정신분열증 환자의 MMPI

이금단,오상우 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

배경 : MMPI는 임상장면에서 가장 유용한 진단도구 중의 하나로 알려져 왔다. 본 연구에서는 정신과에 입원하고 있는 정신분열증 환자들의 MMPI 프로파일이 어떤 유형들로 분류되는 지를 알아보고, 이에 따라 분류된 MMPI 프로파일 유형을 토대로 분할점을 제시하고자 하였으며, 각 프로파일 유형에 따른 내용척도, 인구통계학적 특징 및 증상들을 살펴보았다. 방법 : 본 연구의 대상은 1998년 1월부터 2000년 8월까지 원광대학교병원 신경정신과에 입원하여 임상심리검사에 의뢰된 환자들 중 임상심리전문가와 정신과 주치의에 의해 정신분열증으로 진단된 환자 61명으로 남자 37명, 여자 24명으로, 이들의 MMPI와 정신분열증 프로토콜 자료를 수집하여 분석 하였다. 결과 : 정신분열증으로 입원한 환자들을 대상으로 하여 MMPI 상에서 분할점을 T점수 65점으로 잡았을 때 이들은 F-6은 유형을 보였고, 군집분석결과, 잠재성 정신분열증 유형, 편집형 정신분열증 유형 및 정상 유형이 확인되었다. 의뢰사유에 있어서는 불안/신경예민, 짜증, 과대망상에서만 각 군집간에 차이를 보였다. 결론 : 입원한 정신과 환자 중 MMPI의 F-6-8 척도치가 T점수 65점 이상을 보이는 경우에는 정신분열증으로 진단을 내릴 수 있음이 확인되었다. 그렇지만 정신분열증 환자 집단은 동질적인 특성을 지닌 집단이 아니라 이질적인 특성을 지닌 집단이므로 이들에 대한 치료와 재활을 제대로 수행하기 위해서는 환자의 개별적인 정신병리와 성격특성을 우선 파악하는 것이 중요하다. Background : The MMPI has known one of the most powerful diagnostic tools in clinical setting. This study was to identify the distinct MMPI profile, the cut-off score and chief complaints in inpatients with schizophrenia. Methods : 61 patients with schizophrenia (male 37, female 24) administered the MMPI and Symptom Check Lists were collected by the authors. Results : The MMPI profile of patients with schizophrenia showed F-6-8 profile and 65 T was identified as the cut-off score. K-mean cluster analysis showed three sub-clusters, which were latent schizophrenia profile, paranoid schizophrenia profile and normal profile. And only a few chief complaints were found the differences among sub-clusters. Conclusion : This study concluded that elevations above 65 T in F-6-8 profile could be diagnosed as schizophrenia. However, patients with schizophrenia are not homogeneous but heterogeneous. Thus, it is suggested that their individual psychopathology and psychological characteristics should be examined prior to therapy or rehabilitation.

급성 구강감염부위에서 Staphylococcus lugunensis 의 특성

유용욱,이미성,차정단,김기경,신상희,문상은,김강주 원광대학교 생명공학연구소 1999 생명공학연구소보 Vol.6 No.1

Staphylococcus lugdunensis (S. lugdunensis) is a newly identified pathogenic species of coagulase negative staphylococci and an occasional but not rare cause of severe infections, such as infective endocarditis after dental extraction, bacteremia, osteomyelitis, peritonitis, and soft tissue infections. As antibiotic use increased, resistance rapidly developed. Some strains have plasmids related to antibiotic resistance. To characterize S. lugdunensis in acute oral infection, S. lugdunensis was isolated from the patients with acute oral abscess, osteomyelitis, and normal persons. Antibiotic resistance, in vitro cellular toxicity, in vivo virulence, δ-like hemolysin activity, and synergistic hemolysis on sheep blood agar plates were investigated. The dot blot analysis and Southern blot analysis of staphylococcal DNA was performed with δ-hemolysin gene probe of Staphylococcus aureus. (S. aureus) Staphylococcal DNA was cloned, nucleotide sequence was analysed, and homology was compared with other sequence in Gene Bank. S. aureus, S. lugdunensis, Staphylococcus cohnii (S. cohnii), and other coagulase negative staphylococci (CNS) were isolated from the patients with acute oral infection. The isolation ratio of S. lugdunensis in the patients with infection was higher than that of healthy persons, but the isolation ratio of S. aureus in the patients with infection was similar to that of healthy persons. S. lugdunensis from the patients with acute oral infection showed the resistance to penicillin, methicillin, cephalothin, and clindamycin. S. lugdunensis in the patients had cellular toxicity in vitro and virulence in vivo. All strains of S. lugdunensis had δ-like hemolysin activity against rabbit erythrocytes. Four of the six strains of S. lugdunensis gave synergistic hemolysis with S. aureus on sheep blood agar plates. In dot blot analysis, all strains of S. lugdunensis showed the positive reaction with the probe of δ-hemolysin gene in S. aureus, but a 7.3 kb HindⅢ fragment was observed in the DNA of S. lugdunensis that gave synergistic hemolysis in a Southern blot analysis. The molecular size of partially purified δ-hemolysin was about 50 kd. The cloned fragments from the chromosomal DNA of S. lugdunensis showed the partial homology with the insulin receptor-related and dopamine receptor of humans. These results suggest that S. lugdunensis might be an important pathogen in acute oral infection and show some homology with eukaryotes.

High Pressure Liquid Chromatography를 이용한 인진호의 유효성분 확인

박남선,박성옥,안영은,이진희,장수자,정은진,지경단 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

In present day, components of Artemisiae Carpillaris Herba(A.C.H) was investigated by HPLC method. On condition of ODS-10column, 25% acetonitrile for mobile phase, 254nm of UV Detector, the extracts of A.C.H was analyzed. As the result, peaks of coumarin derivatives, at retention time 2.16 and 2.18, were found.

Application of Volterra Functional Series to the Analysis of Nonlinear Systems Represented by Nonlinear Differential Equations

Sung, Dan-Keun 대한전자공학회 1988 전자공학회논문지 Vol. No.

The input-output relation for nonlinear systems can e explicitly represented by the volterra functional series and it is characterized by the Volterra kernels. A block diagram reduction method is proposed to determine the Volterra kernels for nonlinear differential equations and is compared with the direct substitution techniques. The former method can significantly reduce the computational complexity. A degree of nonlinearity is defined and analyzed for the analysis of nonlinear systems.

Modeling of an Elastomer Constitutive Relation

Dan Keun Sung 제어로봇시스템학회 1988 제어로봇시스템학회 국내학술대회 논문집 Vol.1 No.2

Synthesis, Molecular Engineering, and Photophysical Properties of Fluorescent Thieno[3,2-<i>b</i>]pyridine-5(4<i>H</i>)-ones

Sung, Dan-Bi,Mun, Bohyun,Park, Sol,Lee, Hyi-Seung,Lee, Jihoon,Lee, Yeon-Ju,Shin, Hee Jae,Lee, Jong Seok American Chemical Society 2019 Journal of organic chemistry Vol.84 No.1

High-throughput phenotype analysis of transgenic plants for product development

Dan Sung 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

The world population is projected to reach to 9.6 billion people by 2050. With increasing population and improving living standards, the demand for food is accelerating. In order to meet increasing demand for food while the arable land and other resources are decreasing, agriculture needs all the tools available to sustainably increase crop yields. Development of effective GM traits to protect crops from abiotic and biotic stressors is a critical aspect of sustainable yield improvement. Efficient identification of traits and rapid integration of the traits into commercial elite germplasm requires robust and rapid traits testing. Monsanto have developed numerous high-throughput phenotyping platforms to support rapid trait identification and integration. Selected phenotyping platforms will be reviewed to gain understanding on how they are utilized for trait phenotyping.

Ca<SUP>2⁢</SUP>-induced Ca<SUP>2⁢</SUP> Release from Sarcoplasmic Reticulum Negatively Regulates Myocytic ANP Release in Beating Rabbit Atria

Dan Li,He Xiu Quan,Jin Fu Wen,Jing Yu Jin,Sung Hun Park,Sun Young Kim,Sung Zoo Kim,Kyung Woo Cho 대한생리학회-대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.2

It is not clear whether Ca<SUP>2⁢</SUP>-induced Ca<SUP>2⁢</SUP> release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine increased ANP release, indicating that Ca<SUP>2⁢</SUP> entry via voltage-gated L-type Ca<SUP>2⁢</SUP> channel activation decreases ANP release. The purpose of the present study was two-fold: to define the role of SR Ca<SUP>2⁢</SUP> release in the regulation of ANP release and whether Ca<SUP>2⁢</SUP> entry via L-type Ca<SUP>2⁢</SUP> channel is prerequisite for the SR-related effect on ANP release. Experiments were performed in perfused beating rabbit atria. Ryanodine, an inhibitor of SR Ca<SUP>2⁢</SUP> release, increased atrial myocytic ANP release (8.69⁑3.05, 19.55⁑1.09, 27.31⁑3.51, and 18.91⁑4.76% for 1, 2, 3, and 6μM ryanodine, respectively; all P<0.01) with concomitant decrease in atrial stroke volume and pulse pressure in a dose-dependent manner. In the presence of thapsigargin, an inhibitor of SR Ca<SUP>2⁢</SUP> pump, ryanodine-induced increase in ANP release was not observed. Thapsigargin attenuated ryanodine-induced decrease in atrial dynamic changes. Blockade of L-type Ca<SUP>2⁢</SUP> channel with nifedipine abolished ryanodine-induced increase in ANP release (0.69⁑5.58% vs. 27.31⁑3.51%; P<0.001). In the presence of thapsigargin and ryanodine, nifedipine increased ANP release and decreased atrial dynamics. These data suggest that Ca<SUP>2⁢</SUP>-induced Ca<SUP>2⁢</SUP> release from the SR is inversely involved in the regulation of atrial myocytic ANP release.

Performance Analysis of Orthogonal Frequency and Code Hopping Multiplexing

Sung Ho Moon,Junsu Kim,Dan Keun Sung IEEE 2007 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.6 No.10

<P>Beyond-3G wireless communication systems should support packet traffic with both low/medium rate and high rate services. Scheduling-based resource allocation schemes may cause a problem in accommodating low/medium rate services due to a rate mismatch and a large signaling overhead. Dedicated resource allocation/multiplexing schemes are also inadequate for accommodating packet-type traffic that is characterized by low channel activity and high burstiness. Therefore, we propose a new orthogonal frequency and code hopping multiplexing (OFCHM) scheme for downlink multiplexing to provide efficient support of packet traffic with low/medium data rates in a spread OFDM environment. The performance of the proposed scheme is evaluated in terms of the statistical multiplexing gain, the block error rate, and the overall capacity by using both an analytical approach and simulation. The proposed scheme yields a larger overall downlink capacity than a dedicated resource allocation/multiplexing scheme. A comparison study with the variable spreading factor-orthogonal frequency and code division multiplexing (VSF-OFCDM) system through system-level simulations is also performed. The comparison results show that the OFCHM system yields better performance than the VSF-OFCDM system in packet delay, packet delay variance, and fairness, and has a system throughput advantage with low/medium rate services.</P>

Modeling of an Elastomer Constitutive Relation

Dan Keun Sung 대한전자공학회 1988 대한전자공학회 학술대회 Vol.1988 No.01