제왕자궁절개술시 경막외마취가 산모자궁동맥 및 태아제대동맥 도플러파형에 미치는 영향

강정배,김홍배,이근영,강성원,허진숙,김중석,원임수 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.2

Objective: To study the effects of maternal epidural anaesthesia on the maternal uterine circulation and the fetal umbilical placental circulation by using Doppler ultrasound techniques. Study Design: Twenty-seven patients delivered by elective caesarean section under lumbar epidural anaesthesia were studied. All had a normal pregnancy with no indication of fetal compromise and no indication of maternal disease. Each patient received a 1 litre intravenous crystalloid infusion over 20~30 minutes before an epidural bupivacaine injection. The uterine and fetal umbilical artery velocity waveforms were recorded. And then intravenous cannula and an epidural catheter were inserted. The local anaesthetic agent were injected through the epidural catheter(0.5% bupivacaine 10ml, 20% lidocaine 10 ml). At achieve sensory blockade to the T-4 level after the injection of the anaesthetic agent, the uterine and fetal placental circulation flow velocity-time waveforms were again recorded by using Doppler ultrasound(Multigon 500A, 4 MHz). Significance was tested by means of the paired student t-test. Results: 1. Significant differences were observed between the two groups(Before ana- esthesia, S/D ratio of fetal umbilical artery was 2.48±0.50. Following anaesthesia, S/D ratio of fetal unbilical artery was 2.24±0.40, p$lt;0.005). 2. Significant differences were observed between the two groups(Before anaesthesia, S/D ratio of maternal uterine artery was 2.29±0.41. Following anaesthesia, S/D ratio of maternal uterine artery was 1.95±0.25, p$lt;0.001). Conclusion: This study suggests a beneficial fetal effect from the improved maternal uterine perfusion after epidural anesthesia.

악성 난소종양의 임상병리학적 고찰

강정배,김홍배,이근영,강성원,허진숙,박용완,서찬호,민경택 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.4

1985년 1월부터 1994년 12월말까지 만 10년간 한림대학교부속 강남성심병원 산부인과에서 병리조직학적 검사로 확인된 악성난소종양 41예를 대상으로 임상 및 병리하적 고찰을 하여 다음과 같은 결과를 얻었다. 1. 악성 난소종양의 발생빈도는 전 난소종양의 7.1%이었다. 2. 환자의 연령분포는 20-39세에 가장 빈도가 나ㅍ아쏘, 평균연령은 42세 이었다. 3. 출산경력을 보면, 미산부군은 36.6% 이었고 원발성 불임증이 4.9%이었다. 4. 원경양상은 규칙적이었던 예가 48.8%, 폐경이 29.3%, 생리적 무월경이 2.4%였으며, 월경장애를 나타낸 경우는 19.5%이었다. 5. 자각증상은 복부종양촉지가 70.7%, 하복부동통이 63.4%, 단순 복부팽대가 19.5%, 요로증상이 19.5%, 월경장애가 12.2%순이었다. 6. FIGO에 따른 임상적 분류에 의하면 제 1기 51.2%, 제 2기 9.8%, 제 3기 26.8%, 제 4기 9.8%이었다. 7. 병리조직학적 분류는 상피성 종양이 25예(61%), 비상피성 종양이 13예(31.8%), 전이성 종양이 3예(7.2%) 였고, 그중 장액성 낭선암이 11예(26.8%)로 가장 많았고 점액성 낭선암(19.6%), 자궁내막 양선암 5에(12.2%), 명세포암 1예(2.4%) 순이었고 Krukenberg tumor 1예(2.4%), dysgerminoma 5예(12.2%), malignant teratoma 4예(9.8%)였다. 8. 병리조직학에 의한 악성난소의 양측성은 31.7%이었다. 9. 수술방법으로는 전자궁적출술과 양측 난소 및 난관절제술을 시행한 예가 51.2%로 가장 많았고 그 중 19.5%에서 대망막적출술이 시행되었다. 10. 수술의 범위는 육안적으로 완전히 제거할 수 있었던 경우가 56.1%이었다. 11. 수술 후 합병증으로는 발열 3예, 장폐쇄 2예, 창상감염 1예, 요로감염 1예가 있었다. 12. 보조요법으로 화학요법이 20예 시행되었으며 그 중 CAP 복합요법이 12예로 가장 많았으며 방사선 치료 1예, 화학요법과 방사선요법이 같이 시행된 경우도 2예 있었다. 13. CAP, VAC, VBP의 복합 화학요법의 독성으로는 오심, 구토 18예, 탈모증 15예, leukopenia 8예, thrombocytopenia 3예, anemia 4예, hepatotoxicity 3예가 있었으나 모두 경증이었다. 14. 수술 및 보조적 요법을 시행한 예의 생존율은 치료후의 추적조사가 안되어 정확한 수치를 알 수 없었으며, 다만 6예에서 5년간 생존이 확인되었고 4예에서 1년안에, 6예에서 2년안에 사망한 것으로 나타났다. A clinico-pathological study was made on a series of 41 malignant ovarian tumors treated at the Department of Obstetrics and Gynecology, Kang Nam Sacred-Heart Hospital, Hallym University from the January 1, 1985 to December 31, 1994. The results obtained were as follows: 1. The incidence of malignant ovarian tumors among all ovarian tumors was 7.1%. 2. Age distribution of malignant ovarian tumors showed the highest frequency in 3rd, 4th decade and average age was 42 years old. 3. The frequency of nulliparity was 36.6% and the primary infertility rate was 4.6%. 4. Previous menstrual cycles were normal in 48.8%, postmenopause in 29.3%, physiologic amenorrhea in 2.4% and some menstrual abnormalities in 19.5%. 5. As to the subjective sumptoms of all malignant ovarian tumors, palpable mass in the lower abdomen was noticed in 70.7%, lower abdominal pain in 63.4%, abdominal distension in 19.5%, urinary symptoms in 19.5% and menstrual abnormalities in 12.2%. 6. According to the clinical stages based on FIGO classification, stage I was seen in 51.2%, stage II in 9.8%, stage III in 26.8% and stage IV in 9.8%. 7. According to the histopathological classification of WHO, epithelial tumor was found in 61%, non-epithelial tumor in 31.8%, metastatic tumor in 7.2% and among them serous cystadenocarcinoma was found in 26.8%, mucinous cystadenocarcinoma in 19.6%, endometrioid adenocarcinoma in 12.2%, clear cell carcinoma in 2.4%, dysgerminoma in 12.2%, malignant teratoma in 98% and Krukenberg tumor in 2.4%. 8. Bilaterality was noted in 31.7% by microscopic examination. 9. Treatment was surgical primarily, and its principle was total hysterectomy with bilateral salpingo-oophorectomy with or without omentectomy, which was performed in 51.2% in our study. Postoperative complications were noticed in several cases as follows; fever, ileus, wound infection and UTI. 10. Adjuvant chemotherapy was performed on 20 cases(48.8%) and the complication of combined chemotherapy was seen as follows; nausea and vomiting, alopecia, leukopenia, thrombocytopenia, anemia, and hepatotoxicity. 11. Because of insufficient follow-up, 5 year survival rate could not be calculated, and only 6 cases of 5 year survival were recognized.

침윤성 자궁경부암 123 예에 대한 임상적 연구

강정배,김홍배,이근영,강성원,이한범,허진숙,황선태,박용완 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.4

한림대학교 부속 강남성심병원에서는 1986년부터 1994년까지 침윤성 자궁경부암으로 진단 및 치료받은 123에의 임상 양상과 임상 병기별 생존율을 구하여 다음과 같은 결과를 얻었다. 1. 연평균 환자 수 13.6명이었다. 2. 연령별 분포는 41-50세군이 전체 환자의 34.2%를 차지하여 가장 높은 발생빈도를 보였다. 3. 분만회수는 3-4회가 가장 많았으며(47.2%), 평균 3.4회였다. 4. 자궁경부암의 주된 증상은 불규칙적인 질출혈이었으며(37.4%), 접촉성 출혈이 36.6%, 대하가 10.6%였다. 5. 임상 병기별 분포는 I기가 76.4%로 가장 높은 빈도를 보였으며, II기(22.0%), III기(1.6%), IV기(0%) 순이었다. 6. 조직병리학적 분포는 편평상피세포암이 91.9%; 선암이 6.5%, 선평평상피세포암이 1.6%였다. 7. 임파절 전이는 I기에서는 17.0%, II기에서는 51.9%였다. 8. 수술후 합병증은 32명에게서 발생하였으며, 이중 22명에서 비뇨기계적인 합병증으로 4명에서 비뇨기계 감염, 16명에서 기능적인 방광기능장애가, 1명에서방광질 누공이 발생하였고, 1명에서 요관누공이 발생하였는데, 그외 3명에서 하지의 임파선부종이, 그리고 2명에서 임파낭종이 발생하였다. 9. 1986년 1월부터 1989년 12월까지 치료를 받은 58예의 침윤성 자궁경부암 환자들을 추적조사하여 임상병기별로 5년생존율을 살펴보면 다음과 같다. 1) 대상환자는 Ia기 7예, Ib기 32예, IIa기 17예였으며, IIb, III, IV,기는 환자 수의 부족으로 낼 수 없었다. 2) 5년생존율은 Ia기 100%, Ib기 78.4%, IIa기 70.6%였다. From January 1986 to December 1994, 123 cases of uterine cervical cancer were evaluated at Hallym University Kang Nam Sacred Heart Hospital, Seoul, Korea. The purpose of this study was to analyze the clinical profile and survival rate of invasive cervical cancer.The main results were as follows; 1$gt;The mean number of patients per year was 13.6 cases. 2$gt; The majority of patients, 42 cases(34.2%), was found in the group of age 14 between 41 and 50. 3$gt; The frequent number of pregnancies was 3-8 times(75.7%) and the mean number of pregnancies was 5.6 times. 4$gt; The most frequent clinical sumptoms of the invaisive carcinoma of the urerine cervix were irregular vaginal bleeding(37.4%), contact bleeding(36.6%) and leukorrhea(10.6%). 5$gt; The distributions of patients by the clinical stages were as follws; stage I, 94 cases(76.4%); stage II, 27 cases(22.0%); stage III, 2 cases(1.6%). 6$gt; The results of histopathologic subtype were distributed as follows; squamous cell carcinoma was 91.9%, adenocarcinoma was 6.5% and adenosquamous cell carcinoma was 1.6%. 7$gt; The frequency of lymphnode metastasis was 17.0% in stage I and 51.9% in stage II. 8$gt; Postoperative complications were observed in 32 patients(26.7%) undergoing radical hysterectomy with pelvic lymphadenectomy for cervical cancer and 22 patients of them had urologic complications, 4 cases of urinary tract infection, 16 of functional vesical disturbance, 1 of vesicovaginal fistula, 1 of ureteral fistula, 3 of lymphedema of lower limbs, and 2 cases of lymphocyst were found. 9$gt; We have also evaluatd the 5-year survival rate of the patients treated from January 1986 to December 1989; stage Ia, 100%: stage Ib 78.1%; stage IIa, 70.6%.

사료에 따른 혈액 및 혈액 생화학적 측정치의 차이에 대한 연구

강태석,임채형,김용규,황진희,황대연,강현구,김동훈,송점란,구준서,이미라,임화자,조정식,채갑용 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

실험동물을 이용한 생체실험 연구는 실험동물의 유전적인 특성 및 실험자가 실험동물을 취급하는 방법, 급여하는 사료, 음수와 뽄은 환경적인 요인 등에 영향을 받는다. 이러한 환경적 요인 중 사료의 영양학적인 요인은 유전적 발헌, 번식능, 수면 등에 영향을 미칠 수 있으며, 면역 능력이나 환경적 스트레스에 적응하는 능력에도 영향을 줄 수 있다. 급여되는 사료에 따른 실험동물의 혈액학치, 혈액생화학치, 장기무게 및 체중 등의 ·탱리학적 차이의 자료곡보로 독성시험 등 생체이용 실험결과의 오차를 줄아고 신뢰성 있는 실험결과를 확보하고자 한다. 생산 시판되는 2종의 사료(국내생산사료, 미국생산사료)를 급여한 ICR 마우스 두 군과 5)1 랫드 두 군을 각각 5, 10, 20주령에 심장채혈하여 혈액학적 검사와 혈액생화학적 검사를 실시하였고, 채혈후 부검하여 장기무게를 측정하였다. 마우스에서는 호중구,림프구, 단구, 평균 적혈구 혈색소량, 평균적혈구 혈색소농도 등과 CL, GLU, LD,7G, CA 등바 급여 사료에 따른 차이를 나타냈다 또한 주령별 혈액학치와 혈액생화학치는 평균적혈구용적, CL, Na 등에서 5주령과 10주령 사이에 감소하는 경향을 나타내었다. 랫드에서는 평균적혈구용적, 평균적혈구 혈꺽 소농도, 적혈구용적, 혈색소, 퍽혈구, CHOL, CL, TG, CREA 등에 사료에 따른 차이를 나타내었다. 주령별 차이는 5주령과 10준련 사이에 적혈구수와 CHOL농도에서의 증.가, ALP와 GLU활성도의 감소, 그리고 5, 10,_20주령에 꼰 평균적혈구용적의 감소로 나타났다. 6개월령과 1년령에서도 혈액학치, 혈액생화학치, 장기무게 등을 확보할 것이며 이를 통해 급여 사료 종류별 비교 자료를 제공하고자한다. Experiments using laboratory animals are affected by experimental conditions including animal care and handling, diet and water. Nutritional factor of diet effects reproduction, immune response and response for stressful condition. The study reported here is to provide information that are hematologic and biochemical values, organ massees and body weights in two kind of diet. Commercial diet made in Korea was provided ICR mouse and SD rat. And USA diet used commonly was wupplied the same breed. Whole blood was collected by use of cardiac puncture at 5, 10, 20 weeks of age. Blood was further evaluated for hematology and serum chemistry. Total body and organ masses were determined after blood collection. There were significant differences in neutrophil, lymphocyte and monocyte counts, MCH(Mean Corpuscular Hemoglobin), MCHC(Mean Corpuscular Hemoglobin Concentration), CL, GLU, LD, TG and CA between two groups of ICR mouse. And differences were found in MCV(Mean Corpuscular Volume), MCHC, hematocrit, hemoglobin, erythrocyte counts, CHOL, CL, TG and CREA between two group of SD rat. Hematology, serum chemistry, body and organ masses are to be evaluated at 31, 57 weeks of age.

산전 초음파로 진단된 골형성부전증 Type II 1 례

강정배,김홍배,이근영,강성원,박금자,허진숙,김중석 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1

Osteogenesis imperfecta is a relatively rare genetic condition of breakable bones with an incidence of 1 per 20,000~60,000. The clinical, genetic, and biochemical heterogeneity in osteogenesis imperfecta allows to least four subtypes to be distinguished. Prenatal diagnosis of osteogenesis imperfecta type II have been reported several times with ultrasonography. We recently experienced a case of osteogenesis imperfecta diagnosed in uterus by ultrasonogram and confirmed after termination and autopsy. We report here with a brief review of the literature.

AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants

Kang, CH,Jung, WY,Kang, YH,Kim, JY,Kim, DG,Jeong, JC,Back, DW,Jin, JB,Lee, JY,Kim, MO,Chung, WS,Mengiste, T,Kolwa, H,Kwak, SS,Bahk, JD,Lee, SY,Nam, JS,Yun, DJ,Cho, MJ Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

Calmodulin (CaM) influences many cellular processes by interacting with various proteins. Here, we isolated AtBAG6, an Arabidopsis CaM-binding protein that contains a central BCL-2-associated ethnogeny (BAG) domain. In yeast and plants, overexpression of AtBAG6 induced cell death phenotypes consistent with programmed cell death (PCD). Recombinant AtBAG6 had higher affinity for CaM in the absence of free Ca^2+ than in its presence. An IQ motif(IQXXXRGXXXR, where X denotes any amino-acid) was required for Ca^2+ -independent CaM complex formation and single amino-acid changes within this motif abrogated both AtBAG6-activated CaM-binding and cell death in yeast and plants. A 134-amino-acid stretch, encompassing both the IQ motif and BAG domain, was sufficient to induce cell death. Agents generating oxygen radicals, which are known to be involved in plant PCD, specifically induced the AtBAG6 transcript. Collectively, these results suggest that AtBAG6 is a stress-upregulated CaM-binding protein involved in plant PCD.

난소에 발생한 Sertoli-Leydig Cell Tumor 1 례

강재성,최준식,김용민,이경주,문정석 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

A case of Sertoli-Leydig cell tumor of ovary causing virilization in a post-menopause woman is presented. The patient had increasing facial hair growth, deepening of the voice, a dull pain in the lower part of the abdomen. Considering an ovarian tumor the most likely cause of the above mentioned findings, hysterectomy with bilateral salpingo-oophorectomy was performed. The Sertoli-Leydig cell tumor accounts for less than 0.2-0.5% of all ovarian tumors and belongs to sex cord stromal ovarian tumor. This tumor is the most common type of all virilizing ovarian tumors. This case is presented with a brief review of the literature.

Session Ⅱ : Biochemical Pharmacology and Natural Product Chemistry : A STUDY ON THE PHYSICAL PROPERTIES OF NATIVE AND MODEL MEMBRANES : MICROVISCOSITY AND LOCATION OF 1,3- DI (1- PYRENYL ) PROPANE

JS Kang,I Yun 생화학분자생물학회(구 한국생화학분자생물학회) 1994 추계학술대회집 Vol.- No.-

Session B : Carbohydrates , Lipids and Natural Product Chemistry : EFFECTS OF LINDANE ON MICROVISCOSITY OF BRAIN MEMBRANES

JS Kang,Yun 생화학분자생물학회(구 한국생화학분자생물학회) 1993 추계학술대회집 Vol.- No.-

원발성 난관암 1 예

정재숙(JS Chung),이인우(IW Lee),장중환(CH Chang),곽소명(SM Kwak),강재성(JS Kang),김정례(JR Kim) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.7

저자들은 1984년 1월, 본원 산부인과에서 수술후 병리조직학적으로 확진된 원발성난관암 1예를 치험하고, 그 발생빈도가 극히 적은 점에 비추어, 문헌고찰과 함께 보고하는 바이다.