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김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.1
Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.
( Hyun Chang Ko ),( Jeong Min Kim ),( Hyun Ho Cho1 ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Conventional destructive modalities for warts like cryotherapy or laser ablation have some limitations that are excruciating pain during procedure, in especially pediatric patients. Imiquimod is a topical immune response modifier that was approved for treating genital and perianal warts. But, thick stratum corneum of common warts may act as a barrier against drug permeation via the skin. Objectives: To evaluate efficacy and safety of above treatment. Methods: Eleven pediatric patients (6 female and 5 male, mean age 12.5 years) were included in this study. The lesions were treated by fractional 2940 nm Er:YAG laser for achieving the penetration of stratum corneum with 1 or 2 weeks intervals. Then, imiquimod 5% cream was self-applied once daily for 5 days a week. Assessment of response and adverse effects was performed every 2 weeks until complete clearance or up to maximum of 48 weeks. Pain during procedure was checked by VAS (0-10). Results: 8 out of 11 (72.7%) patients experienced complete clearance of all warts lesions. Mean duration of total treatment was 29.7 (16-48) weeks. Mean number of fractional laser treatment was 17.5 (8-37) times. No significant adverse effect was observed. VAS score of the pain during fractional laser treatment was 2.4 (1-4), comparing with 6.2 (5-8) during cryotherapy. Conclusion: Fractional ErYAG laser-assisted topical 5% imiquimod cream is an effective and safe treatment option for recalcitrant common warts of the children do not tolerate pain well.
Comparison of D-[18F]FMAU and L-[18F]FMAU as PET Imaging Agents for HSV1-TK Gene Expression
Byung Seok Moon,Nam Hyun Jo,이교철,Mohammed I. El-Gamal,Gwang Il An,Su Hee Hong,Tae Hyun Choi,Won-Kyoung Choi,Jin-Hun Park,Jung-Hyuck Cho,천기정,오창현 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
D-[18F]FMAU and L-[18F]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe. D-[18F]FMAU and L-[18F]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice. Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines. D-[18F]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[18F]FMAU. On the other hand, L-[18F]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[18F]FMAU. L-[18F]FMAU can be utilized as a good candidate for HSV1-TK PET imaging. It can be used for antiviral drug evaluation.
P442 : Melanoacanthoma with calcification in patient with arsenic intoxication: their relationship?
( Won Ku Lee ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Revised Soil Survey of Chungju-Si in Chungchungbukdo
Byung-Keun Hyun,Yeon-Kyu Sonn,Sang-Ho Jeon,Soon-Gang Yun,Hyun-Jun Cho,Sug-Jae Jung,Jung-Won Choi,Dong-Sung Lee 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.3
Agricultural lands have decreased continuously because of urbanization, land consolidation, road construction, etc. Especially, rapidly urbanizing areas such as Cheongju-si in South Korea has the severe land-use change. In this regard, Our study was aimed investigating land-use changes including soil properties and soil information to provide the basic soil information and soil management practices in the region. The area of crop cultivated land of South Korea in 2016 reduced by 35,424 ha compared to that of 2014. The paddy and upland field decreased by 12,455 and 22,969 ha respectively. The reasons for the decrease of the paddy field are as follows: converting the paddy field to upland (22,780 ha) > others (3,646) > public facilities (2,740) > building (2,642) > idle land (1,439). The reasons for the increase of the upland filed are as follows: switching paddy to upland (22,780 ha) > others(5,330) > reclamation of upland (1,415). The main reason converting paddy field to upland was cultivating more profitable upland crops or fruit trees. The arable land in Chungju-si had been reduced by 1,087 ha in 2014 since 1999. The ratio of the reduced arable land was about 48%. Our results showed that paddy fields located in alluvial plains were changed into upland or green house. In particular, paddy fields have been changed to not only upland, orchard, greenhouse cultivation but also fallow land. Moreover, our research using 3686 soil codes (soil phases) and 3834.2 ha indicated that the number of soil series and soil phase increased to 74 and 160 from 65 and 126 individually. The largest increased area was Sachon (coarse loamy fluvaquentic endoaquepts) soil series 536.3 ha which were modified from the existing Yecheon, Sanju, Wolgog, and Seongsan soil series.
( Won-young Kim ),( Seungyong Park ),( Hwa Jung Kim ),( Moon Seong Baek ),( Chi Ryang Chung ),( So Hee Park ),( Byung Ju Kang ),( Jin Young Oh ),( Woo Hyun Cho ),( Yun Su Sim ),( Young-jae Cho ),( Sun 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.3
Background: Beyond its current function as a rescue therapy in acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) may be applied in ARDS patients with less severe hypoxemia to facilitate lung protective ventilation. The purpose of this study was to evaluate the efficacy of extended ECMO use in ARDS patients. Methods: This study reviewed 223 adult patients who had been admitted to the intensive care units of 11 hospitals in Korea and subsequently treated using ECMO. Among them, the 62 who required ECMO for ARDS were analyzed. The patients were divided into two groups according to pre-ECMO arterial blood gas: an extended group (n=14) and a conventional group (n=48). Results: Baseline characteristics were not different between the groups. The median arterial carbon dioxide tension/ fraction of inspired oxygen (FiO<sub>2</sub>) ratio was higher (97 vs. 61, p<0.001) while the median FiO<sub>2</sub> was lower (0.8 vs. 1.0, p<0.001) in the extended compared to the conventional group. The 60-day mortality was 21% in the extended group and 54% in the conventional group (p=0.03). Multivariate analysis indicated that the extended use of ECMO was independently associated with reduced 60-day mortality (odds ratio, 0.10; 95% confidence interval, 0.02-0.64; p=0.02). Lower median peak inspiratory pressure and median dynamic driving pressure were observed in the extended group 24 hours after ECMO support. Conclusion: Extended indications of ECMO implementation coupled with protective ventilator settings may improve the clinical outcome of patients with ARDS.