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Erli Sarilita,Yurika Ambar Lita,Harry Galuh Nugraha,Nani Murniati,Harmas Yazid Yusuf 대한해부학회 2021 Anatomy & Cell Biology Vol.54 No.4
The aim of this study is to investigate the volumetric measurements of the maxillary sinus among Indonesian population through computed tomography (CT) scan semi-automated segmentation. This project collected 802 retrospective head CT scan archives from Department of Radiology, Hasan Sadikin Hospital, Bandung, Indonesia between 2019-2020. Patients with craniofacial anomalies/pathology fracture in proximity of the maxillary sinuses, and mediocre image quality were excluded from this study resulting only 97 CT scan archives (194 maxillary sinuses; 52 males; 45 females; age range 0-25 years old). Three-dimensional craniofacial structures were reconstructed and volumetric measurements of the maxillary sinus were computed through semi-automated segmentation using ITK-SNAP. This study recorded the initial phase of maxillary sinus pneumatization during infancy. The maxillary sinus developed until reaching the maximum of average maxillary sinus volume at 13,278.73 mm3 in 16 to 20 years old group in which afterwards fell to 12,325.21 mm3. There was no difference found between right and left maxillary sinus volume. This study revealed that the pneumatization of maxillary sinus begin during infancy and climb until reaching the second decade of life, in which after that slowly decrease. Moreover, no difference between right and left maxillary sinus volume was detected. The volumetric dimension of maxillary sinus presented in this study may serve as the basis knowledge surgical intervention of maxillary sinus and its related structures.
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Erli Zhang,Jingbo Huang,Kun Wang,Qinlei Yu,Chao Zhu,Hua Ren 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9
The purpose of this study was to evaluate the protective effect of pterostilbene (Psb) against lipopolysaccharide and D-galactosamine (L/D)-induced acute liver failure (ALF) in mice and its potential mechanisms. Histology of liver was detected by H&E staining. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum and malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) contents in liver were examined using detection kits. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) secretion were detected by ELISA. Meanwhile, MAPK, NF-κB, NLRP3 inflammasome, and Nrf2 were assessed by western blotting. Our findings showed that pretreatment with Psb protected against L/D-induced ALF by lowering the lethality, improving liver histology, reducing ALT, AST, IL-6, IL-1β, TNF-α, MDA, and MPO levels, and boosting liver GSH content and SOD activity. Moreover, Psb pretreatment effectively suppressed inflammation by decreasing NLRP3 inflammasome, MAPK, and NF-κB pathway activations. Moreover, Psb pretreatment efficiently enhanced the expression of several antioxidant enzymes, mainly depending on Nrf2 activation. This was the first study to demonstrate that Psb protects against L/D-induced ALF by inactivating MAPK, NF-κb, and NLRP3 inflammasome and upregulating the Nrf2 signaling pathway, indicating a potential therapeutic application for ALF treatment.
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Spatial ability and anatomy learning performance among dental students
Sarilita Erli,Lita Yurika Ambar,Firman Dani Rizali,Wilkinson Tracey,Susilawati Sri,Saptarini Risti,Aripin Dudi,Sjamsudin Endang 한국의학교육학회 2022 Korean journal of medical education Vol.34 No.4
Purpose: Spatial perception is an essential skill for professional dentists. The objective of this study was to observe the spatial ability, as well as anatomy module grades, of dental students at a dental education center in Indonesia and relate these to gender and cohort.Methods: A cross-sectional study was carried out where dental students in years (cohorts) 1, 2, 4–6 were invited to take the Revised Purdue Spatial Visualization Test (PSVT-R) and the redrawn Vandenberg and Kuse Mental Rotation Test (MRT) in order to assess spatial ability. In addition, the 1st- and 2nd-year dental students carried out gross anatomy assessments. Spatial ability test results were compared using an independent t-test to detect gender differences, one-way analysis of variance to inspect cohort differences, and correlation relative to anatomy module scores.Results: A total of 326 dental students voluntarily participated. Statistically significant gender differences were found in both spatial ability tests in the overall sample (PSVT-R: p<0.001; MRT: p=0.001). When the 1st- and 2nd-year dental students were pooled, significant gender differences were detected, in which males scored higher than females in both spatial ability tests (PSVT-R: p<0.001; MRT: p=0.003). In anatomy, however, females scored higher than the males (p=0.005). In addition, there were weak to moderate, but significant correlations between spatial ability tests and anatomy scores.Conclusion: This study indicated that spatial ability may not be the only factor predicting the academic performance of dental students. However, dental students with low spatial ability scores may need supplementary educational techniques when learning specific spatial tasks.
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Rafita Erli Adhawiyah,Jungchul Lee 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.4
Sensors are vital components in a wide variety of applications throughout our everyday lives. Two critical factors that contribute to their importance are sensitivity and selectivity. To achieve high-performance sensors, modification and functionalization of the sensing surface become imperative. The process involves altering the surface properties of the sensor and introducing a recognition element to optimize its response to the target analyte. However, when it comes to internal sensing surfaces, such as those found in microchannel-based sensors, challenges arise. Being narrow and confined makes the modification process particularly arduous. Accessing the internal surfaces for modification becomes difficult due to their small size, and achieving uniformity across the microchannel surface poses a considerable challenge. Overcoming these obstacles demands innovative fabrication techniques, specialized equipment, and precise control during the modification process. This paper will review the potential approaches for the modification and functionalization of the sensor surface, as well as offer a variety of strategies to effectively enhance the internal sensing surface.
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Study of anti-inflammatory activities of a-D-glucosylated eugenol
Peng Zhang,Erli Zhang,Min Xiao,Weijian Xu,Chang Chen 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1
Inflammation is an immune response against avariety of noxious stimuli, such as infection, chemicals,and physical injury. Eugenol, a natural phenolic extract,has drawn much attention for its various desirable pharmacologicalfunctions and is, therefore, broadly used in ourdaily life and medical practice. However, further usage ofeugenol is greatly limited due to its unwanted properties,such as physicochemical instability, poor solubility, andhigh-dose cytotoxicity. In hopes of extending its applicabilitythrough glycosylation, we previously reported anovel, efficient, and high throughput way to biosynthesizea-D-glucosylated eugenol (a-EG). In this study, we furtherexplored the potential superior properties of a-EG to itsparent eugenol in terms of anti-inflammatory activities. Wedemonstrated that a-EG was an effective anti-inflammatorymediator in both non-cellular and cellular environments. In addition, the non-cellular inhibitory effect of a-EGcould be amplified by a-glucosidase, which ubiquitouslyexists in cytoplasm. Furthermore, a-EG exhibited a superior anti-inflammatory effect to its parent eugenol in a cellularenvironment. In words, our findings collectively suggest thata-EG is a stronger anti-inflammatory mediator and maythereby serve as a desirable substitute for eugenol and apotential therapeutic prodrug in treating inflammatory diseasesin the future.
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Lingling Deng,Erli Zhang,Chang Chen 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.5
Cisplatin is a platinum-based compound that islargely employed as an effective antitumor drug against awide spectrum of solid neoplasms for many years. Despiteof its initial therapeutic success, cisplatin often results inhigh incidence of chemoresistance and high-dose cytotoxicity. Consequently, considerable efforts in hopes ofreducing the dose-dependent side effects of cisplatin whileretaining, or even enhancing, its antitumor properties havebeen undertaken throughout the past three decades. Nitricoxide (NO) is a small lipophilic free radical gas possessingversatile biological functions, including antitumor activities. However, NO, of itself, is difficult to be used, becauseof its extreme instability and short half-life. Previously, wehave reported a stable NO donor, b-galactosyl-pyrrolidinyldiazeniumdiolate (b-Gal-NONOate), which exerts tumorkilling effects through site-specific intracellular release ofexogenous NO. In this study, we further investigated thecombined inhibitory effect of b-Gal-NONOate and cisplatinagainst C6/LacZ, 9L/LacZ, and HeLa/LacZ tumorcells. It was shown that, in combination with b-Gal-NONOate, the antitumor effects of cisplatin against thesecommon tumor cell lines were increased in a dose-dependentmanner. Furthermore, the combination of thesechemicals resulted in a synergistic suppression on tumorgrowth, which was achieved under a much lower cisplatindosage. Collectively, our findings indicate that b-Gal-NONOate can synergistically improve the antitumor effectof cisplatin, and may therefore reduce its side effectscaused by high dose cisplatin monochemotherapies. Accordingly, b-Gal-NONOate is an important therapeuticassistant reagent with great potential of clinical applicability,and thus worth of continuous research in the comingfuture.
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Qingwu Gao,Erli Zhang,Na Jin 대한수학회 2015 대한수학회보 Vol.52 No.3
Recently, Li [12] gave an asymptotic formula for the ultimate ruin probability in a delayed-claim risk model with constant force of interest and pairwise quasi-asymptotically independent and extendedregularly- varying-tailed claims. This paper extends Li’s result to the case in which the risk model is perturbed by diffusion, the claims are consistently-varying-tailed and the main-claim interarrival times are widely lower orthant dependent.
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Gao, Qingwu,Zhang, Erli,Jin, Na Korean Mathematical Society 2015 대한수학회보 Vol.52 No.3
Recently, Li [12] gave an asymptotic formula for the ultimate ruin probability in a delayed-claim risk model with constant force of interest and pairwise quasi-asymptotically independent and extended-regularly-varying-tailed claims. This paper extends Li's result to the case in which the risk model is perturbed by diffusion, the claims are consistently-varying-tailed and the main-claim interarrival times are widely lower orthant dependent.
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