대두종자의 polymer coating 연구 1 : polymer coating 종자의 conductivity 차이

李成春,J. S. Burris 韓國作物學會 1994 Korean journal of crop science Vol.39 No.2

Polyme coating 종자의 환경적응성을 구명하기 위한 일환으로 콩 종자에 10종의 polymer를 coating하여 각 coating polymer별 conductivity, 발아력, 수분흡수력을 조사하였던 바 그 결과를 요약하면 다음과 같다. 1. Conductivity는 polymer coating한 종자가 coating하지 않은 종자보다 높았으며, 가장 높았던 polymer는 waterlock이었다. 2. Conductivity는 침종 후 시간이 경과할 수록 높아졌고, 100립중이 무거울 수록 높았다. 3. 수확년도가 오래된 종자의 conductivity가 당년에 수확한 종자보다도 높게 나타났다 4. 수분흡수 정도는 coating polymer에 따라 각각 달랐는데 daran 8600은 질이 떨어지는 종자에서는 수분흡수를 크게 저 해하였다. 5. Coating polymer 중 waterlock, captan, klucel, sacrust 등은 발아율을 상승시켰고, daran 8600은 발아율을 저하시켰으며 나머지 polymer는 품종에 따라 각각 달랐고 그 정도는 질이 떨어지는 종자에서 훨씬 컸다. 6. Polymer의 특성에 따라 수분흡수를 저해하거나 조장하였다. These experiment were conducted to evaluate the environmentally acceptable polymers, and 10 polymers were used in these study, and to investigate conductivity, germination percentage, water uptake of polymeric coating soybean seed. The conductivity of polymeric coating seed is higher than that of none coating seed and the highest conductivity was obtained with waterlock coating seed among the 10 polymer coating seed. As the soaking time was long, the conductivity was increased. The conductivity of large seed was higher than that of small seed, and that of long period storage seed was higher than that of short period storage seed. The effects of seed coating polymers on uptake water were various, and daran 8600 inhibited uptake water of low quality seed. The waterlock, captan, klucel and sacrust was rised germination percentage, and daran 8600 was declined germination percentage, and the effect of coating polymers on germination percentage of low quality seed was higher than that of high quality seed.

A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors

Mateo, Joaquin,Ganji, Gopinath,Lemech, Charlotte,Burris, Howard A.,Han, Sae-Won,Swales, Karen,Decordova, Shaun,DeYoung, M. Phillip,Smith, Deborah A.,Kalyana-Sundaram, Shanker,Wu, Jiuhua,Motwani, Monic American Association for Cancer Research 2017 Clinical Cancer Research Vol.23 No.19

<P><B>Background:</B> The PI3K/protein kinase B (AKT) pathway is commonly activated in several tumor types. Selective targeting of p110β could result in successful pathway inhibition while avoiding the on- and off-target effects of pan-PI3K inhibitors. GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ.</P><P><B>Methods:</B> We evaluated the safety, pharmacokinetics, pharmacodynamics and antitumor activity of GSK2636771 to define the recommended phase II dose (RP2D). During the dose-selection and dose-escalation stages (parts 1 and 2), patients with <I>PTEN</I>-deficient advanced solid tumors received escalating doses of GSK2636771 (25–500 mg once daily) using a modified 3+3 design to determine the RP2D; tumor type-specific expansion cohorts (part 3) were implemented to further assess tumor responses at the RP2D.</P><P><B>Results:</B> A total of 65 patients were enrolled; dose-limiting toxicities were hypophosphatemia and hypocalcemia. Adverse events included diarrhea (48%), nausea (40%), and vomiting (31%). Single- and repeat-dose exposure increased generally dose proportionally. GSK2636771 400 mg once daily was the RP2D. Phospho/total AKT ratio decreased with GSK2636771 in tumor and surrogate tissue. A castrate-resistant prostate cancer (CRPC) patient harboring <I>PIK3CB</I> amplification had a partial response for over a year; an additional 10 patients derived durable (≥24 weeks) clinical benefit, including two other patients with CRPC with <I>PIK3CB</I> alterations (≥34 weeks). GSK2636771 400 mg once daily orally induced sufficient exposure and target inhibition with a manageable safety profile.</P><P><B>Conclusions:</B> Genomic aberrations of <I>PIK3CB</I> may be associated with clinical benefit from GSK2636771. <I>Clin Cancer Res; 23(19); 5981–92. ©2017 AACR</I>.</P>

Estimating freeway route travel time reliability from data on component links and associated cost implications

Kartikeya Jha,John P. Wikander,William L. Eisele,Mark W. Burris,David L. Schrank 서울시립대학교 도시과학연구원 2018 도시과학국제저널 Vol.22 No.3

Typically, data on travel time (speed) and traffic volume are collected for relatively short homogenous links of a roadway (e.g. every ½ to 2 miles or 0.8–3.2 km) and not for particular routes from origins to destinations. To accurately estimate a traveller’s trip, there is a need to build information on an entire route from data collected at the link level. Because it can be resource-intensive to define specific routes for the entire network of interest, route reliability performance measures are sometimes estimated using a vehicle-miles of travel (VMT)-weighted average of performance indices from links. In performance measurement, travel time index (TTI) is the ratio of average travel time and free-flow travel time while planning time index (PTI) is the ratio of 95th percentile travel time and free-flow travel time. TTI is considered a mobility measure while PTI reflects system reliability. Using indices based on free-flow (uncongested) travel time, this study finds that the VMT-weighting of link indices to get the corresponding route index gives reasonable results for the travel time index (TTI). However, this approach overestimates the planning time index (PTI). This highlights the statistical insufficiency of estimating route PTI values from link PTI values weighted by VMT. It points to the subsequent need to incorporate factors for dispersion and skewness characteristics of travel time distributions on constituent links. This paper introduces a promising method to estimate freeway route reliability considering these dispersion and skewness properties. For statewide Virginia Interstates considered here, economic analyses based on the value of travel time demonstrate that incorrect travel time reliability estimates result in upwards of 200% higher user costs. Researchers anticipate that the information documented in this paper will be useful for those conducting performance monitoring activities to estimate route reliability with limited resources when only link data are available.

Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors

Wu, Huali,Infante, Jeffrey R,Keedy, Vicki L,Jones, Suzanne F,Chan, Emily,Bendell, Johanna C,Lee, Wooin,Kirschbrown, Whitney P,Zamboni, Beth A,Ikeda, Satoshi,Kodaira, Hiroshi,Rothenberg, Mace L,Burris Dove Medical Press 2015 International journal of nanomedicine Vol.10 No.-

<P>IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11). The objective of this study was to evaluate the factors associated with interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 in patients with advanced solid tumors. IHL-305 was administered intravenously once every 4 weeks as part of a Phase I study. Pharmacokinetic studies of the liposomal sum total CPT-11, released CPT-11, SN-38, SN-38G, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]-carbonyloxycamptothecin, and 7-ethyl-10-[4-amino-1-piperidino]-carbonyloxycamptothecin in plasma were performed. Noncompartmental and compartmental pharmacokinetic analyses were conducted using pharmacokinetic data for sum total CPT-11. The pharmacokinetic variability of IHL-305 is associated with linear and nonlinear clearance. Patients whose age and body composition (ratio of total body weight to ideal body weight [TBW/IBW]) were greater than the median age and TBW/IBW of the study had a 1.7-fold to 2.6-fold higher ratio of released CPT-11 area under the concentration versus time curve (AUC) to sum total CPT-11 AUC. Patients aged <60 years had a 1.3-fold higher ratio of percent decrease in monocytes at nadir to percent decrease in absolute neutrophil count at nadir as compared with patients aged ≥60 years. There was an inverse relationship between patient age and percent decrease in monocytes at nadir, ie, younger patients have a higher percent decrease in monocytes. Patients with a higher percent decrease in monocytes at nadir have a decreased plasma exposure of sum total CPT-11. The pharmacokinetics and pharmacodynamics of IHL-305 are consistent with those of other PEGylated liposomal carriers. Interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 was associated with age, body composition, and monocytes.</P>

Mechanistic Aspects of Ethylbenzene Dehydrogenation with CO₂ over K₂O/B₂O₃-TiO₂-ZrO₂ Bi-Functional Catalysts

Burri, D. R.,Choi, K. M.,Park, S. E. Scitec Publications Ltd. 2007 Solid State Phenomena Vol.124-126 No.2

Use and Abuse of Corticosteroids in Rheumatic Diseases

Burry, H.C. Medical Publications Korea 1976 Medical Progress Vol.3 No.3

Ethylbenzene to styrene over alkali doped TiO₂-ZrO₂ with CO₂ as soft oxidant

Burri, Abhishek,Jiang, Nanzhe,Yahyaoui, Khalid,Park, Sang-Eon Elsevier 2015 Applied Catalysis A Vol.495 No.-

<P><B>Abstract</B></P> <P>Oxidative dehydrogenation of ethylbenzene (EB) to styrene monomer (SM) over alkali metal (Na, K) doped TiO<SUB>2</SUB>-ZrO<SUB>2</SUB> (TZ) has been studied. The EB and CO<SUB>2</SUB> conversions observed over alkali doped TZ are higher than that of non-doped TZ. The enhanced CO<SUB>2</SUB> conversion compared with non-doped counterparts is attributed to improved basicity, formation of TiZrO<SUB>4</SUB> phase with increased CO<SUB>2</SUB> affinity and insertion of K or Na into the lattice which affects the binding energy of “O” in turn providing more labile oxygen species. Alkali doping also effected in fine tuning the surface acid base properties. Moreover, these K and Na doped binary metal oxides system showed high surface area of 256m<SUP>2</SUP>/g and 199m<SUP>2</SUP>/g respectively. There was a 10-fold increase in the CO<SUB>2</SUB> conversions in case of the doped TZ compared to non-doped TZ increasing the stability of the catalyst by decreasing coking on the surface of the catalyst in spite of the high conversions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Acid–base bifunctional TiO<SUB>2</SUB>-ZrO<SUB>2</SUB>. </LI> <LI> Doping of alkali metal into TiO<SUB>2</SUB>-ZrO<SUB>2</SUB>. </LI> <LI> Increasing CO<SUB>2</SUB> conversion by increasing surface basicity. </LI> <LI> Improved surface oxygen species. </LI> <LI> Highly stable alkali doped TiO<SUB>2</SUB>-ZrO<SUB>2</SUB> for oxidehydrogenation of ethylbenzene to styrene with CO<SUB>2</SUB>. </LI> </UL> </P>

Dehydrogenation of Ethylbenzene to Styrene with CO₂ over TiO₂-ZrO₂ Bifunctional Catalyst

Burri, David Raju,Choi, Kwang-Min,Han, Sang-Cheol,Burri, Abhishek,Park, Sang-Eon Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.1

In the dehydrogenation of ethylbenzene to styrene, CO2 could play a role as an oxidant to increase conversion of ethylbenzene and stability as well over TiO2-ZrO2 mixed oxide catalysts. TiO2-ZrO2 catalysts were prepared by co-precipitation method and were characterized by BET surface area, bulk density, X-ray diffraction, temperature programmed desorption of NH3 and CO2. These catalysts were found to be X-ray amorphous with enhanced surface areas and acid-base properties both in number and strength when compared to the respective oxides (TiO2 and CO2). These catalysts were found to be highly active (> 50% conversion), selective (> 98%) and catalytically stable (10 h of time-on-stream) at 600 oC for the dehydrogenation of ethylbenzene to styrene. However, in the nitrogen stream, both activity and stability were rather lower than those in the stream with CO2. The TiO2-ZrO2 catalysts were catalytically superior to the simple oxide catalysts such as TiO2 and ZrO2. The synergistic effect of CO2 has clearly been observed in directing the product selectivity and prolonging catalytic activity.

An Efficient Cr-TUD-1 Catalyst for Oxidative Dehydrogenation of Propane to Propylene with CO2 as Soft Oxidant

Burri, A.,Hasib, M. A.,Mo, Y. H.,Reddy, B. M.,Park, S. E. Springer Science + Business Media 2018 Catalysis letters Vol.148 No.2

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Oxidative dehydrogenation of propane to propylene over alkali promoted mixed metal oxides using CO2 as Soft Oxidant

( Abhishek Burri ),모용환,박상언 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

Oxidative dehydrogenation of propane was studied intensively over Cr and Vanadium based catalysts under CO2. In the dehydrogenation of propane with CO2, different oxide materials were investigated as catalysts. Cr promoted catalysts with different loadings of Cr has been synthesized using MW and applied in the oxidative dehydrogenation of propane to propylene using CO2 as soft oxidant. Loading of chromium ranged from 1 to 5 wt % showing very high surface area. The present catalysts showed high activity (20%) and stability even after 8 hours of reaction. The ratio of Cr6+ and Cr3+ are the main reasons for the high activity. Alkali and alkaline earth metal are proved to activate CO2. The basic nature of these promoters activate COx and enhance the stability of the catalysts. The present study is based on the promotional effect of alkali and alkaline earth metals. Alkali promotion has improved the CO2 conversion by altering the acid base properties of the catalyst and stabilizing the redox nature.