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Matsumoto, Kazuhiro,Hagiwara, Masayuki,Hayakawa, Nozomi,Tanaka, Nobuyuki,Ito, Yujiro,Maeda, Takahiro,Ninomiya, Akiharu,Nagata, Hirohiko,Nakamura, So Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
The aim of this study was to evaluate the efficacy of third-line combined androgen blockade (CAB) therapy for castration-resistant prostate cancer that relapsed after primary and second-line CAB. We retrospectively reviewed the medical records of 52 patients who received first-, second-, and third-line CAB therapy (medical or surgical castration, plus steroidal antiandrogen of chlormadinone acetate, or nonsteroidal antiandrogen of flutamide or bicalutamide). For cumulative analysis, we searched the PubMed database and identified a total of 50 cases published in English. Including our cases, this provided a total of 102 cases for analysis. In our study cohort, 11 cases (21.2%) achieved more than 50% reduction of serum prostate-specific antigen (PSA) on initiation of third-line CAB. We found that third-line CAB with nonsteroidal antiandrogen after second-line CAB with steroidal antiandrogen exhibited favorable results, with a positive response in six of 13 patients (46.2%). Cumulative analysis findings were comparable. Regarding the timing of third-line CAB administration, 15 patients had started at a PSA equal to or less than 4.0 ng/ml, and eight of them (53.3%) showed a positive response to treatment, compared to only three of 37 patients (8.1%) whose PSA at the initiation of third-line therapy was higher than 4.0 ng/ml (p<0.001). We conclude that third-line CAB with nonsteroidal antiandrogen would be particularly useful for patients whose cancer progressed after second-line CAB with steroidal antiandrogen. The timing of treatment seems to be important because the higher the PSA at the start of third-line therapy, the lower the PSA response rate.
Matsumoto, Kazuhiro,Fujita, Tomomichi,Sato, Saki,Chun, Jong-Pil Korean Society of Horticultural Science 2017 원예과학기술지 Vol.35 No.4
We compared the quality of 'Fuji' apples (Malus ${\times}$ domestica) from trees whose leaves were not removed (no artificial defoliation; NAD) with apples from trees that underwent early defoliation (ED, treated in mid September and early October) and conventional defoliation (CD, treated in early and mid October). The experiment was conducted in three consecutive years using 15-year-old 'Fuji' apple grafted on Malus prunifolia. Fruits were harvested on November 7, 16 or 12 in 2011, 2012 and 2013, respectively. Compared to NAD treatment, ED and CD treatment reduced the fresh weight by 4.7% and 0.6%, respectively. The soluble solids content of NAD apples ($14.4^{\circ}Brix$) was slightly higher than that of CD ($14.1^{\circ}Brix$) and ED ($14.0^{\circ}Brix$) apples. Soluble sugar content, flesh firmness, water-core index, and titratable acidity were not affected by defoliation treatment regardless of treatment timing. The skin blush index of NAD apples (2.3) was inferior to that of CD (3.3) and ED (3.4)- treated apples. Furthermore, artificial defoliation treatments increased skin redness ($a^*$) and yellowness ($b^*$) and significantly improved the degree of skin blush compared to NAD fruits.
Kazuhiro Matsumoto,Tomomichi Fujita,Saki Sato,Jong-Pil Chun 한국원예학회 2017 원예과학기술지 Vol.35 No.4
We compared the quality of ‘Fuji’ apples (Malus × domestica ) from trees whose leaves were not removed (no artificial defoliation; NAD) with apples from trees that underwent early defoliation (ED, treated in mid September and early October) and conventional defoliation (CD, treated in early and mid October). The experiment was conducted in three consecutive years using 15-year-old ‘Fuji’ apple grafted on Malus prunifolia . Fruits were harvested on November 7, 16 or 12 in 2011, 2012 and 2013, respectively. Compared to NAD treatment, ED and CD treatment reduced the fresh weight by 4.7% and 0.6%, respectively. The soluble solids content of NAD apples (14.4°Brix) was slightly higher than that of CD (14.1°Brix) and ED (14.0°Brix) apples. Soluble sugar content, flesh firmness, water-core index, and titratable acidity were not affected by defoliation treatment regardless of treatment timing. The skin blush index of NAD apples (2.3) was inferior to that of CD (3.3) and ED (3.4)- treated apples. Furthermore, artificial defoliation treatments increased skin redness (a*) and yellowness (b*) and significantly improved the degree of skin blush compared to NAD fruits.
포도 품종별 과립 성숙에 따른 당 조성 및 품질 변화 비교
마쓰모토가즈히로(Kazuhiro Matsumoto),김병기(Byung-Ki Kim),부티킴완(Vu Thi Kim Oahn),서정학(Jeong-Hak Seo),윤홍기(Hong-Ki Yoon),박문균(Mun-Kyun Park),황용수(Yong-Soo Hwang),천종필(Jong-Pil Chun) 한국원예학회 2007 원예과학기술지 Vol.25 No.3
우리나라 주요 재배 포도 6품종을 공시하여 변색기 이후 성숙기간 중 품질, 착색 및 당축적 패턴 등을 비교 분석하였다. 모든 품종에서 과립의 성숙과 더불어 경도가 지속적으로 감소하여 성숙기에 10N 이하로 떨어졌고 가용성 고형물 함량은 과립의 성숙과 더불어 증가하였고 산 함량은 꾸준히 감소하여 성숙기에 0.5% 이하였다. 과피의 안토시아닌 축적은 품종에 따라 절대 수준은 큰 차이가 있었으나 과립의 성숙과 더불어 증가하는 경향이었는데 당산비의 증가와 유의한 상관을 보였다. 과피의 L<SUP>*</SUP> 값은 변색기 이후 급격히 감소하였고 CIRG 값과 당산비간의 상관계수는 ‘캠벨얼리’(r = 0.802, P<0.05), ‘거봉’(r = 0.853, P<0.01) 및 ‘흑구슬’(r = 0.831, P<0.05)로 유의하였다. 과립내에 축적되는 당의 성분을 과즙을 이용하여 HPLC로 분석한 결과, ‘델라웨어’, ‘캠벨얼리’, ‘거봉’, ‘흑구슬’, ‘MBA’는 환원당 축적형으로 그리고 ‘새단’은 자당 축적형으로 나타났는데 환원당 축적형 품종에서는 성숙이 가까워질수록 포도당의 비율이 급격히 증가하여 과당의 격차가 커지고 자당의 비율이 지속적으로 증가되었다. Berry quality, coloration and sugar accumulation pattern were examined in 6 varieties of grape (Vitis labruscana B.) during ripening after verasion. Considerable drops of berry firmness (<10 N) and titratable acidity (<0.5%) were found at ripening stage, while the content of soluble solids was significantly increased along with the ripening process. Total levels of anthocyanin content among the cultivars were different, the concentration of anthocyanin sharply increased coinciding with the sugar accumulation in berries showing high correlation (r=0.956, P<0.01) with maturity index (brix/acid) regardless of cultivars. L value of berry skin decreased after veraison. Correlations between color index for red grape (CIRG) and sugar/acid ratio were found in cultivars including ‘Campbell Early’ (r=0.802, P<0.05), ‘Kyoho’ (r=0.853, P<0.01), and ‘Heukguseul’ (r=0.832, P<0.05). Sugar analysis of extractable juice by HPLC revealed that cultivars such as ‘Delaware’, ‘Campbell Early’, ‘Kyoho’, ‘Heukguseul’, and ‘MBA’ belonged to reducing sugar accumulating group at maturity and ‘Sheridan’ showed sucrose accumulation one. The rapid accumulation of glucose at ripening in former cultivars resulted in the increase of glucose/fructose ratio. These characteristic pattern of sugar accumulation may have a potential for the development as objective ripening index.
Kazuhiro Takehara,Takashi Matsumoto,Junzo Hamanishi,Kosei Hasegawa,Motoki Matsuura,Kiyonori Miura,Shoji Nagao,Hidekatsu Nakai,Naotake Tanaka,Hideki Tokunaga,Kimio Ushijima,Hidemichi Watari,Yoshihito Y 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objective: The primary objective of this study was to evaluate the safety of niraparib 300 mg/dayin Japanese patients with platinum-sensitive, relapsed ovarian cancer in a maintenance setting. Methods: Phase 2, multicenter, open-label, single-arm study enrolled Japanese patients withplatinum-sensitive, relapsed ovarian cancer who had received ≥2 platinum-based regimens. The primary endpoint (incidence of grade 3 or 4 thrombocytopenia-related events within 30days after initial niraparib administration) was justified by the incidences of a global pivotalphase 3 study and its post-hoc safety analysis on thrombocytopenia, the major hematologicaladverse event of niraparib. The overall safety analysis examined other treatment-emergentadverse events (TEAEs). Results: Enrolled patients (n=19) had a median (min, max) body weight of 53.9 (40.8–79.1)kg; all but one patient weighed <77 kg. Most (94.7%) patients initially received niraparib300 mg/day but this decreased in subsequent cycles (mean±standard deviation doseintensity, 191.6±65.7 mg/day). In total, 6/19 (31.6%) patients experienced grade 3 or 4 thrombocytopenia-related events within 30 days of initial niraparib administration. Other common TEAEs included nausea, and decreased platelet or neutrophil counts. Noprogression-free or overall survival events occurred; only 1 of 4 response-evaluable patientshad a post-baseline tumor assessment (stable disease). Conclusion: The incidence of grade 3 or 4 thrombocytopenia-related events in Japaneseovarian cancer patients was similar to that in the corresponding non-Japanese study. Overall,the safety profile was acceptable and consistent with the known safety profile and previousexperience with niraparib. Trial Registration: ClinicalTrials.gov Identifier: NCT03759587
Role of coupled derivatives on flutter instabilities
Matsumoto, Masaru,Abe, Kazuhiro Techno-Press 1998 Wind and Structures, An International Journal (WAS Vol.1 No.2
Torsional flutter occurs at 2D rectangular cylinders with side ratios B/D smaller than about 8 or 10. On the other hand, slender cylinders indicate the occurrence of coupled flutter, which means the coupled derivatives of slender cylinders have more significant role for flutter instability than that of bluffer ones. In this paper, based upon so called "Step-by-step analysis", it is clarified the coupled derivatives stabilize torsional flutter instability of bluffer cylinders (e.x. B/D=5), while they destabilize torsional flutter or coupled flutter instabilities of mores slender cylinders. The boundary of them exists between B/D=5 and 8.
A Proposal for Prototype-Free Production Preparation Processes Utilizing 3DCG Animations
Shinji Shinoda,Kazuhiro Shimozawa,Akira Niwa,Takeshi Kawase,Toshiyuki Matsumoto,Tadahiro Mizumachi 대한산업공학회 2009 Industrial Engineeering & Management Systems Vol.8 No.2
As the use of 3DCAD data became widespread in designing products in manufacturing, attempts have been made to shorten lead time and reduce cost of production preparation utilizing 3DCAD data for launching assembly lines. In order to create assembly plans not only efficient but easy for operators to operate (‘easy-tooperate’), this study presents approaches, methods, and systems for creating 3DCGAs (3 Dimensional Computer Graphic Animations) which automatically utilize a prototype-free production preparation methodology. Characteristics of this study include that it proposes the methodology for creating assembly operation 3DCGAs automatically, for all the possible assembly operations corresponding each of the possible assembly sequences first. Using the created 3DCGAs, the study next considers assembly methods by evaluating how easy or ‘operator friendly’ they are in implementing, and devises tools or jigs to be used, and plans efficient assembly line organization. The concept of the methodology was formed by focusing on the value-adding assembly steps at which parts turn into products directly. The study also validates the effectiveness of the presented methodology by employing the methods used in actual production preparation process in businesses, and proves that an efficient assembly line can be organized in a shorter period of time utilizing the developed system and by preparing easy-to-operate and efficient plans in 3DCGAs at the design stage.