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Gi‑Su Ham,Young‑Kyun Kim,Young Sang Na,Kee‑Ahn Lee 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.1
This study investigated the effect of Ti addition on microstructure and high-temperature oxidation property of AlCoCrFeNihigh-entropy alloy. Ti content was controlled at 0 at% and 1 at%. The two alloys were found to have BCC single phase, andthe average grain sizes of Ti0.0 and Ti1.0 were 47.3 μm and 49.7 μm, respectively, showing similarity. The EDS mappingof the inside of grains found that both alloys were characterized to be divided into Al-Ni element rich region and Cr–Feelement rich region. As a result of high-temperature oxidation test at 1100 °C, oxidation weight gains were measured atTi0.0: 0.75 mg/cm2 and Ti1.0: 0.17 mg/cm2, respectively. The results indicate that Ti addition largely improved high temperatureoxidation resistance of AlCoCrFeNi HEA. Ti1.0 alloy, in particular, showed remarkably more excellent 1100 °Chigh-temperature oxidation resistance than other previously reported major ones such as NiCrAl and FeCrAl. In the surfaceand cross-section observations after oxidation tests, both alloys were found to have Al2O3oxides mostly. While the Ti0.0material was observed to have Al2O3spallation macroscopically, the Ti1.0 alloy showed Al2O3spallation only in some localareas. In addition, a unique result was found in AlCoCrFeNiTix(x=0,1) alloy that BCC → FCC phase transformation was accelerated,and FCC phase layer was formed in the surficial area where Al element had been depleted due to high-temperatureoxidation. Moreover, as Ti was added, the thickness of FCC layer induced by high-temperature oxidation decreased. Basedon the results, it was also discussed on how to improve the high-temperature oxidation resistance of AlCoCrFeNiTixHEA.
Preventive effect of Flavonoid Wogonin against Ethanol-induced Gastric Mucosal Damage in Rats
박수진 ( Park Su Jin ),여말희 ( Yeo Mal Hui ),김종수 ( Kim Jong Su ),이은희 ( Lee Eun Hui ),오태영 ( O Tae Yeong ),이기명 ( Lee Gi Myeong ),진주현 ( Jin Ju Hyeon ),조요원 ( Jo Yo Won ),함기백 ( Ham Gi Baeg ),조성원 ( Jo Seong Won 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
Whether the wogonin (5, 7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have anti-inflammatory and antitumor activities in various cell types, possesss gastric cytoprotective e
함상수 ( Ham Sang Su ),김욱 ( Kim Ug ),박신성 ( Park Sin Seong ),서영일 ( Seo Yeong Il ),임성희 ( Im Seong Hui ),김병태 ( Kim Byeong Tae ),최문기 ( Choe Mun Gi ),장연복 ( Jang Yeon Bog ),유형준 ( Yu Hyeong Jun ),박성우 ( Park Seo 대한내과학회 1993 대한내과학회지 Vol.44 No.5
연구배경 : 한국인 성인 인슐린의존성 당뇨병의 특성을 알아 보고자 최근 5년간 경험한 당뇨병성 케톤산증의 역학적 특성과 임상상을 분석하였다. 방법 : 전형적인 당뇨병성 케톤산증의 임상상을 나타내고 내원시 혈당치가 250㎎/dl 이상이며 케톤뇨나 케톤혈증이 있고 동맥혈중 pH가 7.34미만인 당뇨병성 케톤산증 72예를 분석하였다. 결과 : 1) 당뇨병성 케톤산증 환자의 남녀비는 1 : 1.25로 여성우위를 나타내었도 젊은 층에서 많이 발생되었으면 전체 평균연령은 36.6세였다. 2) 당뇨병성 케톤산증 발생의 월별 발병수는 3월과 12월에 가장 많았고 6월에 가장 적었다. 3) 당뇨병의 평균 유병기간은 5.4년이었고 당뇨병성 케톤산증이 당뇨병의 첫 임상발현이었던 경우는 23.6%이었다. 4) 발병유발인자로는 감염과 인슐린 투여중지가 가장 많았으며 26.4%에서는 뚜렷한 유발인자를 찾을 수 없었다. 5) 내원시 다뇨 및 다갈, 호흡곤란, 오심과 구토, 복통등의 증상이 주로 있었고 이학적 검사상 Kussmaul 호흡, 빈맥, 저혈압이 관찰되었으며 내원시 의식상태는 40예(55.6%)에서 명료하였다. 6) 감염증이 동반되었던 24예와 감염증이 없었던 48예 사이에 내원시 체온, 말초혈액 백혈구수 및 중성구 비율에는 차이가 없었다. 7) 내원시 43%에서 고칼률혈증이 나타났고 치료 6시간 후 23%에서 저칼륨혈증이 있었으며, 입원초 시행한 공복혈중 C-peptide치는 2/3에서만 인슐린의존성 당뇨병환자에서 관찰되는 범위로 감소되어 있었다. 8) 치료중 합병증으로는 저혈당이 가장 많았고 저칼륨혈증이 그 다음이었으며 고나트륨혈증, 고칼륨혈증, 혈전색전증, 그리고 성인성 호흡장애증후군 등이 있었다. 9) 사망률은 13.9%였고 고연령, 내원시 심한 질소혈증 예후불량 예측인자로 관찰되었고 사망한 예에서 세균성 폐렴의 빈도가 높았다. 결론 : 한국의 당뇨병성 케톤산증의 역학적 특성이나 임상상은 서양의 경우와 비교할 때 연령 및 남녀분포, 계절분포, 당뇨병성 케톤산증이 당뇨병의 첫 임상 발현인 경우, 발병유발인자들의 비율, 검사소견, 치료 합병증 및 사망률, 그리고 예후인자 등에서 매우 비슷하였다. 이같은 관찰은 한국인 성인에서도 서양의 경우와 비슷한 임상경과를 보이는 인슐린의존성 당뇨병이 존재함을 시사한다. Backgrounds: To characterize tha IDDM in Korea, we analyzed the epidemiological and clinical features of DKA in 72 patients. Methods: Seventy-two cases thoses who met following diagnostic criteria were included in the analysis. 1) Clinical manifestation of typical DKA, 2)Blood glucise level>250 mg/dl, 3) Presence of ketonuria or keonemia, 4) Blood pH<7.34 Results: 1) The occurrence of DKA was higher in the young and infemale. 2) DKA occurred most frequently in colder season with apparent two peaks in March and December. 3) In 23.6%, DKA was the first clinical presentation of diabetes and in the remainders, diabetes wer known to be present for average of 5.4 years. 4) The most common precipitating factors of DKA was infection and omission of therapy was the next. No discernible precipitating factor was found in 26.4% of DKA cases. 5) Polyuria, polydipsia, dyspnea, nausea, vomiting and abdominal pain were frequent accompanying symptoms, and physical finding included Kussmaul breathing, tachycardia and hypotension. The mental stutus of patients were alert in 55.6% of DKA cases. 6) There was no significant difference in the body temperature, PB smear, and % of neutrophis between DKA cases with infection and those without infection. 7) On admission potassium was high in 43%, but low in 23% 6 hours after therapy. In only two-thirds of cases, fasting C-peptide level on admission was decreased in the range of classical IDDM. 8) Hypoglycemia was the most freqeunt complication during the treatment of DKA following by hypokalemia, hypernatremia, hyperkalemia, thromboembolism and ARDS. 9) Mortality of DKA was 13.9% and poor prognostic factors include old age, azotemia, associated bacterial pneumonia. Conclusions: The epidemiological and clinical feautures of DKA in Korea were similar to those in western countries, in respect to female preponderance, age, seasonal distribution, % of debut cases, precipitating fators, initial laboratory findings, complications, mortality and prognostic factors. This observation suggests that although the incidence rate of IDDM is low in Korea, there are cases that take clinical courses very similar to those of western countries.
대한간학회지 제2차 춘계학술대회 초록집 : 간경변증에 의한 울혈성 위병변에서의 Nitric Oxide Synthase(NOS) 분포 -면역화학검사-
문영수 ( Mun Yeong Su ),강한걸 ( Kang Han Geol ),홍사준 ( Hong Sa Jun ),이광재 ( Lee Gwang Jae ),김영수 ( Kim Yeong Su ),함기백 ( Ham Gi Baeg ),김진홍 ( Kim Jin Hong ),조성원 ( Jo Seong Won ),임현이 ( Im Hyeon I ) 대한간학회 1996 Clinical and Molecular Hepatology(대한간학회지) Vol.2 No.2(S)
레이저 클래딩 공정을 이용한 Ni-Cr-B-Si + WC/12Co 복합 코팅층의 제조 및 기계적 특성
함기수,김철오,박순홍,이기안,Ham, Gi-Su,Kim, Chul-O,Park, Soon-Hong,Lee, Kee-Ahn 한국분말야금학회 2017 한국분말재료학회지 (KPMI) Vol.24 No.5
In this study we manufacture a Ni-Cr-B-Si +WC/12Co composite coating layer on a Cu base material using a laser cladding (LC) process, and investigate the microstructural and mechanical properties of the LC coating and Ni electroplating layers (reference material). The initial powder used for the LC coating layer is a powder feedstock with an average particle size of $125{\mu}m$. To identify the microstructural and mechanical properties, OM, SEM, XRD, room and high temperature hardness, and wear tests are implemented. Microstructural observation of the initial powder and LC coating layer confirm the layer is composed mainly of ${\gamma}-Ni$ phases and WC and $Cr_{23}C_6$ carbides. The measured hardness of the LC coating and Ni electroplating layers are 653 and 154 Hv, respectively. The hardness measurement from room up to high temperatures of $700^{\circ}C$ result in a hardness decrease as the temperature increases, but the hardness of the LC coating layer is higher for all temperature conditions. Room temperature wear results show that the wear loss of the LC coating layer is 1/12 of the wear level of the Ni electroplating layer. The measured bond strength is also greater in the LC coating than the Ni electroplating.
Ha, Go Eun,Chang, Oun Ki,Jo, Su-Mi,Han, Gi-Sung,Park, Beom-Young,Ham, Jun-Sang,Jeong, Seok-Geun Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.6
Angiotensin-converting enzyme (ACE) inhibitory activity was evaluated for the low-molecular-weight fraction (<3 kDa) obtained from milk fermentation by Bifidobacterium longum KACC91563. The ACE inhibitory activity in this fraction was 62.3%. The peptides generated from the <3 kDa fraction were identified by liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrometry analysis. Of the 28 peptides identified, 11 and 16 were identified as β-casein (CN) and α<sub>s1</sub>-CN, respectively. One peptide was identified as κ-CN. Three peptides, YQEPVLGPVRGPFPIIV, QEPVLGPVRGPFPIIV, and GPVRGPFPIIV, from β-CN corresponded to known antihypertensive peptides. We also found 15 peptides that were identified as potential antihypertensive peptides because they included a known antihypertensive peptide fragment. These peptides were as follows: RELEELNVPGEIVE (f1-14), YQEPVLGPVRGPFP (f193-206), EPVLGPVRGPFPIIV (f195-206), PVLGPVRGPFPIIV (f196-206), VLGPVRGPFPIIV (f197-206), and LGPVRGPFPIIV (f198-206) for β-CN; and APSFSDIPNPIGSENSEKTTMPLW (f176-199), SFSDIPNPIGSENSEKT- TMPLW (f178-199), FSDIPNPIGSENSEKTTMPLW (f179-199), SDIPNPIGSENSEKTTMPLW (f180-199), DIPNPIGSENSEKTTMPLW (f181-199), IPNPIGSENSEKTTMPLW (f182-199), PIGSENSEKTTMPLW (f185-199), IGSENSEKTTMPLW (f186-199), and SENSEKTTMPLW (f188-199) for α<sub>s1</sub>-CN. From these results, B. longum could be used as a starter culture in combination with other lactic acid bacteria in the dairy industry, and/or these peptides could be used in functional food manufacturing as additives for the development of a product with beneficial effects for human health.