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Evaluation of Cucurbita ficifolia Juice as a Hepatoprotective Drug in Human Type 2 Diabetes
( Dhananjay Yadav ),( Amita Jain ),( Meerambika Mishra ),( Arvind Tiwari ),( Gbks Prasad ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The present study has been undertaken to analyze the hepatoprotective potential of Cucurbita ficifolia juice in type 2 diabetic subjects. Methods: A total 34 subjects were selected for the study out of which 14 subjects were with type 2 diabetes mellitus, 10 subjects were selected as a normal control group and 10 subjects were selected as a normal treated group. The patients had type 2 diabetes for more than 2 years, their mean age was less than 45 years, and subjects were then asked to start the Cucurbita ficifolia juice therapy starting at day 0 and continuing up to 40 day both for diabetic and normal subjects. Liver enzymes such as. serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), and bilirubin were measured. Results: After 40 days of Cucurbita ficifolia juice therapy, there was a decrease of 9.45% and 27.85% (P<0.01) for SGPT and total serum bilirubin, while the SGOT levels increased by 2.02% in the case of diabetic treated subjects that was not found to be significant. Conclusions: The liver enzymes measured in our study ameliorated in type 2 diabetic patients. The results suggest that the Cucurbita ficifolia juice therapy could be used as a hepatoprotective drug in type 2 diabetes.
Yadav, Dhananjay,Kim, Suk-Jeong,Bae, Myung Ae,Kim, Jae-Ryong,Cho, Kyung-Hyun Hindawi 2018 Oxidative medicine and cellular longevity Vol.2018 No.-
<P>In the current study, we have tested the nonenzymatic glycation activities of ketohexoses, such as tagatose and psicose. Although tagatose-treated apoA-I (t-A-I) and psicose-treated apoA-I (p-A-I) exerted more inhibitory activity you cupric ion-mediated low-density lipoprotein (LDL) oxidation and oxidized LDL (oxLDL) phagocytosis into macrophage than fructose-treated apoA-I (f-A-I). In the lipid-free state, t-A-I and f-A-I showed more multimerized band without crosslinking. Since t-A-I lost its phospholipid binding ability, the rHDL formation was not as successful as f-A-I. However, injecting t-A-I showed more antioxidant activities in zebrafish embryo under the presence of oxLDL. Three weeks of consumption of fructose (50% of wt in Tetrabit/4% cholesterol) showed a 14% elevation of serum triacylglycerol (TG), while tagatose-administered group showed 30% reduction in serum TG compared to high cholesterol control. Fructose-fed group showed the biggest area of Oil Red O staining with the intensity as strong as the HCD control. However, tagatose-consumed group showed much lesser Oil Red O-stained area with the reduction of lipid accumulation. In conclusion, although tagatose treatment caused modification of apoA-I, the functional loss was not as much severe as the fructose treatment in macrophage cell model, zebrafish embryo, and hypercholesterolemic zebrafish model.</P>
Dhananjay Yadav,Meerambika Mishra,Arvind Tiwari,Prakash Singh Bisen,Hari Mohan Goswamy,G.B.K.S. Prasad 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.3
Objectives: The present study was designed to estimate the prevalence of dyslipidemia and hypertension based on the National Cholesterol Educational Programme Adult Treatment Panel III definition of metabolic syndrome (MetS). The study also focuses on prevalence for MetS with respect to the duration of disease in GwalioreChambal region of Madhya Pradesh, India. Methods: Type 2 diabetic patients (n = 700) were selected from a crosssectional study that is regularly being conducted in the School of Studies in Biochemistry, Jiwaji University Gwalior, India. The period of our study was from January 2007 to October 2009. Dyslipidemia and hypertension were determined in type 2 diabetic patients with MetS as per National Cholesterol Educational Programme Adult Treatment Panel III criteria. Results: The mean age of the study population was 54±9.3 years with 504 (72%) males and 196 (28%) females. The prevalence of MetS increased with increased duration of diabetes in females; however, almost constant prevalence was seen in the males. Notable increase in the dyslipidemia (64.1%) and hypertension (49%) in type 2 diabetic patients were seen. The steep increase in dyslipidemia and hypertension could be the reason for the growing prevalence of diabetes worldwide. The study also noted a close association between age and occurrence of MetS. Conclusion: Individual variable of MetS appears to be highly rampant in diabetic population. Despite treatment, almost half of patients still met the criteria for MetS. Effective treatment of MetS components is required to reduce cardiovascular risk in diabetes mellitus hence accurate and early diagnosis to induce effective treatment of MetS in Indian population will be pivotal in the prevention of cardiovascular disease and type 2 diabetes.
Numerical investigation of the effect of magnetic field on the onset of nanofluid convection
Yadav, Dhananjay,Wang, Junye,Bhargava, Rama,Lee, Jinho,Cho, Hyung Hee Elsevier 2016 Applied Thermal Engineering Vol.103 No.-
<P><B>Abstract</B></P> <P>The present analysis aims at investigating the effect of a uniform vertical magnetic field on the onset of convection in an electrically conducting nanofluid layer with a new set of physical boundary condition. It is assumed that the value of the temperature can be imposed on the boundaries, but the nanoparticle fraction adjusts together with effects of Brownian and thermophoresis so that the nanoparticle flux is zero on the boundaries. Using the Galerkin method, the critical Rayleigh number on the onset of convection and the corresponding wave number are obtained in terms of various parameters numerically. The numerical computations are presented for water-based nanofluids with Al<SUB>2</SUB>O<SUB>3</SUB> and Cu nanoparticles. It is found that the volumetric fraction of nanoparticle, the Lewis number, the modified diffusivity and the density ratios have a destabilizing effect, while the magnetic field has stabilizing effect on the system. The zero flux nanoparticle boundary condition has more destabilizing effect than the constant nanoparticle boundary conditions for Al<SUB>2</SUB>O<SUB>3</SUB>–water nanofluid, while reverse for Cu–water nanofluid.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nanofluid convection with magnetic field is studied with rigid–rigid surfaces. </LI> <LI> Both the zero flux and the constant boundary conditions are taken for nanoparticle. </LI> <LI> The resulting eigenvalue problem is solved numerically using the Galerkin method. </LI> <LI> The numerical computations are presented for Al<SUB>2</SUB>O<SUB>3</SUB>–water and Cu–water nanofluids. </LI> <LI> The zero flux condition has more destabilizing effect for Al<SUB>2</SUB>O<SUB>3</SUB>, while reverse for Cu nanofluid. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Dhananjay Yadav,김장영,이미영,류훈,허지혜,배금석,안성복,정춘희,박종택,고상백 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.4
Purpose: Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associationsbetween changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults. Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 2005–2008 (baseline) and from 2008–2011 (follow-up). Serum GGT levels were determined by enzymatic methods. Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparingthe highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52–2.80). The odds ratio for the highest GGT changes(>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32–2.33). Among participantswith baseline GGT concentrations <the median, the odds ratio for incident MS, comparing participants with the highest GGT changes with the lowest GGT changes, was 1.52 (95% CI: 1.01–2.31). Among participants with baseline GGT concentration ≥the median, the corresponding odds ratio was 2.75 (95% CI: 1.84–4.10). Conclusion: High initial GGT concentration and increases in GGT concentration over time should be considered independent predictors of and to have a combined effect on incident MS.
안성복,Dhananjay Yadav,강대룡,고상백,김장영 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.6
Purpose: There have been few studies on gender difference in the impact of a urine albumin-to-creatinine ratio (UACR) within the normal range on the risk of hypertension. We evaluated whether the association between the UACR below the microalbuminuria range and the incident risk of hypertension is different between men and women. Materials and Methods: A total of 1173 individuals (442 men and 731 women) aged 40 to 70 years without hypertension was examinedat baseline (2005–2008) and followed (2008–2011). We defined the UACR as the amount of albumin (mg/dL) divided by creatinine (g/dL) in randomly voided urine. The subjects were classified according to UACR tertile. Results: During an average of 2.6 years of follow-up, 57 men (12.9%) and 66 women (9.0%) developed hypertension. In multivariable-adjusted models, the odds ratio for new-onset hypertension comparing the highest and lowest tertiles of UACR was 1.83 [95% confidence interval (CI) 0.85–3.94] in men and 2.69 (95% CI 1.27–5.73) in women. In stratified analyses by menopausal status,higher tertiles of UACR were associated with an increased risk of incident hypertension in postmenopausal women. Conclusion: Higher normal UACR levels were associated with an increased risk of incident hypertension in women. The UACR could have a clinical role in predicting the development of hypertension.