Application and Research of Active RFID-Based Positioning System in Sport Competition

Jing Ning 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12

In this paper, it has made a deep research to the application of RFID positioning in sports competitions. It also researched the application of VIRE algorithm in positioning system, and proposed an improved VIRE algorithm, also chose the appropriate interpolation method. Through the improved location algorithm, it builds a relationship between the distance and time in finish line of the athlete, and solves the function to make sure the time that athletes reach the finish line, so that it can achieve the purpose of timing.

The Impact of Gate Leakage Current on PLL in 65 ㎚ Technology

Jing Li,Ning Ning,Ling Du,Qi Yu,Yang Liu 대한전자공학회 2012 Journal of semiconductor technology and science Vol.12 No.1

For CMOS technology of 65 nm and beyond, the gate leakage current can not be negligible anymore. In this paper, the impact of the gate leakage current in ring voltage-controlled oscillator (VCO) on phaselocked loop (PLL) is analyzed and modeled. A voltage-to-voltage (V-to-V) circuit is proposed to reduce the voltage ripple on Vctrl induced by the gate leakage current. The side effects induced by the V-to-V circuit are described and optimized either. The PLL design is based on a standard 65 ㎚ CMOS technology with a 1.8 V power supply. Simulation results show that 97 % ripple voltage is smoothed at 216 ㎒ output frequency. The RMS and peak-to-peak jitter are 3 ps and 14.8 ps, respectively

Design of Intelligent Stadiums Management System Based on ASP.NET

Jing NING 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.12

This paper analyzes the application requirements of stadium, and B / S architecture is used to design of stadium with intelligent management system, including five modules: systematic management, site management, membership management, sparring management and device management. SQLServer2005 database management system is used to establish a database system so that we can achieve seamless and efficient combination of ASP.NET applications. Finally, the basic module functions of the system were tested and the result shows that the system functions achieve the desired goals. It performed well and could improve efficiency greatly.

The Impact of Gate Leakage Current on PLL in 65 nm Technology: Analysis and Optimization

Li, Jing,Ning, Ning,Du, Ling,Yu, Qi,Liu, Yang The Institute of Electronics and Information Engin 2012 Journal of semiconductor technology and science Vol.12 No.1

For CMOS technology of 65 nm and beyond, the gate leakage current can not be negligible anymore. In this paper, the impact of the gate leakage current in ring voltage-controlled oscillator (VCO) on phase-locked loop (PLL) is analyzed and modeled. A voltage -to-voltage (V-to-V) circuit is proposed to reduce the voltage ripple on $V_{ctrl}$ induced by the gate leakage current. The side effects induced by the V-to-V circuit are described and optimized either. The PLL design is based on a standard 65 nm CMOS technology with a 1.8 V power supply. Simulation results show that 97 % ripple voltage is smoothed at 216 MHz output frequency. The RMS and peak-to-peak jitter are 3 ps and 14.8 ps, respectively.

A New Fuzzy Key Generation Method Based on PHY-Layer Fingerprints in Mobile Cognitive Radio Networks

( Ning Gao ),( Xiaojun Jing ),( Songlin Sun ),( Junsheng Mu ),( Xiang Lu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7

Classical key generation is complicated to update and key distribution generally requires fixed infrastructures. In order to eliminate these restrictions researchers have focused much attention on physical-layer (PHY-layer) based key generation methods. In this paper, we present a PHY-layer fingerprints based fuzzy key generation scheme, which works to prevent primary user emulation (PUE) attacks and spectrum sensing data falsification (SSDF) attacks, with multi-node collaborative defense strategies. We also propose two algorithms, the EA algorithm and the TA algorithm, to defend against eavesdropping attacks and tampering attacks in mobile cognitive radio networks (CRNs). We give security analyses of these algorithms in both the spatial and temporal domains, and prove the upper bound of the entropy loss in theory. We present a simulation result based on a MIMO-OFDM communication system which shows that the channel response characteristics received by legitimates tend to be consistent and phase characteristics are much more robust for key generation in mobile CRNs. In addition, NIST statistical tests show that the generated key in our proposed approach is secure and reliable.

FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway

Jing Xiang,Niu Shuai,Liang Yi,Chen Huiping,Wang Ning,Peng Youmei,Ma Fang,Yue Wanying,Wang Qingduan,Chang Junbiao,Zhang Yi,Zhang Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Previously, we published that 4'-azid-2'-deoxy-2'-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. Objective: This study aimed to further explore the role and molecular mechanism of FNC in non-small cell lung cancer (NSCLC). Methods: FNC was tested in the NSCLC H460 cell line, the Lewis mouse model, and the H460 cell xenograft model. The effects of FNC were assessed by cell viability, transwell migration, and wound scratch analyses of cell migration and invasion. Apoptosis was assessed by flow cytometry. Proteins expression was assessed by western blot and immunohistochemistry staining (IHC). Results: FNC inhibits the proliferation and metastasis of H460 cells in a time- and dose-dependent manner. FNC treatment showed efficacy and low toxicity in the Lewis mouse lung cancer model as well as in the H460 cell xenograft model. Further, FNC induced H460 cell apoptosis through the activation of the mitochondrial pathway. Notably, FNC inhibited invasion by increasing E-cadherin protein and reducing the protein expression of VEGF, MMP-2, MMP-9, and CD31. Conclusion: FNC inhibits NSCLC by activating the mitochondrial apoptosis pathway and regulating the expressions of multiple proteins related to cell adhesion and invasion, highlighting its potential as an NSCLC therapeutic.

Environmental Microbiology and Engineering : Microbial Community Dynamics in Batch High-Solid Anaerobic Digestion of Food Waste Under Mesophilic Conditions

( Jing Yi ),( Bin Dong ),( Yong Gang Xue ),( Ning Li ),( Peng Gao ),( Yu Xin Zhao ),( Ling Ling Dai ),( Xiao Hu Dai ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.2

Microbial community shifts, associated with performance data, were investigated in an anaerobic batch digester treating high-solid food waste under mesophilic conditions using, a combination of molecular techniques and chemical analysis methods. The batch process was successfully operated with an organic removal efficiency of 44.5% associated with a biogas yield of 0.82 L/g VSremoval. Microbial community structures were examined by denaturing gel gradient electrophoresis. Clostridium and Symbiobacterium organisms were suggested to be mainly responsible for the organic matter catabolism in hydrolysis and acidogenesis reactions. The dynamics of archaeal and methanogenic populations were monitored using real-time PCR targeting 16S rRNA genes. Methanosarcina was the predominant methanogen, suggesting that the methanogenesis took place mainly via an aceticlastic pathway. Hydrogenotrophic methanogens were also supported in high-solid anaerobic digestion of food waste through syntrophism with syntrophic bacterium. Microbial community shifts showed good agreement with the performance parameters in anaerobic digestion, implying the possibility of diagnosing a high-solid anaerobic digestion process by monitoring microbial community shifts. On the other hand, the batch results could be relevant to the start-up period of a continuous system and could also provide useful information to set up a continuous operation.

Outcome of COVID-19 Infection in Patients With Multiple Sclerosis Who Received Disease-Modifying Therapies: A Systematic Review and Meta-Analysis

Ning Liu,WuHan Yu,Mengjiao Sun,Wenjing Zhang,Dan Zhou,Jing Sun,ManXia Wang 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.4

Background and Purpose A systematic review and meta-analysis was performed of the outcome of Coronavirus disease 2019 (COVID-19) infection in patients with multiple sclerosis (MS) who received disease-modifying therapies (DMTs). Methods Relevant studies published before November 2022 in the PubMed, Cochrane Library, Chinese National Knowledge Infrastructure, and Web of Science databases were retrieved using the following search expression: (“multiple sclerosis” OR “MS”) AND (“DMT” OR “disease modifying therapies”) AND (“COVID-19”). Two authors independently screened the articles and extracted the data. Qualitative analyses and a meta-analysis constituted 22 of the 794 retrieved articles. Differences in the hospitalization and mortality rates were used as the main measures of efficacy, and the meta-analysis was performed using RevMan software. Results 22 clinical trials were selected. The hospitalization rate was lower in the 3,216 patients who received DMTs than in the 774 patients who did not receive any treatment, with a moderate effect size of 0.43 (p<0.00001). The mortality rate was also lower among patients with MS treated using DMTs than in controls (odds ratio [OR]=0.19, 95% confidence interval [CI]=0.13–0.27, p<0.00001). The hospitalization rates for COVID-19 infection in patients with MS treated with anti-CD20 therapy also increased markedly (OR=3.32, 95% CI=2.63–4.20, p<0.00001). However, there was no significant difference between patients with MS who did and did not receive DMTs. Conclusions In summary, the application of DMTs was found to be valuable for patients with MS infected with COVID-19. However, more clinical studies are needed to determine the use of anti-CD20 drugs in patients with MS during the COVID-19 pandemic.

Human Amnion-Derived Mesenchymal Stem Cells Protect Human Bone Marrow Mesenchymal Stem Cells against Oxidative Stress-Mediated Dysfunction via ERK1/2 MAPK Signaling

Ning Chen,Yuli Wang,Junchi Ma,Yifei Du,Jing Miao 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.3

Epidemiological evidence suggests that bone is especial-ly sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of H2O2-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.

Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct

Jing Guo,Qiong Wu,Hongjuan He,Qi Liu,Fengwei Zhang,Jie Lv,Tiebo Zeng,Ning Gu 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.10

Most imprinted genes are concerned with embryonic development, especially placental development. Here, we identified a placenta-specific imprinted gene Qpct. Our results show that Qpct is widely expressed during early embryonic development and can be detected in the telecephalon, midbrain, and rhombencephalon at E9.5-E11.5. Moreover, Qpct is strikingly expressed in the brain, lung and liver in E15.5. Expression signals for Qpct achieved a peak at E15.5 during placental development and were only detected in the labyrinth layer in E15.5 placenta. ChIP assay results suggest that the modification of histone H3K4me3 can result in maternal activating of Qpct.