http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A New Cytotoxic Phenazine Derivative from a Deep Sea Bacterium Bacillus sp.
Dehai Li,Fengping Wang,Xiang Xiao,Xiang Zeng,Qian-Qun Gu,Weiming Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
A New Cytotoxic Phenazine Derivative from a Deep Sea Bacterium Bacillus sp
Zhu, Weiming,Li, Dehai,Wang, Fengping,Xiao, Xiang,Zeng, Xiang,Gu, Qian-Qun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
Two Indolocarbazole Alkaloids with Apoptosis Activity from a Marine-derived Actinomycete Z$_2$039-2
Liu, Rui,Zhu, Tianjiao,Li, Dehai,Gu, Jingyan,Xia, Wei,Fang, Yuchun,Zhu, Weiming 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z$_2$039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 ${\mu}$M, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562cancer cells.
Two Indolocarbazole Alkaloids with Apoptosis Activity from a Marine-derived Actinomycete Z2039-2
Rui Liu,Tianjiao Zhu,Dehai Li,Jingyan Gu,Wei Xia,Yuchun Fang,HongbingLiu,Weiming Zhu,Qianqun Gu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marinederived actinomycete Z2039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 µM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
Penipyrols A–B and peniamidones A–D from the mangrove derived Penicillium solitum GWQ-143
Wenqiang Guo,Xianglan Kong,Tianjiao Zhu,Qian Qun Gu,Dehai Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
Chemical investigation the extract of Penicillium solitum GWQ-143 led to yield four new compounds penipyrols A–B (1–2) and peniamidones A–B (3–4), together with peniamidones C–D (5–6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1–6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 lM.
Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65
Xinhua Sun,Xianglan Kong,Huquan Gao,Tianjiao Zhu,Guangwei Wu,Qianqun Gu,Dehai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Two new meroterpenoids, arisugacins I (1) andJ (2), together with five known meroterpenoids includingarisugacin B (3), arisugacin F (4), arisugacin G (5), territremB (6) and territrem C (7) were isolated from anendophytic fungus Penicillium sp. SXH-65. Their structureswere determined by extensive spectroscopic experimentsand comparison with literature data. Theircytotoxicities were evaluated against Hela, HL-60 andK562 cell lines, and only 3 and 4 exhibited weak cytotoxicitiesagainst Hela, HL-60 and K562 cell lines withIC50 values ranging from 24 to 60 lM.
Xueqian He,Zhenzhen Zhang,Qian Che,Tianjiao Zhu,Qian-Qun Gu,Dehai Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.1
Seven polyketides, including four new onesnamed as varilactones A–B (1–2) and wortmannilactonesM–N (3–4), as well as three biogenetically related knownwortmannilactones E, F and H (5–7), were isolated fromthe fungus Penicillium variabile HXQ-H-1, cultivated inpotato-based medium with the histone deacetylase inhibitorsuberoylanilide hydroxamic acid (SAHA). Their structures(1–7) were established by analysis of NMR and MS data,and the absolute configuration of oxabicyclo[2.2.1]heptaneunit was deduced from 1H-NMR analyses on MPA estersafter chemical reduction reaction. Among them, varilactonesA and B (1 and 2), features a novel skeleton with atriene unit linking an oxabicyclo[2.2.1]heptane and anoxabicyclo[3.3.0]octane rings.
Lin, Aiqun,Wu, Guangwei,Gu, Qianqun,Zhu, Tianjiao,Li, Dehai 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Chemical investigation of an Antarctic deep-sea derived fungus Penicillium sp. PR 19 N-1 yielded five new eremophilane-type sesquiterpenes 1-5 and a new rare lactam-type eremophilane 6, together with three known compounds 7-9. The structures of these diverse sesquiterpenes were determined by extensive NMR and mass spectroscopic analyses. Compounds 1, 2, 4-6, 8 and 9 were evaluated for their cytotoxities against HL-60 and A-549 human cancer cell lines, and 5 was the most active one with $IC_{50}$ value of $5.2{\mu}M$ against the A-549 cells.