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Vladimir Aristov,Anna Frolova,Sergey Zabelok 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.5
Simulations of flows on the basis of kinetic equations for mixtures with chemical reactions are performed. The nonuniform relaxationproblems are solved for different variants. The numerical methods of Unified Flow Solver are used for simulation of 1D and 2D flowswith nonequilibrium boundary conditions. The kinetic approach provides results, which are beyond the traditional theory of macroscopicphenomena based on the Navier-Stokes equations. Nonequilibrium flows with anomalous transport properties in relaxation zones aredescribed. A special attention is paid to study of behavior of the nonequilibrium entropy for 1D and 2D cases both for slow and fastchemical reactions and to investigation of it as a measure of complexity of open systems.
Complex Nonequilibrium Flows with Slow and Fast Chemical Reactions studied by Kinetic Methods
V.V.Aristov,A.A.Frolova,S.A.Zabelok 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10
The present paper studies complex nonequilibrium flows on the basis of the kinetic equations taking into account chemical reactions. Both slow and fast (for which mechanical and chemical relaxation time are of the same order of a magnitude) chemical reactions are considered. Our work is directed towards studying 1D and 2D Nonuniform Relaxation Problems (NRP). The algorithm for numerical simulations in the gases with chemical reactions is implemented within Unifiied Flow Solver (UFS). Flows with the ordinary and anomalous transport properties are investigated for several variants of chemical reactions parameters. A special attention is paid to consideration of the entropy. Comparison of the local magnitudes of nonequilibrium and equilibrium entropy is performed. The value of nonequilibrium entropy provides a characteristics of the complexity of these open systems. This study is focused on nonequilibrium processes keeping in mind simulation of flows in real natural systems.
Yunusova, Natalia V,Spirina, Liudmila V,Frolova, Alena E,Afanas'ev, Sergey G,Kolegova, Elena S,Kondakova, Irina V Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Purpose:To assess IGFBP-6 expression in relation with the presence of the metabolic syndrome, adiponectin receptors (AdipoR1 and AdipoR2) and IGF-IR levels in colorectal adenocarcinoma cases. Materials and Methods: IGFBP-6 mRNA and protein levels were analyzed using real-time quantitative PCR and Western blotting in 46 patients. ELISA and flow cytometry were used for evaluation of AdipoR1, AdipoR2 and IGF-IR. Results: The results showed that IGFBP-6 mRNA expression and the IGFBP-6 content were higher in tumor tissue samples of colorectal cancer patients with tahtn without metabolic syndrome. In addition, the IGFBP-6 mRNA expression was associated with tumor invasion (tumor size) and the IGFBP-6 protein level was associated with nodal status. Positive correlations and positive nonlinear relations were found between the IGFBP-6 level and the AdipoR1 and AdipoR2 contents in colorectal cancer patients. Conclusions: The IGFBP-6 mRNA level and protein level were found to be associated with presence of metabolic syndrome. Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin-mediated signaling pathways in colorectal carcinomas. IGFBP-6 may be considered as a potential biomarker associated with lymphogenous metastasis and the metabolic syndrome in colorectal cancer.
Yunusova, Natalia V,Villert, Alisa B,Spirina, Liudmila V,Frolova, Alena E,Kolomiets, Larisa A,Kondakova, Irina V Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in primary tumors and ascites as predictors of response to neoadjuvant chemotherapy in ovarian cancer (OC) patients. Materials and Methods: Tumor tissue samples and ascitic fluid were obtained from 59 patients with advanced OC. The levels of IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A were determined using ELISA kits. Taking into account the data on expression of these IGF-related proteins and outcome, logistic regression was performed to identify predictors of response to neoajuvant chemotherapy. Results: Human ovarian tumors expressed IGFs, IGFBP-3, IGFBP-4 and PAPP-A and these proteins were also present in ascites fluid and associated with its volume. IGFs and IGFBPs in ascites and soluble PAPP-A might play a key role in ovarian cancer progression. However, levels of proteins of the IGF system in tumors were not significant predictors of objective clinical response (oCR). Univariate analysis showed that the level of IGF-I in ascites was the only independent predictor for oCR. Conclusion: The level of IGF-I in ascites was shown to be an independent predictor of objective clinical response to chemotherapy for OC patients treated with neoadjuvant chemotherapy and debulking surgery.
Nedashkovskaya, Olga I,Vancanneyt, Marc,Cleenwerck, Ilse,Snauwaert, Cindy,Kim, Seung Bum,Lysenko, Anatoly M,Shevchenko, Lyudmila S,Lee, Kang Hyun,Park, Myung Soo,Frolova, Galina M,Mikhailov, Valery V Society for General Microbiology 2006 International journal of systematic and evolutiona Vol.56 No.1
<P>The taxonomic position of three novel, marine, heterotrophic, aerobic, pigmented, gliding bacteria, isolated from the green alga Ulva fenestrata in the Sea of Japan, was determined. 16S rRNA gene sequence analysis revealed that the strains belong to the genus Arenibacter. The results of DNA-DNA hybridization experiments supported by phenotypic and chemotaxonomic data showed that the isolates represent a novel species of the genus Arenibacter, for which the name Arenibacter palladensis sp. nov. is proposed. The type strain is KMM 3961T (= LMG 21972T = CIP 108849T).</P>