발열로 인해 발현된 부루가다 증후군 1례

박혜연,김종훈,박경일,황철웅,김태년,남궁준,도준형,이원로,이성윤 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Brugada syndrome is characterized by right bundle branch block morphology and ST segment elevation in the right precordial leads and a propensity to develop ventricular arrhythmias. Mutations in a cardiac sodium channel gene have been linked to this syndrome, and the ionic mechanisms responsible for the electrocardiographic phenotype are temperature-dependent. This case report describes a patient in whom a typical Brugada ECG pattern developed during fever and returned normal ECG after fever was subsided.

STR 유전자의 개인식별력 측정을 위한 통계량

이혜승,이재원,한길로,황적준 大韓法醫學會 1998 대한법의학회지 Vol.22 No.2

When we intend to do the personal identification using DNA profiles, it will obviously be better to use as much information as possible. The power of identification is increased by using the genetic marker system such as VNTRs or STRs. Although STRs do not have many alleles per locus as VNTRs, these can be compensated by a large number of loci that are potentially usable. However, it will be more efficient to use a morphic loci. Therefore, prior to choose the genetic marker system of STRs for identification, it is essential to consider the statistical parameters of each STR locus, such as obs-H(observed heterozygosity), exp-H(expected heterozygosity), pM(probability of match), DI(discrimination index), PD(power of discrimination), MEC(mean exclusion chance), MEP(mean exclusion paternity), PIC(polymorphic information content) et al. In this article, we described the exact meaning of statistical parameters for the purpose of identification.

DNA 증거의 집단유전학적 분석을 위한 SAS시스템

이효정,이혜승,한길로,이재원,황적준 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

DNA analysis has become one of the most powerful tools in forensic inference for human identification and is now used worldwide. It is used to be statistical technique for the individual identification of a civil and criminal action. The purpose of this article is computerization of the statistical technique for the population study and DNA evidence analysis. The system using SAS/AF and SAS/SCL is the graphic user interface and the correspondence of the changed experimental circumstances

친모의 유전자형을 알 수 없을 때 친자확인 유전자 검사

황적준,이재원,한길로,이혜승 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

In parentage testing DNA profiles are used to link the alleged father with paternity by matching their patterns. The probative value of a match is often calculated by multiplying together the estimated frequencies with which each particular VNTR or STR pattern occurs in a reference population. When this calculating method applies to the motherless case of paternity disputes, a calculation must usually be based on types determined for the child and the alleged father. In such case, the first consideration is to exclude a man from paternity of a child when the man did not have the child's paternal allele at some loci, or if the paternal allele cannot be determined, when the man had neither of the child's alleles. The second is to evaluate the DNA evidence when a man is not excluded by the paternal allele. This work is to provide theories of paternity analysis with three approach methods for the motherless case, and to evaluate their efficiency compared to the trio case when the man tested is not excluded. Consequently, the motherless case offers lower probability exclusion and questionable cumulative paternity index than those of the trio case as being typed with 14 STR loci(CSF1PO, THO1, TPOX, vWA, nity index than those of the trio case as being typed with 14 STR loci(CSF1PO, THO1, TPOX, vWA, D5S818, D13S317, D7S820, D16S539, FGA, D21S11, FES/FPS, F13A1, D18S80, D17S5). Since the motherless case in paternity disputes is less efficient for paternity exclusion of the child, the use of genetic maker systems with the higher value of mean exclusion chance(MEC) and exact levels of the relative probability of paternity must be of importance considered in the analysis of such deficiency cases.

패혈증 이후 발생한 스트레스성 심근병증 2례

김종훈,남궁준,박혜연,황철웅,박경일,도준형,이성윤,이원로 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

The transient left ventricular apical ballooning syndrome, also known as takotsubo cardiomyopathy is a recently described novel cardiac syndrome. This syndrome is characterized by transient asynergy of the ventricular apex or mid-ventricle in the absence of obstructive epicardial coronay artery disease. This report concerns two types of morphologic difference about left ventricular apex and mid-ventricle. In this case, we report two types of stress-induced cardiomyopathy with review of literatures.

Clopidogrel에 의해 발생된 전신 염증 반응 증후군 1례

김민환,김종훈,박경일,박혜연,황철웅,김의석,도준형,남궁준,이성윤,이원로 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Clopidogrel bisulfate, a widely used inhibitor of platelet aggregation, is considered at least as safe as aspirin. We describe a 61 year old male patient who developed a systemic inflammatory response syndrome consisting of high fever, rash, chills, impaired liver function, and mild leukopenia after receiving clopidogrel after coronary angiography and stent implantation. The reaction resolved promptly after withdrawal of the drug, thus making the diagnosis of a clopidogrel induced reaction highly probable.

A Case of Dermal Duct Tumor on the Knee

( Hye Won Shin ),( Ji Hye Park ),( Young Suck Ro ) 대한피부과학회 2007 초록집 Vol.45 No.10

경부와 액와부에 동시에 발생한 소아의 국소형 Castleman 질환

노혜원(Hye Won Ro),유희선(Hee Sun Ryu),조진성(Jin Seong Cho),박민호(Min Ho Park),윤정한(Jung Han Yoon),제갈영종(Young Jong Jegal),이지신(Ji Shin Lee),임효순(Hyo Sun Lim) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.5

Castleman’s disease (CD) is an unusual benign lymphoproliferative disorder of unknown etiology and pathogenesis. It most commonly occurs in the mediastinum, but rarely in the axilla or neck. CD has been rarely reported at pediatric age in Korea. Here we report a 17-month-old male patient with histopathologically proven cervical & axillary CD of the hyline vascular type who presented with a painless axillary palpable mass and was treated with a complete excision of the neck & axilla mass without complication.

Roles of Toll-Like Receptors in Allogeneic Islet Transplantation

Ro, Han,Hong, Juho,Kim, Beom Seok,Lee, Eun Won,Kim, Myung-Gyu,Han, Kyu Hyun,Yeom, Hye-Jung,Lee, Eun Mi,Jeong, Jong Cheol,Oh, Kook-Hwan,Ahn, Curie,Yang, Jaeseok Lippincott Williams Wilkins, Inc. 2012 Transplantation Vol.94 No.10

BACKGROUND: Toll-like receptors (TLRs) are involved in the rejection of solid organ allografts. However, the roles of TLRs in islets are still controversial. We investigated the roles of TLRs in donor islets together with those in recipients in allogeneic islet transplantation. METHODS: To assess the roles of TLRs in either donor islets or recipients, allogeneic islet transplantation was performed using myeloid differentiation factor 88 (MyD88)-knockout (KO), TLR4-KO, or Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-&bgr; (TRIF)-KO mice. RESULTS: Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-&ggr;–inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-&bgr; promoter stimulator-1-KO, and TLR4-KO mice. When islets from MyD88-KO, TLR4-KO, or TRIF-KO C57BL/6 mice were transplanted to BALB/c recipients, graft survival was not better than that of wild-type (WT) islets. However, the survival of the MyD88-KO islet allograft was significantly prolonged when combined with anti-CD40L. In parallel, LPS stimulation in donor islets interfered with anti-CD40L blockade-mediated long-term survival of islet allografts in TLR4-KO recipients. LPS stimulation increased the perigraft infiltration of both T cells and macrophages. Then again, when islets from WT BALB/c mice were transplanted to MyD88-KO, TRIF-KO, or WT C57BL/6 mice, there was no difference in graft survival, although some of the MyD88-KO recipients obtained long-term graft survival. However, anti-CD40L prolonged graft survival significantly in MyD88-KO recipients. The absence of MyD88 in either donors or recipients decreased the perigraft infiltration of inflammatory cells when combined with anti-CD40L. CONCLUSIONS: TLRs in both donor islets and recipients are involved in islet allograft rejection.

Elevation of C-Reactive Protein Level is Associated with High-Risk Adenoma

( Hye-jin Ki ),( Hyae Min Lee ),( Jae Myung Cha ),( Jung Won Jeon ),( Hyun Phil Shin ),( Il Hyun Baek ),( Kwang Ro Joo ),( Joung Il Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: There has been growing evidence supporting the role of inflammation in the pathogenesis of colorectal cancer, recently. However, the associations between serum CRP, a serologic marker of the inflammatory reactions and risk of CRC have been inconsistent, and few studies are known about the association between serum CRP and risk of colorectal adenoma. Thus, we aimed to examine whether risk of colorectal adenoma is associated with serum CRP levels. Methods: A retrospective cross sectional study was performed on a first-time screening colonoscopy performed for asymptomatic subjects, who checked serum CRP level during a routine health check-up, between September 2006 and September 2009in Korea. Serum CRP levels were compared between high- and low-risk adenoma groups, and multivariate regression analysis was performed to determine independent predictors of the high risk adenoma. Results: A total of 3,308 patients were finally enrolled, and patients with high (>0.5 mg/L) serum CRP level was significantly higher in HRAs group than those in LRAs group (8.8% vs. 4.7%, p=0.009). Proportion of subjects with a high-risk adenoma were more frequently included in the high CRP group than low CRPgroup (11.0% vs. 5.9%, p=0.009). Compared with the lowest quartiles of CRP level, the prevalence of high-risk adenoma was 3.5 times higher in highest quartiles (p=0.000). In logistic regression analysis, higher quartiles of CRP was found to be an independent risk factor of high-risk adenomas (odds ratio=1.8, 95% confidence interval=1.3-2.5, p=0.000). Conclusions: Elevated plasma CRP levels are associated with a risk of high-risk colorectal adenoma. These data might be support the hypothesis that inflammation is a risk factor for the development of colorectal neoplasia.