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MPLS망에서의 Soft Preemption 개선 메커니즘 설계
김동희,강승찬 한국기술교육대학교 2003 論文集 Vol.10 No.1
최근 다변화하는 MPLS망에서 재경로(Reroute)를 통한 Traffic Engineering의 필요성이 강조되고 있다. 따라서 기존 LSP에서 새로운 LSP로의 reroute시 traffic의 손실을 최소화 하면서 망의 안정성에 영향을 주지 않는 유연한 메커니즘에 대한 개발이 요구되고 있다. RSVP-TE signling을 통한 LSP 수립 방법을 개선하기 위해 제시된 Soft Preemption 기술은 전송 중인 traffic을 보장할 수 있으나, 경로설정에 대한 모든 처리를 HE가 담당함으로써 시간적 낭비를 초래하게 되었다. 본 논문에서는 RESIGNAL_DATA object를 제안하여 기존 LSP를 재사용하도록 함으로써 reroute시 LSP 재수립 시간을 단축시킬 수 있는 메커니즘을 제시한다. The Reroute is very important mechanism of the Traffic Engineering in MPLS. The adaptive and smooth rerouting requirement necessitates establishing a new LSP tunnel and transferring traffic from the old LSP tunnel onto it before tearing down the old LSP tunnel. Soft preemption protect in-transit traffic using RSVP-TE signaling. But much time is needed because HE make new LSP. In this paper, a RESIGNAL_DATA object is proposed to complement soft preemption. Advanced soft preemption reduce time to make new LSP reusing old LSP.
Kang, Dong Woo,Lee, Shin Wha,Hwang, Won Chan,Lee, Bo Hui,Choi, Yong-Seok,Suh, Young-Ah,Choi, Kang-Yell,Min, Do Sik American Association for Cancer Research 2017 Cancer Research Vol.77 No.1
<P>A phospholipase that functions as a nodal modifier of colon cancer susceptibility mediates the cross-talk between two major tumor suppressor and oncogenic pathways, with implications for disease-selective therapeutic targeting.</P><P>The RB1/E2F1 signaling pathway is frequently deregulated in colorectal cancer and has been suggested to intersect with Wnt/β-catenin and PI3K/Akt pathways, but molecular evidence for this link is lacking. In this study, we demonstrate that phospholipase D1 (PLD1), a transcriptional target of β-catenin/TCF4, orchestrates functional interactions between these pathways during intestinal tumor development. Overexpression of PLD1 in intestinal epithelial cells protected cells from apoptosis induced by PLD1 ablation in the <I>Apc<SUP>min/+</SUP></I> mouse model of intestinal tumorigenesis. Mechanistic investigations revealed that genetic and pharmacologic targeting of PLD1 promote the E2F1-dependent apoptotic program via both miR-192/4465–mediated downregulation of RB1 and inhibition of Akt–TopBP1 pathways. Moreover, the miRNA–RB1 axis and Akt pathway also contributed to the PLD1-mediated self-renewal capacity of colon cancer–initiating cells. Finally, PLD1-driven E2F1 target gene expression positively correlated with tumor stage in patients with colorectal cancer. Overall, our findings suggest that PLD1 mediates cross-talk between multiple major signaling pathways to promote the survival and malignancy of colon cancer cells and may therefore represent an ideal signaling node for therapeutic targeting. <I>Cancer Res; 77(1); 142–52. ©2016 AACR</I>.</P>
Kang, Dong Woo,Lee, Bo Hui,Suh, Young-Ah,Choi, Yong-Seok,Jang, Se Jin,Kim, Yong Man,Choi, Kang-Yell,Min, Do Sik American Association for Cancer Research 2017 Clinical Cancer research Vol.23 No.23
<P><B>Purpose:</B> Dysregulated expression of PLD1 has emerged as a hallmark feature of colorectal cancer, which remains a major cause of mortality worldwide. Aberrant activation of Wnt/β-catenin signaling is a critical event in the development of colorectal cancer. Here, we investigated molecular crosstalk between the Wnt/β-catenin and PI3K/Akt pathways via inhibitor of β-catenin and T-cell factor (ICAT), a negative regulator of Wnt/β-catenin signaling. We also explored the effect of PLD1 inhibition on growth of colorectal cancer hyperactivated by Wnt/β-catenin and PI3K/Akt signaling.</P><P><B>Experimental Design:</B> Expression of ICAT via targeting of PLD1 was assessed <I>in vivo</I> in <I>Apc<SUP>Min/</SUP></I><SUP>+</SUP> mice, an AOM/DSS model, and <I>in vitro</I> using various colorectal cancer cells. The relationship between ICAT/PLD1 expression and prognostic survival value of 153 colorectal cancer patients was examined. The therapeutic efficacy of PLD1 inhibitor was determined using a patient-derived xenograft model carrying <I>APC</I> and <I>PI3K</I> mutations.</P><P><B>Results:</B> PLD1 promoted the Wnt/β-catenin signaling pathway by selectively downregulating ICAT via the PI3K/Akt-TopBP1-E2F1 signaling pathways. Low PLD1 expression and high ICAT expression were significantly associated with increased survival in colorectal cancer patients and vice versa. Furthermore, PLD1 inhibition suppressed growth of colorectal cancer activated by the Wnt/β-catenin and PI3K signaling pathways.</P><P><B>Conclusions:</B> These results suggest that PLD1 linked to ICAT mediates molecular crosstalk between the Wnt/β-catenin and PI3K/Akt pathways and thus could be proposed as a novel colorectal cancer prognostic biomarker. These results may assist in the clinical development of a PLD1 inhibitor for treatment of colorectal cancer patients carrying <I>APC</I> and <I>PI3KCA</I> mutations. PLD1, a nodal modifier, acts as a potential therapeutic target for the treatment of colorectal cancer hyperactivated by the Wnt/β-catenin and PI3K/Akt signaling pathways. <I>Clin Cancer Res; 23(23); 7340–50. ©2017 AACR</I>.</P>
강희동 ( Hui Dong Kang ),오세현 ( Se Hyun Oh ),정상구 ( Sang Ku Jung ) 대한스포츠의학회 2017 대한스포츠의학회지 Vol.35 No.3
Immersion pulmonary edema (IPE) is a form of pulmonary edema that can occur in divers or swimmers. IPE is a rare condition, but can be life-threatening and recurrent condition. The pathophysiology of IPE is still incompletely understood. We present a case of scuba diving induced pulmonary edema in a 46-year-old woman diving in cold seawater. After 20 minutes of diving at 18 m, she felt difficulty of breathing. Symptoms on surfacing were dyspnea, cough, and frothy sputum. Chest X-ray showed pulmonary edema and she was treated with an intravenous diuretic and supplemental oxygen. The patient showed rapid resolution of symptoms and was discharged on the same day. Sport physician should be aware of this potentially life-threatening recurrent condition.
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 사염화탄소 투여 흰쥐에서 간 섬유화 진행에 따른 Propranolol의 약물동태지표와 간문맥-체순환 단락지수에 관한 연구
고동희 ( Go Dong Hui ),김동욱 ( Kim Dong Ug ),박근태 ( Park Geun Tae ),이성희 ( Lee Seong Hui ),김진배 ( Kim Jin Bae ),이항락 ( Lee Hang Lag ),조현석 ( Jo Hyeon Seog ),함준수 ( Ham Jun Su ),최윤영 ( Choe Yun Yeong ),강주섭 ( Kang 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
Dong Hui Ko,Shin Taek Jeong,Hong-Yeon Cho,Keum-Seok Kang 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.1
For the design of wind-power facilities, the highest and lowest astronomical tides (HAT and LAT, respectively) are needed for the tidal-water levels regarding international designs; however, the approximate highest high water and approximate lowest low water AHHW and ALLW, respectively, have been used in Korea. The HAT and LAT in the wind-farm test-bed sea should be estimated to satisfy the international standard. In this study, the HAT and LAT are therefore estimated using the hourly tidal-elevation data of the Eocheongdo, Anmado, Younggwang, Gunsan, Janghang, and Seocheon tidal-gauging stations that are located in the adjacent coastal sea. The nodal variation patterns of the major lunar components, such as M2, O1, and K1 are analyzed to check the expected long-term lunar cycle, i.e., 18.61 year's nodal-variation patterns. The temporal amplitude variations of the M2, O1, and K1 clearly show the 18.61-years periodic patterns in the case of the no-nodal correction condition. In addition, the suggested HAT and LAT elevations, estimated as the upper and lower confidence limits of the yearly HAT and LAT elevations, are 50 cm greater than the AHHW and 40 cm lower than the ALLW, respectively.
New Species of the Genus Mycale from Ieodo Ocean Research Station, Korea
Dong Won Kang,Sang-Hui Lee,Hyung June Kim 한국동물분류학회 2019 Animal Systematics, Evolution and Diversity Vol.35 No.4
A new marine sponges, Mycale (Carmia) ieoensis n. sp., of the family Mycalidae was collected SCUBA diving in June 2017 from Ieodo Ocean Research Station, Korea. M. (C.) ieoensis n. sp. is encrusting to irregular massive type, yellow in life. This new species is similar to M. nullarosette Hoshino, 1981 in color and growth form but it differs in spicule size and sigma shape. Spicule size of M. (C.) ieoensis n. sp. smaller than that M. nullarosette. Also, M. (C.) ieoensis n. sp. has two size toxa, but M. nullarosette is not. The new species are compared to other Mycale species from the Korean region, and similar species from elsewhere.
A Virtual Optical Encryption System Based on Polarization Optics
Kang-Ning Wu,Yu-Xiang Zheng,Dong-Xu Zhang,Yu-Hui Tao,Rong-Jun Zhang,Liang-Yao Chen 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.8
In this paper, an encryption system is proposed based on polarization optics. A modulated image at reference plane was obtained by using a virtual magneto-optical modulator, and the field from the reference plane interfered with that from the information plane having the original image to form an encrypted image. This system not only has the advantages of multiple freedom degrees, high security strength and data manipulation in high-dimension as the traditional optical information processing system but also possesses the advantages of data processing flexibility in the computer information process. Numerical experiments prove that images encrypted by using this system have a high level of security, so it is hard for attackers to analyze the original images.
DONG, JILING,YU, HUI,YOO, DAE-HWANG,HUYNH, QUOCBAO,SHIN, KEESAM,KIM, MINSOO,KANG, SUNGTAE World Scientific 2009 International Journal of Modern Physics B Vol.23 No.6
<P>Investigated in this study are precipitate evolution with and without addition of W , Co , and B in two kinds of 9-12% Cr steels (named as A and B ) used for power plants after various aging time and temperature using OM, SEM, TEM, etc. Three kinds of precipitates ( Cr -rich M23C6, Nb -rich and V -rich MX, W -rich and Mo -rich Laves phase) were observed and investigated in the two alloys. Upon aging, the area fraction of M23C6increased whereas that of Laves phases decreased despite of increase in size. The area fraction of W -rich Laves phase was much higher than that of Mo -rich Laves phase, indicating that W addition, compared to that of Mo addition, is more powerful in the formation of Laves phase precipitation (specimen A ). The martensitic microstructure of specimen B was more stable than that of specimen A due to the addition of cobalt and boron. The tensile test and impact test were measured and studied in relation to the long term aging effect.</P>