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경구면역을 통한 항원 특이적 IgA 항체 합성에 있어 Cholera Toxin과 Alginate-Microsphere의 효과
송민형,유진수,권명상,성승룡,김용희,권익찬,정서영,양재명,김평현 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3
Secretory (S-IgA) isotype antibody (Ab) is known to play an essential role in the primary defense against various infectious agents in mucosal tissue. However, it has been mostly unsuccessful in the induction of antigen (Ag)-specific IgA Ab response in this site by peroral vaccination. In the present study, we investigated the effect of cholera toxin (CI) as a mucosal adjuvant and alginates-microspheres as a carrier on BSA-specific IgA Ab response in gut-associated lymphoid tissue`(GALT). Peroral immunization of BSA plus CT conferred a great BSA-specific IgA response but IgG response on intestinal fluid (IF). In contrast, intraperitoneal immunization of BSA with Freund's adjuvant readily induced BSA-specific IgG response but IgA response in IF. Further, number of CT specific IgA-secreting cells was substantially increased in mesenteric lymph node when CT-encapsulated-VI alginates-microspheres was administered perorally. Taken together, these results indicate that peroral immunization of soluble antigen in combination of CT or microspheres significantly enhances antigen-specific IgA response in GALT.
김종덕,장재익,유문일,정흥우,권찬호,오두식,김창현 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.1
본 시험은 크릴 분말의 사료적 특성을 조사하고, 산란계 사료에 첨가하였을 때 계란의 생산성과 품질을 비교하기 위하여 수해하였다. 크릴 분말을 산란계 사료에 0, 1 및 2% 수준으로 첨가하여 216수에 6주간 사양시험을 실시하였다. 크릴분말의 일반성분은 수분 8.25%, 조단백질 50.52%, 조지방 16.67%, 조회분 15.72%로 단백질과 지방이 높은 동물성 사료원료였다. 그리고 무기질(15.72%), astaxanthin (10ppm) 및 콜레스테롤 함량 (780ppm) 또한 많았다. 산란율, 연파란율, 일일사료섭취량 및 난중은 처리간에 유의적인 차이가 없었다. 황고 및 난황색도는 크릴의 첨가수준이 높을수록 유의적으로 높아 산란계의 난질을 향상시키는 첨가제로서의 가능성을 보였다. 이상의 결과를 볼 때 크릴 분말은 단백질과 지방이 높은 동물성 사료이며, 산란계에서 천연착색제로의 가능성을 보였다. This experiment was conducted to evaluate the chemical composition of Antarctic Krill(Euphausia superba Dana) meal as feed, and to investigate the effect of its supplementation on productivity and egg quality of laying hen. A total of 216 layers at the age 43 weeks in commercial cage were fed for 6 weeks with 3 different diets containing 0, 1, and 2% Krill meal (KM). The chemical composition of KM was consisted of moisture 8.25%, crude protein 50.52%, crude fat 16.67%, curde ash 15.72%, indicating that KM contains large amount of protein and fat. Krill meal also contains large amounts of mineral(15.72%), astaxanthin(10ppm) and cholesterol(780ppm). No differences were found in egg production, broken and soft eggs, and feed intake among treatments. Dietary supplementation of KM resulted in increased egg yolk height(6.1㎜) and yolk color (2) compared with those of control, suggesting that KM can be used as a feed additive for yolk quality improvement. According to the results of this study, Krill meal can be supplemented in laying hen diets as protein and fat sources, and natural coloring pigment.
Kwon, Ick-Chan 가톨릭중앙의료원 가톨릭암센터 2004 암심포지움 Vol.- No.1
The development of chemotherapeutic agents for the treatment of cancer has resulted in overcoming some tumors. Despite advances in the synthesis of new anti-tumor agents, these compounds possess inevitable, serious side effects like non-specific toxicity that limit the dose and uses of the drug.