Cervical Cancer Mortality Trends in China, 1991-2013, and Predictions for the Future

Du, Pei-Ling,Wu, Ku-Sheng,Fang, Jia-Ying,Zeng, Yang,Xu, Zhen-Xi,Tang, Wen-Rui,Xu, Xiao-Ling,Lin, Kun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Background: To analyze cervical cancer mortality trends in China from 1991-2013 and forecast the mortality distribution in future five years (2014-2018), and provide clues for prevention and treatment. Materials and Methods: Mortality data for cervical cancer in China from 1991 to 2013 were used to describe the epidemiological characteristics and distribution, including the trend of the standardized mortality rate, urban-rural differences, and age variation. Trend-surface analysis was used to analyze the geographical distribution of mortality. Curve estimation, time series, gray modeling, and joinpoint regression were performed to predict and forecast mortality trends. Results: In recent years, the mortality rate of cervical cancer has increased, and there is also a steady increase in the incidence from 2003 to 2013 in China. Mortality rates in rural areas are higher than in urban areas. The mortality dramatically increases in the 40+ yr age group, reaching a peak in the >85 yr age group. In addition, geographical analysis showed that the cervical cancer mortality increased from the southwest to west-central and from the southeast to northeast of the country. Conclusions: The incidence rate and the mortality rate are increasing from 1991 to 2013, and the predictions show this will continue in the future. Thus, implementation of prevention and management programs for cervical cancer are necessary in China, especially for rural areas, young women in urban areas, and high risk regions (the west-central).

Analysis of Cancer Incidence in Zhejiang Cancer Registry in China during 2000 to 2009

Du, Ling-Bin,Li, Hui-Zhang,Wang, Xiang-Hui,Zhu, Chen,Liu, Qing-Min,Li, Qi-Long,Li, Xue-Qin,Shen, Yong-Zhou,Zhang, Xin-Pei,Ying, Jiang-Wei,Yu, Chuan-Ding,Mao, Wei-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Objective: The Zhejiang Provincial Cancer Prevention and Control Office collected cancer registration data during 2000 to 2009 from 6 cancer registries in Zhejiang province of China in order to analyze the cancer incidence. Methods: Descriptive analysis included cancer incidence stratified by sex, age and cancer site group. The proportions and cumulative rates of 10 common cancers in different groups were also calculated. Chinese population census in 1982 and Segi's population were used for calculating age-standardized incidence rates. The log-linear model was used for fitting to calculate the incidence trends. Results: The 6 cancer registries in Zhejiang province in China covered a total of 60,087,888 person-years during 2000 to 2009 (males 30,445,904, females 29,641,984). The total number of new cancer cases were 163,104 (males 92,982, females 70,122). The morphology verified cases accounted for 69.7%, and the new cases verified only by information from death certification accounted for 1.23%. The crude incidence rate in Zhejiang cancer registration areas was $271.5/10^5$ during 2000 to 2009 (male $305.41/10^5$, female $236.58/10^5$), age-standardized incidence rates by Chinese standard population (ASIRC) and by world standard population (ASIRW) were $147.1/10^5$ and $188.2/10^5$, the cumulative incidence rate (aged from 0 to 74) being 21.7%. The crude incidence rate was $209.6/10^5$ in 2000, and it increased to $320.20/10^5$ in 2009 (52.8%), with an annual percent change (APC) of 4.51% (95% confidence interval, 3.25%-5.79%). Age-specific incidence rate of 80-84 age group was achieved at the highest point of the incidence curve. Overall with different age groups, the cancer incidences differed, the incidence of liver cancer being highest in 15-44 age group in males; the incidence of breast cancer was the highest in 15-64 age group in females; the incidences of lung cancer were the highest in both males and females over the age of 65 years. Conclusions: Lung cancer, digestive system malignancies and breast cancer are the most common cancers in Zhejiang province in China requiring an especial focus. The incidences of thyroid cancer, prostate cancer, cervical cancer and lymphoma have increased rapidly. Prevention and control measures should be implemented for these cancers.

Enhanced resistive switching performance of spinel MnCo2O4 resistive random access memory devices: Effects of annealing temperatures and annealing atmospheres

Du Ling,Li Jiacheng,Zhang Yu,Qin Ni,Bao Dinghua 한국물리학회 2023 Current Applied Physics Vol.48 No.-

The spinel MnCo2O4 (MCO) thin films were fabricated on Pt/Ti/SiO2/Si substrates for resistive memories via sol-gel spin-coating deposition method under different annealing temperatures and annealing atmospheres. The 650oC-annealing Pt/MCO/Pt device shows better bipolar resistance switching parameters than the devices annealed at 600 ◦C and 700 ◦C. The nitrogen-annealing Pt/MCO/Pt device exhibits optimum resistance switching parameters due to increasing of the oxygen-vacancies proportion, formation of confined and stable conductive filaments, and suppressing of the randomness of oxygen vacancies. The carrier transportation mechanisms of the devices with numerous oxygen-vacancies content in low resistance state (LRS) and high resistance state (HRS) are dominated by Ohmic conduction and Schottky emission, respectively. For the devices with fewer oxygen-vacancies content, the conduction mechanisms at LRS and HRS can be described by nearest-neighboring hopping conduction and space-charge-limited current model, respectively. This work indicates that the spinel MCO films have good potential application in resistive random access memory.

Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

Du, Wei,Ma, Xue-Lei,Zhao, Chong,Liu, Tao,Du, Yu-Liang,Kong, Wei-Qi,Wei, Ben-Ling,Yu, Jia-Yun,Li, Yan-Yan,Huang, Jing-Wen,Li, Zi-Kang,Liu, Lei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Background: MicroRNAs (miRNAs) are an abundant class of endogenous small non-coding RNAs of 20-25 nucleotides in length that function as negative gene regulators. MiRNAs play roles in most biological processes, as well as diverse human diseases including cancer. Recently, many studies investigated the association between SNPs in miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs229283, miR-499 rs3746444 and colorectal cancer (CRC), which results have been inconclusive. Methodology/Principal Findings: PubMed, EMBASE, CNKI databases were searched with the last search updated on November 5, 2013. For miR-196a2 rs11614913, a significantly decreased risk of CRC development was observed under three genetic models (dominant model: OR = 0.848, 95%CI: 0.735-0.979, P = 0.025; recessive model: OR = 0.838, 95%CI: 0.721-0.974, P = 0.021; homozygous model: OR = 0.754, 95%CI: 0.627-0.907, P = 0.003). In the subgroup analyses, miR-$196a2^*T$ variant was associated with a significantly decreased susceptibility of CRC (allele model: OR = 0.839, 95%CI: 0.749-0.940, P = 0.000; dominant model: OR = 0.770, 95%CI: 0.653-0.980, P = 0.002; recessive model: OR = 0.802, 95%CI: 0.685-0.939, P = 0.006; homozygous model: OR = 0.695, 95%CI: 0.570-0.847, P = 0.000). As for miR-149 rs2292832, the two genetic models (recessive model: OR = 1.199, 95% CI 1.028-1.398, P = 0.021; heterozygous model: OR = 1.226, 95% CI 1.039-1.447, P = 0.013) demonstrated increased susceptibility to CRC. On subgroup analysis, significantly increased susceptibility of CRC was found in the genetic models (recessive model: OR = 1.180, 95% CI 1.008-1.382, P = 0.040; heterozygous model: OR = 1.202, 95% CI 1.013-1.425, P = 0.013) in the Asian group. Conclusions: These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.

Enhanced Electrochemical Activity and Chromium Tolerance of the Nucleation‑Agent‑Free La2Ni0.9Fe0.1O4+δ Cathode by Gd0.1Ce0.9O1.95 Incorporation

Yihan Ling,Huixin Xie,Zijing Liu,Xiaoni Du,Hui Chen,Xuemei Ou,Ling Zhao,Riyan Achmad Budiman 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.4

For the sake of improving the electrochemical activity and chromium tolerance of the K2NiF4- type oxide, La2NiO4+ δ (LNO), with nonnucleation agents like Mn and Sr elements, the electrochemical performance and degradation were comparatively studied at two cathodes La2Ni0.9Fe0.1O4+ δ (LNF) and LNF-40wt%Gd0.1Ce0.9O1.95 (LNF-GDC) on the GDC electrolyte,where 5wt%Cr2O3 incorporation provides Cr-containing atmosphere. Compared with non-doped LNO, LNF shows a higherinterstitial oxygen concentration (δ = 0.298) and a lower electrical conductivity, where bivalent Ni ion, Ni×Ni , and trivalentNi ion, Ni⋅Ni , and trivalent Fe ion on Ni-site, Fe⋅Ni , were observed from the XPS measurements. LNF-GDC shows greatlyreduced interfacial polarization resistances (Rp), which are only half of those of LNF, indicating a better electrochemicalperformance. More importantly, no significant degradation of LNF-GDC in performance has been observed under exposureof Cr-containing atmosphere at 700 °C for 350 h, while Rp of LNF increased by nearly 20%, suggesting LNF by GDCincorporation can enhance the electrochemical performance as well as chromium tolerance for intermediate temperaturesolid oxide fuel cells (IT-SOFCs).

Identification of a Novel Streptomyces chattanoogensis L10 and Enhancing Its Natamycin Production by Overexpressing Positive Regulator ScnRII

Yi-Ling Du,Shi-Fei Chen,Liang-Ying Cheng,Xue-Ling Shen,Yuan Tian,Yong-Quan Li 한국미생물학회 2009 The journal of microbiology Vol.47 No.4

A novel Streptomyces strain, L10, which is capable of producing natamycin, was isolated from a soil sample collected from Zhejiang province, China. On the basis of phylogenetic analysis of rpoB gene and 16S rDNA sequences, as well as phenotypic comparison, strain L10 (CGMCC 2644) is proposed to be a previously uncharacterized strain of S. chattanoogensis. By screening a cosmid library of strain L10 and primer walking, a partial sequence of scnRI and the entire sequence of scnRII were obtained, which are orthologues to the pathway-specific positive regulator genes of natamycin biosynthesis in S. natalensis. The engineered S. chattanoogensis D1, generated by inserting an additional copy of scnRII into the chromosome of strain L10, increased its natamycin production by 3.3 fold in YSG medium and 4.6 fold in YEME medium without sucrose.

학문(學問) 목적(目的) 한국어(韓國語) 학습자(學習者) 읽기 텍스트 선정(選定) 과정(過程) 연구(硏究) -상호텍스트성 기반의 다중 텍스트 읽기를 중심(中心)으로-

두이령(杜怡灵) ( Du Yi-ling ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.4

본고는 학문 목적 한국어 학습자가 다중 텍스트 환경에서 자기 주도적으로 텍스트를 선정할 때 어떤 양상을 보이는지 파악하는 데 목적이 있다. 이를 위해 먼저 읽기 전·중·후 단계에 따른 상호텍스트성에 기반한 다중 텍스트 읽기 과정 및 이해 방법을 살펴보았다. 이를 바탕으로 사고구술법을 활용하여 외국인 한국어 학습자 대학생 3명을 대상으로 실험을 하여 그들의 읽기 과정을 관찰하였다. 실험 과정에서 이들은 주어진 텍스트 10편 중 과제 질문에 가장 맞는 것 5편을 찾는 읽기 과제를 수행하였다. 실험 후, 텍스트 선정 이유에 대한 사후 인터뷰를 실시하였다. 실험과 인터뷰 결과를 보면, 학습자는 심층적인 의미를 파악하는 해석하기를 제대로 수행하지 못하면 다중 텍스트를 충분히 이해하는 데 어려움이 있다는 점을 알 수 있다. 또한, 텍스트 간 읽기가 선행되지 않을 시 텍스트 자체에 어려움이 있다고 볼 수 있다. 그리고 텍스트 외 읽기, 즉 독자와 텍스트 간 상호작용이 잘 이루어진다면 다중 텍스트를 이해하는 데 도움이 된다는 점을 알 수 있다. The purpose of this study is to examinethe reading comprehension process of academic-purpose Korean learners when they self-directedly select texts in a multiple-text environment. To this end, first, the multiple text reading process and understanding method based on intertextuality according to the early, middle, and late stages of reading were examined. Based on this, an experiment was conducted on three university students who were foreign Korean learners using the “think-aloud” method and their reading process was observed. During the experiment, they performed a reading task to find five of the 10 texts that best fit the task question. After the experiment, an interview was conducted to discuss the reasons for text selection. From the results of the experiment and interview, it was found that learners face difficulties in fully understanding multiple texts if they do not properly perform interpretations that grasp their in-depth meaning. In addition, the results revealed that it is difficult to understand the texts when intertextual reading is not preceded. Furthermore, if extratextual reading, that is, the interaction between the reader and the text, is well-performed, it helps the reader to understand multiple texts.

Lack of Association between the COMT rs4680 Polymorphism and Ovarian Cancer Risk: Evidence from a Meta-analysis of 3,940 Individuals

Du, Jin-Ze,Dong, Yu-Ling,Wan, Guo-Xing,Tao, Lin,Lu, Li-Xia,Li, Feng,Pang, Li-Juan,Jia, Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Catechol-O-methyltransferase (COMT) is involved in estrogen metabolism and is vital to estrogen-induced carcinogenesis, including that of ovarian cancer. Although many recent epidemiologic studies have investigated associations between the COMT rs4680 polymorphism and ovarian cancer risk, the results remain inconclusive. We therefore performed a meta-analysis to derive a more precise estimate of associations. Systematic searches of the PubMed, Embase, Web of Science, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and Chinese Biomedicine databases were undertaken to retrieve eligible studies. Odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were pooled to assess the strength of the association. In total, 8 case-control studies involving 1,293 cases and 2,647 controls were included in the meta-analysis. Overall, the results showed no evidence of significant association between the COMT rs4680 polymorphism and ovarian cancer risk in any of the assessed genetic models. Subgroup analyses by ethnicity also did not reveal any significant association in any genetic model (p>0.05). In conclusion, our findings suggest that the COMT rs4680 polymorphism may not contribute to the risk of ovarian cancer.

Efficient activation of peroxymonosulfate by magnetic Mn-MGO for degradation of bisphenol A

Du, J.,Bao, J.,Liu, Y.,Ling, H.,Zheng, H.,Kim, S.H.,Dionysiou, D.D. Elsevier Scientific Pub. Co 2016 Journal of hazardous materials Vol.320 No.-

A heterogeneous manganese/magnetite/graphene oxide (Mn-MGO) hybrid catalyst was fabricated through the reduction of KMnO<SUB>4</SUB> by ethylene glycol in the presence of magnetite/GO (MGO) particles. The Mn-MGO catalyst exhibited high efficacy and long-term stability in activating peroxymonosulfate (PMS) to generate sulfate radicals for the removal of bisphenol A (BPA) from water. The results of the batch experiments indicated that an increase in the catalyst dose and solution pH could enhance BPA degradation in the coupled Mn-MGO/PMS system. Regardless of the initial pH, the solution pH significantly dropped after the reaction, which was caused by catalytic PMS activation. The production of sulfate radicals and hydroxyl radicals was validated through radical quenching and electron paramagnetic resonances (EPR) tests. BPA degradation pathways were proposed on the basis of LC@?MS and GC@?MS analyses. Finally, a possible mechanism of catalytic PMS activation was proposed that involved electron transfer from MnO or Mn<SUB>2</SUB>O<SUB>3</SUB> to PMS with the generation of sulfate radicals, protons and MnO<SUB>2</SUB>, as well as the simultaneous reduction of MnO<SUB>2</SUB> by PMS.

Establishment of and Comparison between Orthotopic Xenograft and Subcutaneous Xenograft Models of Gallbladder Carcinoma

Du, Qiang,Jiang, Lei,Wang, Xiao-Qian,Pan, Wei,She, Fei-Fei,Chen, Yan-Ling Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: Gallbladder carcinoma (GBC) is the most common carcinoma of the biliary system. Among its research models, orthotopic xenograft models, important research tools, have been rarely reported in the literature however. Aim: To explore establishment of an orthotopic xenograft model and to evaluate the advantage and disadvantage as compared with other models. Materials and Methods: Subcutaneous xenograft and orthotopic xenograft models of gallbladder carcinoma in nude mice were established and compared with human gallbladder carcinomas. Results: For the orthotopic xenograft model and clinical gallbladder carcinomas, the lymph node metastatic rates were 69.2% and 53.3% (p>0.05); ascites generation rates, 38.5% and 11.7%(p<0.05); liver invasive rates, 100% and 61.7%(p<0.05); and lymphatic vessel densities (LVD), $10.4{\pm}3.02$ and $8.77{\pm}2.92$ (p>0.05), respectively. In the subcutaneous xenograft model, no evidence of ascites generation, lymph node metastasis and liver metastasis were found, and its LVD was lower ($4.56{\pm}1.53$, p<0.05). Conclusions: Compared with the subcutaneous xenograft model, the orthotopic xenograft model better simulates clinical gallbladder carcinoma in terms of metastasis and invasion, which may be attributed to the difference in microenvironment and LVD.