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박정일,조병희,구정완,김광종,김현욱,원종욱,이명숙,이원철,정문희 가톨릭대학교 산업의학센터 2000 韓國의 産業醫學 Vol.39 No.3
This study was carried out to develop the index and the scales for the evaluation of the group occupational health services(GOHS). The possible variables of each step, firstly, based on an evaluation model composed of four steps, input, throughout, output and outcome, were selected through several meetings of professional committee. And five types of questionnaire(for doctor, nurse, industrial hygienist, employer, and employee) were developed based on the selected variables. A pilot survey for four GOHS institutions and 12 enterprises was conducted using the questionnaires and correlation analysis for extracting variables was done. The results were as follows: 1.The evaluation scale was composed of three areas(evaluation on workers' health and work environment, evaluation by institution and employer, and evaluation by employee)which were devided into ten subscales. 2.Among firstly selected ninety-six variables, forty-three variables (11 for input, 14 for throughout, and 18 for output indices) were extracted by correlation analysis. 3.Based on the extracted variables, the questionnaires were simplified as five items for doctor, thirty-six items for nurse, nine items for industrial hygienist, and twenty-six items for employer and employee. 4.The total score of evaluation model was defined on the basis of four-hundred points as sum of four indices (input, throughout, output and outcome) given one-hundred points each.
이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1
Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.
Jung, Hyunwook,Kang, Joonhee,Chun, Hoje,Han, Byungchan Elsevier 2018 Journal of hazardous materials Vol.341 No.-
<P><B>Abstract</B></P> <P>Using first principles calculations we unveil fundamental mechanism of hydrolysis reactions of two hazardous chemicals PCl<SUB>3</SUB> and POCl<SUB>3</SUB> with explicit molecular water clusters nearby. It is found that the water molecules play a key role as a catalyst significantly lowing activation barrier of the hydrolysis via transferring its protons to reaction intermediates. Interestingly, torsional angle of the molecular complex at transition state is identified as a vital descriptor on the reaction rate. Analysis of charge distribution over the complex further reinforces the finding with atomic level correlation between the torsional angle and variation of the orbital hybridization state of phosphorus (P) in the complex. Electronic charge separation (or polarization) enhances thermodynamic stability of the activated complex and reduces the activation energy through hydrogen bonding network with water molecules nearby. Calculated potential energy surfaces (PES) for the hydrolysis of PCl<SUB>3</SUB> and POCl<SUB>3</SUB> depict their two contrastingly different profiles of double- and triple-depth wells, respectively. It is ascribed to the unique double-bonding O=P in the POCl<SUB>3</SUB>. Our results on the activation free energy show well agreements with previous experimental data within 7kcalmol<SUP>−1</SUP> deviation.</P>
Hyaluronidase: An overview of its properties, applications, and side effects
Jung, Hyunwook Korean Society of Plastic and Reconstructive Surge 2020 Archives of Plastic Surgery Vol.47 No.4
Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to increase the absorption of drugs into tissue and to reduce tissue damage in cases of extravasation of a drug. With the increasing popularity of hyaluronic acid filler, hyaluronidase has become an essential drug for the correction of complications and unsatisfactory results after filler injection. For this reason, when performing procedures using hyaluronic acid filler, a sufficient knowledge of hyaluronidase is required. In order for hyaluronidase to dissolve a hyaluronic acid filler, it must interact with its binding sites within the hyaluronic acid. The reaction of a filler to hyaluronidase depends on the hyaluronic acid concentration, the number of crosslinks, and the form of the filler. Hyaluronidase is rapidly degraded and deactivated in the body. Therefore, in order to dissolve a hyaluronic acid filler, a sufficient amount of hyaluronidase must be injected close to the filler. If the filler is placed subcutaneously, injection of hyaluronidase into the filler itself may help, but if the filler is placed within a blood vessel, it is sufficient to inject hyaluronidase in the vicinity of the vessel, instead of into the filler itself. Allergic reactions are a common side effect of hyaluronidase. Most allergic reactions to hyaluronidase are local, but systemic reactions may occur in infrequent cases. Since most allergic responses to hyaluronidase are immediate hypersensitivity reactions, skin tests are recommended before use. However, some patients experience delayed allergic reactions, which skin tests may not predict.
Jung, Hyunwook,Hwang, Jeemin,Chun, Hoje,Han, Byungchan Elsevier 2019 Journal of industrial and engineering chemistry Vol.70 No.-
<P><B>Abstract</B></P> <P>We identify hydrolysis reaction mechanism of water-reactive WF<SUB>6</SUB> and its accompanying intermediates using first-principles calculations. For the purpose, we evaluate activation and free energy diagrams of elementary reaction steps. We find that WF<SUB>6</SUB>, WOF<SUB>4</SUB>, and WO<SUB>2</SUB>F<SUB>2</SUB> form stable adducts, which quickly reacts with H<SUB>2</SUB>O by substituting the ligand F. Gaseous WOF<SUB>4</SUB>, WO<SUB>2</SUB>F<SUB>2</SUB>, WO<SUB>3</SUB> are predicted as unstable in the increasing order, but polymerization reduces their instability, leading to solidification. In overall reaction, WOF<SUB>4</SUB> hydrolysis is the bottleneck due to significantly higher activation barrier of trans isomeric complex than cis counterpart.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First-principles study on the hydrolysis of WF<SUB>6</SUB> and its intermediates. </LI> <LI> Tungsten fluorides and water form stable adduct, which is labile to ligand substitution. </LI> <LI> Hydrolysis of WOF<SUB>4</SUB> is the bottleneck of the overall process. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Free energy diagram of the hydrolysis of WF<SUB>6</SUB> and its reaction intermediates has been calculated using first-principles density functional theory calculation.</P> <P>[DISPLAY OMISSION]</P>
Kim, Hyunwook,Kim, Kyoung Hoon,Park, Kisoo,Kang, Shin-Wook,Yoo, Tae-Hyun,Ahn, Song Vogue,Ahn, Hyeong Sik,Hann, Hoo Jae,Lee, Shina,Ryu, Jung-Hwa,Kim, Seung-Jung,Kang, Duk-Hee,Choi, Kyu Bok,Ryu, Dong-Ry Springer-Verlag 2014 Kidney international Vol.86 No.5
To date, only a few large-scale studies have measured the effect of dialysis modality on mortality in Asian populations. Here, we sought to compare survival between incident hemodialysis (HD) and peritoneal dialysis (PD) patients using the Korean Health Insurance Review & Assessment Service database. This enabled us to perform a population-based complete survey that included 32,280 incident dialysis patients and followed them for a median of 26.5 months. To reduce biases due to nonrandomization, we first matched 7049 patient pairs with similar propensity scores. Using the log-rank test, we found the mortality rate in PD patients was significantly higher than that in HD patients. Subsequent subgroup analyses indicated that in older patients (55 years and older), with the exception of the subgroup of patients with no comorbidities and the subgroup of patients with malignancy, PD was consistently associated with a higher mortality rate. In younger patients (under 55 years), regardless of the covariates, the survival rate of PD patients was comparable to that of HD patients. Thus, while the overall mortality rate was higher in incident PD patients, mortality rates of some incident PD and HD patients were comparable in Korea.
분산형 입자군집최적화 기법을 이용한 열전도 역문제의 해석에 관한 연구
백현욱(Hyunwook Beak),이영일(Youngil Lee),정정열(Jung-Yeul Jung),김태형(Tea-Hyoung Kim) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
In this paper, we study on a meta-heuristic optimization methodology for the estimation of unknown heat source function in inverse heat conduction problems. Physical inverse heat conduction problem usually leads to the formulation of large-scale ill-posed nonlinear optimization problems. In order to solve such problems, a novel meta-heuristic optimization method, DPSO-QI (distributed particle swarm optimization with quantum infusion), is developed. Furthermore, Tikhonov regularization method is introduced to obtain a stabilized solution in this kind of inverse problems. Some numerical simulations are carried out to demonstrate its effectiveness, which clearly shows that the proposed DPSO-QI scheme is a novel and powerful one to estimate an unknown heat source function in inverse heat conduction problems.