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Bae, Donghyuck,Seol, Heejin,Yoon, Ho-Geun,Na, Ju-Ryun,Oh, Kyonyeo,Choi, Chul Yung,Lee, Dong-wook,Jun, Woojin,Youl Lee, Kwang,Lee, Jeongmin,Hwang, Kwontack,Lee, Yoo-Hyun,Kim, Sunoh Informa Healthcare 2012 PHARMACEUTICAL BIOLOGY Vol.50 No.7
<P><I>Context: Chamaecyparis obtusa</I> Sieb. & Zucc., Endlicher (Cupressaceae) forest bathing or aromatherapy has been shown in various studies to have biological functions such as anticancer, antiallergies, antiinflammatory, and antioxidant activity. However, no reports exist on the pharmacological or biological activities of the essential oil of <I>C. obtusa</I> (EOCO) or its effects on central nervous system.</P><P><I>Objective</I>: The aggregation and formation of β-amyloid peptides (Aβ) into fibrils are central events in the pathogenesis of Alzheimer’s disease (AD), and overproduction and aggregation of Aβ into oligomers have been known to trigger neurotoxicity. In this study, we investigated the effects of inhaled EOCO on cognitive function and neuronal apoptosis in rats intrahippocampally injected with Aβ.</P><P><I>Materials and methods</I>: To model AD, 4 μg of aggregated Aβ was injected into the hippocampus. To test the effects of EOCO, behavioral performance in the Morris water maze was tested 4 days after injection. After behavioral testing, brain sections were prepared for TTC staining and TUNEL assay.</P><P><I>Results</I>: Inhaled EOCO protected spatial learning and memory from the impairments induced by Aβ<SUB>1-40</SUB> injection. In addition, the behavioral deficits accompanying Aβ<SUB>1-40</SUB>-induced AD were attenuated by inhalation of EOCO. Furthermore, acetylcholinesterase (AChE) activity and neuronal apoptosis were significantly inhibited in rats treated with Aβ<SUB>1-40</SUB> and EOCO compared to rats treated only with Aβ<SUB>1-40</SUB>.</P><P><I>Discussion and conclusion</I>: EOCO suppressed both AD-related neuronal cell apoptosis and AD-related dysfunction of the memory system. Thus, the results of this study support EOCO as a candidate drug for the treatment of AD.</P>
Donghyuck Lee,Susan Kashubeck-west 한국상담학회 2015 Journal of Asia Pacific counseling Vol.5 No.1
This study examined the fit of Bem’s proposed two-factor structure for the Bem Sex Role Inventory (1974/1981), using a nationally representative sample (N = 3,709) collected from the U.S. in 2002. The sample included four ethnic groups of young adults: African American, Asian American, European American, and Hispanic American. Confirmatory factor analyses (CFA) indicated that the two-factor structure did not fit the data for men or women from any of the four ethnic groups. Exploratory factor analyses indicated that three-factor solutions fit the data best for all groups except Asian American men, for whom a four-factor structure was more suitable. The factor structures differed across the four ethnic groups. Follow-up CFA indicated that although fit was much improved from that of Bem’s (1981) two-factor structure, the data were fit adequately only for men and women from the European American group. Implications of the findings are discussed.
정신전력 기고문의 토픽모델링 적용 탐색적 연구 - 국방일보 오피니언 분석을 중심으로 -
이동혁(Lee Donghyuck),이서희(Lee Seohee) 국방정신전력원 2020 정신전력연구 Vol.0 No.61
본 연구는 정신전력과 관련된 국방일보 기고문의 텍스트를 빈도 분석과 LDA 토픽모델링으로 비교했다. 먼저 대량의 기고문을 네 시기로 나눠 텍스트 분석방법으로 명사 단어의 상위출현 빈도를 확인했다. 분석 결과 ‘교육’과 ‘훈련’ 단어는 네 시기 모두 가장 많이 사용된 단어였다. 시간이 갈수록 ‘군인’과 ‘장병’, ‘전투’ 단어의 출현 순위는 높아졌지만, ‘생활’, ‘시간’, ‘마음’이 사용된 빈도는 낮아졌다. 이는 정신전력 강화의 목적이 ‘전투’와 ‘임무’와 연계하는 경향이 있음을 보여준다. 이어 LDA 토픽모델링을 사용해 시기별 토픽을 추출해 비교했다. 분석 결과 ‘교육훈련’과 ‘군 생활’ 토픽은 여전히 유효한 주제였다. 과거에는 ‘가족’ 토픽이 자주 사용된 반면, 2008년 이후에는 ‘북한도발’ 토픽이 자주 등장했고, 2014년 이후에는 ‘국가관’과 ‘군인정신’ 토픽의 사용이 늘었다. 이러한 변화는 정신전력에 대한 생각과 관점이 어떻게 표현되고 있는지 보여주며, 향후 정신전력 연구 방향에 대해 시사점을 제공한다. This study compared opinion articles of the Kookbangilbo related to mental force enhancement with text frequency analysis and LDA Topic Modeling. First, a large number of articles were divided into four periods over time. Then, the frequency of high-level appearance of noun words by text analysis method for large amounts of articles was checked by the text analysis method. As a result of analysis, the words ‘education’ and ‘training’ were the most used words in all four periods. The appearance ranks of the words ‘military’, ‘soldier’ and ‘battle’ have increased over time, while the frequency of ‘life’, ‘time’ and ‘mind’ has decreased. This analysis indicates that the purpose of mental power enhancement tends to be linked to ‘combat’ and ‘mission’. And then used LDA Topic Modeling to extract by period and compare several topics. As a result, the topics of ‘education and training’ and ‘military life’ were still valid topics for the entire period. In the past, the ‘family’ topic was frequently used, but after 2008, the topic ‘NK provocation’ appeared frequently. And since 2014, the use of ‘view of nation’ and ‘military spirit’ topics increased. These changes tell us how thoughts and perspectives on mental force are expressed. It also provides implications for the future direction of mental force enhancement research.