뱀장어 아가미 율혈증에 관한 연구

김영길,장선일,최상훈,박관하,조정곤,최민순,김종면 한국어병학회 1995 한국어병학회지 Vol.8 No.2

뱀장어에 인위적으로 스트레스를 가하여 아가미 울혈증을 발생시킨 후에 NaCl 처리에 따른 CVS의 울혈증의 치료효과 및 혈액성상의 변화에 미치는 영향을 조사하였다. 스트레스 직후에 고빈도의 발병율을 보였던 아가미 및 간의 울혈증은 염처리 후 3일째 까지는 감소되었으나, 4일 이후에는 별 영향이 없었다. 혈액성분중 스트레스 후 증가되었던 Ht, Met-Hb, Ca^(++), GOT, GPT, LDH 및 glucose치 등과 감소되었던 Mg^(++) 및 Hb치 등은 염처리 3일까지는 회복율이 촉진되었으나, 그 이후에는 큰 차이를 보이지 않았다. 그러나 알부민 및 총단백치는 염처리 기간동안 별 변화가 없었다. 이상의 결과는 스트레스에 의해 발병된 아가미 울혈증에 대한 염처리법은 초기 3일까지는 효과가 있으나, 그 이상의 기간에는 전혀 효과적이지 못함을 보여준다. This experiment was carried out in order to elucidate the effect of NaCl(0.85%) acclimation on congestion symptoms in central venous sinuses(CVS) of gill filaments and on the alteration of blood constituents in cultured eels for 1, 2, 3, 4, 5, 6 and 7days after handling stress. After giving a handling stress on eels, the frequency of gill congestion was about 90%. It gradually decreased to 40% on the 3rd day, then increased to 60% on the 7th day in NaCl(0.85%) acclimation. The values of haematocrit(Ht), methemoglobin(Met-Hb), glucose (GLU), calcium(Ca^(++)), lactic dehydrogenase(LDH), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase(GOT) were lower than those of the control, whereas magnesium(Mg^(++)) and haemoglobin(Hb) were higher than the control. However total protein(Tp) and albumin (ALB) levels similar to the control. When the fish after giving a handling stress were cultured in NaCl-free water as a control, the frequency of gill congestion and the value of blood components showed a similar pattern to that obtained from the NaCl acclimated experiments. However, in the early period(1-3day) after handling stress, NaCl acclimating slightly helped the natural tendancy of recovery. These results suggest that the frequency of gill congestion is not always reduced over the whole period of NaCl acclimation. However, the acclimation to NaCl solution may be a somewhat useful therapy for the gill congestion in stressed eels.

뱀장어 아가미 울혈증에 관한 연구 III. NaCl처리가 울혈증 치료에 미치는 영향

최민순,박관하,최상훈,김영길,김종면,조정곤,장선일,Choi, Min-Soon,Park, Kwan-Ha,Choi, Sang-Hoon,Kim, Young-Gill,Kim, Jong-Myeon,Cho, Jeong-Gon,Jang, Seon-Il 한국어병학회 1995 한국어병학회지 Vol.8 No.2

This experiment was carried out in order to elucidate the effect of NaCl(0.85%) acclimation on congestion symptoms in central venous sinuses(CVS) of gill filaments and on the alteration of blood constituents in cultured eels for 1, 2, 3, 4, 5, 6 and 7days after handling stress. After giving a handling stress on eels, the frequency of gill congestion was about 90%. It gradually decreased to 40% on the 3rd day, then increased to 60% on the 7th day in NaCl(0.85%) acclimation. The values of haematocrit(Ht), methemoglobin(Met-Hb), glucose (GLU), calcium($Ca^{++}$), lactic dehydrogenase(LDH), glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase(GOT) were lower than those of the control, whereas magnesium($Mg^{++}$) and haemoglobin(Hb) were higher than the control. However total protein(Tp) and albumin (ALB) levels similar to the control. When the fish after giving a handling stress were cultured in NaCl-free water as a control, the frequency of gill congestion and the value of blood components showed a similar pattern to that obtained from the NaCl acclimated experiments. However, in the early period(1-3day) after handling stress, NaCl acclimating slightly helped the natural tendancy of recovery. These results suggest that the frequency of gill congestion is not always reduced over the whole period of NaCl acclimation. However, the acclimation to NaCl solution may be a somewhat useful therapy for the gill congestion in stressed eels. 뱀장어에 인위적으로 스트레스를 가하여 아가미 울혈증을 발생시킨 후에 NaCl 처리에 따른 CVS의 울혈증의 치료효과 및 혈액성상의 변화에 미치는 영향을 조사하였다. 스트레스 직후에 고빈도의 발병율을 보였던 아가미 및 간의 울혈증은 염처리 후 3일째 까지는 감소되었으나, 4일 이후에는 별 영향이 없었다. 혈액성분중 스트레스 후 증가되었던 Ht, Met-Hb, $Ca^{++}$, GOT, GPT, LDH 및 glucose치 등과 감소되었던 $Mg^{++}$ 및 Hb치 등은 염처리 3일까지는 회복율이 촉진되었으나, 그 이후에는 큰 차이를 보이지 않았다. 그러나 알부민 및 총단백치는 염처리 기간동안 별 변화가 없었다. 이상의 결과는 스트레스에 의해 발병된 아가미 울혈증에 대한 염처리법은 초기 3일까지는 효과가 있으나, 그 이상의 기간에는 전혀 효과적이지 못함을 보여준다.

비인강암 환자의 고선량 강내 방사선 치료의 효과

조정길 (Jeong Gill Cho),장혜숙 (Hye Sook Chang),최은경 (Eun Kyung Choi) 대한방사선종양학회 1993 Radiation Oncology Journal Vol.11 No.1

From September 1989 to June 1992, 22 patients with nasopharyngeal carcinoma were treated in Asan Medical Center with an external beam of 60 Gy followed by a boost dose of 15 Gy HDR brachytherapy. There were 5 females and 17 males with median age of 44 years (range: 20-69 years). All patients were histologically confirmed and staged by physical examination, CT scan and/or MRI. By the AJCC TNM staging system, there were 2 patients with stage II (T2NO), 4 with stage III (T3NO, T1-3N1), and 16 with stage IV (T4 or N2-3). Four patients received chemotherapy with 5-FU and cisplatin prior to radiotherapy. All patients were followed up periodically by a telescopic examination and radiologic imaging study of CT scan or MRI with a median follow-up thime of 13 months (range: 3-34 months). Twenty one patients showed a complete response one month after completing therapy and one patient showed a compete response after three months. At the time of this analysis, seventeen patients remain alive without evidence of disease, but four patients developed distant metastasis and one patient died a month after treatment. the local control rate was 100% in a median follow-up time of 13 months. The two year overall and disease free survival rates by the Kaplan-Meier method were 94% and 67%, respectively. Serious radiation sequelae have not been observed yet. Although longer follow-up in needed, this retrospective analysis suggests that HDR brachytherap. given as a boost therapy for nasoharyngeal carcinoma may improve the local control. To reduce the incidence of distant metastasis, we need to develop a more effective systemic chemotherapy.

심실상성 빈맥의 기전 규명에 있어서 심전기생리학적 지표인 △VACT와 VACT Ratio 의 가치

조정관(Jeong Gwan Cho),박상진(Sang Jin Park),류제영(Jay Young Rhew),배열(Youl Bae),김성희(Sung Hee Kim),김준우(Jun Woo Kim),김주한(Ju Han Kim),길광채(Gwang Chae Gill),박주형(Joo Hyung Park),정명호(Myung Ho Jeong),박종춘(Jong Chun Pa 대한내과학회 1996 대한내과학회지 Vol.51 No.2

N/A Background: Electrophysiologic methods useful in determining the mechanism of paroxysmal supra- ventricular tachycardia (PSVT) accurately and easily have been continuously studied. Most studies were focused on the development of a method to differentiate AVNRT and AVRT using the septal atrioventricular bypass tract, since these two tachycardias are very difficult to differentiate even with electrophysiologic study (EPS). Several methods previously reported have some limitation in accuracy and/or applicability, Objectives: The purpose of this study is to develop a new electrophysiologic parameter by evaluating the usefulness of the difference (△VACT) and ratio(VACT ratio) of VA conduction time (VACT) during right ventricular pacing at the cycle length of supraventricular tachycardia (SVT) in determining the mechanism of SVT and localizing accessory pathways (AP) in AVBT. Methods: Total of 94 SVT patients undergoing EPS and radiofrequency (RF) catheter ablation for 35 AVNRT (17 male, 18 female; mean age 45.6±17.2 years) and 59 AVRT (36 male, 23 female; mean age 37.5 ±15.3 years) were included in this study, The electrophysiologic mechanism of SVT and the location of APs in A VRT were confirmed by RF catheter ablation in all the patients. AVNRT was typical form in 34 patients and atypical (slow-slow) form in one. Among 59 APs, 19 (32.2%) APs were right side (12: free wall, RFW group; 7: septum, SPT group), 40 (67.8%) APs were left side (37: free wall, LFW group; 3: septum, SPT group), EPS was performed using the standard technique. 6F multipolar electrode catheters were positioned at the high right atrium (HBA), atrioventricular junction (HIS), right ventricular apex (RVA) in all the patients, and coronary sinus if needed. SVT was induced in all the patients with programmed electrical stimulation. VA conduction time (VACT) was measured from the onset of QRS complex to the onset of atrial electrogram from the HRA during SVT (VACT-SVT) and during RVA pacing at the SVT cycle length (VACT-RVP). △VACT was calculated by subtracting VACT-SVT from VACT- RVP and VACT ratio by dividing VACT-RVP by VACT-SVT. AVNRT and AVRT were differentiated using the previously reported criteria and then RF catheter ablation was performed. RF was delivered at the target site through a 7F 4 mm-tipped deflectable ablation catheter using continuous unmodulated sine wave with 350 KHz or 500 KHz generated from RF generator (RFG-3B, Radionics, Burlington, Mass or HAT 200S, Osypka, Germany). Results: The preexcitation index (PI) could be measured with a single ventricular extrastimulus in 22 (62.9%) of 35 AVNRT patients and 49 (83.1%) of 59 AVRT patients. PI was 139±31 (range 90-200) in AVNRT, 30±11 (range 15-40) in RFW group, 29 20 (range 10-70) in SPT group, and 92±24 (range 55- 160) in LFW group, showing a significant difference between each groups, but considerable overlap (52.6% of 76) between each groups except between AVNRT and AVRT with right side AP, DVACT was 126±20 (range 76-168) ms in AVNRT, 179 (range 4-35) ms in RFW group, 29 ±25 (5-76) ms in SPT group, 79±16 (50-110) ms in LFW group, showing a significant difference between AVNBT and 3 groups of AVRT and between 3 groups of AVRT except between RFW group and SPT group (p<0.01). The frequency of the patients with overlap in AVACT was lower than that in PI(52.6% vs. 24.5%, p<0.05). △VACT with a cut-off value of 50 ms differentiated the sideness (right vs. left) of APs in 58 (98.3%) of 59 AVRT patients, VACT ratio was 3.671.22 (range 2.20-8.30) in AVNRT, 1.10,1 (range 1.03-1.29) in RFW group, 120.2 (range 1.03-1.29) in SPT group, and 1.5±0.1 (range 1.30-1,86) in LFW group, showing no overlap between AVNRT and AVRT. AVNRT and AVRT were completely differentiated with VACT ratio with a cut-off value of 2.0. Conclusion : It is concluded that the mechanism of SVT may be accurately differentiated into AVNRT or AVRT using VACT ratio with a cut-off value of 2.0 and the location of accessory pathwa

영구형 심박조율기 시술에 대한 임상경험

조정관(Jeong Gwan Cho),정명호(Myung Ho Jeong),박종춘(Jong Chun Park),양승진(Seung Jin Yang),박찬형(Chan Hyung Park),길광채(Gwang Chae Gill),조길우(Keal Woo Cho),강정채(Jung Chaee Kang) 대한내과학회 1989 대한내과학회지 Vol.37 No.1

N/A Pacemaker implantation for symptomatic bradycardia is becoming popular recently in this country. Though its clinical benefit has been documented clearly there are still a lot of clinical problems arising from surgical problems, implanting techniques and pacemaker inherited problems. This study was designed to evaluate the indications, clinical manifestations and complications of 62 implantation procedures in 55 patients who had undergone the implantation procedure in Chonnam University Hospital by reviewing the pertinent clinical records. From 1983 to 1988, 62 implantation procedures in 55 patients (19 men and 36 women) were carried out. Annual numbers of implantation had been increasing, with 5 cases in the beginning year up to 20 cases in 1987, the numbers increased. The most common age was the fifties and patients older than fifty years comprised 74.5% of the total. The main symptoms which brought the 52 patients who underwent the first implantation to the hospital were syncope in 26, dyspnea in 14, dizziness in 9, shock in 2, and nonspecific in l. Electrocardiographic manifestations of the patients were atrioventricular block in 32 (58.2%, 28 complete AV blocks, 3 type II 2nd AV blocks, and one trifascicular block) and sick sinus syndrome in 23 patients (41.8%, 10 sinus arrests, 9 sinus bradycardias, 3 tachy-bradycardias, and one second degree SA block). Associated diseases were hypertension in 20, coronary artery disease in 7, cerebral infarction in 4, surgical correction of VSD in 2, dilated cardiomyopathy in 2, diabetes mellitus in 2, thyrotoxicosis in l, and liver cirrhosis in 1 patient. But, abaut one fourth of the patients had no associated disease. The systems implanted were all ventricular demand pacing system, among which 41 (70%) were multi-programmable. Pacing leads were introduced via the cephalic vein in most of the cases and via the external jugular vein in some cases. At implantation the pacing threshold was 0.67±0.25 volts (M±SD), electrode impedance 1258±266 ohm (M±SD), and intracardiac R wave amplitude 10.3±9.7 mvolts (M±SD). The causes of revision due to complications were 2 chronic exit blocks, 2 erosions of the generator or lead, one preerosion followed by infection after a revision, one generator pocket abscess shortly after an implantation, one power depletion, and 3 occasions of twiddler's syndrome in a patient. Other complications which were controllable without revision of the system were one indifferent electrode skeletal muscle pacing treated by reprograming the output, chronic increase of threshold in another 2, pacemaker syndrome in one treated by reprograming, and a hematoma in the generator pocket resolved by needle aspiration. We learned from this review that although pacemaker implantation has been helpful in the majority of the patients treated, same annoying and potentially life threatening complications warranted, and efforts to prevent or detect them early are necessary mention.

Doxazosin의 강압효과에 대한 임상적 연구

조길우,이기운,길광채,박찬형,조정관,박종춘,강정채,김상형 최신의학사 1990 最新醫學 Vol.33 No.1

Carcinoembryonic Antigen (CEA) 陽性 胃腺癌細胞에 對한 免疫組織化學的 및 免疫細胞化學的 硏究

鄭琮吉,鄭相愚,曺圭赫 全南大醫大 1984 전남의대학술지 Vol.21 No.3

Highly Luminescent (Zn_0.6Sr_0.3Mg_0.1)₂Ga₂S₅:Eu²⁺ Green Phosphors for a White Light-Emitting Diode

Jeong, Yong-Kwang,Cho, Dong-Hee,Kim, Kwang-Bok,Kang, Jun-Gill Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8

Green phosphors $(Zn_{1-a-b}M_aM^{\prime}_b)_xGa_yS_{x+3y/2}:Eu^{2+}$ (M, M' = alkali earth ions) with x = 2 and y = 2-5 were prepared, starting from ZnO, MgO, $SrCO_3$, $Ga_2O_3$, $Eu_2O_3$, and S with a flux $NH_4F$ using a conventional solidstate reaction. A phosphor with the composition of $(Zn_{0.6}Sr_{0.3}Mg_{0.1})_2Ga_2S_5:Eu^{2+}$ produced the strongest luminescence at a 460-nm excitation. The observed XRD patterns indicated that the optimized phosphor consisted of two components: zinc thiogallate and zinc sulfide. The characteristic green luminescence of the $ZnS:Eu^{2+}$ component on excitation at 460 nm was attributed to the donor-acceptor ($D_{ZnGa_2S_4}-A_{ZnS}$) recombination in the hybrid boundary. The optimized green phosphor converted 17.9% of the absorbed blue light into luminescence. For the fabrication of light-emitting diode (LED), the optimized phosphor was coated with MgO using magnesium nitrate to overcome their weakness against moisture. The MgO-coated green phosphor was fabricated with a blue GaN LED, and the chromaticity index of the phosphor-cast LED (pc-LED) was investigated as a function of the wt % of the optimized phosphor. White LEDs were fabricated by pasting the optimized green (G) and the red (R) phosphors, and the commercial yellow (Y) phosphor on the blue chips. The three-band pc-WLED resulted in improved color rendering index (CRI) and corrected color temperature (CCT), compared with those of the two-band pc-WLED.

Improving enrichment for laboratory dogs by introducing new feeder

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Plasma-pads and plasma-wraps for biomedical applications

Yeon-Jeong KIM,Jung-Gill KIM,Hyun CHO,Yunjung KIM,Gook-Hee HAN,Eun-Ha CHOI,Guangsup CHO 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8