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EBSmath를 활용한 거꾸로 수업이 수학 학습과 수학적 성향에 미치는 영향
오혜진 ( Oh¸ Hyejin ),박성선 ( Park¸ Sungsun ) 한국수학교육학회 2021 初等 數學敎育 Vol.24 No.4
The purpose of this study was to investigate the effects of flipped learning through EBSmath on Students’ ‘rate and ratio’ learning. By increasing demands for change in education, an innovative teaching and learning paradigm, ‘Flipped Learning’, has been presented and drawing attentions. In South Korea, Flipped Learning is also highly recognized for its effectiveness by many scholars and various media. However, this innovative learning model has limitations in application and expansion due to the excessive burden of class preparation of teachers. As remote learning becomes more active, it would be possible to overcome the limitations of Filliped learning by using the platform provided by the Korea Educational Broadcasting System (EBS). EBSmath is an online learning module that is designed to assist students’ self-directed learning. Thus, EBSmath would reduce teachers’ burden to prepare mathematics classes for the application of Flipped Learning; and led to students’ better understanding of mathematical concepts and problem solving. In this study, the effect of Flipped Learning through EBSmath on learning ‘rate and ratio’ was investigated. In order to scrutinize the effects of flipped learning, students’ achievement and mathematical disposition were examined and analyzed. Students’ achievement, specifically, was divided into two subcategories: concept understanding and problem solving. As a result, Flipped learning through EBSmath had a positive effect on students’ ‘rate and ratio’ problem solving. In addition, a statistically significant change was identified in the ‘willingness’, which is subdomain of students’ mathematical disposition.
Hyejin Kim,Juyoung Park,Handule Lee,Jinseon Son,Yeonjung Park,Heekyung Bae,Sun-Young Park,Sang Hee Lee,Jungkwan Seo,Sunkyung Shin,Kwangsik Park 환경독성보건학회 2023 환경독성보건학회지 Vol.38 No.4
Regulatory decisions for skin sensitization are now based on adverse outcome pathway (AOP) and integrated approaches to testing and assessment (IATA). Based on these, Organisation for Economic Co-operation and Development (OECD) guidelines on defined approaches for skin sensitization were adopted with a fixed data interpretation procedure (DIP). In the guidelines, “Defined Approaches” (DA) on skin sensitization uses the results from multiple information sources of in chemico, in vitro, and in silico data to achieve an equivalent predictive capacity as those of the animal tests. In this review, we evaluated the skin sensitization of eleven isothiazolinone compounds including 4,5-Dichloro-2-octyl-3(2H)-isothiazolone (DCOIT), 2-n-Octyl-4-isothiazolin-3-one (OIT), 2-Methyl-4-isothiazolin-3-one (MIT), 1,2-Benzisothiazolin-3-one (BIT), 1,2-Benzisothiazolin-3-one, 2-butyl (BBIT), 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT), 2-methyl-4,5-trimethylene-4-isothiazolin-3-one (MTMIT), 2-methyl-1,2-benzothiazol-3-one (MBIT), 2-methyl-1,2-benzothiazole-3-thione (MBIT-S), 1,2-benzisothiazolin-3-one, 2-methyl-, 1,1-dioxide (BBIT-O), and a mixture of CMIT/MIT. Data from direct peptide reactivity assay (DPRA), human cell line activation (h-CLAT) test, and quantitative structure activity relationship (QSAR) Toolbox were evaluated and were applied to the DIP to derive a prediction of hazard identification and a potency classification. Among the evaluated chemicals, six isothiazolinone compounds were classified to be UN GHS 1A, one compound to be UN GHS 1, and four compounds could not be classified due to lack of data. The results of sensitizer chemicals were found to coincide well with those of in vivo test.
The Pyramid of Injury: Estimation of the Scale of Adolescent Injuries According to Severity
Han, Hyejin,Park, Bomi,Park, Bohyun,Park, Namsoo,Park, Ju Ok,Ahn, Ki Ok,Tak, Yang Ju,Lee, Hye Ah,Park, Hyesook The Korean Society for Preventive Medicine 2018 Journal of Preventive Medicine and Public Health Vol.51 No.3
Objectives: Due to their developmental characteristics, adolescents have a higher probability than other age groups of experiencing injuries caused by accidents, violence, and intentional self-harm. The severity and characteristics of injuries vary by the intentionality and mechanism of injury; therefore, there is a need for a national-level estimate of the scale and the severity of injuries in adolescents that takes these factors into account. Methods: By using data from the Emergency Department-based Injury In-depth Surveillance Data, National Emergency Department Information System, the Korean National Hospital Discharge In-depth Injury Survey, and cause of death statistics, we calculated the emergency department (ED) visit rate, hospitalization rate, and death rate of injuries per 100 000 adolescents for each injury mechanism. The calculated rates were used to generate the injury pyramid ratio (ratio of death rate to hospitalization rate to ED visit rate) to visualize the scale and the severity of the injury. Results: The mortality rate in adolescents due to injury was 10/100 000; the corresponding rates for hospitalization and ED visits were 1623 and 4923, respectively, resulting in an injury pyramid ratio with the general pyramid form, with a 1:162:492 ratio of deaths to hospitalizations to ED visits. The mortality rate due to suicide/intentional self-harm was 5/100 000, while 35 were hospitalized for this reason and 74 made ED visits. The pyramid ratio of 1:7:15 for intentional self-harm/suicide showed a steep pyramidal form, indicating considerable lethality. The mortality rate due to motor vehicle collisions (MVCs) was 3/100 000; 586 were hospitalized for this reason, while 1023 made ED visits. The pyramid ratio of 1:195:341 for MVCs showed a gradual pyramid form, indicating that the lethality was low and the scale of injury was high. Conclusions: The main categories of injuries in adolescents were visualized in pyramid form, contributing to an understanding of the scale of each injury by mechanism in terms of levels of death, hospitalization, and ED visits. These findings will be helpful for understanding how to prioritize injuries in adolescents.
SERS imaging of HER2-overexpressed MCF7 cells using antibody-conjugated gold nanorods
Park, Hyejin,Lee, Sangyeop,Chen, Lingxin,Lee, Eun Kyu,Shin, Soon Young,Lee, Young Han,Son, Sang Wook,Oh, Chil Hwan,Song, Joon Myong,Kang, Seong Ho,Choo, Jaebum Royal Society of Chemistry 2009 Physical chemistry chemical physics Vol.11 No.34
<P>Antibody-conjugated gold nanorods (GNRs) have been used for the targeting and imaging of specific cancer markers expressed on the surface membrane of cancer cells. GNRs with various aspect ratios were fabricated, and their surface-enhanced Raman scattering enhancement effects were evaluated. To attach the GNRs selectively onto the targets in cancer cells, specific antibodies were immobilized on the surface of GNRs using the layer-by-layer deposition method. First, Raman reporter molecules, mercaptopyridine, were attached to the surface of GNRs, and their surface charge was modified using poly(sodium 4-styrene-sulfonate) to make the surface charge negative. Then, anti-rabbit IgGs were immobilized onto the surface of the GNRs by electrostatic interactions. HER2 markers, expressed on the cell surface, were treated with anti-HER2 primary antibodies. Finally, the functionalized nanoprobes, conjugated with secondary antibodies, were attached to the markers on cancer cells by antibody–antibody interactions. In the present study, MCF7 cells overexpressing breast cancer marker HER2 were used as the optical imaging targets. Our experimental results demonstrate the potential feasibility of antibody-conjugated GNRs for the highly sensitive targeting and imaging of biomarkers expressed on the surface membrane of cancer cells.</P> <P>Graphic Abstract</P><P>We report the application of antibody-conjugated gold nanorods for the targeting and imaging of biomarkers expressed on cancer cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b904592a'> </P>
Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.
Park, Hyejin,Kam, Tae-In,Kim, Youngdoo,Choi, Hyunwoo,Gwon, Youngdae,Kim, Changsoo,Koh, Jae-Young,Jung, Yong-Keun IRL Press ; Oxford University Press 2012 Human Molecular Genetics Vol.21 No.12
<P>Abnormally hyperphosphorylated tau is often caused by tau kinases, such as GSK3β and Cdk5. Such occurrence leads to neurofibrillary tangle formation and neuronal degeneration in tauopathy, including Alzheimer's disease (AD). However, little is known about the signaling cascade underlying the pathologic phosphorylation of tau by Aβ(42). In this study, we show that adenylate kinase 1 (AK1) is a novel regulator of abnormal tau phosphorylation. AK1 expression is markedly increased in the brains of AD patients and AD model mice and is significantly induced by Aβ(42) in the primary neurons. Ectopic expression of AK1 alone augments the pathologic phosphorylation of tau at PHF1, CP13 and AT180 epitopes and enhances the formation of tau aggregates. Inversely, downregulation of AK1 alleviates Aβ(42)-induced hyperphosphorylation of tau. AK1 plays a role in Aβ(42)-induced impairment of AMPK activity and GSK3β activation in the primary neurons. Pharmacologic studies show that treatment with an AMPK inhibitor activates GSK3β, and a GSK3β inhibitor attenuates AK1-mediated tau phosphorylation. In a Drosophila model of human tauopathy, the retinal expression of human AK1 severely exacerbates rough eye phenotype and increases abnormal tau phosphorylation. Further, neural expression of AK1 reduces the lifespan of tau transgenic files. Taken together, these observations indicate that the neuronal expression of AK1 is induced by Aβ(42) to increase abnormal tau phosphorylation via AMPK-GSK3β and contributes to tau-mediated neurodegeneration, providing a new upstream modulator of GSK3β in the pathologic phosphorylation of tau.</P>
Growth of nanostructured ZnO on wearable fabrics for functional garment
Park, Hyejin,Tong, Fei,Sujan, Achintya,Chung, Yoonsung,Park, Minseo,Tatarchuk, Bruce J.,Koo, Helen,Ahn, Hosang,Yoon, Young Soo,Kim, Dong-Joo Elsevier 2014 Materials letters Vol.118 No.-
<P><B>Abstract</B></P> <P>ZnO thin films and nanorods were grown via a wet chemical route on various wearable fabrics such as cotton, nylon, and polyester. The seed layer of ZnO was deposited by a dip-pad-cure method, and thermolysis assisted chemical solution method was used to grow well-aligned ZnO nanorods. The growth behaviors were investigated by comparing ZnO nanorods with/without a seed layer and on different fabrics. The seed layer significantly influenced the growth of ZnO nanorods while the types of fabrics did not. Nanostructured ZnO on fabrics showed reduced diffused reflectance near 380nm by absorbing UV light. Increased electrical conductivity was also observed due to the ZnO nanorods.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ZnO nanostructures were grown at low temperature via solution methods on fabrics. </LI> <LI> The ZnO seed layer was critical for the growth of ZnO nanorods on fabrics. </LI> <LI> The ZnO nanorods on fabrics showed comparable properties with solid substrates. </LI> </UL> </P>