만성기침 환자의 면역학적 지표와 기도과민성

나문준,백만순 凡石學術奬學財團 2000 凡石學術論文集 Vol.4 No.-

치료하지 않은 폐암 환자군의 생존율

백만순,나문준 凡石學術奬學財團 2000 凡石學術論文集 Vol.4 No.-

Facile and fast Na-ion intercalation employing amorphous black TiO_2-x/C composite nanofiber anodes

Lee, Na-Won,Jung, Ji-Won,Lee, Jun-Seo,Jang, Hye-Yeon,Kim, Il-Doo,Ryu, Won-Hee Elsevier 2018 ELECTROCHIMICA ACTA Vol.263 No.-

<P><B>Abstract</B></P> <P>Structural and electronic modification of titanium oxide (TiO<SUB>2</SUB>) nanomaterials induced by the co-introduction of fully disordered glass phase and oxygen vacancies can lead to remarkable advances in the electrode performance in emerging energy storage systems. We report on the effective co-creation of fully amorphous nanofibers (NFs) composed of black TiO<SUB>2-x</SUB> and conductive carbons throughout the NF structure, and evaluate the materials as potential anodes in sodium-ion batteries. The black TiO<SUB>2-x</SUB> nanofiber is successfully fabricated by electrospinning a precursor solution followed by a two-step sequential thermal treatment in an air and reducing atmosphere. The NF electrode could deliver approximately two-fold higher 2nd discharge capacity and an excellent kinetic performance even under high rates compared to that delivered by anatase-structured white TiO<SUB>2</SUB> NFs used as reference, because of (i) an inherent free volume in the glass phase corresponding to the enlarged Na<SUP>+</SUP> sites, (ii) increased electrical conductivity (low bandgap) resulting from the presence of Ti<SUP>3+</SUP>, (iii) introduction of conductive carbon agents around the TiO<SUB>2-x</SUB> domain, and (iv) one-dimensional NF feature allowing numerous Na<SUP>+</SUP> reaction sites at the electrochemical interface. We also elucidate the morphological and structural changes in the nanofibers after discharge and charge by <I>ex-situ</I> characterizations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We succeed in co-creating amorphous nanofiber structure composed of black TiO<SUB>2-x</SUB> and conductive carbons. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofibers are prepared by electrospinning followed by a two-step thermal treatment. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofiber delivers excellent electrochemical performance compared to those of anatase TiO<SUB>2</SUB> nanofiber. </LI> <LI> The benefits and reaction mechanism of the black TiO<SUB>2-x</SUB>/carbon nanofiber anode in the Na-ion cell operation is elucidated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

논에서 우분액비 시용이 총체보리 및 이탈리안 라이그라스의 생산성과 사료가치 및 환경오염에 미치는 영향

최기춘,나상필,정민웅,임영철,박형수,김종근,김원호,김맹중,최기준,김명화,이상락,김다혜,육완방,Choi, Ki-Choon,Na, Sang-Pil,Jung, Min-Woong,Lim, Young-Chul,Park, Hyung-Su,Kim, Jong-Geun,Kim, Won-Ho,Kim, Maeng-Jung,Choi, Gi-Jun,Kim, Myeong-Hwa,L 한국축산환경학회 2012 축산시설환경학회지 Vol.18 No.2

본 연구는 논에서 조사료 생산을 위한 작부형태별 우분액비의 시용효과를 규명하기 위하여 총체 벼 재배 후 우분액비 시용에 따른 총체보리 및 IRG의 생산성, 사료가치, 토양성분 및 용탈수중의 무기물 농도를 조사하였다. 본 연구는 2006년 5월부터 2009년 4월까지 3년 동안 전라북도 김제군 백산면 시험포장에서 완전임의배치 3반복으로 수행되었다. 총체보리의 2년간 평균수량은 7,520 kg/ha, 그리고 IRG는 평균 10,320 kg/ha으로 IRG가 총체보리 보다 현저하게 높은 수량을 보였다 (p<0.05). 이탈리안 라이그라스는 1번초가 2번초 보다 약 2배 이상의 수량을 보였다. IRG의 조단백질 함량은 총체보리보다 높았고 NDF, ADF 및 TDN 함량은 작물간에 큰 차이는 보이지 않았다. 경작형태별 우분액비 시용에 따른 토양내 pH, $P_2O_5$, T-N, OM 농도는 시험전에 비해 시험종료 후에 현저하게 증가하는 경향을 나타냈다 (p<0.05). 경작형태별 우분액비 시용에 따른 토양내 Ca, Na, Mg 및 K 농도는 시험전에 비해 시험종료 후에 현저하게 증가하는 경향을 나타냈다 (P<0.05). 경작형태별 우분액비 시용에 따른 용탈수중 $NH_4$-N, $NO_3$-N, $PO_4$-P, Cl, Ca, K, Mg, Na의 농도는 경작형태에 따른 확실한 차이를 보여주지 않았다. 따라서 논에서 우분액비를 이용하여 동계작물을 재배할 경우에는 수량도 중요하지만 환경적인 부분도 고려하여 우분액비를 이용해야 한다. This study was conducted to investigate the effects of cattle slurry on productivity of whole crop barley and Italian ryegrass and environmental pollution in paddy land. Cropping systems used in this study were consisted of two designs, such as whole crop barley applied with cattle slurry (WCB) and Italian ryegrass applied with cattle slurry (IRG). The field experiments were conducted on the clay loam at Backsanmyun, Kimje, Chunlabukdo province in Korea for three years (May 2006 to Apr. 2009). This study was arranged in completely randomized design with three replicates. The yields of WCB and IRG were 7,520 kg/ha and 10,320 kg/ha, respectively. The yields of IRG significantly increased as compared with that of WCB (p<0.05). The yield of Italian ryegrass in 1st cutting time was about 2-fold higher than that of 2nd cutting time. The contents of crude protein of IRG were higher than that of WCB. However, the contents of NDF, ADF and TDN were no difference between WCB and IRG treatments. The pH, and contents of T-N, $P_2O_5$ and organic matter (OM) in soil samples collected at the end of the experiment increased as compared with those at the beginning of the experiment (p<0.05). After the end of experiment, the concentrations of CEC (Ca, Na, Mg and K) in soil samples collected at the end of the experiment were remarkably higher than those at the beginning of the experiment (p<0.05). The concentrations of $NH_4$-N, $NO_3$-N, $PO_4$-P, Cl, Ca, K, Mg and Na in leaching water in paddy land cultivated with WCB and IRG were no difference between WCB and IRG treatments.

Insecticidal toxicities of carvacrol and thymol derived from Thymus vulgaris Lin. against Pochazia shantungensis Chou & Lu.

Jun?Hwan Park,Na-Hyun Lee,Sang-Guei Lee,Hoi-Seon Lee 한국농약과학회 2017 한국농약과학회 학술발표대회 논문집 Vol.2017 No.4

소아 심장 CT 검사시 Dual Source CT의 High pitch mode를 이용한 선량감소에 관한 연구

이예나(Ya Na Lee),강헌효(Heon Hyo Kang),손성실(Sung Sil Son),박찬혁(Chan Hyuk Park),현진경(Jin Kyung Hyun),신명호(Myung Ho Shin),김준혁(Jun Hyuk Kim),강동원(Dong Won Kang) 대한CT영상기술학회 2012 대한CT영상기술학회지 Vol.14 No.1

I. Purpose This study examines if accurate images can be realized with less dose than sequential mode, one of the existing methods applying DSCT’s high-pitch mode in pediatric cardiography. II. Materials and Methods For 20 patients who came to our hospital from Jan. 1 to Jun. 30, 2011, a test was carried out using MDCT 128 channel dual source; Somatom Definition Flash (Siemens Medical System: Germany). As the test method, the veins of the lower limbs of the patients were secured and contrast medium of 7ml was injected at 0.3ml/s anda CT scan was carried out about 36 s. later. Af first, sequential mode was used, and then high-pitch mode was followed as follow-up examination. The DLP (Dose Length Product) provided by the equipment and effective dose were compared for the assessment of the dose exposed to the patients, after the CT scan. The effective does was calculated by multiplying children’s chest index: 0.021 of the effective dose rate of EUR16262 (European Guide) to DLP value. The images scaned in high-pitch method were compared and assessed quantitatively by a heart decoding specialist and 2 radiologists if the typical diseases of pediatric cardiacs such as coarctation of aorta, atresia of the pulmonary artery and Tetralogy of Fallot can be assessed. III. Results When it was compared to sequential mode, one of the existing cardiography, the effective dose exposed to the patient had decrease by 32% in high-pitch mode. As a result of a comparison with imaging assessment, it was also evaluated as a better imaging than sequential mode IV. Conclusion Pediatric Cardiography using high pitch in Dual source MDCT showed superior effects on the reduction of exposed does than sequential mode, which is considered a useful testing method. 목적 본 연구에서는 소아 심장 검사 시 DSCT의 High-pitch mode를 적용하여 기존의 검사방법 중 하나인 Sequential mode보다 적은 선량으로도 정확한 영상을 구현할 수 있는지 알아본다. 대상 및 방법 2011년 1월 1일부터 6월 30일까지 본원에 내원한 20명의 환자를 대상으로 하여 MDCT 128 channel dual source; Somatom Definition Flash(Siemens medical system: Germany) 장비를 사용하여 검사를 시행하였다. 검사방법은 환자의 하지에 정맥을 확보하고 조영제를 0.3 ml/s로 7ml를 주입한 후 36초 후에 CT검사를 하였다. 처음에는 Sequential mode로 검사한 후 추적 검사할 땐 High-pitch mode로 검사한다. 환자가 받은 피폭선량의 평가는 선량평가는 CT검사 후 장비에서 제공하는 DLP(dose length product)와 유효선량(effective dose)를 비교하였다. 유효선량은 DLP 값에 EUR16262(European Guide) 유효선량비 중 소아 흉부 지수 0,021을 곱하여 계산하였다. 검사한 영상을 심장 판독 전문의 1명과 방사선사 2명이 high-pitch mode로 검사한 영상을 소와 심장의 대표적 질환인 대동맥협착증, 폐동맥 폐쇄증, 팔로씨 사증을 평가할 수 있는지 비교하여 정성적으로 평가하였다. 결과 기존의 심장 검사방법 중 하나인 Sequential mode와 비교했을 때 High pitch mode로 검사했을 때에 32%의 선량 감소 효과가 있었다. 또한 영상 평가 비교 결과 Sequential mode 보다 좋은 영상으로 평가되었다. 결론 Dual source MDCT로 소아심장 검사를 할 때 high pitch mode를 이용하면 sequential mode로 검사했을 때보다 환아가 받는 피폭선량은 낮고 더 우수한 영상을 획득하여 심장질환을 진단하는데 유용한 검사법으로 사료된다.

Nematicidal and egg‐hatching inhibition activities of Kaempferia galanga rhizome‐derived materials and constituents toward root‐knot nematode (Meloidogyne incognita)

Tae‐Kyun Hong,Kym‐Na‐Ra Hwang,Jun‐Ran Kim,Young‐Joon Ahn 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10

The toxicity of Kaempferia galanga rhizome materials and constituents against Meloidogyne incognita second‐stage juveniles (J2) and eggs were examined. The active principles of K. galanga rhizome were identified as the phenylpropanoids ethyl (E)‐cinnamate (EC, 1) and ethyl (E)‐p‐methoxycinnamate (EMC, 2) by spectroscopic analysis. Results were compared with those of carbofuran, fosthiazate, and metam‐sodium. In direct‐contact mortality bioassay, EC (LC50, 0.037 mg/ml) was the most toxic constituent, followed by EMC (0.041 mg/ml). EC was more effective than carbofuran (LC50, 0.092 mg/ml) but less active than fosthiazate (0.002 mg/ml). EC, egg hatch was inhibited 100, 93, and 87% at 125, 62.5, and 31.25 μg/ml, respectively. EMC caused 100, 81, and 75% inhibition of egg hatch at 125, 62.5, and 31.25 μg/ml, respectively. The inhibition of two phenylpropanoids were similar or more inhibition to that of either carbofuran or metam‐sodium but was lower than that of fosthiazate. In contact + fumigant mortality bioassay, EC and EMC treatments resulted in 86 and c 73% mortality at 0.5 and 0.125 mg/g soil, respectively. The lethality of these phenylpropanoids was almost similar to that of either carbofuran or metam‐sodium but was lower than that of fosthiazate. In vapor‐phase mortality bioassay, EC and EMC were more effective in closed container than open containers, indicating that the mode of delivery of these compounds was, in part, a result of vapor action. K. galanga rhizome‐derived materials, merit further study as potential nematicides and hatching inhibitors for the control of M. incognita populations.

Structural basis for the ATP-independent proteolytic activity of LonB proteases and reclassification of their AAA+ modules.

An, Young Jun,Na, Jung-Hyun,Kim, Myung-Il,Cha, Sun-Shin Microbiological Society of Korea 2015 The journal of microbiology Vol.53 No.10

<P>Lon proteases degrade defective or denature proteins as well as some folded proteins for the control of cellular protein quality. There are two types of Lon proteases, LonA and LonB. Each consists of two functional components: a protease component and an ATPase associated with various cellular activities (AAA+ module). Here, we report the 2.03 -resolution crystal structure of the isolated AAA+ module (iAAA+ module) of LonB from Thermococcus onnurineus NA1 (TonLonB). The iAAA+ module, having no bound nucleotide, adopts a conformation virtually identical to the ADP-bound conformation of AAA+ modules in the hexameric structure of TonLonB; this provides insights into the ATP-independent proteolytic activity observed in a LonB protease. Structural comparison of AAA+ modules between LonA and LonB revealed that the AAA+ modules of Lon proteases are separated into two distinct clades depending on their structural features. The AAA+ module of LonB belongs to the -H2 & Ins1 insert clade (HINS clade)- defined for the first time in this study, while the AAA+ module of LonA is a member of the HCLR clade.</P>

Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

Song, Daesub,Kim, Hyekwon,Na, Woonsung,Hong, Minki,Park, Seong-Jun,Moon, Hyoungjoon,Kang, Bokyu,Lyoo, Kwang-Soo,Yeom, Minjoo,Jeong, Dae Gwin,An, Dong-Jun,Kim, Jeong-Ki Society for General Microbiology 2015 The Journal of general virology Vol.96 No.2

<P>We investigated the infectivity and transmissibility of the human seasonal H3N2, pandemic (pdm) H1N1 (2009) and B influenza viruses in dogs. Dogs inoculated with human seasonal H3N2 and pdm H1N1 influenza viruses exhibited nasal shedding and were seroconverted against the viruses; this did not occur in the influenza B virus-inoculated dogs. Transmission of human H3N2 virus between dogs was demonstrated by observing nasal shedding and seroconversion in naïve dogs after contact with inoculated dogs. The seroprevalence study offered evidence of human H3N2 infection occurring in dogs since 2008. Furthermore, serological evidence of pdm H1N1 influenza virus infection alone and in combination with canine H3N2 virus was found in the serum samples collected from field dogs during 2010 and 2011. Our results suggest that dogs may be hosts for human seasonal H3N2 and pdm H1N1 influenza viruses.</P>

Acute inflammation reveals GABAA receptor‐mediated nociception in mouse dorsal root ganglion neurons via PGE ₂ receptor 4 signaling

Jang, In Jeong,Davies, Alexander J.,Akimoto, Nozomi,Back, Seung Keun,Lee, Pa Reum,Na, Heung Sik,Furue, Hidemasa,Jung, Sung Jun,Kim, Yong Ho,Oh, Seog Bae John Wiley and Sons Inc. 2017 Physiological reports Vol.5 No.8

<P><B>Abstract</B></P><P>Gamma‐aminobutyric acid (GABA) depolarizes dorsal root ganglia (DRG) primary afferent neurons through activation of Cl<SUP>−</SUP> permeable GABAA receptors but the physiologic role of GABAA receptors in the peripheral terminals of DRG neurons remains unclear. In this study, we investigated the role of peripheral GABAA receptors in nociception using a mouse model of acute inflammation. In vivo, peripheral administration of the selective GABAA receptor agonist muscimol evoked spontaneous licking behavior, as well as spinal wide dynamic range (WDR) neuron firing, after pre‐conditioning with formalin but had no effect in saline‐treated mice. GABAA receptor‐mediated pain behavior after acute formalin treatment was abolished by the GABAA receptor blocker picrotoxin and cyclooxygenase inhibitor indomethacin. In addition, treatment with prostaglandin E2 (PGE<SUB>2</SUB>) was sufficient to reveal muscimol‐induced licking behavior. In vitro, GABA induced sub‐threshold depolarization in DRG neurons through GABAA receptor activation. Both formalin and PGE<SUB>2</SUB> potentiated GABA‐induced Ca<SUP>2+</SUP> transients and membrane depolarization in capsaicin‐sensitive nociceptive DRG neurons; these effects were blocked by the prostaglandin E2 receptor 4 (EP4) antagonist AH23848 (10 <I>μ</I>mol/L). Furthermore, potentiation of GABA responses by PGE<SUB>2</SUB> was prevented by the selective Na<SUB>v</SUB>1.8 antagonist A887826 (100 nmol/L). Although the function of the Na<SUP>+</SUP>‐K<SUP>+</SUP>‐2Cl<SUP>‐</SUP> co‐transporter NKCC1 was required to maintain the Cl<SUP>‐</SUP> ion gradient in isolated DRG neurons, NKCC1 was not required for GABAA receptor‐mediated nociceptive behavior after acute inflammation. Taken together, these results demonstrate that GABAA receptors may contribute to the excitation of peripheral sensory neurons in inflammation through a combined effect involving PGE<SUB>2</SUB>‐EP4 signaling and Na<SUP>+</SUP> channel sensitization.</P>