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Cefotaxime과 Furosemide의 賢排泄 및 血漿蛋白 結合에 미치는 影響
鄭址昌,金載學,韓大燮,高啓昌 慶熙大學校 1984 論文集 Vol.13 No.-
The cephalosporins are eliminated by both glomerular filtration and tubular excretion. Chronic administration of cephalosporins may cause renal tubular necrosis. Cefotaxime is a new semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum. Therefore, to determine whether any variations at plasma protein binding with furosemide by cefotaxime were responsible for its diuretic action of urine volume and electrolytes in rabbits, author studies effects on drug-interaction of cefotaxime and furosemide. The following results were obtained. 1. The group, administrated simultaneously furosemide and cefotaxime, was significantly increased compared with furosemide alone group on the urine volume, urinary electrolytes, because markedly increased the inhibition of Na^+ and Cl^- reabsorption in the renal tubule, and glomerular filtration rate without any differences. 2. Serum concentration of cefotaxime in rabbits was significanly elevated by the combination with furosemide, and markedly inhibited the elimination levels of cefotaxime in urine of rabbits. Conclusion of above results; Synergistic effect of cefotaxime on diuretic action of furosemide showed the comparative inhibition of plasma protein binding with furosemide by cefotaxime, and the continuation of diuretic effect seems excretion of furosemide on the in-hibited by competition between furosemide and cefotaxime in renal tubular excretion.
Ampicillin과 Furosemide의 相互作用에 관한 硏究
李昇宰,鄭址昌,高啓昌,韓大燮 慶熙大學校 1986 論文集 Vol.15 No.-
In order to investigate the durg-interaction between furosemide and ampicillin, the influences of ampicillin on the diuretic action of furosemide and the effects of furosemide on the urinary elimination rate and serum concentration of ampicillin were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-ampicillin combined group, the furosemide-ampicillin combined group showed significant increase in urine flow and urinary electrolytes amounts. Those findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. Throughout the combined administration of furosemide and ampicillin. the serum concentration of ampicillin were significantly elevated, but the urinary elimination rate of ampicillin were markedly decreased in the observed rabbits. It is concluded from the results that synergistic effect of ampicillin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by ampicillin. It is also postulated that the competition between furosemide and ampicillin in renal tubular secretion.
Glutaraldehyde로 처리된 이종 및 자가 미세혈관 이식에 대한 실험적 연구
육홍미,윤진호,우동훈,김한중,김대섭 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3
During microvascular procedures there frequently arises a need for a vascular graft. In this study the efficacy of preserving microvascular heterografts with glutaraldehyde tanning was investigated. These were compared with nonprepared autografts. Autogenous non-prepared rat femoral arterial grafts and glutaraldehyde-tanned rabbit femoral arterial grafts were interposed in fat femoral arteries. Ninty-one per cent and 74per cent patency rates were achieved respectively at 4weeks. This study has shown that glutaraldehyde tanning reduces the antigenicity of rabbit femoral arteries used as heterografts in the rat. This reduction in antigenicity prevented necrosis of the rabbit femoral the tendency to thrombosis, but as unacceptable occlusion rate (26% occluded) persisted. We assumed that thrombosis occurred because of incomplete reduction of the antigenicity of the heterografts. The exact mechanism resulting in occlusion of glutaraldegyde-tanned grafts is not known. Further work is therefore required to establish a tanning technique which can reduce antigenicity without leading to occlusion and without and without rendering the graft the difficult to use.
농아에서의 측두골 전산화 단층촬영 소견과 다른검사 요인과의 연관성
조태환,이상흔,권대구,엄규상,성창섭,김용선,한기원 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1
Temporal bone high resolution computed tomogram(TBHRCT)is a essential diagnostic tool in considering for cochlear implantation in patients with profound sensorineural hearing loss. This study was designed for an effort to provide and efficacy of TBHRCT in determination of inner ear malformations for the patients who have profound sensorineural hearing loss and to examine the relationships between TBHRCT findings and other preoperative evalutions for cochlear implantation in that patients. Authors examined 68 deaf patients to provide fundamental data for cochlear implantation. Inner ear abnormalities were founded in 13(19%) patients, among which 10(14.7%) patients had Mondini'dysplasia in which 5 patients were hypoplastic type and 5 patients were hydrops type. Other inner ear abnormalities were as follows : lateral semicircular canal hypoplasia ; internal auditory canal abnormality ; cochlear aqueduct widening ; vestibular aqueduct widening. No relationships were found between TBHRCT findings and other test results. : promontory test, K-WISC cognitive test etc.(Korean J Otolaryngol 39 : 8, 1996)
Han, Dae-Yong,Park, Hyeon-Soo,Park, Kwang-Il,Kang, Sang-Rim,Cho, Jae-Hyeon,Lee, Won-Sup,Kim, Eun-Ju,Kim, Eun-Hee,Kim, Gon-Sup The Pharmaceutical Society of Japan 2009 Journal of health science Vol.55 No.6
<P>Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two phenyl groups well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on serum cholesterol levels in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection, and the effect of PCB118 on the serum levels of total cholesterol, high density lipoprotein-cholesterol (HDL-cholesterol), and low density lipoprotein-cholesterol (LDL-cholesterol) was investigated. The protein expression level of apolipoprotein A-I (apo A-I) and 3-hydroxy-3-methylgulutaryl coenzyme A (HMG-CoA) reductase was also examined. In this study, the administration of PCB118 induced hyperalphacholesterolemia in rats. In addition, the protein expression level of HMG-CoA reductase and apo A-I was higher in the PCB118-treated rats than in the control. These results suggest that the hyperalphacholesterolemia induced by PCB118 in male rats may be associated with an increase in HMG-CoA reductase and apo A-I expression.</P>
Chung, Kang-Sup,Lee, Jae-Chun,Kim, Kun-Han,Han, Tae-Sam,Kil, Dae-Sup,Kim, Eun-Jin,Hwang, Taek-Sung 공주대학교 자원재활용신소재지역협력센터 2000 2차년도 센터 사업 성과집 Vol.2000 No.1
On-line determination of trace uranium in sea water by flow injection-inductively coupled plasma-mass spectrometry(FI-ICP-MS) has been investigated. The method of flow injection equipped wth microcolumn was used for on-line separation and enrichment of uranium prior to determination by ICP-MS because the influences of concomitant matrix in sea water are serious problem in introducing to ICP-MS. In order to take high accuracy and precision, flow injection parameters such as time response, acid concentration, sampling volume, flow rate, etc., and other instrumental conditions were optimized. A sampling volume of 3mL resulted in a preconcentration factor of about 30, and precision at the 3 ng/mL level was 3.5%(RSD). Developed method was applied to natural sea water samples off the coast of Young Kwang nuclear power plant in Korea and the results were assessed through either analysis of synthetic sea water reference sample or recovery experiment
Dae Sup Lee,Sung Wook Park,염석란,Sang Kyoon Han,Sung Hwa Lee,Ji Ho Ryu 대한중환자의학회 2011 Acute and Critical Care Vol.26 No.4
Background: Pulmonary contusion is the most common pulmonary parenchymal injury in blunt chest trauma and may constitute a life-threatening thoracic injury. In this study, we evaluated the usefulness of high-frequency chest wall oscillation (HFCWO) therapy in patients with pulmonary contusion. Methods: Patients with lung contusion either received HFCWO therapy using the Vest system (Vest group; n = 18) or received conventional chest physiotherapy (non-Vest group; n = 23). The physiological parameters of the patients, length of stay in hospital and ICU, and the duration of mechanical ventilation were compared between the two groups. Variables, including pulmonary contusion score, percentage of patients receiving mechanical ventilation therapy, and PaO_2/FiO_2 ratio, were also analyzed. Results: The pulmonary contusion score was higher in the Vest group (p < 0.01), and mechanical ventilation was used more frequently in the Vest group (p = 0.027). Improvement in the PaO_2/FiO_2 ratio over the first 48 h did not differ between the Vest and Non-Vest groups. No significant differences in the physiological parameters, hospital and ICU stays, and duration of mechanical ventilation were observed between the two groups. Conclusions: The therapeutic effect of the Vest system in patients with pulmonary contusion was similar to that of conventional chest physiotherapy. Therefore, the Vest system could be considered as an airway clearance technique in the management of patients with pulmonary contusion.