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맹장을 제거한 성계숫닭에 의한 國內産 肉鷄 내장분말의 有效 아미노산 利用率
李乙衍,金炯浩,車章玉,朴弘錫 全北大學校 1994 論文集 Vol.38 No.-
This study was designed to compare true digestible amino acid values for broiler offal meal with available amino acid values. Broiler offal meal was each force-fed to 6 intact and 6 caecectomised adult cockerels For each test, Cockerels were starved of food for 24 h, fed, and then excreta collected for 48 h. Crude protein, ether extract and ash of broiler offal meal were 50.5%, 16.7%, and 11.7%, respectively. True digestibilities of all seventeen measured amino acids were lower for caecectomised than intact cockerels, with the average difference being approximately 0. 10. True available amino acid of broiler offa meal was higher values for cystine and aspartic acid in intact than in caecetomised cockerels. Generally leucine, isoleucine and glutamic-acid were among the most available amino acids, while cystine, aspartic acid and threonine were among the least available amino acids in broiler offal meal for caecectomised cockerels.
Nam Jun Cho,Ho-Sung Lee,Si-Hyong Jang,Jae Sung Choi,Ju Ock Na,Ki Hyun Seo,Yong Hoon Kim,Hyo-Chul Kang,Dae-Yeon Kim1 순천향의학연구소 2013 Journal of Soonchunhyang Medical Science Vol.19 No.2
In patients with advanced non-small cell lung cancer harboring epidermal growth factor receptor (EGFR) mutations, the epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are used as first treatment option. Because adenosquamous carcinoma (ASC) is a rare histologic subtype, evidences about EGFR-TKIs as first treatment option for advanced ASC are lacking. We report a case of an advanced ASC patient with the EGFR mutation, who showed good responses during 4-month treatment with gefitinib. And we will review about a necessity of EGFR mutation test and efficacy of EGFR-TKIs in ASC patients from the recent studies.
Differences of Multiple Comparison Methods for Treatment Means
Jang-Ock Cha,Sehwan Shim,Sokho Kim,Gee-Wook Shin,Jong-Hoon Kim,Myungjo You,Jun-Gyo Suh,Jungkee Kwon 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.4
Contrary to T-test in only two groups, ANOVA (Analysis of Variance) is commonly used technique for comparing the means of two or more groups. Multiple comparison methods are often performed following a significant finding in the ANOVA. There are a number of multiple comparison procedures in the literature. Although several methods are commonly available in statistical software packages, some researchers face difficulties in interpreting their data. In this paper, we demonstrate the differences of several methods for the treatment means using SAS program.
Jang, Hye-Ock,Kim, Dong-Won,Kim, Byeong-Ill,Sim, Hong-Gu,Lee, Young-Ho,Lee, Jong-Hwa,Bae, Jung-Ha,Bae, Moon-Kyoung,Kwon, Tae-Hyuk,Yun, Il The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.2
The purpose of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Large unilamellar vesicles (OPGTL) were prepared with total lipids extracted from cultured Porphyromonas gingivalis outer membranes (OPG). The anthroyloxy probes were located at a graded series of depths inside a membrane, depending on its substitution position (n) in the aliphatic chain. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine effects of chlorhexidine digluconate on differential rotational mobility, while changing the probes' substitution position (n) in the membrane phospholipids aliphatic chain. Magnitude of the rotational mobility of the intact six membrane components differed depending on the substitution position in the descending order of 16-(9-anthroyloxy)palmitic acid (16-AP), 12, 9, 6, 3 and 2-(9-anthroyloxy)stearic acid (12-AS, 9-AS, 6-AS, 3-AS and 2-AS). Chlorhexidine digluconate increased in a dose-dependent manner the rate of rotational mobility of hydrocarbon interior of the OPGTL prepared with total lipids extracted from cultured OPG, but decreased the mobility of membrane interface of the OPGTL. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
Jang, Hye-Ock,Kim, Ji-Suk,Kwon, Woo-Cheol,Kim, Jeong-Kuk,Ko, Myung-Suk,Kim, Dong-Hoo,Kim, Won-Il,Jeon, Young-Chan,Chung, In-Kyo,Shin, Sang-Hun,Chung, Jin,Bae, Moon-Kyung,Yun, Il 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.2
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). $Pb^{2+}$ inhibited the immediate CRACI dose-dependent manner. Influx of $Pb^{2+}$ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of $Pb^{2+}$ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of $Ca^{2+}$ upon $Ca^{2+}$ readdition, is partially inhibited by $Pb^{2+}$ and (2) the influx of $Pb^{2+}$ was enhanced after CRACI had been induced.
Panax ginseng Protects Against Global Ischemia Injury in Rat Hippocampus
Kim, Young-Ock,Kim, Hak-Jae,Kim, Geum-Soog,Park, Ho-Gi,Lim, Sang-Jong,Seong, Nak-Sul,Ham, Yung-Woon,Lee, Sung-Dong,Jang, Ki-Hyo,Jung, Kyung-Hee,Chung, Joo-Ho,Kang, Soon-Ah The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
Based on the use of Panax ginseng C.A. Meyer (Family Araliaceae) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of P. ginseng after transient global cerebral ischemia using the four-vessel occlusion rat model. Nissl staining, lipid peroxidation (malondialdehyde [MDA] formation), and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of rat brain were assessed. Ethanolic P. ginseng extract (200 mg/kg, i.p.) significantly protected CA1 neurons against 10 minutes of transient forebrain ischemia as demonstrated by measuring the density of neuronal cells. P. ginseng also significantly decreased the level of MDA and increased the expression of GPx and SOD. These results suggest that P. ginseng might be neuroprotective against cerebral ischemia-induced injury in rat brain by decreasing lipid peroxides and increasing the expression of GPx and SOD.
Jang, Hyun Seon,Lee, Kwang Ho,Jeong, Moon Jin,Park, Joo Cheol,Kim, Heung Joong,Kwon, Young Sun,Kim, Chong Kwan,Kim, Byung Ock Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.330 No.-
<P>This study evaluated the histology results of surgically created bone cavities in the calvaria of rabbits that were subsequently filled with a HA/ß-TCP composite powder developed in Korea (Dentium, Korea). Ten young adult rabbits were used. Four defects were surgically produced in the calvaria of each rabbit. These defects were classified into 4 groups: the control group, no graft materials; experimental group I, normal saline + graft materials; experimental group II, venous blood + graft materials; and experimental group III, graft materials only. The defects were randomly filled with the graft materials. The rabbits were sacrificed with at 1-, 2-, 4-, 6- and 8- weeks after surgery. The histology specimens were prepared using the general method with H & E staining at a 6 ㎛ thickness. Histologically, the degree of new bone formation was similar in all experimental groups. However, for experimental group II, many cells had gathered around the graft materials 1-week after surgery, and new bone formed slightly faster and than in the other groups. No bone formation was observed in the control group. Based on histology findings, the new HA/ß- TCP composite powders appeared to act as a scaffolding material for the regeneration of osseous defects.</P>
Hye-Ock Jang,Dong-Won Kim,Byeong-Ill Kim,Hong-Gu Sim,Young-Ho Lee,Jong-Hwa Lee,Jung-Ha Bae,Moon-Kyoung Bae,Tae-Hyuk Kwon,Il Yun 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.2
The purpose of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Large unilamellar vesicles (OPGTL) were prepared with total lipids extracted from cultured Porphyromonas gingivalis outer membranes (OPG). The anthroyloxy probes were located at a graded series of depths inside a membrane, depending on its substitution position (n) in the aliphatic chain. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine effects of chlorhexidine digluconate on differential rotational mobility, while changing the probes substitution position (n) in the membrane phospholipids aliphatic chain. Magnitude of the rotational mobility of the intact six membrane components differed depending on the substitution position in the descending order of 16-(9-anthroyloxy)palmitic acid (16-AP), 12, 9, 6, 3 and 2-(9-anthroyloxy)stearic acid (12-AS, 9-AS, 6-AS, 3-AS and 2-AS). Chlorhexidine digluconate increased in a dose-dependent manner the rate of rotational mobility of hydrocarbon interior of the OPGTL prepared with total lipids extracted from cultured OPG, but decreased the mobility of membrane interface of the OPGTL. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
Seon Ock Kim,Woo Jin Kim,Kab-Jin Kim,Sug-Bong Choe,Young Man Jang,Seung Ha Yoon,Beong Ki Cho,Taek Dong Lee IEEE 2008 IEEE transactions on magnetics Vol.44 No.11
<P>The current-induced domain-wall depinning in ferromagnetic nanowires with perpendicular magnetic anisotropy is investigated. The nanowire patterns with 500-nm width are fabricated from 8-nm-thick Co-Re-Pt alloy films on 1-nm-thick Ta underlayer. By injecting the current into the nanowire, the domain wall motion via depinning from extrinsic structural pinning sites is observed. The depinning time ranging over 1 mus-1 s is found to be exponentially dependent on the current density. Based on generalized Neel-Brown formula, the slope of the exponential dependence is analyzed to estimate the depinning energy barrier as a function of the current density under a constant bias magnetic field.</P>