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Zhou, Wei,Huang, Hai,Zhu, Haiyan,Zhou, Pei,Shi, Xunlong The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.2
Background: Ginseng is a well-known traditional Chinese medicine that has been widely used in a range of therapeutic and healthcare applications in East Asian countries. Microbial transformation is regarded as an effective and useful technology in modification of nature products for finding new chemical derivatives with potent bioactivities. In this study, three minor derivatives of ginsenoside compound K were isolated and the inducing effects in the Wingless-type MMTV integration site (Wnt) signaling pathway were also investigated. Methods: New compounds were purified from scale-up fermentation of ginsenoside Rb1 by Paecilomyces bainier sp. 229 through repeated silica gel column chromatography and high pressure liquid chromatography. Their structures were determined based on spectral data and X-ray diffraction. The inductive activities of these compounds on the Wnt signaling pathway were conducted on MC3T3-E1 cells by quantitative real-time polymerase chain reaction analysis. Results: The structures of a known 3-keto derivative and two new dehydrogenated metabolites were elucidated. The crystal structure of the 3-keto derivative was reported for the first time and its conformation was compared with that of ginsenoside compound K. The inductive effects of these compounds on osteogenic differentiation by activating the Wnt/b-catenin signaling pathway were explained for the first time. Conclusion: This study may provide a new insight into the metabolic pathway of ginsenoside by microbial transformation. In addition, the results might provide a reasonable explanation for the activity of ginseng in treating osteoporosis and supply good monomer ginsenoside resources for nutraceutical or pharmaceutical development.
Foreign Ownership and Information Asymmetry
Haiyan Zhou,최종무,Kevin C. K. Lam,Heibatollah Sami 한국증권학회 2013 Asia-Pacific Journal of Financial Studies Vol.42 No.2
Foreign ownership has two competing effects on information asymmetry. Short term investment horizon, superior information processing capability, controlling positions, and increased agency costs associated with foreign ownership increases information asymmetry, while demand for more disclosure, better accounting and auditing standards, use of international auditors,incentive alignments, long term investment horizon and greater monitoring decreases information asymmetry. In this article, we examine and find a significant and positive impact of foreign ownership on information asymmetry measured by bid-ask spread in China. On balance, foreign equity investors tend to enhance their informational advantages more than improving the general informational environments in local markets. These results have implications for transparency and disclosure policies as well as privatization in emerging markets.
Haiyan Mao,Dingguo Zhou,Zaher Hashisho,Sunguo Wang,Heng Chen,Haiyan (Helena) Wang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
The effect of flow rate, microwave power, and humidity of purge gas on microwave regeneration ofagricultural based activated carbon saturated with toluene and acetone was investigated. To comparewith microwave heating, conductive heating was also employed to follow the effect on adsorptioncapacity, regeneration ratio, desorption rate, time and energy consumption. Desorption rate of constantpower microwave heating was 32.9% per minute, which was 20 and 40 times higher than constanttemperature microwave and conductive heating, respectively. Energy consumption of microwaveheating (constant power) was only 4.5 kJ/g. Adsorption isotherms data can be well fitted with Dubinin–Radushkevich model.
Guo Zhou,Haiyan Meng,Yan Cao,Xuejun Kou,Shuxiang Duan,Leilei Fan,Ming Xiao,Fangzhou Zhou,Zhenzi Li,Zipeng Xing 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
The tiny Ag nanoparticles-uniformly decorated Ti3+ self-doped porous black TiO2 pillars (Ag-TPBTPs) are prepared, which show obvious surface plasmon resonance (SPR) and extend the photoresponse to visible light and near-infrared region (∼1500 nm). The Ag-TPBTPs exhibit excellent solar-driven photocatalytic activities by mineralizing of high-toxic 2,4-dichlorophenol (∼99%), which is three times higher than that of the pristine TiO2. The remarkable solar-driven photocatalytic performance can be ascribed to the porous pillars structure offering more surface active sites, the self-doped Ti3+ and SPR effect of Ag nanoparticles improving the utilization of solar light, and enhancing the spatial separation efficiency of photogenerated charge carriers.
Min Liao,Jinlin Zhou,Haiyan Gong,Damdinsuren Boldbaatar,Rika Umemiya-Shirafuji,Banzragch Battur,Jianbao Dong,Yoshifumi Nishikawa,Myungjo You,Kozo Fujisaki 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
A full-length sequence of a thrombin inhibitor (designated as hemalin) from the midgut of pathenogenetic Haemaphysalis longicornis has been identified. Sequence analysis shows that this gene belongs to a Kunitz-type family, containing two Kunitz domains with high homology to boophilin, the thrombin inhibitor from Rhipicephalus (Boophilus) microplus. The recombinant protein expressed in insect cells delays bovine plasma clotting time and inhibits both thrombin-induced fibrinogen clotting and platelet aggregation. A 20-kDa protein was detected from the midgut lysate with antiserum against recombinant hemalin. The gene expresses at all stages of the tick except for the egg stage and mainly in the midgut of the female adult tick. Real-time PCR analysis shows that this gene has a distinctly high expression level in the rapid bloodsucking period of the larvae, nymphs, and adults. Disruption of the hemalin gene led to a 2-day extension of the tick blood feeding period, and 27.7% of the ticks did not successfully complete the blood feeding. These findings indicate that the newly indentified thrombin inhibitor from the midgut of H. longicornis might play an important role in tick blood feeding.
Inhomogeneous Fatigue Characteristics of Welded Ti–6Al–4V Thick Plate by the Electron Beam Method
Haiyan Wang,Caiyou Zeng,Caiyou Zeng,Yupeng Zhang,Yu Zhou,Chunlin Dong 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.11
To recognize the specific safety problem brought by an increasing thickness, the layered microstructures, fatigue propertiesand the fractographies of a 100 mm-thick Ti–6Al–4V joint via electron beam welding were investigated. The results showthat the seam zone has textural and mechanical heterogeneities in the layered thickness regions. The mid layer has the lowestfatigue life and different fracture-position tendency (more broken in seam zone) due to the hybrid influences of the grain sizeand the phase fraction of α′ and β phases. The fatigue cracks initiate on the surfaces of fatigue specimens and grow in thetransgranular fracture mode. The fatigue deformation mode is adapted to the planar-slip mechanism with different degreesof dislocation blocking in distinct layers, which results in a “mid-layer favorite” crack initiation trend. Moreover, the midlayer has the highest crack propagation rate either.
Haiyan Zhuang,Shujun Fang,Man Zhou,Mostafa Fahmi Hassanein 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.9
The dimensioning of the cross section is a critical step in designing wide box girder bridges with long cantilevers. The typical box girder cross section may not be the most economical and reasonable choice for wide box girder bridges considering the stress conditions and construction costs. Arranging transverse stiffened ribs underneath the top slab is an effective way to widen the bridge deck. In this study, the influence of the transverse stiffened ribs on the mechanical performance of the ribbed top slab is investigated by finite element (FE) modelling. The results show that the transverse mechanical properties of the box girders with ribbed slabs are significantly different from those of the traditional box girders with solid slabs. The ribbed slabs can provide additional transverse capacities over those of the traditional solid slabs. Furthermore, the transverse tensile stress in the root section of the ribbed cantilever slab is found to fluctuate periodically along its length, and a considerable stress concentration is observed in the transverse ribs. The key design parameters of the transverse ribs (depth, width and spacing) influencing the tensile stress amplitude at the cantilever root section are determined through FE parametric analysis.
경북산 지황과 중국산 지황의 Catalpol 함량 비교
주미,장해연,나민균 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-
Rehmanniae Radix (Scrophulariaceae) has been traditionally used to treat hemoptysis, polydipsia, diabetes, anemia, palpitation, insomnia, and menstrual disorders. To compare the Rehmanniae Radix produced from Gyeongbuk with that of Chinese, a quantitative analysis on the major component, catalpol, was preformed by reversed-phase HPLC. Using a Luna C18(2) column, we carried out quantitative analysis with an isocratic solvent of acetonitrile and 0.1% phosphoric acid in water (2.5:97.5). Our results demonstrated that the content of catalpol in the Gyeongbuk's Rhemanniae Radix was 1.8 times higher than that of Chinese.
Current Status of Indoor Positioning System Based on Visible Light
Kun Yan,Haiyan Zhou,Hailin Xiao,Xiangli Zhang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
With the flourishing of wireless information access, indoor positioning is becoming a topic of interest in both academic and industry community. Numerous techniques have been proposed to address this problem under diverse circumstances. Recently, the area of indoor positioning is dominated by three kinds of methodologies, such as rangebased positioning, fingerprint-based positioning and inertial positioning. This paper is presented to overview the indoor positioning techniques using visible light based on the range-based positioning. The state-of-the-art research results will be studied. The typical localization mechanisms used in visible light positioning systems are analyzed by evaluation metrics to provide an insight of the systems’ performances.