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신현아;이애정;이지선;우혜임;조아라;채유진;엄애선 한양대학교 2010 韓國 生活 科學 硏究 Vol.30 No.1
Over the past decade, there has been growing scientific evidence that dietary milk plays a role in beneficial effects for human health. Milk provides a number of good ingredients, in particular with growth factors and different types of proteins such as α -lactalbumin and β-casein. As well as essential amino acids of leucine and isoleucine are make to a positive way of human physical conditions. Therefore, those ingredients are directly involved in the human body, fluid composition and involved in metabolism of protein or carbohydrate. In addition, the development of physical strength and bone health associated with milk consumption. Thus, milk is one of good food for prevention of osteoporosis. Nowadays, several dietary guidelines suggest that people should intake two or three cups of dairy products including milk a day. However, some people cannot drink milk because they appear many adverse effects with regard to intake of milk like allergic reactions, lactose intolerance and weight gain problem. Consequently, it is worthy to discuss about these matters. Person pose the health problems regarding milk consumption should select dairy products carefully. Milk substitutes such as partially-hydrolyzed formula, yogurt, cheese and non- and low-fat dairy products are suggested. They prevent the allergy and lactose intolerance due to lactase in fermented milk digesting the lactose into glucose and galactose. Taking all of these into account, milk consumption is very important to maintain the human health. Although there are several adverse effects with regard to milk consumption, it would not be shown any health problem only if it follows the milk dietary guidelines. Therefore, a milk drinking should be actively encouraged for the public health.
신경세포의 Outgrowth 향상을 위한 마이크로 파이버 지지체와 전단응력의 영향
김인애,박수아,김영직,김수향,신호준,이용재,신지원,신정욱 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-
We introduced mechanical stimuli and micro patterned substrate with micro fibers to investigate the effects of those on neurite outgrowth along with nerve growth factor (NGF) in vitro. Micro fiber substrates were fabricated using an electros pinning process. And PC-12 cells cultured on substrates were simulated with newer growth factor and laminar flow shear stress in a fluid flow system. The results suggest that micro fiber substrates and fluid-induced shear stress are promising for simulating neuronal regeneration in a desired direction.
GG-38 : Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen
( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.
OB-33 : The effect of early third trimester emergency cervical cerclage on pregnancy outcome
( Ji Hye Lee ),( Ji Eun Park ),( Jeong Kyu Shin ),( Won Jun Choi ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ),( Ji Kwon Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
To evaluate the effectiveness of early third trimester (26-30 weeks gestation) emergency cervical cerclage on pregnancy outcome in women with cervical incompetence. Medical records were reviewed for demographic and clinical data, gestational age at cerclage, functional cervical length after cerclage, cerclage-delivery interval, gestational age at delivery, and neonatal birth weight. Forty-one patients underwent emergency cervical cerclage between 16-30 weeks gestation. Sixteen patients underwent cerclage at 16-21 6/7 weeks (Period I); 12 patients, at 22-25 6/7 weeks (Period II); and 13 patients, at 26-29 6/7 weeks (Period III). There were no significant differences among Periods I, II, and III with respect to functional cervical length after cerclage (2.6 ± 0.6, 2.4 ± 0.3, and 2.3 ± 0.5 cm, respectively), cerclage-to-delivery interval (71.7 ± 54.2, 69.2 ± 36.3, and 55.5 ± 25.2 days, respectively), gestational age at delivery (30 2/7 weeks ± 59 days, 34 5/7 weeks ± 36 days, and 35 3/7 weeks ± 30 days, respectively), rate of deliveries after 28 weeks (56.2, 83.3, and 84.6%, respectively), rate of deliveries after 32 weeks (50.0, 75.0, and 84.6%, respectively), rate of deliveries after 36 weeks (37.5, 58.3, and 53.8%, respectively), or neonatal birth weight (1871 ± 1473, 2588 ± 1006, and 2678 ± 944 g, respectively). Gestational age at emergency cerclage and gestational age at delivery were significantly correlated (p=0.001, R2 = 0.24). These results address the benefits of attempting emergency cerclage during the early third trimester.
Shin, Ji-Ae,Han, Gyoonhee,Kim, Hyun-Jung,Kim, Hwan-Mook,Cho, Sung-Dae Lippincott Williams & Wilkins 2014 EUROPEAN JOURNAL OF CANCER PREVENTION Vol.23 No.4
Histone deacetylase inhibitors (HDACi) have been reported to have potent chemopreventive activity because of their effects on the inhibition of cell growth and apoptosis in human cancer cell lines. In the present study, we investigated the apoptotic effect of a novel HDACi, Ky2, and its molecular mechanism in MDA-MB-231 human breast cancer cells in vitro. The chemopreventive effects of Ky2 in MDA-MB-231 cells were evaluated using the MTS assay, anchorage-independent cell transformation assay, DAPI staining, western blot analysis, reverse transcriptase-PCR, and small interfering RNA. Ky2 enhanced histone acetylation and decreased cell viability. Ky2 induced apoptosis evidenced by nuclear condensation and fragmentation, the accumulation of sub-G1 phase, and caspase-dependent PARP cleavage. In addition, Ky2 released cytochrome c from mitochondria to cytosol through the regulation of mitochondria-related proteins (Bid, Bim, and Bcl-xL). Ky2 markedly decreased the level of Sp1 protein expression through both the decrease of Sp1 mRNA level and proteasome-dependent protein degradation. Interestingly, the apoptotic effect of Ky2 is more potent than SAHA, a well-known HDACi. Furthermore, the knockdown of Sp1 protein by Sp1-specific inhibitor, mithramycin A, and siRNA resulted in the alteration of truncated Bid and Bim to induce apoptosis. Furthermore, Ky2 significantly decreased TPA-induced or EGF-induced neoplastic cell transformation in JB6 cells. Our results suggest that Ky2 may be a potential chemopreventive and chemotherapeutic agent by modulating Sp1 in human breast cancer cells.
Ji Eun Park,Ji Kwon Park,In Ae Cho,Jong Chul Baek,Min Young Kang,Jae Ik Lee,Jeong Kyu Shin,Won Jun Choi,Soon Ae Lee,Jong Hak Lee,Won Young Paik 대한의학유전학회 2014 대한의학유전학회지 Vol.11 No.2
Purpose: To assess the outcomes of increased fetal nuchal translucency (NT), to aid in prenatal counseling and management in our practice. Materials and Methods: We retrospectively reviewed the medical records of patients who underwent first trimester fetal karyotyping using chorionic villi sampling (CVS) and second trimester level II sonography for a fetal NT thickness ≥3.0 mm between 11 weeks and 13 weeks 6 days' gestation, at Gyeongsang National University Hospital. Pediatric medical records and a telephone interview were used to follow-up live-born children. Exclusion criteria included incomplete data and CVS for other indications. Results: Seventy cases met the inclusion criteria (median NT thickness, 4.7 mm; range, 3.0-16.1 mm). Twenty-nine cases (41.4%) were aneuploid. The prevalence of chromosomal defects increased with NT thickness: NT 3.0-3.4 mm, 16.7%; NT 3.5-4.4 mm, 27.3%; NT 4.5-5.4 mm, 66.7%; NT 5.5-6.4 mm, 37.5%; NT ≥6.5 mm, 62.5%. The most common karyotype abnormality was trisomy 18 (n=12), followed by trisomy 21 (n=9). In chromosomally normal fetuses (n=41), fetal death occurred in 2 cases (4.9%), and structural malformations were found in 11 cases (26.8%). In chromosomally and anatomically normal fetuses (n=28), one child had neurodevelopmental delay (3.6%). Twenty-eight infants who had a prenatal increased NT were alive and well at follow-up (40%). Conclusion: Outcomes of increased fetal NT might help inform prenatal counseling and management. The high prevalence of chromosomal defects associated with increased fetal NT implies that CVS should be performed in the first trimester, particularly considering the stress associated with an uncertain diagnosis.