching meantime.
Kim, Sung Jin,Lee, Han Saem,Shin, June Ho,Kim, Chul Geun,Jeong, Sunjoo,Park, Keerang,Choe, Han,Lee, Heuiran National Hellenic Research Foundation 2006 ONCOLOGY REPORTS Vol.16 No.5
<P>Although the human telomerase reverse transcriptase (hTERT) promoter can regulate cancer-specific genes, it is generally too weak to be effective. We therefore attempted to improve the potency of synthetic hTERT promoters by fusing the core element (E) of the hTERT promoter (H) and the tripartite leader sequence (T) from human adenovirus 5 in a combinatorial manner. To determine the potential as cancer-specific promoters, we measured luciferase activity driven by the chimeric hTERT promoters in human cancer cells. Among various constructs, the E3-H-T promoter induced the strongest luciferase activity in all the tested cancer cells. SK-Hep1 and Hela cells experienced 1000- and 11-fold higher expression than the basic hTERT promoter, respectively. Relative to the SV40 universal promoter, the E3-H-T promoter led to higher levels of gene expression. Using EMSA, we found that the hTERT enhancer region was specifically bound to c-Myc and Sp1. Thus, the data suggest that the E3-H-T promoter with up-regulated cancer-specific gene expression could be useful in cancer gene therapy.</P>
( Han Saem Kim ),( Jae Yun Lim ),( Ju Yeon Choi ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Although alopecia areata (AA) shows a high rate of spontaneous remission, there are many treatment options applied for rapid clinical results. Intralesional corticosteroid is first-line therapy for patients with less than 50% scalp involvement. Most studies with intralesional corticosteroid reported 60-75% of patients experienced hair regrowth within 4 months. However, if there is no regrowth after 4 months of treatment, topical corticosteroids, minoxidil and immunotherapy would be considered. Polydeoxyribonucleotide (PDRN), deoxyribonucleotide polymers ranging between 50 and 2000 base pairs, stimulates the adenosine receptor. The receptor is closely associated with the mechanism of minoxidil, used in the treatment of AA. Therefore, we presumed that PDRN would also have a clinical effect on AA, but there is limited data on the effectiveness of PDRN in AA. Herein, we report that two AA patients, recalcitrant to intralesional corticosteroid, show a significant clinical effect of hair regrowth with intralesional PDRN.
A case of xanthoma disseminatum
( Han Saem Kim ),( Jae Yun Lim ),( Ju Yeon Choi ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Xanthoma disseminatum (XD) is a rare benign form of non-langerhans cell histiocytosis, affecting the skin and mucous membranes. The cutaneous manifestations consist of multiple yellowish papules which symmetrically involve the face, trunk and proximal extremities. Involvement of other organs including brain, bone and bone marrow also may be seen, and a case of hepatic involvement with XD has been reported in a child. A 60-year-old male presented with a two year history of asymptomatic yellowish-brown papules on the face, neck, both axillae, inguinal and perianal areas with size ranging from 0.1 to 0.3cm in diameter. The lesions were first appeared on intertriginous areas such as both axillae, inguinal and perianal areas with unknown etiology, and then disseminated to the neck, periocular and perioral areas with acute exacerbation of liver function. An abdomen CT revealed acute hepatitis with common bile duct (CBD) dilatation. Although liver function was normalized after removing CBD stones, multiple laryngeal masses causing dyspnea were found and surgically removed. Histopathology of the skin lesions and laryngeal masses revealed dermal infiltration of foam cells with few Touton-type giant cells and immunohistochemical analysis showed positive labeling for CD68, but negative for S-100. Routine testing including serum lipid profiles was normal. Consequently, this case was diagnosed with XD.
Determination of hesperidin in mixed tea by HPLC
Saem Han(한샘),So-Youn Mok(목소연),Hye-Min Kim(김혜민),Jeong-Min Lee(이정민),Dong Gu Lee(이동구),Sook-Young Lee(이숙영),Jongkee Kim(김종기),Sun-Ju Kim(김선주),Sanghyun Lee(이상현) 충남대학교 농업과학연구소 2011 농업과학연구 Vol.38 No.2
The content of hesperidin in the mixed tea, which was composed of dried orange peel, laurel leaf, mulberry leaf, silver magnolia leaf, oriental melon tap, cassia seed, and licorice root, was determined by high performance liquid chromatography (HPLC). Hesperidin was quantified by a reverse phase column with gradient solvent system (watcr:acetonitrile = 80:20 to 35:65 for 30 min) and UV/VIS detection (280 ㎚). The How rate was kept constant at 1.0 ㎖/min. The content of hesperidin in the mixed tea was measured in depending on extraction time 1, 2, 3, and 4 min (29.07, 52.39, 52.45, and 88.35 ㎎/g, respectively).
Ca<SUP>2</SUP>-activated K<SUP></SUP> Currents of Pancreatic Duct Cells in Guinea-pig
Han-Wook Lee,Jingchao Li,Na-Youn Koo,Zheng Gen Piao,Sung Min Hwang,Jae-Woong Han,Han-Saem Choi,Jong-Heun Lee,Joong Soo Kim,Kyungpyo Park 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.6
There are numerous studies on transepithelial transports in duct cells including Cl<SUP></SUP> and/or HCO<SUB>3</SUB><SUP></SUP>. However, studies on transepithelial K<SUP></SUP> transport of normal duct cells in exocrine glands are scarce. In the present study, we examined the characteristics of K<SUP></SUP> currents in single duct cells isolated from guinea pig pancreas, using a whole-cell patch clamp technique. Both Cl<SUP></SUP> and K<SUP></SUP> conductance were found with KCl rich pipette solutions. When the bath solution was changed to low Cl<SUP></SUP>, reversal potentials shifted to the negative side, 75⁑4 mV, suggesting that this current is dominantly selective to K<SUP></SUP>. We then characterized this outward rectifying K<SUP></SUP> current and examined its Ca<SUP>2</SUP> dependency. The K<SUP></SUP> currents were activated by intracellular Ca<SUP>2</SUP>. 100 nM or 500 nM Ca<SUP>2</SUP> in pipette significantly (P<0.05) increased outward currents (currents were normalized, 76.8⁑7.9 pA, n=4 or 107.9⁑35.5 pA, n=6) at 100 mV membrane potential, compared to those with 0 nM Ca<SUP>2</SUP> in pipette (27.8⁑3.7 pA, n=6). We next examined whether this K<SUP></SUP> current, recorded with 100 nM Ca<SUP>2</SUP> in pipette, was inhibited by various inhibitors, including Ba<SUP>2</SUP>, TEA and iberiotoxin. The currents were inhibited by 40.4⁑% (n=3), 87.0⁑% (n=5) and 82.5⁑% (n=9) by 1 mM Ba<SUP>2</SUP>, 5 mM TEA and 100 nM iberiotoxin, respectively. Particularly, an almost complete inhibition of the current by 100 nM iberiotoxin further confirmed that this current was activated by intracellular Ca<SUP>2</SUP>. The K<SUP></SUP> current may play a role in secretory process, since recycling of K<SUP></SUP> is critical for the initiation and sustaining of Cl<SUP></SUP> or HCO<SUB>3</SUB><SUP></SUP> secretion in these cells.