http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Anti-inflammatory components of the Vietnamese starfish <i>Protoreaster nodosus</i>
Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Koo, Jung Eun,Kim, Sohyun,Koh, Young Sang,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Van Kiem, Phan,Kim, Young Ho,Van Minh, Chau BioMed Central 2015 Biological research Vol.48 No.1
<P><B>Background</B></P><P>In the present study, we examined the inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols <B>(1–4)</B> isolated from the Vietnamese starfish <I>Protoreaster nodosus</I> on pro-inflammatory cytokine (IL-12 p40, IL-6, and TNF-α) production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) using enzyme-linked immunosorbent assays (ELISA).</P><P><B>Results</B></P><P>The methanolic extract and dichloromethane fraction exerted potent inhibitory effects on the production of all three pro-inflammatory cytokines, with IC<SUB>50</SUB> values ranging from 0.60 ± 0.01 to 26.19 ± 0.64 μg/mL. Four highly pure steroid derivatives <B>(1–4)</B> were isolated from the dichloromethane fraction and water layer of <I>P. nodosus</I>. Potent inhibitory activities were also observed for (25<I>S</I>) 5α-cholestane-3β,4β,6α,7α,8β,15α,16β,26-octol <B>(3)</B> on the production of IL-12 p40 and IL-6 (IC<SUB>50s</SUB> = 3.11 ± 0.08 and 1.35 ± 0.03 μM), and for (25<I>S</I>) 5α-cholestane-3β,6α,8β,15α,16β,26-hexol <B>(1)</B> and (25<I>S</I>) 5α-cholestane-3β,6α,7α,8β,15α,16β,26-heptol <B>(2)</B> on the production of IL-12 p40 (IC<SUB>50s</SUB> = 0.01 ± 0.00 and 1.02 ± 0.01 μM). Moreover, nodososide <B>(4)</B> exhibited moderate inhibitory effects on IL-12 p40 and IL-6 production.</P><P><B>Conclusion</B></P><P>This is the first report of the anti-inflammatory activity from the starfish <I>P. nodosus</I>. The main finding of this study is the identification oxygenated steroid derivatives from <I>P. nodosus</I> with potent anti-inflammatory activities that may be developed as therapeutic agents for inflammatory diseases.</P>
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Duy Nguyen Ngoc,Ho Phuong-Thao,Uyen Nguyen Kim 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.10
We report on the variations of the astrophysical rates due to mass uncertainties of the exotic nuclei in rp-process reactions. With the current mass precision obtained in the AME2016 database, only the 71Br(p,γ)72Kr and the 65As(p,γ)66Se reactions have rate uncertainties of about 10% - 20% at T9 = 0.5 while the 61Ga(p,γ)62Ge, 61, 64, 65Ge(p,γ)62, 65, 66As, 68, 69Se(p,γ)^{69, 70}Br, 69,70Br(p,γ)70,71Kr, and 75Rb(p,γ)76Sr reactions have large uncertainties of more than 50%. If an uncertainty of 10% at T9 = 1.0 is to be achieved, the mass precisions for the isotopes must be less than 10 keV. Evaluations of the photodisintegrations corresponding to proton captures and β+ decays of the waiting points, 64Ge and 68Se, indicate that the orientation of the nucleosynthesis at these waiting points is still unknown due to the large astrophysical rate variations because of the mass uncertainties of the 65As and the 69Br isotopes. The astrophysical rate variations corresponding to the mass precision levels at specific temperatures are presented in this work.
Cembranoid Diterpenes from the Soft Coral Lobophytum crassum and Their Anti-inflammatory Activities
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol.62 No.2
Cuong, Nguyen Xuan,Thao, Nguyen Phuong,Luyen, Bui Thi Thuy,Ngan, Nguyen Thi Thanh,Thuy, Dinh Thi Thu,Song, Seok Bean,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Chau Van WILEY‐VCH Verlag 2014 Chem Inform Vol.45 No.28
<P><B>Abstract</B></P><P>isolation, structure determination and antiinflammatory effects of nine cembranoid diterpenes including four new compounds, crassumols D—G (I)—(IV), respectively</P>