여대생의 인유두종 바이러스 및 인유두종 바이러스 백신 관련 지식과 예방접종 실태와의 상관관계

Xu, Meiling,김현지,이희수,이윤지,한동연,박소영,엄효윤,최정민,홍서진,홍예림,이경은,이혜림 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51

Purpose: Human Papillomavirus (HPV) vaccination is readily available, but immunization rate is minimal. Lack of knowledge concerning the HPV infection and vaccine is expected as the primary reason. The correlation between knowledge levels and vaccination will provide applicable guidelines for successful interventions. Method: 309 female university students have completed surveys September 2016, reporting of HPV infection knowledge, HPV vaccine knowledge, source of knowledge, and attitudes concerning vaccination. Result: HPV infection and vaccine knowledge levels were both suboptimal(9.57±1.84, 7.59±1.58), and the Internet(16.2%) was recognized as the most generally used means of obtaining information on the HPV vaccine. However, vaccination rates were reported to be low(28.2%), with lack of information(46.6%) hindering immunization. Correlations were found between HPV infection knowledge and cervical cancer insight, but the correlations between knowledge levels and vaccination rates were insignificant. Conclusion: Prior information on cervical cancer had an effect on the knowledge levels of HPV infection, but other factors were insignificant. Lack of information on the HPV vaccine was speculated, thus programs should focus on accessibility and effectiveness.

Constraints on kinematic models from the latest observational data

Lu, J.,Xu, L.,Liu, M. North-Holland Pub. Co 2011 Physics letters: B Vol.699 No.4

Kinematical models are constrained by the latest observational data from geometry-distance measurements, which include 557 type Ia supernovae (SNIa) Union2 data and 15 observational Hubble data. Considering two parameterized deceleration parameter, the values of current deceleration parameter q<SUB>0</SUB>, jerk parameter j<SUB>0</SUB> and transition redshift z<SUB>T</SUB>, are obtained. Furthermore, we show the departures for two parameterized kinematical models from ΛCDM model according to the evolutions of jerk parameter j(z). Also, it is shown that the constraint on jerk parameter j(z) is weak by the current geometrical observed data.

Understanding of the capacity contribution of carbon in phosphorus-carbon composites for high-performance anodes in lithium ion batteries

Xu, J.,Jeon, I. Y.,Ma, J.,Dou, Y.,Kim, S. J.,Seo, J. M.,Liu, H.,Dou, S.,Baek, J. B.,Dai, L. Springer Science + Business Media 2017 Nano research Vol.10 No.4

<P>Phosphorus has recently received extensive attention as a promising anode for lithium ion batteries (LIBs) due to its high theoretical capacity of 2,596 mAh.g(-1). To develop high-performance phosphorus anodes for LIBs, carbon materials have been hybridized with phosphorus (P-C) to improve dispersion and conductivity. However, the specific capacity, rate capability, and cycling stability of P-C anodes are still less than satisfactory for practical applications. Furthermore, the exact effects of the carbon support on the electrochemical performance of the P-C anodes are not fully understood. Herein, a series of xP-yC anode materials for LIBs were prepared by a simple and efficient ball-milling method. 6P-4C and 3P-7C were found to be optimum mass ratios of x/ y, and delivered initial discharge capacities of 1,803.5 and 1,585.3.mAh.g(-1), respectively, at 0.1 C in the voltage range 0.02-2 V, with an initial capacity retention of 68.3% over 200 cycles (more than 4 months cycling life) and 40.8% over 450 cycles. The excellent electrochemical performance of the 6P-4C and 3P-7C samples was attributed to a synergistic effect from both the adsorbed P and carbon.</P>

Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes

Park, J.Y.,Rha, S.W.,Choi, B.,Choi, J.W.,Ryu, S.K.,Kim, S.,Noh, Y.K.,Choi, S.Y.,Akkala, R.G.,Li, H.,Ali, J.,Xu, S.,Ngow, H.A.,Lee, J.J.,Lee, G.N.,Kim, J.,Lee, S.,Na, J.O.,Choi, C.U.,Lim, H.E.,Kim, J.W Elsevier/North-Holland Biomedical Press 2015 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.184 No.-

Background: High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact of low dose atorvastatin (LDA, 10mg or 20mg) on the development of NODM up to three years in Asian patients. Methods: From January 2004 to September 2009, we investigated a total of 3566 patients who did not have DM. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM (C-statistics: 0.851), a total of 818 patients (LDA group, n=409 patients and control group, n=409 patients) were enrolled for analysis. Results: Before PSM, the cumulative incidence of NODM (5.8% vs. 2.1%, p<0.001), myocardial infarction (0.5% vs. 0.1%, p-value=0.007), and major adverse cardio-cerebral event (MACCE, 1.8% vs. 0.7%, p-value=0.012) at three-years were higher in the LAD group. However, after PSM, there was a trend toward higher incidence of NODM (5.9% vs. 3.2%, p=0.064) in the LDA group, but the incidence of MACCE (1.2% vs. 1.5%, p-value=1.000) was similar between the two groups. In multivariable analysis, the LDA administration was tended to be an independent predictor of NODM (OR: 1.99, 95% CI: 1.00-3.98, p-value 0.050). Conclusions: In this study, the use of LDA tended to be a risk factor for NODM in Asian patients and reduced clinical events similar to the control group. However, large-scale randomized controlled trials will be needed to get the final conclusion.

Five-year clinical outcomes in patients with significant coronary artery spasm: A propensity score-matched analysis

Choi, B.G.,Park, S.H.,Rha, S.W.,Park, J.Y.,Choi, S.Y.,Park, Y.,Xu, S.,Ngow, H.A.,Ali, J.,Li, H.,Kim, J.B.,Lee, S.,Na, J.O.,Choi, C.U.,Lim, H.E.,Kim, J.W.,Kim, E.J.,Park, C.G.,Seo, H.S.,Oh, D.J. Elsevier/North-Holland Biomedical Press 2015 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.184 No.-

Background: Coronary artery spasm (CAS) is known to be a risk factor of acute coronary syndrome and angina pectoris. However, there is no currently available data with larger study population regarding long-term clinical outcomes of CAS in real world clinical practice. Objectives: We evaluated the prevalence of CAS and the impact of CAS on 5-year clinical outcomes in a series of Asian CAS patients documented by intracoronary acetylcholine (Ach) provocation test. Methods: A total of 1413 consecutive patients without significant coronary artery disease (CAD) who underwent Ach provocation test between Nov. 2004 and Oct. 2008 were enrolled. Significant CAS was defined as >70% of narrowing by incremental intracoronary injection of 20, 50 and 100μg. Patients were divided into two groups based on the presence of significant CAS (the non-CAS group: n=640, the CAS group; n=773). To adjust potential confounders, a propensity score matched (PSM) analysis was performed using the logistic regression model. Results: A total of 54.7% (773/1413) patients were diagnosed as CAS documented by Ach provocation test. After PSM analysis, 2 propensity-matched groups (451 pairs, n=902, C-statistic=0.677) were generated. Despite of similar incidence of individual hard endpoints including mortality, myocardial infarction and revascularization, the CAS group showed the higher trend of recurrent angina requiring follow up angiography than the non-CAS group up to 5years (HR; 1.56, 95% C.I.; 0.99-2.46, p=0.054). Conclusions: The prevalence of CAS was 54.7%. Although the cumulative incidence of recurrent angina requiring follow up coronary angiography seems to be increased up to 5years in CAS patients, CAS patients was not associated with major individual and composite clinical outcomes such as mortality, MI, PCI, CVA with optimal medical therapy as compared with patients without CAS.

Stability of multi-step flexural-shear plates with varying cross-section

Xu, J.Y.,Li, Q.S. Techno-Press 2003 Structural Engineering and Mechanics, An Int'l Jou Vol.16 No.5

In this paper, multi-story buildings with shear-wall structures and with narrow rectangular plane configuration are modeled as a multi-step flexural-shear plate with varying cross-section for buckling analysis. The governing differential equation of such a plate is established. Using appropriate transformations, the equation is reduced to analytically solvable equations by selecting suitable expressions of the distribution of stiffness. The exact solutions for buckling of such a one-step flexural-shear plate with variable stiffness are derived for several cases. A new exact approach that combines the transfer matrix method and closed from solution of one-step flexural-shear plate with continuously varying stiffness is presented for stability analysis of multi-step non-uniform flexural-shear plate. A numerical example shows that the present methods are easy to implement and efficient.

Suboptimal control strategy in structural control implementation

Xu, J.Y.,Li, Q.S.,Li, G.Q.,Wu, J.R.,Tang, J. Techno-Press 2005 Structural Engineering and Mechanics, An Int'l Jou Vol.19 No.1

The suboptimal control rule is introduced in structural control implementation as an alternative over the optimal control because the optimal control may require large amount of processing time when applied to complex structural control problems. It is well known that any time delay in structural control implementation will cause un-synchronized application of the control forces, which not only reduce the effectiveness of an active control system, but also cause instability of the control system. The effect of time delay on the displacement and acceleration responses of building structures is studied when the suboptimal control rule is adopted. Two examples are given to show the effectiveness of the suboptimal control rule. It is shown through the examples that the present method is easy in implementation and high in efficiency and it can significantly reduce the time delay in structural control implementation without significant loss of performance.

Kinetics of microbial hydrogenation of free linoleic acid to conjugated linoleic acids

Xu, H.,Lee, H.Y.,Hwang, B.,Nam, J.H.,Kang, H.Y.,Ahn, J. Blackwell Publishing Ltd 2008 Journal of applied microbiology Vol.105 No.6

<P>Abstract</P><P>Aims: </P><P>To investigate the ability of selected probiotic bacterial strains to produce conjugated linoleic acid (CLA) and also to estimate the biohydrogenation kinetics of <I>Lactobacillus acidophilus</I> on the production of CLA from free linoleic acid (LA).</P><P>Methods and Results: </P><P>Six probiotic bacteria, <I>Lact</I>. <I>paracasei</I>, <I>Lact</I>. <I>rhamnosus</I> GG, <I>Lact</I>. <I>acidophilus</I> ADH, and <I>Bifidobacterium longum</I> B6, <I>Lact</I>. <I>brevis</I>, and <I>Lact</I>. <I>casei</I>, were used to examine their ability to convert LA to CLA. LA tolerance was evaluated by addition of different LA concentrations in MRS broth. <I>Lact</I>. <I>acidophilus</I> showed the major tolerant to LA and the greatest CLA-producing ability (36–48 &mgr;g ml<SUP>−1</SUP> of CLA). The rate-controlling steps were <I>k</I><SUB>2</SUB> and <I>k</I><SUB>1</SUB> for the addition of 1 and 3 mg ml<SUP>−1</SUP> of LA, respectively. The percentage of CLA conversion was higher in MRS broth supplemented with 1 mg ml<SUP>−1</SUP> (65%) than 3 mg ml<SUP>−1</SUP> (26%).</P><P>Conclusion: </P><P>The results provide useful information and new approach for understanding the biohydrogenation mechanisms of CLA production.</P><P>Significance and Impact of the Study: </P><P>This study would help elucidate the pathway from LA to stearic acid (SA), known as biohydrogenation. In addition, the use of selected probiotic bacteria might lead to a significant improvement in food safety.</P>

Pulse energy comparison based on on/off time of a R-C mode EDM pulse power generator

J. L. Chen(천지에린),M. R. Xu(쉬모란),G. C. Park(박건철),T. J. Ko(고태조) 한국기계가공학회 2021 한국기계가공학회 춘추계학술대회 논문집 Vol.2021 No.6

Role of CK1 in GSK3β-mediated phosphorylation and degradation of Snail

Xu, Y,Lee, S-H,Kim, H S,Kim, N H,Piao, S,Park, S-H,Jung, Y S,Yook, J I,Park, B-J,Ha, N-C Macmillan Publishers Limited 2010 Oncogene Vol.29 No.21

The epithelial to mesenchymal transition (EMT) that occurs during embryonic development has begun to attract attention as a potential mechanism for tumor cell metastasis. Snail is a well-known Zn-finger transcription factor that promotes EMT by repressing E-cadherin expression. It is known that Snail is phosphorylated by GSK3β and degraded by β-TrCP-mediated ubiquitination. Here we described another protein kinase, CK1, whose phosphorylation of Snail is required for the subsequent GSK3β phosphorylation. Specific inhibition or depletion of CK1ɛ inhibits the phosphorylation and degradation of Snail and promotes cell migration, suggesting a central role of CK1ɛ in the EMT process. Furthermore, our study uncovered distinct roles and steps of Snail phosphorylation by CK1ɛ and GSK3β. Taken together, we identified CK1ɛ as a new component of the Snail-mediated EMT process, providing insight into the mechanism of human cancer metastasis.