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      • KCI등재

        Tunable paclitaxel release carrier using diselenide-disulfide balance as regulator

        Jingwen Xu,Xiangji Yan,Yue Zhang,Kangsheng Tu,Wen Shen,Zhaoqing Tian,Guoliang Li,Wei Zhao,Mingzhen Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

        There are many reasons that lead to the failure of cancer chemotherapy, such as uncontrolled drugrelease, low drug utilization, and severe side effects. To overcome these obstacles, two kinds of thermaland redox-responsive copolymers with multiple diselenide/disulfide linkages, polyethylene glycol -altdiselenodipropionate/disulfhydryldipropionate-b-poly(N-isopropylacrylamide) (abbreviated as PEG-alt-DSeDP-b-PNIPAM and PEG-alt-DSDP-b-PNIPAM) were fabricated by alternative esterification and followingatom transfer radical polymerization. Afterward, these prepared copolymers were mixed in line withthe mass ratio of 8:0, 5:3, 3:5, 0:8 (denoted as S1, S2, S3, and S4, respectively), and self-assembled withpaclitaxel (PTX) to obtain PTX-loaded S1, S2, S3, and S4 nanomicellar assemblies, aiming to realize PTXtunable release using diselenide-disulfide balance as regulator. The chemical structures of these twocopolymers were characterized by gel permeation chromatography, indicating eight diselenide/disulfidelinkages and eight PEG units were contained in these copolymers. Moreover, the thermal-responsiveproperty was detected by UV–vis spectroscopy, meanwhile, the redox responsiveness was observed byTEM in the presence of 10 mM glutathione. We found that 76.90% of PTX was released from S1 nanomicelleswithin 23 h. In contrast, this percentage decreased to 64.53% for S4 nanomicelles even the incubationtime prolonged, indicating explosive and slow release behaviors of S1 and S4 nanomicelles,respectively. In addition, gradually decreased fluorescence intensity around the cellular nucleus wasoccurred from S1 to S4 orderly, which was consistent with cellular uptake and in vivo anti-tumor experiments. Taken together, this work not only provides a strategy for tunable PTX release, but also improveseffectiveness of PTX in cancer treatment.

      • KCI등재

        중국 패션브랜드 SNS(WEIBO) 특성이 지각된 유용성, 만족도, 브랜드 충성도에 미치는 영향

        장채리 ( Jingwen Zhang ),김미숙 ( Mi Sook Kim ) 복식문화학회 2018 服飾文化硏究 Vol.26 No.1

        As the number of SNS(Weibo) users in China is growing rapidly, Chinese fashion brands are heavily dependent on SNSs as a fashion marketing communication tool. For this reason, the characteristics of SNS accounts and their influences on SNS users’ responses need to be studied. Thus, the present study aimed to investigate the influences of the characteristics of Chinese fashion brands’ SNS accounts(Weibo) on the perceived usefulness of and satisfaction with the SNS acount, and brand loyalty. Data were collected via a questionnaire survey of men and women living in Beijing or Shanghai aged from 18 to 49 with experience of SNSs(Weibo). After a pilot survey of 70 subjects, the preliminary questionnaire was revised and then translated into Chinese. The questionnaire translated into Chinese was back-translated into Korean to ensure the translation was correct. The final questionnaire was administered to 600 subjects. Exploratory and confirmatory factor analyses, reliability analysis, and structural equation model analysis were conducted for data analysis. The results of this study were as follows: Five factors were extracted for Weibo characteristics: interaction, information provision, information recency, information reliability, and information playfulness. The information reliability, information playfulness, and interaction of SNS accounts(Weibo) had significant influences on perceived usefulness. The information playfulness, information reliability, and information recency showed significant influences on satisfaction. The perceived usefulness exerted significant influences on satisfaction and brand loyalty. The satisfaction also had statistically significant influences on brand loyalty.

      • The Film Style of Xavier Dolan

        张竞文(Jingwen Zhang) YIXIN 출판사 2023 Journal of Humanities and Social Sciences Vol.1 No.2

        Xavier Dolan, a young director known for his distinctive personal style, has consistently explored the fusion of artistic expression and personal experience in his creations, establishing himself as a prominent figure in Quebec, Canada's auteur film scene. Throughout his body of work, the theme of the mother-child relationship is a recurring and central motif. This essay aims to analyze the portrayal of maternal roles in two of his films ‘I killed my mother’ (2009) and ‘Mommy’ (2014). By comparing these works and delving into the aesthetics of his filmmaking style, we will explore the evolution of Xavier Dolan’s film style concerning the mother figure. This analysis will encompass artistic expression, compositional changes, musical connotations, and ultimately convey the artistry of his films from a personal perspective. 泽维尔·多兰是以其独特的个人风格而闻名的年轻导演,他在创作中不断探索艺术表达与个人经历的融合,使自己成为加拿大魁北克电影界的杰出人物。在他的作品中,母子关系是一个被反复提及和呈现的中心主题。本文旨在分析泽维尔·多兰的两部电影《我杀了我的母亲》(2009 年)和《妈妈》(2014 年)中对母亲角色的刻画,加之作品对比与个人经历的分析,深入探讨其电影美学的独特性。本文力图通过泽维尔·多兰对母亲形象的塑造与呈现来追溯其电影风格的演变,其中涵盖了艺术表现、构图变化和音乐内涵,并最终从个人视角传达其电影的艺术性。

      • KCI등재

        Design of an Optical System for a Space Target Detection Camera

        Liu Zhang,Jiakun Zhang,Jingwen Lei,Yutong Xu,Xue-Ying Lv 한국광학회 2022 Current Optics and Photonics Vol.6 No.4

        In this paper, the details and design process of an optical system for space target detection cameras are introduced. The whole system is divided into three structures. The first structure is a short-focus vis-ible light system for rough detection in a large field of view. The field of view is 2°, the effective focallength is 1,125 mm, and the F-number is 3.83. The second structure is a telephoto visible light systemfor precise detection in a small field of view. The field of view is 1°, the effective focal length is 2,300mm, and the F-number is 7.67. The third structure is an infrared light detection system. The field ofview is 2°, the effective focal length is 390 mm, and the F-number is 1.3. The visible long-focus narrowfield of view and visible short-focus wide field of view are switched through a turning mirror. Design results show that the modulation transfer functions of the three structures of the system are close to the diffraction limit. It can further be seen that the short-focus wide-field-of-view distortion is controlledwithin 0.1%, the long-focus narrow-field-of-view distortion within 0.5%, and the infrared subsystem distortion within 0.2%. The imaging effect is good and the purpose of the design is achieved.

      • KCI등재

        De novo Assembly and Analysis of Amur Sturgeon (Acipenser schrenckii) Transcriptome in Response to Mycobacterium Marinum Infection to Identify Putative Genes Involved in Immunity

        ( Qianqian Zhang ),( Xiehao Wang ),( Defeng Zhang ),( Meng Long ),( Zhenbing Wu ),( Yuqing Feng ),( Jingwen Hao ),( Shuyi Wang ),( Qian Liao ),( Aihua Li ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.8

        Fish mycobacteriosis is a common bacterial disease in many species of freshwater and marine fish and has caused severe loss of fish production. Mycobacterium marinum has been the most prevalent pathogen observed in several outbreaks of mycobacteriosis of farmed sturgeons in China. However, the immune responses and pathology of sturgeons in mycobacterial infection are rarely studied. Therefore, we used the Illumina RNA-seq method to analyze the transcriptome profile of Acipenser schrenckii challenged with Mycobacterium marinum. To begin, 168,220 non-redundant contigs were acquired from the infection and control groups, and among these, 33,225 contigs have acquired annotations. A total of 4,043 differently expressed (DE) contigs between the two groups were identified, and among these, 2479 were upregulated and 1564 were down-regulated in the infected fish. A total of 1,340 DE contigs with acquired annotations in KEGG were enriched for 124 pathways including the TNF signaling pathway, and the Toll-like receptor signaling pathway. The roles of DE genes involved in significant pathways and other processes were discussed. The 2,209 DE contigs that have yet to acquire proper annotation may represent candidate genes associated with infection in sturgeons and are expected to serve as immunogenetic resources for further study. To our best knowledge, this is the first transcriptome study on sturgeons under bacterial infection.

      • KCI등재

        Energy management for households considering uncertainty in solar irradiance with various probability distribution

        Jingwen Liu,Wei Wang,Yumin Zhang,Xingming Xu 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.5

        The electricity load scheduling problem in a household with roof-top photovoltaic (PV) system can efficiently reduce customers’ payments. Compared with previous works in which common flat rate (CFR) has been used, this paper study the case where the time-of-use pricing (TOUP) is adopt. Two conditional equations are constructed for different gains of customers. This is caused by different power direction between the household and the main grid. The two conditional gains equations for the customer are transformed into linear equations by introducing auxiliary variables and linear expression techniques. As a result, established mathematical model to maximize gains for customer is transformed into a mixed integer linear programing (MILP) problem. Thus the resulting MILP model can be easily solved by existing powerful commercial solver. The adjustable and rating power consumption property of appliances are both considered. There are two different mathematic models for them respectively. The impact of reduction of the maximum exchange power between the household and the main grid on gains of the customer, gains of the main grid, load demand during off-peak time and energy exported to the main grid is also studied. The validity and feasibility of the proposed model is illustrated by the case studies.

      • KCI등재

        Wear Behavior of P/M High Nb Containing γ-TiAl Alloy in Different Environments

        Jingwen Qiu,Zhengfan Fu,Bin Liu,Yong Liu,Jianhui Yan,Di Pan,Weidong Zhang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6

        The wear behavior of Ti–45Al–7Nb–0.3W (at%) alloy prepared by powder metallurgy (P/M) has been investigated using pinon-disk wear tests at the room temperature. The dry sliding wear tests were performed against on a zirconia disk in differentenvironments, viz, argon, hydrogen in nitrogen mixture, air and oxygen. The worn surfaces of Ti–45Al–7Nb–0.3W pins andwear debris were examined by scanning electron microscope, X-ray diffractometer and X-ray photoelectron spectroscopy. It was found that the high Nb containing Ti–45Al–7Nb–0.3W alloy didn’t exhibit better wear resistance in the presence ofoxygen than commercial γ-TiAl (Ti–47Al–2Nb–2Cr–0.2W) alloy. The oxidation on the worn surface and spalling of oxidescaused by the mechanical force during sliding were the main reason for the high wear losses in the air and oxygen. Thezirconia disk underwent a phase transformation caused by the high contact temperature and stress during the sliding tests. The abrasive particles produced in the wear tests largely consisted of the zirconia particles in different environments, exceptin the pure oxygen. The hard zirconia debris was embedded into the friction layer on the worn surfaces of TiAl pins, whichprovided protection against wear to some extent. The main wear mechanisms of Ti–45Al–7Nb–0.3W alloy were abrasivewear of two-body and three-body, some delamination and plastic deformation.

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