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Kim, H.S.,Yadav, P.,Patel, M.,Kim, H.,Pandey, K.,Kim, J. North-Holland ; Elsevier Science Ltd 2016 Solar energy materials and solar cells Vol.154 No.-
The present work describes a method for the development of an efficient silver nanowire (AgNWs) embedded indium tin oxide (ITO) based silicon heterojunction solar cell. The working mechanism of the heterojunction solar cell is studied by using the current-voltage (J-V) and Impedance spectroscopy (IS) techniques. The charge transfer mechanism and recombination process of the solar cell were explained by resistance, capacitance and ideality factor derived from both these techniques. A relatively high efficiency has been achieved for AgNWs embedded ITO-Si heterojunction solar cell in which AgNWs network acts as a transparent buried contact. This study also provides a new architecture for various heterojunction solar cells with a simple route of fabrication.
Kumar, S.,Lim, W.,Lee, Y.,Yadav, J.S.,Sharma, D.,Sharma, V.K.,Moon, I. Elsevier 2010 Journal of molecular liquids Vol.155 No.1
Speeds of sound data, u<SUB>ijk</SUB> of 1,3-dioxolane or 1,4-dioxane(i)+benzene or toluene (j)+formamide or N,N-dimethylformamide (k) ternary mixtures and their sub-binary mixtures, u<SUB>ij</SUB> of 1,3-dioxolane or 1,4-dioxane (i)+benzene or toluene or formamide or N,N-dimethylformamide (j); benzene or toluene (i)+formamide or N,N-dimethylformamide (j) have been measured using a quartz crystal interferometer as a function of composition at 308.15K. The experimental data have been utilized to evaluate excess isentropic compressibilities of binary, (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ij</SUB> and ternary, (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ijk</SUB> mixtures and the same have been fitted to Redlich-Kister equation to predict binary and ternary adjustable parameters along with standard deviations. (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ij</SUB> and (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ijk</SUB> data have also been analyzed in terms of Graph and Flory theories. It has been observed that predicted (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ij</SUB> and (κ<SUB>S</SUB><SUP>E</SUP>)<SUB>ijk</SUB> values by Graph theory compare well with their corresponding experimental values.
Yadav, H. M.,Kolekar, T. V.,Barge, A. S.,Thorat, N. D.,Delekar, S. D.,Kim, B. M.,Kim, B. J.,Kim, J. S. Chapman and Hall 2016 Journal of materials science Materials in electron Vol. No.
<P>The photocatalytic degradation of methylene blue (MB) has been investigated under visible light irradiation with an incandescent light bulb using chromium doped TiO2 nanoparticles. Cr-TiO2 photocatalysts were successfully synthesized by sol-gel method at room temperature and characterized by X-ray diffraction (XRD), UV-Vis diffuse reflectance spectroscopy (UV-Vis DRS), Raman spectroscopy, Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy. The band gap energy of the nanoparticles were estimated using UV-Vis DRS technique. With increasing Cr3+ cations content into TiO2 host lattice, the optical absorption band tuned in the visible region. XRD and TEM results reveal uniform and crystalline anatase TiO2 nanoparticles. The photodegradation of MB indicated that the photocatalytic activity of pure TiO2 nanoparticles increased with increasing Cr3+ cations concentration.</P>
Chae, S.Y.,Yadav, J.B.,Kim, K.J.,Joo, O.S. Pergamon Press ; Elsevier Science Ltd 2011 INTERNATIONAL JOURNAL OF HYDROGEN ENERGY - Vol.36 No.5
We studied the durability of the previously reported low mass loaded, highly efficient electrospray deposited Pt film as a cathode and Ni mesh as anode electrode in PV assisted water electrolysis system for 1000 h. This assembly showed no detectable decline in performance for initial 200 h, but thereafter it started to decline with time and showed 18% decline after 1000 h. For conclusion, we analyzed the electrode surfaces by different analyzing techniques. Results showed that Pt film was detaching from the surface and there was a deposition of passive layer of Fe<SUB>2</SUB>O<SUB>3</SUB> on edge side of cathode surface. The iron derivative might be come from the corrosion of the stainless steel connectors that we used in PV assisted water electrolysis system. The etching and oxidation of anode surface was also observed but it might not be responsible for deterioration of performance.
Cheon, J.H.,Kim, K.S.,Yadav, D.K.,Kim, M.,Kim, H.S.,Yoon, S. Academic Press 2017 Biochemical and biophysical research communication Vol. No.
P-glycoprotein (P-gp) is overexpressed in cancer cells in order to pump out chemotherapeutic drugs, and is one of the major mechanisms responsible for multidrug resistance (MDR). It is important to identify P-gp inhibitors with low toxicity to normal cells in order to increase the efficacy of anti-cancer drugs. Previously, a JAK2 inhibitor CEP-33779 demonstrated inhibitory actions against P-gp and an ability to sensitize drug-resistant cancer cells to treatment. In the present study, we tested another JAK2 inhibitor NVP-BSK805 for P-gp inhibitory activity. In molecular docking simulation modeling, NVP-BSK805 showed higher binding affinity docking scores against a P-gp member (ABCB1) than CEP-33779 did. Furthermore, we found that lower doses of NVP-BSK805 are required to inhibit P-gp in comparison with that of CEP-33779 or verapamil (an established P-gp inhibitor) in KBV20C cells, suggesting that NVP-BSK805 has higher specificity. NVP-BSK805, CEP-33779, and verapamil demonstrated similar abilities to sensitize KBV20C cells to vincristine (VIC) treatment. Our results suggested that the JAK2 inhibitors were able to inhibit P-gp pump-action via a direct binding mechanism, similar to verapamil. However, JAK2 inhibitor-induced sensitization was not observed in VIC-treated sensitive KB parent cells, suggesting that these effects are specific to resistant cancer cells. FACS, western-blot, and annexin V analyses were used to further investigate the mechanism of action of JAK2 inhibitors in VIC-treated KBV20C cells. Both CEP-33779 and NVP-BSK805 induced the sensitization of KBV20C cells to VIC treatment via the same mechanisms; they each caused a reduction in cell viability, increased G2 arrest, and upregulated expression of the DNA damaging protein pH2AX when used as co-treatments with VIC. These findings indicate that inhibition of JAK2 may be a promising target in the treatment of cancers that are resistant to anti-mitotic drugs.
Knox, J. J.,Barrios, C. H.,Kim, T. M.,Cosgriff, T.,Srimuninnimit, V.,Pittman, K.,Sabbatini, R.,Rha, S. Y.,Flaig, T. W.,Page, R. D.,Beck, J. T.,Cheung, F.,Yadav, S.,Patel, P.,Geoffrois, L.,Niolat, J.,B Oxford University Press 2017 ANNALS OF ONCOLOGY Vol.28 No.6
<P><B>Background</B></P><P>RECORD-3 compared everolimus and sunitinib as first-line therapy, and the sequence of everolimus followed by sunitinib at progression compared with the opposite (standard) sequence in patients with metastatic renal cell carcinoma (mRCC). This final overall survival (OS) analysis evaluated mature data for secondary end points.</P><P><B>Patients and methods</B></P><P>Patients received either first-line everolimus followed by second-line sunitinib at progression (<I>n = </I>238) or first-line sunitinib followed by second-line everolimus (<I>n = </I>233). Secondary end points were combined first- and second-line progression-free survival (PFS), OS, and safety. The impacts of neutrophil lymphocyte ratio (NLR) and baseline levels of soluble biomarkers on OS were explored.</P><P><B>Results</B></P><P>At final analysis, median duration of exposure was 5.6 months for everolimus and 8.3 months for sunitinib. Median combined PFS was 21.7 months [95% confidence interval (CI) 15.1–26.7] with everolimus-sunitinib and 22.2 months (95% CI 16.0–29.8) with sunitinib-everolimus [hazard ratio (HR)<SUB>EVE-SUN/SUN-EVE</SUB>, 1.2; 95% CI 0.9–1.6]. Median OS was 22.4 months (95% CI 18.6–33.3) for everolimus-sunitinib and 29.5 months (95% CI 22.8–33.1) for sunitinib-everolimus (HR<SUB>EVE-SUN/SUN-EVE</SUB>, 1.1; 95% CI 0.9–1.4). The rates of grade 3 and 4 adverse events suspected to be related to second-line therapy were 47% with everolimus and 57% with sunitinib. Higher NLR and 12 soluble biomarker levels were identified as prognostic markers for poor OS with the association being largely independent of treatment sequences.</P><P><B>Conclusions</B></P><P>Results of this final OS analysis support the sequence of sunitinib followed by everolimus at progression in patients with mRCC. The safety profiles of everolimus and sunitinib were consistent with those previously reported, and there were no unexpected safety signals.</P><P><B>Clinical Trials number</B></P><P>ClinicalTrials.gov identifier, NCT00903175</P>
X-RAY ASTRONOMY EXPERIMENT ON THE INDIAN SATELLITE IRS-P3
AGRAWAL P. C.,PAUL B.,RAO A. R.,SHAH M. R.,MCKERJEE K.,VARIA M. N.,YADAV J. S.,DEDHIA D. K.,MALKAR J. P.,SHAH P.,DAMLE S. V.,MARAR T. M. K.,SEETHA S. The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1
An x-ray astronomy experiment consisting of three collimated proportional counters and an X-ray Sky Monitor (XSM) was flown aboard the Indian Satellite IRS-P3 launched on March 21, 1996 from SHAR range in India. The Satellite is in a circular orbit of 830 km altitude with an orbital inclination of $98^{\circ}$ and has three axis stabilized pointing capability. Each pointed-mode Proportional Counter (PPC) is a multilayer, multianode unit filled with P-10 gas ($90\%$ Ar + $10\%\;CH_4$) at 800 torr and having an aluminized mylar window of 25 micron thickness. The three PPCs are identical and have a field of view of $2^{\circ}{\times}2^{\circ}$ defined by silver coated aluminium honeycomb collimators. The total effective area of the three PPCs is about 1200 $cm^2$. The PPCs are sensitive in 2-20 keV band. The XSM consists of a pin-hole of 1 $cm^2$ area placed 16 cm above the anode plane of a 32 cm$\times$32 cm position sensitive proportional counter sensitive in 3-8 keV interval. The position of the x-ray events is determined by charge division technique using nichrome wires as anodes. The principal objective of this experiment is to carry out timing studies of x-ray pulsars, x-ray binaries and other rapidly varying x-ray sources. The XSM will be used to detect transient x-ray sources and monitor intensity of bright x-ray binaries. Observations of black-hole binary Cyg X-1 and few other binary sources were carried out in early May and July-August 1996 period. Details of the x-ray detector characteristics are presented and preliminary results from the observations are discussed.