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Chunyan Zeng,Chen Gao,Li Yuan,Tao Liang,Ruisong Yang,Wei Zhang,Song Nie 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.2
In this paper, hierarchical CuO/MnO2 composite hollow nanospheres have been successfully fabricated by water evaporation-induced self-assembly through a redox transformation reaction between Cu2O nanospheres and KMnO4 solution at 120℃ for 6 h, followed by removing the residual Cu2O cores with ammonia hydroxide solution. The outstanding feature of this method is that the reaction system is in a dynamic environment due to the evaporation of the solvent water, which benefits the self-assembly of nanostructures to form hierarchical structures. Both Kirkendall effect and Ostwald ripening mechanism are suggested to be responsible for the formation of the hierarchical CuO/MnO2 nanocomposites according to the characterization results. The electrochemical properties of the products were studied, and the results show that the hierarchical CuO/MnO2 hollow nanospheres exhibit high capacity and good rate performance (a stable capacity of about 480 mAh g-1 after 80 cycles of variable charging rate), which is probably attributed to the hierarchical hollow nanostructures.
A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples
Chen, Han,Li, Chunyan,Peng, Xinxin,Zhou, Zhicheng,Weinstein, John N.,Caesar-Johnson, Samantha J.,Demchok, John A.,Felau, Ina,Kasapi, Melpomeni,Ferguson, Martin L.,Hutter, Carolyn M.,Sofia, Heidi J.,Ta Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers. Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on “chromatin-state” to explain their interplay. Integrating eQTL, mRNA co-expression, and Hi-C data analysis, we developed a computational method to infer causal enhancer-gene interactions, revealing enhancers of clinically actionable genes. Having identified an enhancer ∼140 kb downstream of PD-L1, a major immunotherapy target, we validated it experimentally. This study provides a systematic view of enhancer activity in diverse tumor contexts and suggests the clinical implications of enhancers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Systematic analysis of enhancer expression across ∼9,000 samples of 33 cancer types </LI> <LI> Global enhancer activation positively correlates with aneuploidy but not mutations </LI> <LI> A computational method that infers causal enhancer-target-gene relationships </LI> <LI> Enhancers as key regulators of therapeutic targets, including PD-L1 </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Intestinal mucus components and secretion mechanisms: what we do and do not know
Song Chunyan,Chai Zhenglong,Chen Si,Zhang Hui,Zhang Xiaohong,Zhou Yuping 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs. The mucus layer has attracted the attention of the scientific community in recent years, and with the discovery of new mucosal components, it has become increasingly clear that the mucosal barrier is a complex system composed of many components. Moreover, certain components are jointly involved in regulating the structure and function of the mucus barrier. Therefore, a comprehensive and systematic understanding of the functional components of the mucus layer is clearly warranted. In this review, we summarize the various functional components of the mucus layer identified thus far and describe their unique roles in shaping mucosal structure and function. Furthermore, we detail the mechanisms underlying mucus secretion, including baseline and stimulated secretion. In our opinion, baseline secretion can be categorized into spontaneous Ca2+ oscillation-mediated slow and continuous secretion and stimulated secretion, which is mediated by massive Ca2+ influx induced by exogenous stimuli. This review extends the current understanding of the intestinal mucus barrier, with an emphasis on host defense strategies based on fortification of the mucus layer.
Xiaoqin Chen,Qian Xiang,Chunyan Yong,Zu Liang Liu,Xiao Dong Xing 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.12
The bactericidal magnetic nanoparticles were prepared by modifying magnetic nanoparticles (MNPs) with N-halamine polymer coating and quaternary ammonium polymer coating via a two-step soap-free emulsion polymerization method. The success of the surface functionalization was confirmed by Fourier transform infrared (FT-IR), X-ray photoelectron spectra (XPS), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and zeta-potential measurement. The results of antibacterial tests showed that the functional MNPs exhibited excellent antibacterial efficiency against both Gram negative bacteria E. coli and Gram positive bacteria S. aureus. Meanwhile the nanoparticles could be removed easily from water by an external magnetic field after antibacterial tests.
Li Yuan,Chen Gao,Chunyan Zeng,Yue Lu,Xuzheng Qian,Fuyi Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.10
Porous Ni–Cu alloy electrodes were conveniently fabricated by galvanic displacement reaction (GDR) between Ni foam and copper ion in copper ion solutions, followed by cyclic voltammetry (CV) treatment to form a hierarchical microstructure. The electrocatalytic performance of prepared electrodes in terms of the hydrogen evolution reaction (HER) was investigated in a 1 mol/L KOH solution at room temperature. Different copper ion solutions were tested to determine the best copper ion solution and the optimum GDR time, and experimental results show that all cathodes obtained by GDR between Ni foam and copper ion exhibit a superior HER activity over the pure Ni foam cathode, while the HER activity of electrode obtained by GDR between Ni foam and copper ion in 0.5 mol/L CuCl2 solutions for 1 h is the highest. Furthermore, it is found that the HER activity of electrode obtained by GDR between Ni foam and copper ion in 0.5 mol/L CuCl2 solutions for 1 h can be further enhanced through a CV treatment and the optimal number of CV cycles is 3, which can be attributed to a hierarchical microstructure (a needle-like nano–microstructure formed on the surface of the electrode during the CV treatment process).
Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
Zhou Xinyang,Yu Miaomei,Chen Daiyue,Deng Chunyan,Zhang Qi,Gu Xiaosong,Ding Fei 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.2
BACKGROUND: Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular vesicles (EVs) from various cell types have been developed to bridge peripheral nerve defects. In our previous research, EVs obtained from skin-derived precursor Schwann cells (SKP-SC-EVs) were demonstrated to promote neurite outgrowth in cultured cells and facilitate nerve regeneration in animal studies. METHODS: To further assess the functions of SKP-SC-EVs in nerve repair, we incorporated SKP-SC-EVs and Matrigel into chitosan nerve conduits (EV-NG) for repairing a 15-mm long-distance sciatic nerve defect in a rat model. Behavioral analysis, electrophysiological recording, histological investigation, molecular analysis, and morphometric assessment were carried out. RESULTS: The results revealed EV-NG significantly improved motor and sensory function recovery compared with nerve conduits (NG) without EVs incorporation. The outgrowth and myelination of regenerated axons were improved, while the atrophy of target muscles induced by denervation was alleviated after EVs addition. CONCLUSION: Our data indicated SKP-SC-EVs incorporation into nerve grafts represents a promising method for extended peripheral nerve damage repair.
Bing He,Yao Chen,Hua Zhang,Chunyan Xia,Qing Zhang,Wei Lin 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.4
Light intensity and quality affect photosynthesis, plant morphology, and the synthesis of primary and secondary metabolites. Dysosma versipellis (Hance) M. Cheng is an endangered species endemic to China, and a highly valued medicinal and ornamental plant. In this study, we discuss the effects of different light spectrums conferred by colored plastic films on photosynthesis and the contents of active ingredients of D. versipellis. D. versipellis plants were cultured for 90 days under white, red, yellow, or blue film. The blue film treatment generally increased the chlorophyll content, photosynthetic rate (Pn), maximal photochemical efficiency of PSII (Fv/Fm), actual photochemical efficiency of PSII (ФPSII), photochemical quenching (qP), and the podophyllotoxin content of the rhizomes. The blue film treatment also decreased the maximum net photosynthetic rate (Amax), apparent photosynthetic quantum efficiency (AQY), and podophyllotoxin contents of the stems. The yellow film treatment resulted in a decline of the Amax, AQY, Fv/Fm, ФPSII, qP, chlorophyll contents, and podophyllotoxin contents of the leaves and rhizomes; however, the light compensation point (LCP), light saturation point, and minimum fluorescence (Fo) were increased. There were no significant differences in chlorophyll content, Amax, LCP, AQY, Fv/Fm, ФPSII, or qP between the white and red film treatments. These results suggest that in D. versipellis, blue film treatments promote photosynthesis and the accumulation of podophyllotoxin, while yellow film treatments inhibit photosynthesis and the accumulation of podophyllotoxin.
Jianfeng Li,Junfeng Tong,Peng Zhang,Chunyan Yang,Dejia Chen,Yuancheng Zhu,Yangjun Xia,Duowang Fan 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
A new donor-accepter-donor-accepter-donor (D-A-D-A-D) type 2,1,3-benzothiadiazole-thiophene-based acceptor unit 2,5-di(4-(5-bromo-4-octylthiophen-2-yl)-2,1,3-benzothiadiazol-7-yl)thiophene (DTBTTBr2) was synthesized. Copolymerized with fluorene and indeno[1,2-b]fluorene electron-rich moieties, two alternating narrow band gap (NBG) copolymers PF-DTBTT and PIF-DTBTT were prepared. And two copolymers exhibit broad and strong absorption in the range of 300-700 nm with optical band gap of about 1.75 eV. The highest occupied molecular orbital (HOMO) energy levels vary between –5.43 and –5.52 eV and the lowest unoccupied molecular orbital (LUMO) energy levels range from –3.64 to –3.77 eV. Potential applications of the copolymers as electron donor material and PC71BM ([6,6]-phenyl-C71 butyric acid methyl ester) as electron acceptors were investigated for photovoltaic solar cells (PSCs). Photovoltaic performances based on the blend of PF-DTBTT/PC71BM (w:w; 1:2) and PIF-DTBTT/PC71BM (w:w; 1:2) with devices configuration as ITO/ PEDOT: PSS/blend/Ca/Al, show an incident photon-to-current conversion efficiency (IPCE) of 2.34% and 2.56% with the open circuit voltage (Voc) of 0.87 V and 0.90 V, short circuit current density (Jsc) of 6.02 mA/ cm2 and 6.12 mA/cm2 under an AM1.5 simulator (100 mW/cm2). The photocurrent responses exhibit the onset wavelength extending up to 720 nm. These results indicate that the resulted narrow band gap copolymers are viable electron donor materials for polymer solar cells.