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Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility
Jin-Yan Zhang,Lei Cao,Cang-Bao Xu,Yong-Xiao Cao,Xiao-Hui Zheng 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentrationcontractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased Emax. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased Emax. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and the Emax mediated with ETA receptor and ETB receptor. DSP 0.2 and 0.4 mL/L shifted the concentration-contractile curves induced by noradrenaline toward the right with decreased Emax. Neither did nicotine 0.06 and 0.96 mg/L. Both DSP and nicotine shifted the concentration-contractile curves induced by 5-hydroxytryptamine (5-HT) toward the right parallely. DSP changed the phenotypes towards an increased efficacy of ETA receptor and ETB receptor, and a reduced efficacy of 5-HT receptor and α-adrenocceptor. The effects of DSP on ETB receptor, ETA receptor and α-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine.
Cao, Qing-Ri,Ren, Shan,Park, Mi-Jin,Choi, Yun-Jaie,Lee, Beom-Jin 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8
This study was performed in order to validate an effective high performance liquid chromatograpy (HPLC) method to determine L-carnitine in biological samples such as plasma, milk and muscle in cows. An L-carnitine derivative for fluorescence absorption was synthesized with 1-aminoanthracene (16 mg/mL in acetone) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDAC: 160 mg/mL in 0.01 M $NaH_2PO_4$ buffer) as a precolumn fluorescent derivative reagent. ${\gamma}-Butyrobetaine$ HCI was used as an internal standard. A reversed-phase column with fluorescence detection at the excitation and emission wavelengths of 248 and 418 nm were used. The mobile phase consisted of 30% acetonitrile with 0.1 M ammonium acetate in water (pH 3.5) adjusted with acetic acid and delivered at a flow rate of 1.5 mL/min. The L-carnitine concentration in plasma, milk and muscle samples of cows after oral feeding with 24 g L-carnitine/day for 2 months was then determined. All biological samples were deproteinated by barium hydroxide and zinc sulfate heptahydrate before the derivative reaction. Blank cow plasma was dialyzed using cellulose membrane for standard calibration. The calibration curve showed good linearity ($r^2$ >0.999) over the concentration range of 50 to 5000 ng/mL. The precision and accuracy were also satisfactory with less than 15% intra- and inter- day coefficiency of variations. The peaks of L-carnitine and internal standard in HPLC chromatography were successfully separated in plasma, milk and muscle samples of cows. The current derivatization method of L-carnitine for fluorescence detection was simple and adequately sensitive and could be applied to determine L-carnitine in biological samples.
Enhanced Reflectance of Cholesteric Liquid Crystal Device with Quantum Dots
Cao, Jin,Chen, Chao Ping,Bae, Byung Seong,Song, Jang-Kun,Kim, Dae Soo,Jhun, Chul Gyu Informa UK (TaylorFrancis) 2015 Molecular Crystals and Liquid Crystals Vol.613 No.1
<P>Cholesteric liquid crystal (CLC) has a helical structure with either of left-handedness or right-handedness. Due to the helical structure, the selective reflection occurs depending on the chrial pitch. However, the reflectance of the CLC layer is theoretically limited to 50% because only one of right- or left-handed circularly polarized light is reflected. In this paper, we demonstrate high reflectance of CLC layer with quantum dots for the color reflector application.</P>
Access Authentication of Mass Device Connections for MTC in LTE Networks
Jin Cao,Maode Ma,Hui Li 한국산학기술학회 2014 SmartCR Vol.4 No.4
Machine Type Communication, also called Machine to Machine communication, is one of the next generations of sophisticated techniques for future wireless communications. It is attracting tremendous interest in standardization organizations such as the third Generation Partnership Project. Accommodating data and signaling traffic from massive Machine Type Communication devices is a challenging task to ensure the security of Machine Type Communication applications in Long Term Evolution networks, as the number of Machine Type Communication devices continues to increase. Since each Machine Type Communication device has to implement an independent access authentication procedure specified by the current third Generation Partnership Project standard, it will incur severe signaling congestions in the Long Term Evolution networks when a large number of Machine Type Communication devices simultaneously connect to the network. In this paper, we propose a new access authentication and key agreement scheme based on an aggregate signature to avoid signaling overload in Long Term Evolution network elements. Our scheme can greatly reduce the signal traffic for a multitude of Machine Type Communication devices connected to the network and also provide robust security protection with desirable efficiency. The experimental results and formal verification using the AVISPA and SPAN tools show that the proposed scheme is efficient and secure against various malicious attacks.