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Are the long–short term memory and convolution neural networks really based on biological systems?
David Balderas Silva,Pedro Ponce Cruz,Arturo Molina Gutierrez 한국통신학회 2018 ICT Express Vol.4 No.2
In general, it is not a simple task to predict sequences or classify images, and it is even more problematic when both are combined. Nevertheless, biological systems can easily predict sequences and are good at image recognition. For these reasons Long–Short Term Memory and Convolutional Neural Networks were created and were based on the memory and visual systems. These algorithms have shown great properties and shown certain resemblance, yet they are still not the same as their biological counterpart. This article reviews the biological bases and compares them.
( Donato D. Balderas,Jr ),( Marites M. Tabuga ),( Jupiter L. Petilla ) 대구대학교 한국특수교육문제연구소 2018 한국특수교육문제연구소 학술대회발표자료집 Vol.2018 No.1
The UN 2030 Education Agenda is a global platform directed towards creating opportunities for learners with special educational needs (LSENs) for their holistic development and eventual mainstreaming in the society. The schools being the catalysts of societal transformation are focal points for provision of instruction and intervention that emphasize inclusion, equity and gender equality among learners. Policies, programs, activities as well teachers’ trainings and orientation must be crafted to address the proper mainstreaming and placement of LSENs that will prepare them for self-independence and enhancement of their skills while ensuring that incidents of gender bias and bullying is eliminated, thus creating a wholesome learning environment. The objectives of this paper are mainly focused on the following areas; emphasis on the level of awareness of the goals of UN 2030 Education Agenda; assess the level of effectiveness of initiatives and activities for implementation; point out the severity of the problems that hinder implementation. A plan of action reflected as roadmap in order to attain the UN 2030 Education Agenda was conceptualized. Descriptive-analytical method of research was employed with survey-questinnaire as its data-gathering instrument. Respondents were teachers and stakeholders of the eleven (11) special education centers of DepEd Division of Pangasinan II. From the data gathered, it was concluded that respondents have very high awareness of the goals of UN 2030 education agenda, the iniatives and activities to be undertaken were perceived very much effective while the problems were moderately severe. The findings indicated that principals should keep track of the activities being implemented to ensure alignment with the set of goals, stakeholders must work collaboratively to intensify implementation of the activities and that applicable solutions must be thought of to minimize the problems encountered. Hence, principals in unison with the teachers and stakeholders must religiously implement the plan of action to ensure achievement of the goals on providing inclusive, equitable and gender equality education for learners with special educational needs of DepEd, Pangasinan Division II, Philippines.
Victor E. Balderas Hernandez,Luz M. T. Paz Maldonado,Emilio Medina Rivero,Ana P. Barba de la Rosa,Leandro G. Ordonez Acevedo,Antonio De Leon Rodriguez 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.1
The production of human interferon gamma (hIFN-γ) using a synthetic gene in Escherichia coli BL21-SI was optimized by response surface methodology (RSM) and a Box-Behnken design. The process variables studied were temperature, biomass concentration at induction time and the NaCl concentration as inducer. According to the Box-Behnken design, a second order response function was developed. The optimal expression conditions were a temperature of 32.6℃, induction biomass of 0.31 g/L and 0.3 M NaCl in minimal medium. The model prediction for the maximum hIFN-γ production was 77.3 mg/L, which corresponded satisfactorily with the experimental data. The hIFN-γ concentration attained under optimized conditions was 13-times higher than that obtained using the non-optimized conditions. We conclude that RSM is an effective method for the optimization of recombinant protein expression using synthetic genes in E. coli.
Francisco-Javier Jiménez-Balderas,Janete García-Jaimes,Rita Ríos,Abraham Zonana-Nacach,Raquel Tapia-,Nayeli Villanueva,Patricia Méndez-Samperio,Jorge-Luis de-la-Rosa-Arana 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.3
Purpose: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS)patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine thepresence of antibodies against Toxocara canis in AS patients with ANGAU. Methods: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAUwas accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determinedby enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were alsotested to verify non-specific reactions. Results: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients withANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positivefor T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens inthe serum samples of patients with AS. Conclusions: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patientswith AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated withthe pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
Kim, Jin Yeong,Balderas-Xicohté,ncatl, Rafael,Zhang, Linda,Kang, Sung Gu,Hirscher, Michael,Oh, Hyunchul,Moon, Hoi Ri American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.42
<P>Deuterium plays a pivotal role in industrial and scientific research, and is irreplaceable for various applications such as isotope tracing, neutron moderation, and neutron scattering. In addition, deuterium is a key energy source for fusion reactions. Thus, the isolation of deuterium from a physico-chemically almost identical isotopic mixture is a seminal challenge in modern separation technology. However, current commercial approaches suffer from extremely low separation efficiency (i.e., cryogenic distillation, selectivity of 1.5 at 24 K), requiring a cost-effective and large-scale separation technique. Herein, we report a highly effective hydrogen isotope separation system based on metal–organic frameworks (MOFs) having the highest reported separation factor as high as ∼26 at 77 K by maximizing synergistic effects of the chemical affinity quantum sieving (CAQS) and kinetic quantum sieving (KQS). For this purpose, the MOF-74 system having high hydrogen adsorption enthalpies due to strong open metal sites is chosen for CAQS functionality, and imidazole molecules (IM) are employed to the system for enhancing the KQS effect. To the best of our knowledge, this work is not only the first attempt to implement two quantum sieving effects, KQS and CAQS, in one system, but also provides experimental validation of the utility of this system for practical industrial usage by isolating high-purity D<SUB>2</SUB> through direct selective separation studies using 1:1 D<SUB>2</SUB>/H<SUB>2</SUB> mixtures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2017/jacsat.2017.139.issue-42/jacs.7b07925/production/images/medium/ja-2017-079254_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja7b07925'>ACS Electronic Supporting Info</A></P>
Jecong J.F.M.,Hila F.C.,Balderas C.V.,Guillermo N.R.D. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.9
The accuracy of the photoatomic cross-section data is of great importance in the field of radiation protection, particularly in the characterization of radiation shielding materials. With the release of the latest and probably the most accurate photoatomic data library, EPDL2017, the need to re-evaluate all the existing and already established mass attenuation coefficients (MACs) of all radiation shielding materials arises. The MACs of several polymers, alloy-based, glasses, and building materials used in a nuclear medicine facility were investigated using the EPDL2017 library embedded in EpiXS software and were compared to MACs available in the literature. The relative differences between MACEpiXS and MACXCOM were negligible, ranging from 0.02% to 0.36% for most materials. However, for material like a glass comprising of elements Te and La evaluated near their corresponding K-edge energies, the relative differences in MACs increased up to 1.46%. On the other hand, a comparison with MACs calculated based on EPDL97 (a predecessor of EPDL2017) revealed as much as a 6.61% difference. Also, it would seem that the changes in MACs were more evident in the materials composed of high atomic number elements evaluated at x-ray energies compared to materials composed of low atomic number elements evaluated at gamma-ray energies.
Selective Hydrogen Isotope Separation via Breathing Transition in MIL-53(Al)
Kim, Jin Yeong,Zhang, Linda,Balderas-Xicohté,ncatl, Rafael,Park, Jaewoo,Hirscher, Michael,Moon, Hoi Ri,Oh, Hyunchul American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.49
<P>Breathing of MIL-53(Al), a flexible metal–organic framework (MOF), leads to dynamic changes as narrow pore (<I>np</I>) transitions to large pore (<I>lp</I>). During the flexible and reversible transition, the pore apertures are continuously adjusted, thus providing the tremendous opportunity to separate mixtures of similar-sized and similar-shaped molecules that require precise pore tuning. Herein, for the first time, we report a strategy for effectively separating hydrogen isotopes through the dynamic pore change during the breathing of MIL-53(Al), a?representative of flexible MOFs. The experiment shows that the selectivity for D<SUB>2</SUB> over H<SUB>2</SUB> is strongly related to the state of the pore structure of MIL-53(Al). The highest selectivity (<I>S</I><SUB>D<SUB>2</SUB>/H<SUB>2</SUB></SUB> = 13.6 at 40 K) was obtained by optimizing the exposure temperature, pressure, and time to systematically tune the pore state of MIL-53(Al).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2017/jacsat.2017.139.issue-49/jacs.7b10323/production/images/medium/ja-2017-10323j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja7b10323'>ACS Electronic Supporting Info</A></P>
Medicinal Plant Extracts and Their Use As Wound Closure Inducing Agents
Mitzzy F. Medellin-Luna,Julio E. Castan˜eda-Delgado,V. Yordani Martı´nez-Balderas,Alberto R. Cervantes-Villagrana 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
Skin insult and damage start a complex healing process that involves a myriad of coordinated reactions at both the cellular and molecular level occurring simultaneously. These processes can be divided into that of cell migration and tissue remodeling of the wound. In addition, it is well known that deep wounds that derive from surgical procedures need a multidisciplinary approach to have a successful wound healing process. Recently, there has been a renowned interest in the identification of active compounds derived from ornamental, edible, and wild plants being used in the cosmetic and skin product industry. Recent reports suggest that active components of several plants such as Propolis and Aloe vera could be used to induce the process of wound healing and tissue regeneration and reducing therefore the time to complete wound closure. Other plant species such as Achillea millefolium or Salvia officinalis have anti-inflammatory properties and promote cellular proliferation contributing to faster tissue regeneration. It has been described that Malva sylvestris influences the formation of fibrosis-free granulation tissue in the skin. Recent observations suggest that Casearia sylvestris induces the angiogenic process. These effects have been evaluated in cell lines, different animal models, and some in randomized clinical trials. In this review we summarize the evidence of plant extracts and their active components (when known) in the acceleration of the wound closure process and tissue repair.