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Kim, Ho Yong,Kim, So Young,Lee, Hye-Young,Lee, Jin Ho,Rho, Gyu-Jin,Lee, Hyeon-Jeong,Lee, Hee-Chun,Byun, June-Ho,Oh, Se Heang American Chemical Society 2019 Biomacromolecules Vol.20 No.2
<P>Sufficient oxygen delivery into tissue-engineered three-dimensional (3D) scaffolds to produce clinically applicable tissues/organs remains a challenge for researchers and clinicians. One potential strategy to overcome this limitation is the use of an oxygen releasing scaffold. In the present study, we prepared hollow microparticles (HPs) loaded with an emulsion of the oxygen carrier perfluorooctane (PFO; PFO-HPs) for the timely supply of oxygen to surrounding cells. These PFO-HPs prolonged the survival and preserved the osteogenic differentiation potency of human periosteal-derived cells (<I>h</I>PDCs) under hypoxia. <I>h</I>PDCs seeded onto PFO-HPs formed new bone at a faster rate and with a higher bone density than <I>h</I>PDCs seeded onto phosphate buffered saline-loaded control HPs. These findings suggest that PFO-HPs provide a suitable environment for the survival and maintenance of differentiation ability of <I>h</I>PDCs at bony defects without vascular networks until new blood vessel ingrowth occurs, thus enhancing bone regeneration. PFO-HPs are a promising system for effective delivery of various functional cells, including stem cells and progenitor cells, to regenerate damaged tissues/organs.</P> [FIG OMISSION]</BR>
( So Jin Bing ),( Manh Tin Ho ),( Phorl Sophors ),( Sang Gyu Park ),( Young Min Yun ),( Young Heun Jee ),( Moon Jae Cho ) 한국응용생명화학회(구 한국농화학회) 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.1
Extracted mushroom water showed an ability to suppress the accumulation of body fat in female mice after feeding 5 weeks with high fat diet. Particularly, in parametrial and mesenteric adipose, it significantly reduced 44 and 47% of weight, respectively. In non-obese mice, maturated NK cell (CD11bhiCD27lo) population were increased (70.9±3.8% ) in mushroom water fed mice compared to control (61.4±4.3%) and NK cell population were augmented in mushroom fed mice compared to control.
Lumbar Spine Kinematics during Anterior and Posterior Pelvic Tilting in Supine and Prone Positions
( So-hyun Park ),( Goon-chang Yuk ),( Sang-ho Ahn ),( Dong-gyu Lee ),( Jin-ho Choi ),( Hyun-ju Oh ),( Kwan-yong Park ) 대한물리치료학회 2011 대한물리치료학회지 Vol.23 No.6
Purpose: The pelvic tilting exercise is a well recognized rehabilitation maneuver. However, little information is available on the changes of lumbar segmental motion during pelvic tilting. This study was conducted to measure the kinematics of the pelvic tilting exercise on the supine and prone positions via fluoroscopy. Methods: A total of 10 female subjects were enrolled. During anterior, neutral, and posterior pelvic tilting, radiographs were taken in each exercise via fluoroscopy (ARCADIS Orbic, Siemens, USA). Images were sent to the picture archiving communication system (PACS), and the digitized images were analyzed using LabVIEW software (National Instruments, USA). Lumbosacral lordosis and the intervertebral body angle, intervertebral disc angle, and intervertebral displacement were analyzed. Results: The results of lumbar kinematic analysis during three tilting postures in the supine and prone positions demonstrated that lumbosacral lordosis and the intervertebral body angle and intervertebral disc angle were significantly higher when the pelvis was tilted anteriorly (p>0.05). However, there was no significant difference between anterior and neutral tilting in the intervertebral disc angle at the L3/4 level in the prone position (p>0.05), and there was no significant difference among tilting positions in intervertebral body displacement in the prone position (p>0.05). Conclusion: This study provides scientific evidence about the pelvic tilting exercise in lumbosacral segmental motion. Depending on the pelvic tilting exercise, kinematic changes were demonstrated in both positions, especially in the supine position. It is suggested that the supine position is effective for mobility, but it should be used carefully for the LBP (Low back pain) patient with hypermobility.
Association between primary immunodeficiency and asthma exacerbation in adult asthmatics
So-Hee Lee,Ga-Young Ban,Su-Chin Kim,Chang-Gyu Chung,Hyun-Young Lee,Ji-Ho Lee,Hae-Sim Park 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: Primary immunodef iciency (PID) is a serious comorbid condition in adult asthmatics that have frequent exacerbations, which requires monthly replacement of intravenous immunoglobulin (IVIG). However, the prevalence and clinical significance of PID in adult asthmatics in Korea have not yet been reported. The aim of this study is to assess the prevalence of PID and its association with asthma exacerbation in Korean adult asthmatics. Methods: A total of 2,866 adult asthmatics were enrolled in this study. The PID group was defined as subjects who had lower levels of immunoglobulin G (IgG)/ A/M and/or IgG subclass presenting with recurrent respiratory infections. Serum samples were assayed for total IgG/A/M by immunoturbidimetry, and IgG subclasses by nephelometry. Results: Of the 2,866 asthmatic patients enrolled, 157 (5.49%) had PID (classified as the PID group), while those without PID was classified as the non-PID group. IgG subclass deficiency (58%) is most prevalent, among which IgG3 subclass deficiency was most common (58%). The relative risk of asthma exacerbation was 1.70 times higher in the PID group compared to the non-PID group (1.696; 95% confidence interval, 1.284 to 2.239; p < 0.001); the prevalence of severe asthma was significantly higher in the PID group than in the non-PID group (32.48% vs. 13.00%, p < 0.001). Thirty-five among 157 patients in the PID group d maintained IVIG to prevent asthma exacerbation. Conclusions: It is suggested that PID, especially IgG3 subclass deficiency, is a significant risk factor for asthma exacerbation. Screening of IgG subclass levels and IVIG replacement should be considered in the management in adult asthmatics.
Ho Bum Cho,Sun Young Park,So Jin Na,Hyerim Kwon,Jae Hwa Yoo,Mun Gyu Kim,Ji-Won Chung,Sang Ho Kim 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.2
Objective: Although the reference value of cardiac index (CI) is derived by pulmonary arterial pressure, the use of pulmonary arterial catheterization is limited by low cost effectiveness and many concerns regarding complications. Therefore, relatively noninvasive indirect measurement is used widely perioperatively. The goal of this study was to determine the accuracy of the CI derived by Mobil-O-Graph NG (cCI) noninvasively in patients undergoing general anesthesia by comparing that measured by FloTrac/Vigileo (fCI), the minimal invasive method. Methods: The Bland–Altman method was used to quantify agreement. Bias (mean difference between fCI–cCI) represents the systematic error between methods and precision (standard deviation of the bias) represents the random error or variability between techniques. The percentage error was considered clinically acceptable, and the tested method (Mobil-O-Graph NG) was regarded as interchangeable with the reference method (FloTrac/Vigileo), if it was below 30%. Results: One hundred and ninety-five patients were included in this study, and CI, measured in the 121 patients. The Bland–Altman analysis revealed a bias -0.01 and the percentage error of 32.4%. And the difference is inversely increased according the mean CI. Conclusion: Results showed that CI measured by Mobil-O-Graph NG had a wide limit of agreement with that measured by FloTrac/ Vigileo, therefore regarded as not interchangeable.
So Min Park,Yun Woo Cho,Sang Ho Ahn,Dong Gyu Lee,조희경,Sung Yup Kim 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.5
Objective To investigate the comparative treatment effects of ultrasound-guided pulsed radiofrequency treatment (UG-PRF) in the gastrocnemius interfascial space and ultrasound-guided interfascial injection (UG-INJ) on myofascial pain syndrome. Methods Forty consecutive patients with myofascial pain syndrome of the gastrocnemius were enrolled and were allocated to one of the two groups. Twenty patients were treated by UG-PRF delivered to the gastrocnemius interfascial space (UG-PRF group) and the other 20 patients were treated by interfascial injection (UG-INJ group). The primary outcome measure was the numeric rating score (NRS) for pain on pressing the tender point in the gastrocnemius, and the secondary outcome measure was health-related quality of life as determined by the Short Form-36 questionnaire (SF-36). NRSs were obtained at the first visit, immediately after treatment, and at 2 and 4 weeks post-treatment, and physical component summary scores (PCS) and mental component summary scores (MCS) of the SF-36 questionnaire were measured at the first visit and at 4 weeks post-treatment.Results Immediately after treatments, mean NRS in the UG-PRF group was significantly higher than that in the UG-INJ group (p<0.0001). However, at 2 and 4 weeks post-treatment, the mean NRS was significantly lower in the UG-PRF group (both p<0.0001). Similarly, at 4 weeks post-treatment, mean PCS and MCS were significantly higher in the UG-PRF group (p<0.0001 and p=0.002, respectively).Conclusion Based on these results, the authors conclude that ultrasound-guided gastrocnemius interfascial PRF provides an attractive treatment for myofascial pain syndrome of the gastrocnemius.
( So-mi Kang ),( Min-ho Yoon ),( So-young Park ),( Tae-gyun Woo ),( Ah-young Oh ),( Nam-chul Ha ),( Gyu-yong Song ),( Bum-joon Park ) 한국장기요양학회 2018 한국장기요양학회 추계학술대회자료집 Vol.2018 No.-
In our previous study, we found that progerin-Lamin A binding inhibitor (JH4) can improve the pathological features of Hutchinson Gilford progeria syndrome (HGPS) such as nuclear deformation and growth suppression in patient’s cells and very short life span in in vivo mouse model (1,2). Despite favorable effect of this chemical, JH4 is very rapidly eliminated in in vivo pharmacokinetic (PK) analysis. Thus, we improved the chemical property through chemical modification and finally obtained the optimized drug candidate, Progerinin (Code No. SLC-D011). This chemical can extend 5 weeks of life span of Lamn<sup>G609G/G609G</sup> mouse (from 14.5 week to 19.5; maximum life span is 20 week) with increase of body weight. In addition, we can observe the favorable effect of progerinin in werner syndrome (WS) cells, such as enhancing cell proliferation and inhibition of SA-β-galactosidase expression. Moreover, elimination of progerin in WS cells can restore the nuclear morphology and enhance H3K9me3 expression. These results indicate that progerinin is one of strong candidate for HGPS as well as WS syndrome.