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Magnetic Resonance Imaging Evaluation of L5–S1 Intervertebral Disc Degeneration in Japanese Women
Hiroaki Hagiwara,Hirofumi Shibata,Hideya Sakakibara,Tomio Inoue 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.5
Study Design: Retrospective case series. Purpose: To calculate the prevalence of L5-S1 intervertebral disc degeneration (IDD) by evaluating gynecological disease findings, obtained by pelvic magnetic resonance imaging (MRI), and reveal the risk factors for IDD by analyzing its relationship with age, sacral structure, body mass index (BMI), number of deliveries, and intrapelvic space-occupying lesions. Overview of Literature: Age, obesity, height, smoking history, occupation, and lumbosacral structure are reportedly the main factors of lumbar IDD. However, in women, the relationship of IDD with obstetric and gynecological history is unclear. Methods: The presence of L5–S1 IDD was evaluated on sagittal T2-weighted pelvic MRI during gynecological evaluations in 660 Japanese women. We measured the sacral table angle (STA), sacral kyphosis angle (SKA), and intrapelvic space-occupying lesion size. Age, height, weight, BMI, number of deliveries, lumbosacral structure, size of space-occupying lesions, and presence of uterine leiomyoma based on medical records were compared between the IDD-positive and IDD-negative groups. Results: Lumbosacral IDD was observed in 405 cases (61.4%), and its prevalence increased with age. Differences in age, height, weight, BMI, and number of deliveries between the IDD-positive and -negative groups were significant, but differences in STA, SKA, and presence of uterine leiomyoma and space-occupying lesion size were not. Logistic regression analysis indicated that age, BMI, and STA were risk factors for lumbosacral IDD. Conclusions: Age is the biggest risk factor for lumbosacral IDD in Japanese women, with BMI and STA also contributing to its development. However, SKA and obstetric and gynecological history were not significantly involved.
High-Performance Computation Using a Single-Flux Quantum Accelerator
Farhad Mehdipour,Hiroaki Honda,Hiroshi Kataoka,Koji Inoue,Kazuaki Murakami 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
A large-scale reconfigurable data-path (LSRDP) processor based on single-flux quantum circuits has been proposed to overcome the barriers originating from the CMOS technology. LSRDP is integrated to a general purpose processor in a high-performance computing system to accelerate the execution of data flow graphs extracted from scientific applications. The LSRDP micro-architecture and its specifications will be presented in this paper. A preliminary performance evaluation of the reconfigurable processor will be given as well.
Nakamura, Satoshi,Inoue, Masao,Fujimoto, Hiroaki,Kasamatsu, Kiyoshi Korean Society of Applied Entomology 2007 Journal of Asia-Pacific Entomology Vol.10 No.1
A tape formulation of pyriproxyfen was pre-pared by coating the chemical onto yellow plastic film. We evaluated the trans ovarial ovicidal activity of the tape formulation against Bemisia tabaci and investigated the optimal application method and efficacy in a greenhouse. The tape formulation showed high ovicidal activity of over 80% mortality against B. tabaci for 4 days by a 30-second compulsory contact test. The formulation controlled the B. tabaci population on tomatoes by both "sideways spreading application" and "vertical hanging application". "Sideways spreading application" was considered to be more practical, although there was no significant difference in efficacy between the two application methods. In a large-scale greenhouse trial of "sideways spreading application", the tape formulation suppressed the B. tabaci population for 77 days. The results suggested that the tape formulation is promising as a tool for IPM because of its high efficacy and lower environmental impact.
Satoshi Nakamura,Masao Inoue,Hiroaki Fujimoto,Kiyoshi Kasamatsu 한국응용곤충학회 2007 Journal of Asia-Pacific Entomology Vol.10 No.1
A tape formulation of pyriproxyfen was prepared by coating the chemical onto yellow plastic film. We evaluated the transovarial ovicidal activity of the tape formulation against Bemisia tabaci and investigated the optimal application method and efficacy in a greenhouse. The tape formulation showed high ovicidal activity of over 80% mortality against B. tabaci for 4 days by a 30-second compulsory contact test. The formulation controlled the B. tabaci population on tomatoes by both “sideways spreading application” and “vertical hanging application”. “Sideways spreading application” was considered to be more practical, although there was no significant difference in efficacy between the two application methods. In a large-scale greenhouse trial of “sideways spreading application”, the tape formulation suppressed the B. tabaci population for 77 days. The results suggested that the tape formulation is promising as a tool for IPM because of its high efficacy and lower environmental impact.
Satoshi Sugino,Ken Inoue,Reo Kobayashi,Ryohei Hirose,Toshifumi Doi,Akihito Harusato,Osamu Dohi,Naohisa Yoshida,Kazuhiko Uchiyama,Takeshi Ishikawa,Tomohisa Takagi,Hiroaki Yasuda,Hideyuki Konishi,Yasuko 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.4
Background/Aims Several studies have assessed the effect of cool temperature on colonic peristalsis. Transient receptor potential melastatin 8 (TRPM8) is a temperature-sensitive ion channel activated by mild cooling expressed in the colon. We examined the antispasmodic effect of cool temperature on colonic peristalsis in a prospective, randomized, single-blind trial and based on the video imaging and intraluminal pressure of the proximal colon in rats and TRPM8-deficient mice. Methods In the clinical trial, we randomly assigned a total of 94 patients scheduled to undergo colonoscopy to 2 groups: the mildly cool water (n = 47) and control (n = 47) groups. We used 20 mL of 15°C water for the mildly cool water. The primary outcome was the proportion of subjects with improved peristalsis after treatment. In the rodent proximal colon, we evaluated the intraluminal pressure and performed video imaging of the rodent proximal colon with cool water administration into the colonic lumen. Clinical trial registry website (Trial No. UMIN-CTR; UMIN000030725). Results In the randomized controlled trial, after treatment, the proportion of subjects with no peristalsis with cool water was significantly higher than that in the placebo group (44.7% vs 23.4%; P < 0.05). In the rodent colon model, cool temperature water was associated with a significant decrease in colonic peristalsis through its suppression of the ratio of peak frequency (P < 0.05). Cool temperature-treated TRPM8-deficient mice did not show a reduction in colonic peristalsis compared with wild-type mice. Conclusion For the first time, this study demonstrates that cool temperature-dependent suppression of colonic peristalsis may be associated with TRPM8 activation.