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Change in radial artery pulse wave in stroke hemiplegic patients
Kim, Jaeuk U.,Kim, Jae Kyoun,Shin, Jae-Young,Ku, Boncho,Bae, Jang-Han,Yeom, Seungryong,Lee, Sangkwan Williams & Wilkins Co 2018 Medicine Vol.97 No.13
<P><B>Abstract</B></P><P><B>Introduction:</B></P><P>About 55% to 75% of stroke survivors have motor disorders and problems that affect their quality of life. The prevention of secondary neurological damages through relapse prevention and the rehabilitation of stroke patients suffering from morbidities are crucial to improve the prognosis of patients with stroke. Pulse examinations can be used to determine the stroke progression. This study will investigate the differences and changes in radial artery pressure-pulse waves during the treatment of hemiplegia caused by stroke.</P><P><B>Methods/design:</B></P><P>This study protocol is for a prospective matched case-control study. A total of 84 participants will be recruited, 56 patients with hemiplia caused by stroke, and 28 control patients matched by age, gender, and body mass index. The primary outcome of this study will be the differences and changes in the radial augmentation index.</P><P><B>Discussion:</B></P><P>The results of the study will help to determine the differences and changes in radial artery pressure-pulse waves during the treatment of hemiplegia caused by stroke. The findings will provide information about the physiological and hemodynamic mechanisms.</P><P><B>Conclusion:</B></P><P>This will be the first study to analyze the pulse wave of the radial artery (PWRA) on the affected side and on the normal side in stroke patients with hemiplegia. This study will clarify whether the radial artery pressure pulse wave can be used to evaluate the result of stroke treatment objectively. The results of the study will be available in February 2019. The version of the protocol is v1.6 written in March 7, 2016.</P><P><B>Ethics and dissemination:</B></P><P>Written informed consent will be obtained from all participants. This study has been approved by the Institutional Review Board (IRB) of Wonkwang University Gwangju Hospital, Gwangju, Republic of Korea (WKIRB-2016/8). The study findings will be published in peer-reviewed journals and presented at national and international conferences.</P><P><B>Trial registration number:</B></P><P>This trial was registered with the Clinical Research Information Service (CRIS) of the Korea National Institute of Health (NIH), Republic of Korea (KCT0002147).</P>
Study of Single-dose Toxicity of Aconitum Kusnezoffii Reichb. Pharmacopuncture in Rats
Kim, Jae-Kyoun,Kim, Sung-Ha,Lee, Sang-Mi,Jeong, Ho-Hyun,Park, Man-Yong,Kim, Dong-Woung,Song, Bong-Keun,Lee, Jong-Deok,Kim, Sung-Chul KOREAN PHARMACOPUNCTURE INSTITUTE 2012 Journal of pharmacopuncture Vol.15 No.3
Objective: This study was performed to analyze the single-dose toxicity of Aconitum kusnezoffii Reichb. pharmacopuncture (AKRP). Methods: All experiments were conducted at the Korea Testing & Research Institute (KTRI), an institute authorized to perform non-clinical studies, under the regulations of Good Laboratory Practice (GLP). Twenty (20) Sprague-Dawley rats were chosen for the pilot study. The animals were divided into four groups of five animals per group: group 1 (G1) being the control group with each animal receiving an injection of 0.3 ml of saline and groups 2, 3, and 4 (G2, G3, and G4) being the experimental groups with each animal receiving an injection of 0.1, 0.2 or 0.3 ml of AKRP, respectively. This study was conducted with the approval of the Institutional Animal Ethics Committee. Results: No deaths occurred in any of the 4 groups, and the $LD_{50}$ of AKRP administered via IV was higher than 1.77 ml/kg. Some changes in the weights of the male rates were observed between the control group and the experimental groups, but no significant differences were noted in the weights of the female rats. To check for abnormalities in organs and tissues, we stained representative sections of each specified organ with Hematoxylin & Eosin for light microscopic examination. The results showed no significant differences in any of the organs or tissues. Conclusions: The above findings suggest that Aconitum kusnezoffii Reichb. pharmacopuncture is a relatively safe treatment. Further studies on the subject should be conducted to yield more concrete evidence.
Acupuncture and Spontaneous Regression of a Radiculopathic Cervical Herniated Disc
Kim, Sung-Ha,Park, Man-Young,Lee, Sang-Mi,Jung, Ho-Hyun,Kim, Jae-Kyoun,Lee, Jong-Deok,Kim, Dong-Woung,Yeom, Seung-Ryong,Lim, Jin-Young,Park, Min-Jung,Park, Se-Woon,Kim, Sung-Chul KOREAN PHARMACOPUNCTURE INSTITUTE 2012 Journal of pharmacopuncture Vol.15 No.2
The spontaneous regression of herniated cervical discs is not a well-established phenomenon. However, we encountered a case of a spontaneous regression of a severe radiculopathic herniated cervical disc that was treated with acupuncture, pharmacopuncture, and herb medicine. The symptoms were improved within 12 months of treatment. Magnetic resonance imaging (MRI) conducted at that time revealed marked regression of the herniated disc. This case provides an additional example of spontaneous regression of a herniated cervical disc documented by MRI following non-surgical treatment.
추출방법에 따른 돼지감자 잎의 항산화 및 생리활성 비교
김재원(Jae-Won Kim),김종규(Jong-Kyoun Kim),송인성(In-Seong Song),권은성(Eun-Sung Kwon),윤광섭(Kwang-Sup Youn) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.1
돼지감자 잎의 활용 및 생리활성을 증가시킬 수 있는 적정추출방법을 알아보고자 환류냉각, 상온교반, 가압가열 및 저온고압 추출법을 이용하여 추출한 돼지감자 잎 추출물의 생리활성을 비교하였다. 추출수율은 가압가열추출, 환류냉각추출, 상온교반추출, 저온고압추출 순으로 높은 수율을 나타내었다. 폴리페놀 함량은 상온교반추출 및 환류냉각추출의 경우 대등한 함량을 나타낸 반면 가압가열추출 및 저온고압 추출에서는 유의적으로 높은 함량을 나타내었으며, 플라보노이드 함량은 가압가열추출 및 저온고압추출에서 높은 함량을 나타내었다. Proanthocyanidin 함량에서는 저온고압추출에서 가장 높은 함량이 검출된 반면 가압가열추출에서는 상온교반 및 환류냉각추출에 비해 낮은 함량을 나타내었다. 항산화 활성에서는 모든 추출물이 농도가 증가함에 따라 활성은 비례적으로 증가하였다. 가압가열추출 및 저온고압추출에서 유의적으로 높은 활성을 나타내었으며, α-glucosidase,xanthine oxidase 및 angiotensin I-converting enzyme 저해활성에서는 저온고압추출물에서 우수한 활성을 나타내었다. 이러한 결과를 종합해 볼 때 가압가열 및 저온고압추출물이 소재 활용가치가 높을 것으로 사료되며 천연 항산화제 및 기능성 증진을 위한 소재로 이용 가능할 것으로 판단된다. The physiological properties of water extracts from Jerusalem artichoke (Helianthus tuberosus L.) leaves (JAL) with different extraction processes (stirrer extraction, SE; reflux extraction, RE; autoclave extraction, AE; low temperature high pressure extraction, LTPE) were investigated. The freeze-dried powder yields of SE, RE, AE, and LTPE were 22.33%, 29.88%, 31.65, and 15.74%, respectively. AE showed the highest value of extract yield. The a* and b* values were higher in AE compared to other extracts. Total polyphenolics and flavonoids contents in AE was significantly higher than in other extracts. The amount of proanthocyanidin related substances were highest in LTPE (29.36 mg/g), followed by RE (21.57 mg/g), SE (20.35 mg/g), and AE (13.02 mg/g). The electron donating abilities of SE, RE, AE, and LTPE at a concentration of 500 μg/mL (w/v) were 76.16%, 39.55%, 25.50%, and 12.59%, respectively. Reducing power for the four different processes was 1.79, 1.60, 1.51, and 1.17, respectively. Additionally the same tendency was observed with electron donating ability and reducing power for ABTS radical and nitrite scavenging abilities. AE and LTPE showed relatively high antioxidant activities. Alpha-glucosidase, xanthine oxidase, and angiotensin I-converting enzyme inhibitory ctivities of LTPE at a concentration of 500 μg/mL (w/v) were somewhat higher than other extracts. Additionally, there was significantly higher or little lower inhibitory activity compared to the control group. In conclusion, we provided experimental evidence that extracts of JAL have potential as functional materials, and component analysis of JAL could be used as new cosmeceuticals. Also, LTPE is the superior method for the enhancement of biological activity.
『난경(難經)』 맥진조(脈診條) 중 구난(九難)~십오난(十五難)의 영역(英譯) 연구(硏究)
김재균 ( Jae Kyoun Kim ),강혜원 ( Hye Won Kang ),백진웅 ( Jin Ung Baek ) 대한한의학원전학회(구 대한원전의사학회) 2010 대한한의학원전학회지 Vol.23 No.5
Globalization describes a process by which regional cultures have become integrated through a global network of communication. In order to communicate among different cultural groups, standardization of terminology is one of the most important steps among its processes. In the field of oriental medicine, there have been continuous efforts to communicate through various methods. Translation of oriental medical classics is one of the significant approaches in terms of transmitting medical theories and clinical experiences of thousands of years to the people of different cultural backgrounds. However, previous translation studies have had difficulties in delivering its underlying principles and assumptions due to lack of standardization of terminology. 『WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region(WHO-IST)』is the outcome of developing standard terminologies on oriental medicine based on mutual agreement of researchers of Korea, China and Japan. As a movement to find more efficient methodology for communication between heterogeneous communities, this study aims to translate parts of 『Classic of difficult issues(難經)』into English adopting 『WHO-IST』hoping to set a model of translation study.
Urea-SCR 시스템에서 De-NO<SUB>x</SUB> 성능 향상을 위한 배기관 설계 최적화에 관한 실험적 연구
이재균(Jae-Kyoun Lee),윤여빈(Yu-Bin Yoon),송춘섭(Chun-Sub Song),박영준(Young-Joon Park),조용석(Yong-Seok Cho),주재근(Jae-Geon Joo),김현옥(Hyun-Ok Kim) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
The selective catalytic reduction(SCR) system is potentially a highly-effective means of NOx reduction for diesel engine. Generally, SCR makes use of a reductant added to the exhaust gas that can be used for reacting nitric acids to nitrogen. The reductant, ammonia(NH₃) generated from a liquid urea-water solution. The ideal ratio of NH₃ molecules to NOx molecules is 1:1 based on NH₃ consumption and having NH₃ available for reaction of all of the exhaust NOx. The SCR system has good NOx conversion performance in the temperature window about 250 to 400℃, low space velocity also leads to increase of NOx conversion efficiency, due to long residence time in the catalyst. In this paper, Urea-SCR system has tried to find the optimal shape of the exhaust pipe for improvement of de-NOx performance. This study used the blade-type mixer and various pipes for reduction at up stream of catalyst to improve the uniformity. As a result, the de-NOx performance of Urea-SCR system was improved and exhaust geometry was optimized, too.