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      • The effects of oriental raisin tree supplementation on skin whitening activity of Ganoderma lucidum extract

        Jong-Hyeon Kim,Hong-il Kim,Ji-Woong Kim,O-Chul Kown,Chang-Soo Lee,Young-Jin Park 한국버섯학회 2016 버섯 Vol.20 No.1

        In our previous study, active-single compound (ASC), inhibitor of melanogenesis in B16F10 melanoma cell, was identified from Ganoderma lucidum. Thus, the aim of this study is to analyze the change of the ASC contents in G. lucidum when oriental raisin tree (ORT) was added in cultivation of G. lucidum. In HPLC analysis, significantly increased ASC peak was observed in G. lucidum extract supplemented with 15% (v/v) of ORT. In addition, melanogenesis inhibitory effect of G. lucidum extract supplemented with 15% of ORT significantly increased when compared to G. lucidum extract without ORT supplementation. Furthermore, ORT supplementation increased mycelial growth of G. lucidum in both solid and liquid cultivation. These results suggest that oriental raisin tree is useful as natural ingredient for increasing bioactivity including skin-whitening effect and mycelial growth of G. lucidum.

      • Bioactive compounds content analysis of the changes added additives in Ganoderma lucidum

        Jong-Hyeon Kim,O-Chul Kown,Hong-il Kim,Won-Sik Kong,Young-Jin Park,Chang-Soo Lee 한국버섯학회 2015 버섯 Vol.19 No.1

        The purpose of this experiment is to measure the change in the growth rate and the amount of bioactive compounds when additives are added to mushrooms. According to the additive content, Ganoderma lucidum ASI7004, Ganoderma lucidum ASI7071, Ganoderma. meredithae KACC42868 and Ganoderma lucidum ASI7013 mycelial growth rate variation analysis, oriental raisin tree, Siberian ginseng, chestnut shell, apple pomace, and Korean cabbage additive increased mycelial growth by approximately 2.5 times when compared to the control group(MCM medium). The results of analyzing the total amount of polyphenol in mycelia of G. lucidum based on different kinds of additives have shown that the amount of polyphenol increased only in G. lucidum ASI7004 with 2% Korean cabbage additive. However, when other additives are added, the amount of polyphenol turned out to be lower than original G. lucidum and other individual additives. The results of analyzing the total amount of triterpenoid in mycelia of G. lucidum based on different kinds of additives have shown that the amount of triterpenoid increased in G. lucidum mycelia with apple pomace and Korean cabbage additives. Siberian ginseng additive was effective in increasing the amount of triterpenoid only when 4% Siberian ginseng was added to G. lucidum ASI7004, yet the increased amount was not significant. Although the addition of additives turned out to be effective to the growth rate, it was not effective enough towards the amount of bioactive compounds. Further experiments are required.

      • SCOPUSKCI등재

        Clinical Study of Lumbar Spine Stenosis Treated by Using Acupotomy Combined with Oriental Medical Treatments

        Yuk, Dong-Il,Sung, In-Su,Song, Da-Hyung,Kim, Min-Jung,Hong, Kown-Eui KOREAN PHARMACOPUNCTURE INSTITUTE 2013 Journal of pharmacopuncture Vol.16 No.3

        Objectives: The aim of this study is to evaluate the effect of acupotomy in patients with degenerative lumbar spine stenosis. Methods: A total of 437 patients who had been diagnosed as having lumbar spine stenosis and who had been admitted to Daejeon Oriental hospital from June 1, 2008, to September 31, 2012, were included in this study. The patients underwent acupotomy once, twice or three times on the lumbar spine, according to their symptoms. Then, the patients were asked to complete the verbal numeric rating scale (VNRS) and the oswestry disability index (ODI) before and after acupotomy and underwent a global assessment. The resulting data were analyzed. Results: The gender ratio of the participants was 1:1.54, and the mean age was $65{\pm}10.0$ yr. The number of patients over the age of 65 yr was less than that of the patients under the age of 65 yr in the ratio of 1:1.3. The average disease period was $30.17{\pm}56.63$ months. The verbal numeric rating scale (VNRS) significantly decreased from 10 to an average of $7.10{\pm}2.50$ after one acupotomy, $6.30{\pm}2.60$ after two acupotomies, and $5.50{\pm}2.50$ after three acupotomies. The ODI was significantly decrease from $20.60{\pm}8.70$ to $17.80{\pm}8.60$ after once acupotomy, $17.10{\pm}8.50$ after two acupotomies, and $16.70{\pm}8.60$ after three acupotomies. High scores were also observed on the global assessment. Conclusion: These results provide evidence that acupotomy is effective to relieve pain and to improve quality of life in patients with degenerative lumbar spinal stenosis.

      • The Effects of Lacquer Tree Supplementation on Skin Whitening Activity of Ganoderma lucidum Extract

        Jong-Hyeon Kim,Hong-il Kim,O-Chul Kown,Chang-Soo Lee,Young-Jin Park 한국버섯학회 2016 버섯 Vol.20 No.2

        In our previous study, active-single compound (ASC), inhibitor of melanogenesis in B16F10 melanoma cell, was identified from Ganoderma lucidum. Thus, the aim of this study is to analyze the change of the ASC contents in G. lucidum when lacquer tree (LT) was added in cultivation of G. lucidum. In HPLC analysis, significantly increased ASC peak was observed in G. lucidum extract supplemented with 15% (v/v) of LT. In addition, melanogenesis inhibitory effect of G. lucidum extract supplemented with 15% of LT significantly increased when compared to G. lucidum extract without LT supplementation. Furthermore, LT supplementation increased mycelial growth of G. lucidum in both solid and liquid cultivation. These results suggest that is useful as natural ingredient for increasing bioactivity including skin-whitening effect and mycelial growth of G. lucidum.

      • KCI등재

        A Study on Efficient Operation of the Disaster Management Organization of Regional Local Governments in Korea - Analyzing the Organizational Structure of Disaster Management -

        Seol A Kown,Sang Il Ryu,Jee Eun Kim,Jae Eun Lee 위기관리 이론과 실천 2016 Crisisonomy Vol.12 No.5

        우리나라의 지방정부는 재난대응에 있어서 일차적 책임을 지닌다. 현재 지방정부의 재난관리 조직의 운영형태는 대체로 분산관리방식을 택하고 있다. 현재 지방정부별로 재난을 담당하고 있는 부서의 명칭과 운영체계는 통일성이 확보되지 못하고 있고, 재난관리업무 협조, 지역의 민간단체와 협력, 재난관리인력, 장비부족과 같은 다양한 문제점이 지적되고 있다. 이 논문은 우리나라의 지방정부별재난관리 조직운영을 분석하여 한국의 지방정부 재난관리 조직을 효율적으로 운영하기 위하여 정책적 방향을 제시하는 데 연구의 목적이 있다. 연구결과 지역 재난통합컨트롤 타워 확보를 통한 운영체계의 일원화, 상시기구와 비상기구의 혼란을 방지, 재난관련 유관부서의 이기주의 극복, 전문성과실효성 있는 재난관리 조직에 대한 계획 수립이 필요하다고 본다. 지방정부의 특수성이 포함될 수있도록 포괄적인 범위에서 협력적 네트워크 구축과 함께 적시적 여건과 전망 분석을 통해 현실적인계획 수립에 힘쓰고, 현재의 재난관리 역량수준을 진단하여 재난안전예산 확보를 위한 나름대로의근거를 마련하고 재난관리 역량의 강화에 노력을 쏟아야 할 것이다. Local governments in Korea bear the primary responsibility for disaster response. This study aims to explore an efficient way to operate disaster management organizations of Korea’s regional local governments. The findings are as follows. First, the unification of operating system should be needed by securing a regional-level integrated disaster control tower. Second, any confusion between a permanent organization and an emergency organization should be prevented. Third, institutional egoism related to disaster management should be overcome. More efforts should be made to construct a comprehensive cooperative network to incorporate region-specific characteristics and contents, collect all disaster-related information within each administrative area, establish a realistic plan through an analysis of appropriate conditions and prospects, and prepare the foundation to reinforce disaster management capability.

      • Bioactive compounds content analysis of the changes added additives in Ganoderma lucidum

        Jong-Hyeon Kim,O-Chul Kown,Hong-il Kim,Won-Sik Kong,Young-Jin Park,Chang-Soo Lee 한국버섯학회 2015 버섯 Vol.19 No.2

        The purpose of this experiment is to measure the change in the growth rate and the amount of bioactive compounds when additives are added to mushrooms. According to the additive content, Ganoderma lucidum ASI7004, Ganoderma lucidum ASI7071, Ganoderma. meredithae KACC42868 and Ganoderma lucidum ASI7013 mycelial growth rate variation analysis, oriental raisin tree, Siberian ginseng, chestnut shell, apple pomace, and Korean cabbage additive increased mycelial growth by approximately 2.5 times when compared to the control group (MCM medium). The results of analyzing the total amount of polyphenol in mycelia of G. lucidum based on different kinds of additives have shown that the amount of polyphenol increased only in G. lucidum ASI7004 with 2% Korean cabbage additive. However, when other additives are added, the amount of polyphenol turned out to be lower than original G. lucidum and other individual additives. The results of analyzing the total amount of triterpenoid in mycelia of G. lucidum based on different kinds of additives have shown that the amount of triterpenoid increased in G. lucidum mycelia with apple pomace and Korean cabbage additives. Siberian ginseng additive was effective in increasing the amount of triterpenoid only when 4% Siberian ginseng was added to G. lucidum ASI7004, yet the increased amount was not significant. Although the addition of additives turned out to be effective to the growth rate, it was not effective enough towards the amount of bioactive compounds. Further experiments are required.

      • KCI등재

        글로벌 재무 연구의 동향 및 시사점: 2013-2022

        유정 ( Zheng Liu ),권일숙 ( Il Sook Kown ),김태중 ( Tae-joong Kim ) 한국국제경영학회 2013 國際經營硏究 Vol.34 No.3

        2013년부터 시작된 선진국의 양적완화 정책은 신흥국을 포함한 전세계 경제에 많은 영향을 주었다. 양적완화 외에도 전세계는 미·중 패권전쟁, 러-우전쟁, COVID-19 등 충격을 겪으면서 경제·경영환경에도 급격한 변화를 겪게 된다. 따라서 지난 10년간 보고된 글로벌 재무 관련 연구를 포괄적으로 리뷰하면서 시사점 찾을 필요가 있다. 이를 위해 본 연구는 2013-2022년 국제경영연구 및 국제경영리뷰에 게재된 글로벌 재무 분야 논문에 대해 메타분석 및 문헌연구를 통해 연구동향을 심층적으로 고찰하였다. 지난 10년 동안 발표된 국제경영연구 및 국제경영리뷰의 총 605편 논문 중 전략 253편, 글로벌 재무 124편, 글로벌 마케팅 95편, 글로벌 인사조직 77편, 해외직접투자 33편, 지역 6편, 기타 17편으로 구성되었다. 이 중 글로벌 재무 관련 논문은 20.5%를 차지하였고, 게재편수는 증가하였다. 글로벌 재무 분야의 논문은 기업재무 관련 논문 55편(44.4%), 국제금융시장 관련 44편(35.5%), 위험관리 관련 25편(20.2%)으로 분류할 수 있다. 기업재무 관련 논문 중에서도 ‘외국인투자자 및 기업지배구조’에 대한 논문이 36편(29.0%)으로 가장 많이 발표되어, 외국인투자자의 영향력과 기업지배구조 이슈에 대한 관심이 높음을 알 수 있다. 글로벌 재무 분야는 다양한 연구주제가 활발히 이루어지고 있으며, 확장되고 있는 추세이다. 본 연구는 글로벌 재무의 연구동향을 파악하고 연구자들에게 향후 연구의 방향과 새로운 아이디어를 제시하는 데 도움을 줄 것으로 사료된다. Since 2013, the quantitative easing policies implemented by advanced countries have had a significant impact on the global economy, including emerging economies. Alongside quantitative easing, the world has experienced various shocks such as the US-China power rivalry, the Russia-Ukraine war, and the COVID-19 pandemic, resulting in rapid changes in the economic and business environment. Therefore, it is essential to conduct a comprehensive review of globally reported research on finance over the past 10 years to identify key insights. In this study, we conducted a thorough analysis of research trends in the field of global finance by performing a meta-analysis and literature review of papers published in international management research and international management review from 2013 to 2022. Out of the total of 605 papers published in International Business Journal and International Business Review during the past decade, 253 were related to strategy, 124 to global finance, 95 to global marketing, 77 to global human resources and organizations, 33 to foreign direct investment, 6 to regions, and 17 to other topics. Among these, papers related to global finance accounted for 20.5% of the total, and the number of publications has been increasing. The papers in the field of global finance can be further categorized into 55 papers (44.4%) on corporate finance, 44 papers (35.5%) on international financial markets, and 25 papers (20.2%) on risk management. Notably, within the realm of corporate finance, the most prevalent topic was “foreign investors and corporate governance” with 36 papers (29.0%), indicating a significant interest in the influence of foreign investors and corporate governance issues. The field of global finance exhibits a diverse range of research topics and is continuously expanding. This study aims to provide valuable insights into the research trends in global finance and is expected to assist researchers in identifying future research directions and generating new ideas.

      • KCI등재

        한국에서 분리된 Streptococcus mutans의 분자 역학 및 특성

        김세연 ( Se-yeon Kim ),배일권 ( Il Kown Bae ),이정하 ( Jung-ha Lee ),신정환 ( Jeong Hwan Shin ),김진범 ( Jin-bom Kim ) 대한예방치과·구강보건학회 2020 大韓口腔保健學會誌 Vol.44 No.1

        Objectives: We investigated the characteristics of Streptococcus mutans in the national culture collection from Korea. Twenty-nine (dental plaque, n=27; endodontic infections, n=1; blood, n=1) isolates were included in this study. Methods: Antimicrobial susceptibilities were tested using the disk diffusion test. Multilocus sequence typing (MLST), serotyping, and collagen-binding genes were used for polymerase chain reaction (PCR) and direct sequencing. A collagen-binding (to assess the adhesion properties) assay was performed. S. mutans demonstrated high susceptibility to antimicrobial agents. Differences in collagen-binding abilities of the cnm-positive and -negative groups were compared using the Mann-Whitney U test (P<0.05). Results: MLST analyses revealed 25 sequence types (STs), 17 of which (ST213-ST229) contained new alleles. The strains were classified into four serotypes with the c type encompassing 79.3% of all strains, while the e , f , and k types representing 6.9% each. Analysis of the cnm and cbm genes, which encode the two surface adhesin components of S. mutans , revealed three cnm -positive strains, each displaying greater adhesion ability than those of the cnm -negative strains. Conclusions: This study highlights the presence of a wide variety of S. mutans genotypes in Korea. These findings may provide useful information regarding the pathogenesis of infectious diseases, such as dental caries.

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