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RISS 인기검색어
- 검색키워드
- 저자 : Hazel M. Dockrell (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Diagnostic Potential of a PPE Protein Derived from Mycobacterium tuberculosis Beijing/K Strain
김아름,박광주,김영선,조상래,Hazel M. Dockrell,허윤경 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.9
Purpose: The prevalence of Mycobacterium tuberculosis (M. tb) and the status of M. bovis BCG vaccination may affect host immuneresponses to M. tb antigens. Understanding of the predominant local M. tb strain and immune signatures induced by itsstrain-specific antigens may contribute to an improved diagnosis of tuberculosis (TB). The aim of this study was to determine immuneresponses to M. tb antigen which was identified from the hyper-virulent Beijing/K strain in South Korea. Materials and Methods: Pulmonary TB patients (n=52) and healthy subjects (n=92) including individuals with latent TB infection(n=31) were recruited, and QuantiFERON-TB Gold In-Tube tests were performed. The Beijing/K-antigen specific immune signatureswere examined by diluted whole blood assays and multiplex bead arrays in a setting where nationwide BCG vaccination isemployed. Results: Statistical analyses demonstrated that three [C-X-C motif chemokine (CXCL10), interleukin (IL)-6, interferon (IFN)-α] of17 cytokines/chemokines distinguished active cases from healthy controls following stimulation with the Beijing/K-specific antigen. IFN-α also differentiated between active diseases and latent TB infection (p<0.01), and the detection rate of TB was dramaticallyincreased in combination with IL-6 and CXCL10 at the highest levels of specificity (95–100%). Conclusion: Our data indicate that immune signatures to the M. tb Beijing/K-specific antigen can provide useful information forimproved TB diagnostics. The antigen may be developed as a diagnostic marker or a vaccine candidate, particularly in regionswhere the M. tb Beijing/K strain is endemic.
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허윤경,홍지영,최동환,김아름,박소영,권민석,강경준,이정민,Hazel M. Dockrell,이윤석,주후돈,조상래 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.4
Purpose: This study aimed to evaluate ichromaTM IGRA-TB, a novel point-of-care platform for assaying IFN-γ release, and to compareit with QuantiFERON-TB Gold In-Tube (QFT-GIT) for identifying Mycobacterium tuberculosis (M. tb) infection. Materials and Methods: We recruited 60 healthy subjects, and blood samples were obtained in QFT-GIT blood collection tubes. The blood collection tubes were incubated at 37ºC, and culture supernatant was harvested after 18–24 hours. IFN-γ responseswere assessed by the ichromaTM IGRA-TB cartridge and the QFT-GIT IFN-γ enzyme-linked immunosorbent assay. Three activeTB patients were recruited as a positive control for M. tb infection. Results: The area under the receiver operating characteristic curve of the ichromaTM IGRA-TB test for differentiating between infectedand non-infected individuals was 0.9706 (p<0.001). Inconsistent positivity between the two tests was found in three participantswho showed weak positive IFN-γ responses (<1.0 IU/mL) with QFT-GIT. However, the two tests had excellent agreement(95.2%, κ=0.91, p<0.001), and a very strong positive correlation was observed between the IFN-γ values of both tests (r=0.91,p<0.001). Conclusion: The diagnostic accuracy demonstrated in this study indicates that the ichromaTM IGRA-TB test could be used as arapid diagnostic method for detecting latent TB infection. It may be particularly beneficial in resource-limited places that requirecost-effective laboratory diagnostics.
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The Current Status of BCG Vaccination in Young Children in South Korea
( Hye Jon Lee ),( Hazel M. Dockrell ),( Deok Ryun Kim ),( Sian Floyd ),( Sue Yeon Oh ),( Jin Bum Lee ),( Hee Jin Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.4
Background: Delivery of Bacille Calmette-Gurein (BCG) Tokyo vaccine, with the multipuncture device, has been much preferred over BCG Pasteur, with the intradermal method, possibly due to the easier manner of administration, a desire to avoid any trouble with scars, as well as side effects and higher profits to providers in South Korea. Methods: To determine BCG scar status in 0~6 year old children vaccinated with two BCG vaccines (Pasteur BCG vaccine with intradermal method and BCG Tokyo vaccine with percutaneous method), the data from the national BCG scar survey in 2006 was analyzed. Results: Based on the national survey, the high proportion that were vaccinated with BCG Tokyo vaccines with the multipuncture method (64.5%) was noted in 0~6 year old Korean children. From inspection of scar formation, as an indicator of vaccination, the median number of the visible pin scars from the percutaneous method was 16 (interquartile range, 12~18) in the Korean children, and pin scars decreased as the age of the children increased (p<0.001). Conclusion: The findings in this survey clearly showed a growing preference of parents for the BCG Tokyo vaccines by the multipuncture method in South Korea.
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The Current Status of BCG Vaccination in Young Children in South Korea
Lee, Hye-Jon,Dockrell, Hazel M.,Kim, Deok-Ryun,Floyd, Sian,Oh, Sue-Yeon,Lee, Jin-Bum,Kim, Hee-Jin The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.4
Background: Delivery of Bacille Calmette-Gur$\acute{e}$in (BCG) Tokyo vaccine, with the multipuncture device, has been much preferred over BCG Pasteur, with the intradermal method, possibly due to the easier manner of administration, a desire to avoid any trouble with scars, as well as side effects and higher profits to providers in South Korea. Methods: To determine BCG scar status in 0~6 year old children vaccinated with two BCG vaccines (Pasteur BCG vaccine with intradermal method and BCG Tokyo vaccine with percutaneous method), the data from the national BCG scar survey in 2006 was analyzed. Results: Based on the national survey, the high proportion that were vaccinated with BCG Tokyo vaccines with the multipuncture method (64.5%) was noted in 0~6 year old Korean children. From inspection of scar formation, as an indicator of vaccination, the median number of the visible pin scars from the percutaneous method was 16 (interquartile range, 12~18) in the Korean children, and pin scars decreased as the age of the children increased (p<0.001). Conclusion: The findings in this survey clearly showed a growing preference of parents for the BCG Tokyo vaccines by the multipuncture method in South Korea.
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