http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Boland, Wilfred (검색결과 28 건)
- 무료
- 기관 내 무료
- 유료
-
Clozapine in the Time of COVID-19
Xavier Boland,Luiz Dratcu 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.3
Clozapine is the most effective antipsychotic for treatment resistant schizophrenia but adverse reactions to clozapine include neutropenia. The current COVID-19 pandemic may raise specific concerns for clinicians prescribing clozapine for patients who need it. We report on two actively psychotic patients with treatment resistant schizophrenia who required admission to our inner-London acute psychiatric unit during the COVID-19 pandemic and who were treated with clozapine. One was a young patient who developed COVID-19 symptoms and tested positive for the SARS-CoV-2 virus while receiving clozapine and the other was an aging man who tested negative for the SARS-CoV-2 virus but had contact with COVID-19 during initiation of clozapine treatment. Both responded to clozapine treatment and were safely discharged from hospital without any complication. These cases suggest that, in the absence of complications, exposure to COVID-19 per se and the onset of mild symptoms in those infected may not warrant withdrawal or postponement of clozapine treatment when this is indicated.
-
-
-
-
Promoter Methylation in the Genesis of Gastrointestinal Cancer
Clement Richard Boland,신성관,Ajay Goel 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.3
Colorectal cancers (CRC)-and probably all cancers-are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these alterations. Oncogenes are frequently activated by point mutation, gene amplification, or changes in the promoter (typically caused by chromosomal rearrangements). TSGs are typically inactivated by mutation, deletion, or promoter methylation, which silences gene expression. About 15% of CRC is associated with loss of the DNA mismatch repair system, and the resulting CRCs have a unique phenotype that is called microsatellite instability, or MSI. This paper reviews the types of genetic alterations that can be found in CRCs and hepatocellular carcinoma (HCC), and focuses upon the epigenetic alterations that result in promoter methylation and the CpG island methylator phenotype (CIMP). The challenge facing CRC research and clinical care at this time is to deal with the heterogeneity and complexity of these genetic and epigenetic alterations, and to use this information to direct rational prevention and treatment strategies. Colorectal cancers (CRC)-and probably all cancers-are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these alterations. Oncogenes are frequently activated by point mutation, gene amplification, or changes in the promoter (typically caused by chromosomal rearrangements). TSGs are typically inactivated by mutation, deletion, or promoter methylation, which silences gene expression. About 15% of CRC is associated with loss of the DNA mismatch repair system, and the resulting CRCs have a unique phenotype that is called microsatellite instability, or MSI. This paper reviews the types of genetic alterations that can be found in CRCs and hepatocellular carcinoma (HCC), and focuses upon the epigenetic alterations that result in promoter methylation and the CpG island methylator phenotype (CIMP). The challenge facing CRC research and clinical care at this time is to deal with the heterogeneity and complexity of these genetic and epigenetic alterations, and to use this information to direct rational prevention and treatment strategies.
-
Simulation of corroded RC structures using a three-dimensional irregular lattice model
Kim, Kunhwi,Bolander, John E.,Lim, Yun Mook Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.5
Deteriorative effects of steel corrosion on the structural response of reinforced concrete are simulated for varying degrees of corrosion. The simulation approach is based on a three-dimensional irregular lattice model of the bulk concrete, in which fracture is modeled using a crack band approach that conserves fracture energy. Frame elements and bond link elements represent the reinforcing steel and its interface with the concrete, respectively. Polylinear stress-slip properties of the link elements are determined, for several degrees of corrosion, through comparisons with direct pullout tests reported in the literature. The link properties are then used for the lattice modeling of reinforced concrete beams with similar degrees of corrosion of the main reinforcing steel. The model is successful in simulating several important effects of steel corrosion, including increased deflections, changes in flexural cracking behavior, and reduced yield load of the beam specimens.
-
-
Katie Nolan,Michael R. Boland,Arnold D.K. Hill 한국유방암학회 2022 Journal of breast cancer Vol.25 No.6
Purpose: Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. Methods: We conducted a systematic review of the available studies on pregnancy after ERpositive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Results: Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Conclusions: Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5–10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.
-
Expanding the Radicalization Framework: A Case Study of Tajik Migration to Russia
Siniša Vuković,India Boland 경남대학교 극동문제연구소 2022 ASIAN PERSPECTIVE Vol.46 No.3
The purpose of this article is to explore what explains radicalization of migrant communities and their families in their home country. Contemporary scholarship on radicalization has identified a broad range of explanatory variables, such as poverty, discrimination and/or lack of social mobility, that have the capacity to push individuals toward violence and radical beliefs. Yet, there is still a significant gap in current literature over the question why entire ethnic or national migrant groups are more represented in radical groups than others despite similar experiences. Using the case of Tajik migrants in Russia this article posits that the legacy of collective grievances and cyclical, systemic injustices, rather than a specific or personal experience of discrimination or mistreatment, are more accurate in explaining radicalization. The article pays specific attention to the role of religious or social remittances and, given a shared set of experiences, the susceptibility of the migrant’s own family in the home country to the same radical ideology—despite their never leaving their country’s borders. The findings suggest that the home country context, the collective account of society, is a more substantial predictor of radicalization than reception alone.
-
A Topology Measurement Method Examining Hydraulic Abrasion of High Workability Concrete
최석환,John E. Bolander 대한토목학회 2012 KSCE JOURNAL OF CIVIL ENGINEERING Vol.16 No.5
This research concerns the abrasion resistance of high workability concrete with various amounts of Supplementary Cementitious Materials (SCM). Various factors affect abrasion resistance, including the strength of concrete, water-binder ratio, amount of SCM,surface finishing, degree of aggregate exposure, and severity of the abrasive loading. An underwater abrasion test method, in which specimens are sectors of a circle, was newly proposed based on the modification from a typical method for simultaneous comparison of the abrasion resistance of concrete of differing mix proportions. Abraded concrete volumes were determined using a non-contact 3D measurement system. It was found that initial surface irregularities affect the development of ensuing erosion. Concrete containing more fly ash showed less abrasion erosion resistance at early age. Concrete mixed with blast-furnace slag showed higher abrasion resistance for approximately 20% replacement of cement, within the test range of 0~60%. In addition, the abrasion resistance increases as the aggregate exposure ratio increases for concrete with fly ash.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
