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Xianglan Kong,Xinhua Ma,Yunying Xie,Shengxin Cai,Tianjiao Zhu,Qian Qun Gu,De-Hai Li 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
In our screening for antitubercular agents, fivenaphtho-c-pyrones including two new naphtho-c-pyronesglycosides, indigotides G and H (1 and 2), and two diphenylethers were isolated from the extract of a sponge-derivedfungus Metarhizium anisopliae mxh-99. Their structureswere established on the basis of chemical and spectroscopicevidence. The antitubercular activities of all the compoundswere evaluated against Mycobacterium phlei. The knownisochaetochromin B2 (6) and ustilaginoidin D (7) exhibitedthe highest activity with MICs 50.0 lg/mL.
Penipyrols A–B and peniamidones A–D from the mangrove derived Penicillium solitum GWQ-143
Wenqiang Guo,Xianglan Kong,Tianjiao Zhu,Qian Qun Gu,Dehai Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
Chemical investigation the extract of Penicillium solitum GWQ-143 led to yield four new compounds penipyrols A–B (1–2) and peniamidones A–B (3–4), together with peniamidones C–D (5–6), which had been previously described as synthetic intermediates, not obtained from natural resource. The structures of those new compounds were established through extensive spectroscopic analysis. Compounds 1–6 exhibited great radical scavenging activities against DPPH with IC50 values ranged from 4.7 to 15.0 lM.
Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65
Xinhua Sun,Xianglan Kong,Huquan Gao,Tianjiao Zhu,Guangwei Wu,Qianqun Gu,Dehai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Two new meroterpenoids, arisugacins I (1) andJ (2), together with five known meroterpenoids includingarisugacin B (3), arisugacin F (4), arisugacin G (5), territremB (6) and territrem C (7) were isolated from anendophytic fungus Penicillium sp. SXH-65. Their structureswere determined by extensive spectroscopic experimentsand comparison with literature data. Theircytotoxicities were evaluated against Hela, HL-60 andK562 cell lines, and only 3 and 4 exhibited weak cytotoxicitiesagainst Hela, HL-60 and K562 cell lines withIC50 values ranging from 24 to 60 lM.