조정선수의 좌심실 비대에 관한 연구

김영준,김복주,김주혁 東亞大學校 附設 스포츠科學硏究所 1993 스포츠科學硏究論文集 Vol.11 No.-

The purpose of this study was to elucidate the left ventricular hypertrophy of the rowers and non-athletes. Left ventricular dimensions measured by 2-dimension echocardiography. For the subjects this experiment, 10 rowers(Age : 19.9) and 7 non-athlets(Age : 23.1) were choson from collage. The conclusion obstained were as follows. Rowers demanstrated significantly greater left ventricular end-diastolic and systolic dimensions(LVDD and LVSD) compared to non-athletes, but LVDD/S and LVSD/S did not differ significantly to non-athletes(s : body surface area) In rowers, this was due to increase left ventricular septum(end-systolic and diastolic) and posterior wall thickness(end-systolic and diastolic) compared to non-athletes. Rowers demonstrated significantly greater left ventricular mass compared to non-athletes(268.9g vs 135.7g).

Metagenomic Analysis of Fungal Communities Inhabiting the Fairy Ring Zone of Tricholoma matsutake

( Miae Kim1 ),( Hyeok Jun Yoon ),( Young Hyun You ),( Ye Eun Kim ),( Ju Ri Woo ),( Yeong Gyo Seo ),( Gyeong Min Lee ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.10

Tricholoma matsutake, an ectomycorrhiza that has mutual relationships with the rootlet of Pinus denisflora, forms a fruiting body that serves as a valuable food in Asia. However, the artificial culture of this fungus has not been successful. Soil fungi, including T. matsutake, coexist with many other microorganisms and plants; therefore, complex microbial communities have an influence on the fruiting body formation of T. matsutake. Here, we report on the structures of fungal communities associated with the fairy ring of T. matsutake through the pyrosequencing method. Soil samples were collected inside the fairy ring zone, in the fairy ring zone, and outside the fairy ring zone. A total of 37,125 sequencing reads were obtained and 728 to 1,962 operational taxonomic units (OTUs) were observed in the sampling zones. The fairy ring zone had the lowest OTUs and the lowest fungal diversity of all sampling zones. The number of OTUs and fungal taxa inside and outside the fairy ring zone was, respectively, about 2 times and 1.5 times higher than the fairy ring. Taxonomic analysis showed that each sampling zone has different fungal communities. In particular, out of 209 genera total, 6 genera in the fairy ring zone, such as Hemimycena, were uniquely present and 31 genera, such as Mycena, Boletopsis, and Repetophragma, were specifically absent. The results of metagenomic analysis based on the pyrosequencing indicate a decrease of fungal communities in the fairy ring zone and changes of fungal communities depending on the fairy ring growth of T. matsutake.

청소년 비행의 영향 요인 분석

김혁주 朝鮮大學校 社會科學硏究所 2004 社會科學硏究 Vol.25 No.2

장기간의 중강도 트레이닝이 면역기능에 미치는 영향

김주혁,장성동,김영준 東亞大學校附設스포츠科學硏究所 2001 스포츠科學硏究論文集 Vol.19 No.-

The purpose of this study was to investigate the change of immune reaction in moderate intensity training in young males. To achieve the purpose, Six healthy young males(Age:24.3±1.23yr) were recruited for this study. Exercise training consisted of a standardized 12-wk moderate intensity running program(60%HRmax, 3day/wks and 50min/day) performed in the laboratory on a computer-controlled treadmill. Pre- and post-training blood samples were obtain before and after completion of a maximal exercise test on the treadmill. The results of this was obtained as follows: In resting monocyte and eosinophil were no significantly difference between 12weeks pre- and post- running training. Monocyte and eosinophil of post maximal exercise were no significantly difference between 12weeks pre- and post- running training. NK cell were significantly increased after maximal exercise than rest. NK cell were significantly difference to rest and after maximal exercise in pre- and post- running training.

경제성장과 국가홍보 : 아일랜드의 해외자본 유치를 중심으로

이동근,김혁주 朝鮮大學校 社會科學硏究所 2004 社會科學硏究 Vol.25 No.1

장기간의 장거리 달리기가 골대사 마커에 미치는 영향

장성동,이은희,홍명엽,문성진,김주혁,이윤관,김영준 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

This study is purposed to analyse the effects of long-term & one-time 10km running exercise from bone metabolic marker change on bone metabolism. 7 male members(18.6±1.08) from a marathon club were subjected to the study. They were allowed to do long-term 10 km running training once a week for 6 months. And bone metabolism mark was determined according to the respective times : before/after 6 months training, before/after 10 km race, one day after the race, 3 days after the race. The examination items of bone metabolism mark were serum calcium, phosphorus, paratyroid hormone, osteocalcin, calcitonin, alkaline phosphatase in blood and calcium, phosphorus, deoxypyridinolin in urine. The results of study were as follows; 1) There was no change in deoxypyridinolin and alkaline phosphatase but there was significant change in calcitonin, paratyroid hormone and osteocalcin(p<.01). 2) There was no change of Calcium in serum and urine but there was significant change of phosphorus in blood(p<.01). To make a conclusion, it is determined that long-term 10 km running at low intensity and low frequency tends to restrict bone metabolism circulation, but exercise at a little high level activates bone metabolism into building up bones and absorbing bones and finally shows up high bone metabolism circulation, which is inferred to have an effective influence on bone health. It is considered there is a possibility that different exercise intensity, even same kind of exercise, influences on bone metabolism sdifferently.

Prognostic value of preoperative 18-FDG PET/CT in high-grade neuroendocrine carcinoma of cervix

( Ju-hyun Kim ),( Jong Jin Lee ),( Shin-wha Lee ),( Jeong-yeol Park ),( Dae-yeon Kim ),( Dae-shik Suh ),( Jong-hyeok Kim ),( Yong-man Kim ),( Young-tak Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: We investigate prognostic value of metabolic parameters measured by preoperative 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in surgically treated early-stage high-grade(HG) neuroendocrine cervical carcinoma (NECC). Methods: Between 1993 and 2017, 29 patients with FIGO 2009 stage IA-IIA HG NECC who underwent preoperative 18F-FDG PET/CT were initially treated with radical hysterectomy in Asan Medical Center. The PET/CT parameters and clinicopathological variables of the patients were retrospectively reviewed from electronic medical records. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV2.5, MTV3.0), and total lesion glycolysis (TLG2.5, TLG3.0) of the primary tumors were measured. Cox proportional hazards regression was used to identify potential prognostic factors. Results: The median follow-up period was 28.2 months (range, 3.83-202.5). The overall survival (OS) rate was 65.5%(19/29), and the disease-free survival (DFS) rate was 31.0%(9/29). Univariate analysis determined that hazard ratios (HRs) for disease progression for SUVmax, MTV2.5, MTV3.0, TLG2.5, TLG3.0 were 1.046 (95% confidence interval [CI]=0.955-1.146), 1.015 (95% CI=0.996-1.034), 1.017 (95% CI=0.996-1.038), 1.33 (95% CI=1-1.58) and 1.003(95% CI=1-1.005) respectively. And, HRs for death were 1.023 (95% CI=0.935-1.12), 1.009 (95% CI=0.987-1.031), 1.002(95% CI=0.999-1.005) and 1.001 (95% CI=0.998-1.005), respectively. Only TLG 2.5 was significantly risk factor for recurrence (p value =0.044). Conclusion: In conclusion, TLG2.5 of primary HG NECC was significant prognostic factor for predicting recurrence. Because of small sample size, further studies need to be warranted.

Oncologic outcomes of laparoscopic radical trachelectomy versus laparoscopic radical hysterectomy for early-stage cervical cancer

( Ju-hyun Kim ),( Shin-wha Lee ),( Jeong-yeol Park ),( Dae-yeon Kim ),( Dae-shik Suh ),( Jong-hyeok Kim ),( Yong-man Kim ),( Young-tak Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: To compare the oncologic outcomes between laparoscopic radical trachelectomy (LRT) versus laparoscopic radical hysterectomy (LRH) for early-stage cervical cancer. Methods: Between 2011 and 2018, total 622 patients with FIGO stage IA2-IIA1 cervical cancer (CC) were initialy surgically treated by laparoscopy in Asan Medical Center. The cases of prior neoadjuvant chemotherapy for CC or intraoperative converted laparotomy were excluded. Clinicopathological variables of the patients were retrospectively reviewed from electronic medical records. Survival curves were compared using the Kaplan-Meier method with log-rank test. Results: All patients were divided into LRT (n=69) and LRH (n=563). The median follow-up period was 32.4 months (range, 2.5-85.1). Stage IB1 disease was the most common (67.0%). Between two group, there were no significantly different clinicopathologic characteristics. In tumor size ≤ 2cm there was no significant difference in OS (94.4 % vs. 96.3%, p value=) and DFS (97.2% vs. 98.5% p=) between the LRT and LRH group. Moreover, in tumor size over 2cm below 4cm, LRT group has similar OS (86.6% vs. 86.4%, p=) and DFS (100% vs. 92.5%, p=) compared with LRH group. Conclusion: In tumor size below 4cm in early-stage CC, oncologic outcomes are similar between LRT and LRH group. In selective CC patients who want of fertility sparing, LRT could be a feasible.

Identification of genes contributing to the intracellular replication of <i>Brucella abortus</i> within HeLa and RAW 264.7 cells

Kim, Dong Hyeok,Lim, Jeong Ju,Lee, Jin Ju,Kim, Dae Geun,Lee, Hu Jang,Min, Wongi,Kim, Kwang Dong,Chang, Hong Hee,Rhee, Man Hee,Watarai, Masahisa,Kim, Suk Elsevier 2012 Veterinary microbiology Vol.158 No.3

<P><B>Abstract</B></P><P><I>Brucella abortus</I>, the causative agent of brucellosis, can survive and replicate within host cells. Understanding bacterial virulence factors and bacteria–host cell interactions is critical for controlling brucellosis, yet very little is known about the virulence strategies and signaling pathways activated in phagocytes during infection to ensure their growth and survival. <I>B. abortus</I> was mutagenized by mini-Tn5Km2 transposon mutagenesis to identify virulence genes related to the internalization and intracellular replication of the bacteria. Of the total 2300 mutants used to infect HeLa cells, 23 mutants defective for intercellular growth and the mutated genes were identified. Sequence analysis of DNA flanking the transposon showed various insertion sites in bacterial genes that might be associated with virulence, including genes associated with lipoproteins, amino acid metabolism, translation, transcription, carbohydrate transport, coenzyme transport, inorganic ion transport, energy metabolism, membrane transport, and cell wall/membrane biogenesis. Moreover, mutants were classified into class I, class II and class III as higher, similar, and lower internalization, respectively, into HeLa cells. Furthermore, defective mutants for intracellular growth in HeLa cells were found to be defective in RAW 264.7 cells. Taken together, we suggest that the identified virulence associated genes might contribute to the intracellular growth and survival of <I>B. abortus</I> in phagocytes.</P>

Development and assessment of the applicability of integrative tumour response assays in advanced epithelial ovarian cancer

( Ju-hyun Kim ),( Yong-man Kim ),( Shin-wha Lee ),( Dae-yeon Kim ),( Jong-hyeok Kim ),( Young-tak Kim ),( Joo-hyun Nam ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: To prospectively correlate clinical responses to second-line chemotherapy for recurrent epithelial ovarian cancer (EOC) with in vitro integrative tumour-response assay (ITRA) results. Methods: Forty-four advanced EOC patients were enrolled from 2015-2017 at our institution. ITRA comprised of two sequential histoculture drug response assays (HDRAs) of the tumours tissues. ITRAs first stage was HDRA with paclitaxel/carboplatin, paclitaxel, and carboplatin chemotherapy. ITRAs second stage was performed with surviving tumour cells from the first stage using topotecan, belotecan, gemcitabine, doxorubicin, ifosfamide, vinorelbine, and etoposide. Results: Eighteen patients (40.9%) completed the second-line chemotherapy, based on the ITRA results. The Objective response rate was 38.9%. Four patients (22.2%) showed complete responses and 3 (16.7%) had partial responses in target lesions. The clinical response rate was 50%; 2 patients (11.1%) had stable disease. ITRAs sensitivity was 85.7% (specificity: 18.2%; accuracy: 44.44%). Conclusion: In conclusion, although ITRA has relatively low accuracy and specificity, it is feasible and applicable and may be a useful tool to help physicians choose second-line chemotherapy regimens in patients with advanced EOC.