PREDICTION OF THE ACOUSTIC PERFORMANCE OF MUFFLERS FOR SLEEP APNOEA DEVICES: PRELIMINARY STUDY

Peter Jones,Nicole Kessissoglou 한국소음진동공학회 2008 한국소음진동공학회 국제학술대회논문집 Vol.2008 No.7

Maritime CBMs in the Asia-Pacific: The Application of the INCSEA Concept in the Redion

( Peter L Jones ) 한국국방연구원 1996 The Korean Journal of Defense Analysis Vol.8 No.1

This paper examines the potential for the application of the INCSEA concept to the Asia-Pacific region. Drawing on the recent Middle East discussions as the first-ever example of the application of the concept in a multilateral regional setting, the paper begins by identifying and reviewing those factors that may arise in any attempt to apply the concept elsewhere. These are held to be: (a) the difficulties that may arise in attempting to translate a CBM that was originally designed for blue-water navies to situations where the primary naval forces are dedicated to coastal patrol; (b) the need to consider the requirements of global maritime powers in fashioning a regional maritime agreement; and (c) the need to keep politics to a minimum in any negotiation over this type of CBM, focusing instead on the technical problems to be addressed. The specific application of the INCSEA concept to the Asia-Pacific region is then examined. It is concluded, for technical reasons, that it may be best to subdivide the Asia-Pacific region into different sub regions for the purposes of achieving INC SEA agreements. This being the case, it is demonstrated that a classical INCSEA-type regime may be applicable in the North Pacific; a modified regime may be applicable to Southeast Asia; and an INCSEA regime is not necessary in the South Pacific. An umbrella approach to maritime security in the region should also be pursued through a larger forum for maritime cooperation in the area, such as the Western Pacific Naval Symposium. More specifically, with respect to the North Pacific the navies of the region are. generally formed along the lines of blue-water navies, and the Chinese navy, which has not yet achieved this status, is striving in this direction. It is also shown that it would be highly desirable from a political standpoint to include the DPRK and Taiwan in any sub regional regime. Perhaps this could be accomplished by downplaying the political aspects of the issue and finding workable solutions to political issues, solutions that protect everyone`s larger positions. In Southeast Asia, the navies of the region are still primarily coastal defense forces, though they are building quickly and acquiring blue-water capabilities. Though INCSEA might not be necessary among the ASEAN countries, it would be desirable to link China to such an exercise if possible. Even if this were not possible, an ASEAN INCSEA might serve as an investment in the future. In the South Pacific, the needs of the regional navies are such that an INCSEA regime would not advance their interests. They are already involved in a wide variety of cooperative maritime activities that correspond to their needs.

Multinational Hotel Chains' Expansion in Asia Compared with Europe and the Middle East

Jones Peter,Hong Jung-Hwa 한국관광레저학회 2004 관광레저연구 Vol.16 No.4

고콜레스테롤혈증 환자를 대상으로 한 아토르바스타틴 대 심바스타틴, 프라바스타틴,로바스타틴,풀르바스타틴을 비교한 용량대비 지질저하 효과에 대한 임상연구

Jones, Peter,Kafonek, Stephanie,Laurora, Irene,Hunninghake, Donald 약업신문사 1999 의약정보 Vol.1999 No.2

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

Jones, Michael R.,Mathieu, Emilie,Dyrager, Christine,Faissner, Simon,Vaillancourt, Zavier,Korshavn, Kyle J.,Lim, Mi Hee,Ramamoorthy, Ayyalusamy,Wee Yong, V.,Tsutsui, Shigeki,Stys, Peter K.,Storr, Tim Royal Society of Chemistry 2017 Chemical Science Vol.8 No.8

<▼1><P>A series of multi-target-directed ligands are described that bind Cu, act as antioxidants, modulate Aβ peptide aggregation, and abolish Aβ toxicity in primary neurons.</P></▼1><▼2><P>Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits. Increased oxidative stress, metal ion dysregulation, and the formation of toxic Aβ peptide oligomers are all considered to contribute to the etiology of AD. In this work we have developed a series of ligands that are multi-target-directed in order to address several disease properties. 2-(1-(3-Hydroxypropyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>POH</B>), 2-(1-(2-morpholinoethyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>PMorph</B>), and 2-(1-(2-thiomorpholinoethyl)-1<I>H</I>-1,2,3-triazol-4-yl)phenol (<B>PTMorph</B>) have been synthesized and screened for their antioxidant capacity, Cu-binding affinity, interaction with the Aβ peptide and modulation of Aβ peptide aggregation, and the ability to limit Aβ<SUB>1–42</SUB>-induced neurotoxicity in human neuronal culture. The synthetic protocol and structural variance incorporated <I>via</I> click chemistry, highlights the influence of R-group modification on ligand-Aβ interactions and neuroprotective effects. Overall, this study demonstrates that the phenol–triazole ligand scaffold can target multiple factors associated with AD, thus warranting further therapeutic development.</P></▼2>

A Reliable Surgical Approach to Revision Total Knee Arthroplasty

Jonathan Quinn,Peter Jones,Ray Randle 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.2

Background: The surgical exposure obtained in revision total knee arthroplasty should facilitate the utilisation of instrumentation and implants, including adjuncts such as stemmed prostheses, bone allograft, and artificial augments. We have previously identified within this cohort of revision total knee arthroplasty patients a high satisfaction rate of 93.5% at a mean 6.5 years of followup and a high level of postoperative function. We, therefore, seek to describe in detail the operative technique and perioperative care and report the early postoperative complications. Methods: We report on the surgical approach, closure technique, and postoperative care used by the senior author for revision total knee arthroplasty procedures. The patient demographics, intraoperative details, and postoperative outcomes are also reported. We aim to provide a clear description of the intraoperative technique and postoperative outcome, facilitating adoption or comparison with other surgeons or techniques. Patient inclusion criteria were revision total knee arthroplasty performed by the senior author using the PFC (Depuy) prosthesis at John Flynn Private Hospital with a minimum of 2-year postoperative follow-up. A retrospective chart review was combined with a structured telephone assessment questionnaire to assess outcomes. Results: A total of 202 revision total knee arthroplasties were available for follow-up in 185 patients. The mean 1-year postoperative range of motion was 110°. Key features of surgical approach include incision planning, soft-tissue plane development, parapatellar scar debridement, safe removal of implants, management of bone defects, and closure technique. The overall 90-day complication rate was 9%, including 4.4% requiring manipulation under anaesthesia and 3% superficial surgical site infections (1 patient requiring intravenous antibiotics). Conclusions: We suggest that the described technique is reproducible and reliable. It rarely requires modification and facilitates successful postoperative outcomes with a low complication rate. The adoption of this surgical technique allows surgeons to approach complex knee arthroplasty with confidence in the appropriate exposure of anatomy, facilitating subsequent steps in their arthroplasty procedures.

캐나다 Ontario 주 Coldwell 알카리 복합체의 반려암에 배태된 반려암질 페그마타이트에 관한 연구

이혜임,정지곤,Peter C. Jones 한국지구과학회 1989 韓國地球科學會誌 Vol.10 No.1

Coldwell alkaline complex adjacent to the north of Lake Superior in Ontario, Canada is an isolated plutonic body composed chiefly of syenite and gabbros and Archean metamorphic rocks intruded by above mentioned igneous rocks. A pegmatite swarm is developed in olivine gabbro, a member of the complex. Zonal distribution is found in most of pegmatites and is composed of three zones, that is, leucocratic fine-grained zone of anorthosite, melanocratic fine-grained zone of gabbronorite and pyroxenite and coarse-grained zone of gabbronorite. The mean grain size of the rock forming minerals in fine-grained zone is 0.27㎜ and that of coarse-grained zone 10.4㎜. An content of most plagioclases is in the range from An50 to An70 indicating that the pegmatite is mafic pegmatite. In a grain of plagioclase, An content decreases gradually from core to margin. Paragenetic sequence of main minerals in pegmatite is plagioclase, olivine, pyroxene, hornblende, biotite and opaque mineral from the earlier stage. Mineralogy in pegmatite is similar to that of the country rock, so it can be classified as simple and pure pegmatite. Fine-grained zone might be formed by rapid crystallization with high viscosity caused by rapid reduction in P_(H₂O) when coexisting vapor phase is suddenly released and raising the sotidus and liquidus temperatures abruptly. Coarse-grained zone is probably formed by high diffusion rate and low viscosity caused by depolymerization, formation of aqueous phase and decrease of solidus temperature. The rate of increase in viscosity caused by cooling of magma from the magmatic stage and high content of SiO₂ is ignorable compared with the rate of decrease in viscosity caused by concentration of water.

Clinical Outcomes Following Revision Total Knee Arthroplasty: Minimum 2-Year Follow-up

Jonathan Quinn,Peter Jones,Ray Randle 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.1

Background: The longer-term outcomes of revision total knee arthroplasty are not well described in the current literature. Managing patient expectations of revision total knee arthroplasty can be challenging for orthopedic surgeons due to a paucity of data to guide decision-making. We present outcomes of revision total knee arthroplasty performed by a single surgeon over a 12-year period from 2004 through 2015. Methods: A retrospective review of hospital and private medical records demonstrated 202 revision total knee arthroplasties performed by the senior author in 178 patients from 2004 through 2015. Of these, 153 patients were available for assessment. Patients were contacted and invited to participate in a structured telephone interview to assess Oxford Knee Score (OKS) and patient satisfaction. All patients received the PFC (Depuy) prosthesis at a single institution and were followed up for minimum 2 years postoperatively at the time of review. Retrospective chart review was used to obtain other data for analysis including patient demographics, preoperative and postoperative range of motion (ROM), and intraoperative details. Results: This cohort demonstrated a 93.5% survival rate and an 85% satisfaction rate at a mean of 6.5 years postoperatively. Mean ROM improved from 100° (range, 5°–145°) to 112° (range, 35°–135°) (p < 0.001). The mean OKS was 39.25 (range, 14–48). The factors associated with improved postoperative outcomes included male sex, fewer previous revision total knee arthroplasty procedures, increased preoperative ROM, and receiving a less constrained implant. Conclusions: This study provides a comprehensive description of outcomes following revision total knee arthroplasty in a large patient cohort with a long follow-up. Although revision total knee arthroplasty is a challenging and complex aspect of arthroplasty surgery, high patient satisfaction and good functional outcomes can be achieved for the majority of patients.

Juvenile Probation in the United States : Current Practices and How It Can Be Improved

Ira M. Schwartz,Peter Jones,David Schwartz. 한국보호관찰학회 2009 보호관찰 Vol.9 No.2

소년사법에 신경회로망을 이용한 선구적 연구는 미국에서 진행되었는데, 우리는 신경회로망 기술이 다른 나라에서도 적용되면 미국의 경우만큼의 성과가 있을지 궁금하다. 한국에서도 그러한 성과가 있을지 살펴보는 것은 흥미로운 일이 아닐 수 없다. 나의 동료들과 나는 그 가능성에 대해 낙관적이며 체계적 방법으로 조심스레 가능성을 타진하는 것이 중요하다고 생각한다. 그러므로 우리는 한국의 보호관찰 관계자들이 우리와 유사한 연구의 진행을 고려해볼 것을 권하고자 한다. 의미 있는 결과를 산출하기 위해 종종 수년이 소요되는 전통적인 기존의 연구방법과 달리, 신경회로망을 활용한 연구는 비교적 저렴한 수행비용이 들며, 1년 이내에 완료 할 수 있는 장점이 있다. 신경회로망 기반 모델을 형성할 만큼 의 충분한 데이터가 필요할 뿐이며, 모델 형성 후 현장에서 검증 절차를 거치고 기존의 도구와 비교하면 일단락된다. 또한 이와 같은 연구를 수행하기 위해 새로운 데이터를 수집할 필요가 없다. 예를 들어, 미국에서 신경회로망을 이용하였던 연구는 소년사법과 사회복지 기관에서 일상적으로 수집되는 자료를 활용하여 수행되었으므로 새로운 데이터를 수집하거나 기존의 자료 축적체계를 수정할 필요가 없었다. 한국 소년사법 자료와 그 수집과정에 대해 아는 바가 없으나, 이미 수집된 자료만으로도 이연구가 수행될 수 있을 것으로 생각한다.

Chronic Intake of Fractionated Yellow Pea Flour Reduces Postprandial Energy Expenditure and Carbohydrate Oxidation

Christopher P.F. Marinangeli,Peter J.H. Jones 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.12

Effects of dietary fibers on human postprandial energetics remain undefined. The objective of the present study was to explore effects of whole yellow pea flour (WPF) and fractionated pea flour (FPF) on postprandial energy expenditure,substrate utilization, and hepatic triglyceride synthesis rate. Using a crossover-diet controlled design, 23 overweight men and women received muffins containing WPF, FPF, and white wheat flour (WF) for 28 days, followed by 28-day washout periods. Subjects received 50 g/day WPF and WF. Given that FPF is approximately 84% fiber, the amount of FPF administered to volunteers was equivalent to the amount of pea-derived fiber in the WPF treatment. Four weeks of FPF consumption reduced (P = .007) total postprandial energy expenditure (333.0±3.6 kcal/330 minutes) compared with WF (349.3±3.6 kcal/330minutes). When values were normalized to the level of food energy consumed, FPF (4.6±0.3%) decreased (P = .018) the thermic effect of food (TEF) compared with WF (5.7±0.3%). Carbohydrate oxidation tended to be lower (P = .075) with FPF (44.7±2.1 g/330 minutes) versus WF (51.2±0.1.9 g/330 minutes). WPF had no effect on total energy expenditure, TEF, or carbohydrate oxidation. Only after 370 minutes was cumulative oxidation of [1-13C]palmitic acid higher (P = .045) in the WPF group (0.96±0.05%) compared with FPF (0.81±0.05%). Neither treatment had any effect on hepatic triglyceride synthesis rate. In conclusion, chronic ingestion of different fractions of yellow peas imposes distinctive effects on postprandial energy expenditure and substrate utilization.