Design and Implementation of Transfusion Auxiliary Device by Patient Manual Control Dressing Change

Jiang Jin-gang,Shen Rui-chao,Wang Bao-fu,Gu Bo-yang,Tang Hai-bo,Jiang Ze-hao 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11

Transfusion auxiliary device by patient manual control dressing is proposed. It is realized by one-way rotation ratchet mechanism, which is consistent of slider-crank mechanism and double pawl ratchet mechanism. Dressing change is automatically realized by patient manual control rope. This reduces the labor intensity of the medical staff, shortens the waiting time of the patients. This device has the advantage of low cost, large market space.

An Antiviral Mechanism Investigated with Ribavirin as an RNA Virus Mutagen for Foot-and-mouth Disease Virus

Gu, Chao-Jiang,Zheng, Cong-Yi,Zhang, Qian,Shi, Li-Li,Li, Yong,Qu, San-Fu Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.1

To prove whether error catastrophe /lethal mutagenesis is the primary antiviral mechanism of action of ribavirin against foot-and-mouth disease virus (FMDV). Ribavirin passage experiments were performed and supernatants of $Rp_1$ to $Rp_5$ were harvested. Morphological alterations as well as the levels of viral RNAs, proteins, and infectious particles in the BHK-21 cells infected using the supernatants of $Rp_1$ to $Rp_5$ and control were measured by microscope, real-time RT-PCR, western-blotting and plaque assays, respectively. The mutation frequency was measured by sequencing the complete P1- and 3D-encoding region of FMDV after a single round of virus infection from ribavirin-treated or untreated FMDV-infected cells. Ribavirin treatment for FMDV caused dramatically inhibition of multiplication in cell cultures. The levels of viral RNAs, proteins, and infectious particles in the BHK-21 cells infected were more greatly reduced along with the passage from $Rp_1$ to $Rp_5$, moreover, nucleocapsid protein could not be detected and no recovery of infectious virus in the supernatant or detection of intracellular viral RNA was observed at the $Rp_5$-infected cells. A high mutation rate, giving rise to an 8-and 11-fold increase in mutagenesis and resulting in some amino acid substitutions, was found in viral RNA synthesized at a single round of virus infection in the presence of ribavirin of $1000\;{\mu}M$ and caused a 99.7% loss in viral infectivity in contrast with parallel untreated control virus. These results suggest that the antiviral molecular mechanism of ribavirin is based on the lethal mutagenesis/error catastrophe, that is, the ribavirin is not merely an antiviral reagent but also an effective mutagen.

An Antiviral Mechanism Investigated with Ribavirin as an RNA Virus Mutagen for Foot-and-mouth Disease Virus

Chao Jiang Gu,Cong Yi Zheng,Qian Zhang,Li Li Shi,Yong Li,San Fu Qu 한국생활환경학회 2006 BMB Reports Vol.39 No.1

FRACTAL ANALYSIS FOR FRACTURE PROCESS OF ROLYMER MATERIALS

Liu, Liu, Xiaobo,Gu, Gu, Yi,Jiang, Jiang, Luxia,Cai, Cai, Xingxian 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.3

This work focuses on fractal analysis for fracture process of polymer materials in theoric model and experimental ditermination. A series of theoric fractal model based on fracutred surface for fracutre process of polymer materials are founded, and the fractal dimension of fractured surface wa obtained under various break mechanism including crack in shear bands, crack development in stonely wave, crack cross, break in brittle, fractured pocess for the rigid filtered polymers and self-reinforced liquid crystal thermotes. These results retlected that the bigger the fractal dimensiion of the fractured surface, the higher the toughenss of polymer materials. According to Griffith strength, the mechanical properties of polymers increased lindarly with the rise of fractal dimension value.

Radix ranunculus temate saponins induces apoptosis via the death receptor and mitochondrial pathways in SGC-7901 cells

Mao-lin Li,Han-min Gu,Hong-ya Hang,Yao-li Jiang,Jiao Jiang,Qian-na Gu,Wen-yan Wu,M.-L. Li 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4

Radix ranunculus temate saponins (RRTS), one of the main constituents extracted from the popular traditional Chinese medicine Radix Ranunculi ternati, has been reported to have various biological activities including anti-cancer effect. The aim of this study is to investigate the effect of RRTS on the cell proliferation and apoptosis in human gastric adenocarcinoma SGC-7901 cells. The data showed that exposure to RRTS for 24 h produced cytotoxic effects on SGC- 7901 cells in a dose-dependent manner (with an IC50 value of 21.22±2.76 μg/mL), which was accompanied by apoptosis induction (from 2.18±0.89% (control) to 63.72±13.16% (100 μg/mL)). Both the extrinsic or death receptor pathway and the intrinsic or mitochondrial pathway were involved in RRTS-induced apoptosis in SGC-7901 cells. Furthermore, apoptotic signaling induced by RRTS was amplified by cross-link between the two pathways via the signal-integrating protein Bid. In conclusion, our findings contribute to better understanding the molecular mechanism of RRTS’ effect on gastric cancer cells and form the basis of the therapeutic development of RRTS in treating gastric cancer in the future.

An investigation into the effects of voids, inclusions and minor cracks on major crack propagation by using XFEM

Jiang, Shouyan,Du, Chengbin,Gu, Chongshi Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.49 No.5

For the structures containing multiple discontinuities (voids, inclusions, and cracks), the simulation technologies in the framework of extended finite element method (XFEM) are discussed in details. The level set method is used for representing the location of inner discontinuous interfaces so that the mesh does not need to align with these discontinuities. Several illustrations have been given to verify that the implemented XFEM program is effective. Then, the implemented XFEM program is used to investigate the effects of the voids, inclusions, and minor cracks on the path of major crack propagation. For a plate containing cracks and voids, two possibly crack path can be observed: i) the crack propagates into the void; ii) the crack initially curves towards the void, then, the crack reorients itself and propagates along its original orientation. For a plate with a soft inclusion, the final predicted crack paths tend to close with the inclusion, and an evident difference of crack paths can be observed with different inclusion material properties. However, for a plate with a hard inclusion, the paths tend to away from the inclusion, and a slightly difference of crack paths can only be seen with different inclusion material properties. For a plate with several minor cracks, the trend of crack paths can still be described as that the crack initially curves towards these minor cracks, and then, the crack reorients itself and propagates almost horizontally along its original orientation.

Protein corona on magnetite nanoparticles and internalization of nanoparticle-protein complexes into healthy and cancer cells

Jiang, Wen,Lai, Kuilin,Wu, Yao,Gu, Zhongwei 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1

Superparamagnetic magnetite nanoparticles (MNPs) of different surface properties are incubated in complicated living fluid, including fetal bovine serum solution, cell complete culture medium and cell culture system with/without serum, to investigate the alteration of protein corona and its impact on cell internalization. The MNPs prepared by co-precipitation method are functionalized with L-Lysine (Lys), Glucosamic acid (GA) to obtain amine, carboxyl and hydroxyl groups, separately. All the particles adsorb serum proteins to form MNPs-protein complexes with the surface charge changing into negative. 1D SDS/PAGE gel images analysis indicates that the composition and content of hard protein corona on the surface of NPs are related to their functional groups and agglomeration, and the total amount of protein in the medium. In cell culture system, particles not only adsorb serum proteins, but also associate with cytosolic proteins arising from HepG2 and L02 cells. GA modified MNPs (MNPs-GA) exhibit bovine serum albumin anti-adsorption capability because of the terminal hydroxyl and carboxyl groups. MNPs-GA also shows the highest cellular uptake and label efficiency compared with uncoated MNPs and Lys modified MNPs, due to larger aggregates formation and specific protein corona composition, rather than commonly approved electrostatic interaction between particles and cells. For the first time, our results provide visualized reports on previously neglected, but indispensable protein corona of the MNPs after interaction with both healthy and cancer cells, suggesting that cytosolic protein corona from cells and aggregation of particles are important factors needed to be account for on studying the nano-bio interface.

Influence of water content on dynamic mechanical properties of coal

Gu, Helong,Tao, Ming,Wang, Jingxiao,Jiang, Haibo,Li, Qiyue,Wang, Wen Techno-Press 2018 Geomechanics & engineering Vol.16 No.1

Water affects the mechanical properties of coal and stress wave propagation. To comprehensively investigate the effect of water content on the properties of coal, laboratory tests including X-Ray Diffraction (XRD) analysis, P-wave test, S-wave test, static and dynamic compression test with different water contents were conducted. The compressive strength, elastic modulus and failure strain and their mechanism of coal specimen under coupled static-dynamic load with the increased water content were observed. Meanwhile, energy transmission and dissipation characteristics of a stress wave in coal specimens with different water contents under dynamic load and its relation with the failure features, such as fragmentation and fractal dimension, of coal was analyzed. Furthermore, the dynamic interpretation of water infusion to prevent coal burst based on water infusion model of coal seam roadway was provided.

Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Jiang, Hu Lin,Arote, Rohidas B.,Quan, Ji Shan,Yoo, Mi Kyong,Kim, You Kyoung,Kim, In Yong,Hong, Zhong Shan,Lee, Hong Gu,Jin, Xun,Choi, Yun Jaie,Cho, Chong Su Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-

<P>Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.</P>

Modification of the structural properties of NiTiO₃ materials by transition metal dopants: The dopant size effect

Jiang, Kaiming,Pham, Thanh-Truc,Kang, Sung Gu,Men, Yong,Shin, Eun Woo Elsevier 2018 Journal of alloys and compounds Vol.739 No.-

<P><B>Abstract</B></P> <P>In this study, we investigated the changes of the structural and optical properties of NiTiO<SUB>3</SUB> materials modified by transition metal doping. Cobalt (Co) or tungsten (W)-doped NiTiO<SUB>3</SUB> materials were successfully prepared by a modified Pechini method via solvothermal treatment. Raman, FTIR, and XRD spectroscopic analyses showed that the Co<SUP>2+</SUP> ions were selectively doped into Ni<SUP>2+</SUP> sites in the NiTiO<SUB>3</SUB> lattice while maintaining an ilmenite structure, resulting in a solid solution of triple transition metal oxides. The size similarity between Co and Ni induced the formation of a solid solution, Co<SUB>x</SUB>Ni<SUB>1-x</SUB>TiO<SUB>3</SUB>, in the ilmenite structure. In contrast, W doping into the NiTiO<SUB>3</SUB> ilmenite structure resulted in an irregularity of the materials due to the characteristics of the heavy transition metal dopant. Along with increasing the W content, the crystallite size in the ilmenite structure decreased from 90.2 to 74.5 nm and new Raman bands at 831 and 892 cm<SUP>−1</SUP> for WO<SUB>x</SUB> appeared at high W contents. However, the PL emission intensities gradually decreased with increasing doping content, implying that the recombination process was inhibited in the NiTiO<SUB>3</SUB> materials by the dopants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Co (W)-doped NiTiO<SUB>3</SUB> materials were successfully prepared by a modified Pechini method. </LI> <LI> Selective Co<SUP>2+</SUP> ion doping into Ni<SUP>2+</SUP> sites in the NiTiO<SUB>3</SUB> lattice formed a solid solution. </LI> <LI> W doping into the NiTiO<SUB>3</SUB> lattice resulted in an irregularity in the lattice structure. </LI> <LI> The PL emission intensities gradually decreased with increasing dopant concentration. </LI> <LI> The recombination process in the NiTiO<SUB>3</SUB> materials was inhibited by the metal dopants. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>