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몬테카를로 시뮬레이션을 활용한 스마트 도시재생서비스 도출 및 중요도 산정
강수연(Gang, Su-Yeon),정연준(Jeong, Yeon-Jun),이경환(Lee, Kyung-Hwan),고은정(Ko, Eun-Jeong) 대한건축학회 2022 대한건축학회논문집 Vol.38 No.6
In the current 4th industrial revolution era, there is an increasing interest worldwide in smart cities with smart technology applied to established cities. However, in the process of promoting these smart urban regeneration projects, specific and relevant services must first be introduced; few studies have been conducted on the importance of each. Therefore, this study derives several smart urban regeneration services that can be applied to smart urban regeneration projects while utilizing the Monte Carlo simulation (MCS) to supplement the sample limitations and uncertainty risks of existing decision-making methodologies. Therefore, in this study, four types and thirteen detailed services were derived through existing research and related guidelines. Through an expert survey, the importance of each service was calculated, and risks were considered by defining unavoidable, uncertainty factors in a probability distribution using MCS; the process was repeated 100,000 times. The most important service scored 28.4% for Work·Employment, in the detailed service category 9.4% was for the job information service, 9.3% for safe return home service and 9.2% for fire monitoring. These results suggest that smart urban regeneration services should be applied differently according to the location of the target site and the size of the project. Additionally, when implementing smart urban regeneration projects, it is necessary to actively introduce smart urban regeneration services that can help local residents solve job issues, crime and disaster prevention concerns, and environmental problems. From a methodological point of view, this study is significant in that it proposed and utilized MCS to supplement the risk of uncertainty in the existing expert survey. These results are expected to be useful in the process of further promoting smart urban regeneration.
Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells
Heo, Jun-Young,Jing, Kaipeng,Song, Kyoung-Sub,Seo, Kang-Sik,Park, Ji-Hoon,Kim, Jong-Seok,Jung, Yeon-Joo,Hur, Gang-Min,Jo, Deog-Yeon,Kweon, Gi-Ryang,Yoon, Wan-Hee,Lim, Kyu,Hwang, Byung-Doo,Jeon, Byeong Wiley (John WileySons) 2009 Stem Cells Vol.27 No.6
<P>The senescence of human mesenchymal stem cells (hMSCs) causes disruption of tissue and organ maintenance, and is thus an obstacle to stem cell-based therapies for disease. Although some researchers have studied changes in the characteristics of hMSCs (decreases in differentiation ability and self-renewal), comparing young and old ages, the mechanisms of stem cell senescence have not yet been defined. In this study, we developed a growth curve for human bone marrow derived MSCs (hBMSCs) which changes into a hyperbolic state after passage number 7. Senescence associated beta-galactosidase (SA beta-gal) staining of hBMSCs showed 10% in passage 9 and 45% in passage 11. We detected an increase in endogenous superoxide levels during senescence that correlated with senescence markers (SA beta-gal, hyperbolic growth curve). Interestingly, even though endogenous superoxide increased in a replicative senescence model, the expression of APE1/Ref-1, which is sensitive to intracellular redox state, decreased. These effects were confirmed in a stress-induced senescence model by exogenous treatment with H(2)O(2). This change is related to the p53 activity that negatively regulates APE1/Ref-1. p21 expression levels, which represent p53 activity, were transiently increased in passage 9, meaning that they correlated with the expression of APE1/Ref-1. Overexpression of APE1/Ref-1 suppressed superoxide production and decreased SA beta-gal in hBMSCs. In conclusion, intracellular superoxide accumulation appears to be the main cause of the senescence of hBMSCs, and overexpression of APE1/Ref-1 can rescue cells from the senescence phenotype. Maintaining characteristics of hBMSCs by regulating intracellular reactive oxygen species production can contribute to tissue regeneration and to improved cell therapy.</P>
뇌졸중 환자의 아탈구에 기능적 전기 자극치료 적용 시 상지기능과 삶의 질의 변화에 관한 연구
심준호(Sim Jun-Ho),고주연(Ko Joo-Yeon),허진강(Hur Jin-Gang) 대한치료과학회 2010 대한치료과학회지 Vol.2 No.1
Objective: To determine the effects of subluxation functional electrical stimulation(FES) on the upper extremity function and quality of life of stroke patients. Method: Tools used for analysis were Manual function test (MFT) and WHOQOL-BREFF to assess the quality of life. Research was conducted on 40 stroke patients, who were divided into 2 groups of 20 people each - FES group and pain control group respectively. Upper limbs treatment was conducted for 30minutes, once a day, 5 days a week, over 8 weeks on both groups. FES group undertook functional electrical stimulation, and pain control group undertook pain therapy for 30 minutes each. Results: MFT before and after the experiment did not show a significant difference between the groups. In the case of quality of life, there was a significant difference(p<.05) between the 2 groups for overall quality of life and environment criteria. Conclusion: The results of this study will prove useful in treating subluxation of stroke patients with functional electrical stimulation(FES).
Identification of ultraviolet B radiation-induced microRNAs in normal human dermal papilla cells
CHA, HWA JUN,KIM, OK-YEON,LEE, GANG TAI,LEE, KWANG SIK,LEE, JAE HO,PARK, IN-CHUL,LEE, SU-JAE,KIM, YU RI,AHN, KYU JOONG,AN, IN-SOOK,AN, SUNGKWAN,BAE, SEUNGHEE SPANDIDOS PUBLICATIONS 2014 MOLECULAR MEDICINE REPORTS Vol.10 No.4
<P>Ultraviolet (UV) radiation impairs intracellular functions by directly damaging DNA and by indirectly generating reactive oxygen species (ROS), which induce cell cycle arrest and apoptosis. UV radiation can also alter gene expression profiles, including those of mRNA and microRNA (miRNA). The effects of UV radiation on cellular functions and gene expression have been widely documented in human skin cells such as keratinocytes, melanocytes and dermal fibroblasts, but the effect it has on other types of skin cell such as dermal papilla cells, which are crucial in the induction of hair follicle growth, remains unknown. In the current study, the effect of UV radiation on physiological changes and miRNA-based expression profiles in normal human dermal papilla cells (nHDPs) was investigated. UVB radiation of ≥50 mJ/cm<SUP>2</SUP> displayed high cytotoxicity and apoptosis in a dose-dependent manner. In addition, ROS generation was exhibited in UVB-irradiated nHDPs. Furthermore, using miRNA microarray analysis, it was demonstrated that the expression profiles of 42 miRNAs in UVB-irradiated nHDPs were significantly altered compared with those in the controls (35 upregulated and 7 downregulated). The biological functions of the differentially expressed miRNAs were studied with gene ontology analysis to identify their putative target mRNAs, and were demonstrated to be involved in cell survival- and death-related functions. Overall, the results of the present study provide evidence that miRNA-based cellular mechanisms may be involved in the UVB-induced cellular response in nHDPs.</P>
Revised Soil Survey of Chungju-Si in Chungchungbukdo
Byung-Keun Hyun,Yeon-Kyu Sonn,Sang-Ho Jeon,Soon-Gang Yun,Hyun-Jun Cho,Sug-Jae Jung,Jung-Won Choi,Dong-Sung Lee 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.3
Agricultural lands have decreased continuously because of urbanization, land consolidation, road construction, etc. Especially, rapidly urbanizing areas such as Cheongju-si in South Korea has the severe land-use change. In this regard, Our study was aimed investigating land-use changes including soil properties and soil information to provide the basic soil information and soil management practices in the region. The area of crop cultivated land of South Korea in 2016 reduced by 35,424 ha compared to that of 2014. The paddy and upland field decreased by 12,455 and 22,969 ha respectively. The reasons for the decrease of the paddy field are as follows: converting the paddy field to upland (22,780 ha) > others (3,646) > public facilities (2,740) > building (2,642) > idle land (1,439). The reasons for the increase of the upland filed are as follows: switching paddy to upland (22,780 ha) > others(5,330) > reclamation of upland (1,415). The main reason converting paddy field to upland was cultivating more profitable upland crops or fruit trees. The arable land in Chungju-si had been reduced by 1,087 ha in 2014 since 1999. The ratio of the reduced arable land was about 48%. Our results showed that paddy fields located in alluvial plains were changed into upland or green house. In particular, paddy fields have been changed to not only upland, orchard, greenhouse cultivation but also fallow land. Moreover, our research using 3686 soil codes (soil phases) and 3834.2 ha indicated that the number of soil series and soil phase increased to 74 and 160 from 65 and 126 individually. The largest increased area was Sachon (coarse loamy fluvaquentic endoaquepts) soil series 536.3 ha which were modified from the existing Yecheon, Sanju, Wolgog, and Seongsan soil series.