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아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향
최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4
연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.
허철(Cheol Huh),강정원(Jeong-Won Kang),문일성(Il-Sung Moon),장대준(Dae-June Chang),최항석(Hang-Seok Choi),민동주(Dong-Joo Min),강성길(Seong-Gil Kang) 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6
이산화탄소 포집 및 저장기술(Carbon dioxide Capture and Storage, CCS)이 기후변화 대응 기술로서 국내외적으로 주목 받고 있다. CCS 기술은 발전소 및 제철소 등 대규모 발생원에 서 배출되는 CO2를 포집, 파이프라인이나 선박 등을 통해 수송, 그리고 이를 지중에 장기간 저장하는 저장공정으로 이루어진다. 본 연구에서는 CO2 해양지중저장 실용화를 위한 CO2 물성 특성, 수송·주입 공정설계, 선박 수송 안전성, 중간저장 개념설계 그리고 저류층 내 CO2 거동 안전성 평가를 위한 탄성파 모니터링 기술을 개발하고 있다. 본 논문에서는 이에 대한 연구내용을 정리하고 주요 결과를 소개하고자 한다. Carbon dioxide Capture and Storage(CCS) is regarded as one of the most promising options to response climate change. CCS is a three-stage process consisting of the capture of carbon dioxide, the transport of CO2 to a storage location, and the long term isolation of CO2 from the atmosphere for the purpose of carbon emission mitigation. To carry out demonstration and commercialization of CO2 marine geological storage, property analysis focused on the hydrate phase equilibrium, process design of transport and injection, safety analysis of CO2 carrier, design of offshore intermediate storage facility and seismic wave propagation modeling were studied. In this paper, major results of these studies were introduced and summarized.
농촌지역 여성고령자의 현미덤벨체조가 체조성, 체력 및 식습관에 미치는 영향
이기철 ( Lee Gi Cheol ),정창주 ( Jeong Chang Ju ),손기수 ( Son Gi Su ),우임수 ( U Im Su ),이원경 ( Lee Won Gyeong ),공무현 ( Gong Mu Hyeon ),이수천 ( Lee Su Cheon ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.2
The present study evaluated the possibility of dumbbell exercise as to improve the physical fitness and the health starus of old people in rural area. Although eighty seven volunteers of old women (over 64) living in Seonsan, Gumi city were subjected, twenty of them were attended the whole program for 6 months and the data from the twenty was analysed in this study. The results were drawn out from comparison of the body constitutuion, the physical strength, the medical aspectrs, and the questionaires of before and after this program. They showed increased physical fithess tested by grip strength (left), bar gripping reaction time, standing trunk flexibility, on foot standing test through dumbbell exercise for 6 months. Questionaire revealed the betterment of dietary pattem during this program. In the light of in these results, it is possible to conclude that dumbbell exercise had improved the basic physical condition and the health status through the increasement of physical fitness and dietary pattem change. Therefore, dumbbell exercise would be a useful program for the old people in reual area to improved their health status.
프로스타글란딘 유도체의 합성과 그의 생물학적 활성에 관한 연구 2. 위궤양과 위산분비에 대한 프로스타글란딘 유도체의 효과
조태순(Tai Soon Cho),이선미(Sun Mee Lee),함원훈(Won Hun Ham),이병무(Byung Mu Lee),김경례(Kyoung Rae Kim),지상철(Sang Cheol Chi),고준일(Jun Ill Ko),박인(In Park),오창영(Chang Young Oh),박호군(Ho Koon Park),김형자(Hyoung Ja Kim),이향우(H 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.1
The antiulcer effects of newly synthesized prostaglandin derivatives were investigated in various experimental ulcer models and on gastric secretion in rats. HK-3 and HK-4, PGE₂ derivatives, prevented the formation of acute gastric ulcer induced by ethanol or aspirin in pylorus-ligated rats. The ulcer formation was moderately inhibited by HK-1 and HK-2, PGF_(2α) derivatives, and aggravated by SK-1, SK-2 and SK-3, PGF_(2α) derivatives. HK-3 and HK-4 reduced the volume, acid output and pepsin output of gastric juice in pylorus-ligated rats. The gastric perfusion with physiologic saline(pH 6.0) showed relatively constant acid secretion and indomethacin increased the acid secretion. The acid secretion was markedly decreased by PGE₂ but PGF_(2α) caused little change. Prostaglandin derivatives, especially HK-3 and HK-4, significantly inhibited the acid secretion induced by indomethacin. The results show that, PGE₂ derivatives, HK-3 and HK-4, inhibit acid secretion and also have protective effects on gastric ulceration induced by ethanol or aspirin.
Eye and Skin Irritation Tests for Cell Wall Glucan and Mannoproteins, from Saccharomyces cerevisiae
Chang Hoon Ha,Hye Young Kim,Cheol Won Youn,Hyun Dong Paik,Seung Wook Kim,Chang Won Kang,Hyo-Ihl Chang 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
Yeast cell wall matrix particles are entirely composed of mannoprotein and β-glucan. Yeast cell wall β-glucans and mannoproteins were isolated and purified from cell wall mutants in the previous study (Ha et al., 2002). The mannoproteins and the alkali-soluble glucan of yeast cell wall have been shown to systemically enhance immune system function. These nonspecific immunostimulators was evaluated for primary skin and eye irritation in male New Zealand White rabbits. In skin irritation test of β-glucans and mannoproteins, body weights were not significantly changed and there were no responses after treatment for 24 hours and the primary irritation index (P.I.I.) was ‘0’. And, in the eye irritation test, there were no chemosis in any rabbits in washing group and non-washing group. Taken together, these results indicate that yeast cell wall β-glucans and mannoproteins may be non-irritant materials.
( Cheol Su Kim ),( Ho Sup Lee ),( Chang Ki Min ),( Je Jung Lee ),( Ki Hyun Kim ),( Dok Hyun Yoon ),( Hyeon Seok Eom ),( Hyewon Lee ),( Won Sik Lee ),( Ho Jin Shin ),( Ji Hyun Lee ),( Young Park ),( Ja 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Many prognostic factors have been studied with development of treatment in MM. However, serologic infiammatory markers such as serum beta2-microglobulin (B2MG), albumin, absolute lymphocyte count(ALC), C-reactive protein (CRP), lactate dehydrogenase (LDH), serum ferritin level which were easily tested in patients to find disease status have been reported that these were correlated with prognosis in many studies, respectively. Therefore, the purpose of this study is to estimate correlation between frequency of combined infiammatory parameters such as ALC, LDH, B2MG, albumin, CRP, and ferritin and prognosis for survival in patients with MM treated with induction chemotherapy containing thalidomide underwent autologous stem cell transplantation (ASCT). Methods: Data from patients at thirteen university hospitals in South Korea between December 2005 and May 2013 were collected retrospectively. All included patients were treated with thalidomide containing chemotherapy and then underwent ASCT. The infiammatory score was defined that each infiammatory parameters including ALC level under 1000/μL, Serum B2MG level above 3.5 mg/L Serum albumin under 3.5 g/dL and LDH above 450 IU/L were scored 1 point and sum of those were used infiammatory scores such as 0 to 4 points. Results: In the multivariate analysis, Infiammatory score (<2) was only independent prognostic factor for superior PFS (RR;0.618, 95% C.I. 0.409-0.933, p=0.022) and platelet counts of more than 100×109/L, infiammatory score of less than 2 were independent prognostic factors for superior OS (RR 7.856, 95% C.I. 2.502-24.670, p<0.001 and RR 0.216, 95% C.I. 0.067-0.696, p=0.010, respectively). Conclusions: Patients combined many infiammatory factors who treated with thalidomide induction chemotherapy underwent ASCT were shown significant short survival and these results might be helped to predict prognosis.
Won, Byeong-Muk,Park, Gong-Seok,Hwang, Cheol-Ho,Han, Su-Deok,Kim, In-U,Gwon, Yong-Beom,Seol, Seung-Gwon,Jo, Chang-Sik,Je, Jeong-Ho,Hwu, Y.,Tsai, W.L.,Ruterana, P. 한국정보디스플레이학회 2003 인포메이션 디스플레이 Vol.4 No.4
우리는 연-X-선 흡수 분광법(soft-X-ray Absorption Spectroscopy ; XAS)을 사용하여 실제 산화물 음극 전자 방출 물질 표면의 화학 구조에 대해 연구하였다. 바륨 3d 흡수단의 고-에너지 분해 스펙트럼은 활성화 과정(온도와 전압 인가) 후에 산화물 음극표면에서 수십 나노미터 깊이 아래까지 바륨 함량이 현저히 증가한다는 것을 보여주었다. 바륨과 산소의 XAS 데이터를 비교해보면 표면에서 과잉 바륨이 형성되는 것을 확실히 입증하고 있다. 게다가 우리는 표면에서의 과잉 바륨의 증가가 활성화 과정에서 열에너지에 의한 것이 아니라 인가된 전압에 의한 것임을 밝혀냈다. 이 결과로 우리는 표면의 과잉 바륨 형성 전체 과정을 규명하고 활성화 동안 표면의 바륨 증가가 분말 입자로부터 니켈 계면으로의 바륨 이온의 전해 이동 속도에 의해 제어된다는 것을 제안한다. 우리는 또한 표면 바륨 증가가 전해 이동에 의한 분말 입자 내의 바륨의 고갈에서 비롯되는 것으로 추정한다.
Won, Sehoon,Kim, Hae-Deun,Kim, Ji-Yeon,Lee, Byoung-Cheol,Chang, Sunghoe,Park, Chul-Seung Elsevier 2010 Biophysical journal Vol.99 No.9
<P><B>Abstract</B></P><P>The movements of BK<SUB>Ca</SUB> channels were investigated in live cells using quantum dots (QDs). The extracellular N-terminus was metabolically tagged with biotin, labeled with streptavidin-conjugated QDs and then monitored using real-time time-lapse imaging in COS-7 cells and cultured neurons. By tracking hundreds of channels, we were able to determine the characteristics of channel movements quantitatively. Channels in COS-7 cells exhibited a confined diffusion in an area of 1.915 <I>μ</I>m<SUP>2</SUP>, with an initial diffusion coefficient of 0.033 <I>μ</I>m<SUP>2</SUP>/s. In neurons, the channel movements were more heterogeneous and highly dependent on subcellular location. While the channels in soma diffused slowly without clear confinement, axodendritic channels showed more rapid and pseudo-one-dimensional movements. Intriguingly, the channel movement in somata was drastically increased by the neuronal <I>β</I>4 subunit, in contrast to the channels in the axodendritic area where the mobility were significantly decreased. Thus, our results demonstrate that the membrane mobility of BK<SUB>Ca</SUB> channels can be greatly influenced by the expression system used, subunit composition, and subcellular location. This QD-based, single-molecule tracking technique can be utilized to investigate the cellular mechanisms that determine the mobility as well as the localization of various membrane proteins in live cells.</P>