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State Indicator of Water Quality for Surface Water and Groundwater in Agriculture
Kim, Min-Kyeong,Jung, Goo-Bok,Ro, An-Sung,Choi, Seung-Chul,Choi, Won-Il,Kim, Eun-Jeong,Lee, Jong-Eun,Yun, Yeo-Uk,Kim, Kab-Cheol,Ko, Do-Young,Kim, Byeong-Ho,Kim, Hyeon-Ji,Park, Sang-Jo,Lee, Seong-Tae,H 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990's. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate ($NO_3{^-}$) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.
State Indicator of Water Quality for Surface Water and Groundwater in Agriculture
Min-Kyeong Kim,Goo-Bok Jung,An-Sung Ro,Seung-Chul Choi,Won-Il Choi,Eun-Jeong Kim,Jong-Eun Lee,Yeo-Uk Yun,Kab-Cheol Kim,Do-Young Ko,Byeong-Ho Kim,Hyeon-Ji Kim,Sang-Jo Park,Seong-Tae Lee,Jae-Young Heo,S 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990’s. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate(NO₃<SUP>-</SUP>) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Y Ong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Idiopathic pulmonary fi brosis (IPF) is characterized chronic progressive lung fi brosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjectsand performed global metabolomic profi ling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confi rmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identifi ed metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verifi ed the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Yong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Idiopathic pulmonary fibrosis (IPF) is characterized chronic progressive lung fibrosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjects and performed global metabolomic profiling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confirmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identified metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verified the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
An Jae Seong,Kim Do Hyun,Kim Soo Whan,Kim Sung Won,Lee Il Hwan 대한비과학회 2023 Journal of rhinology Vol.30 No.1
Background and Objectives: We compared pain levels, cardiovascular parameters, and complications according to whether patients underwent nasal packing with non-absorbable or biodegradable materials. Methods: Patients who underwent septoplasty from May 2015 to April 2020 were retrospectively reviewed. Numeric rating scale (NRS) scores for pain, blood pressure, and heart rate were measured three times (immediately after surgery, 6 hours later, and on postoperative day [POD] 1). We collected data on complications, including postoperative bleeding, septal hematoma, adhesions, septal perforation, and the recurrence of septal deviation. Results: In total, 200 patients underwent septoplasty, of whom 100 underwent nasal packing with Merocel and 100 underwent packing with Nasopore. The summed NRS scores over the three time points did not differ significantly between the groups. The NRS scores at 6 hours after surgery were highest in both groups. The systolic and diastolic blood pressure and the heart rate immediately after surgery were significantly higher than before surgery in both groups. The blood pressure and heart rate at 6 hours after surgery and on POD 1 did not differ significantly from those before surgery in either group. The incidence of sleep disturbance, postoperative bleeding, septal hematoma, adhesions, septal perforation, and recurrence of septal deviation did not differ significantly between the two groups. Conclusion: Although the level of postoperative pain and the cardiovascular parameters changed over time, we found no significant differences in pain, blood pressure, heart rate, or the complication rate according to whether patients underwent nasal packing with Nasopore or Merocel.
Overexpression of fatty acid synthase attenuate bleomycin induced lung fibrosis
( Sung Woo Park ),( Mi So Kim ),( Ae Rin Baek ),( Jong Sook Park ),( June Hyuk Lee ),( An Soo Jang ),( Do Jin Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Excessive alveolar epithelial cell (AEC) death by repeated injury play a role in the pathogenesis of lung fibrosis. Recently reports show defective lipid metabolism in AEC contributes to development or progression of lung fibrosis. Fatty acid synthase (FASN) is enzyme catalyzes the conversion of acetyl-CoA and malonyl-CoA to saturated fatty acids. Transcriptomic profiling revealed mRNA levels of FASN are significantly reduced in IPF lung. Objectives: We investigated whether regulation of FASN expression in AECs modulate severity of lung fibrosis and to evaluate its precise mechanism. Methods: We generated FASN knock-down, overexpression stable cell lines and human FASN transgenic (TG) mice, with conditionally induced alveolar epithelium to overexpress FASN. Cell proliferation and apoptosis assay were performed treated with bleomycin (BLM). Lung fibrosis was established by BLM inhaled FASN TG mice. Measurement and Results: FASNs mainly expressed at AECs and are significantly reduced in IPF and BLM treated mice lung. Knockdown of FASN significantly increased but overexpression of FASN down-regulate apoptotic cell death. FASN TG mice dramatically attenuated BLM-induced lung inflammation and fibrosis. Conclusions: These findings suggest that defective FASN production may associated with IPF pathogenesis and augmentation of FASN in the lung may have therapeutic potential in preventing lung fibrosis. GRANT: NRF-2019R1A2C1006351
Darapladib Binds to Lipoprotein-Associated Phospholipase A2 with Meaningful Interactions
Do, Kyoung-Rok,Kim, Chul,Chang, Byungha,An, Seong Soo A.,Shin, Jae-Min,Yea, Sang-Jun,Song, Mi-Young,No, Kyoung Tai,Lee, Jee-Young Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.1
Lipoprotein-associated phospholipase A2 (Lp-$PLA_2$) is a crucial enzyme in atherosclerosis as a potential drug target. The most remarkable Lp-$PLA_2$ inhibitory drug is Darapladib. We determined the binding pose of Darapladib to Lp-$PLA_2$ through docking study. Darapladib formed two hydrogen bonding interactions with the side chain of Tyr160 and Gln352 and several pi-pi interactions with aromatic and aliphatic hydrophobic residues of Lp-$PLA_2$. It is known that the dietylpropan-amine moiety of Darapladib has influence on the improvement of its oral bioavailability and we supposed this in our docking results.
Song, In-Uk,Kim, Young-Do,Cho, Hyun-Ji,Chung, Sung-Woo,Chung, Yong-An Lippincott WilliamsWilkins, Inc. 2013 Alzheimer disease and associated disorders Vol.27 No.1
Previous studies have demonstrated a decreased density of dopamine transporters (DAT) in basal ganglia in patients with idiopathic Parkinson disease (IPD) using I-n-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (FP-CIT), and the reductions in striatal DAT levels were inversely correlated with the severity of motor dysfunction in IPD. However, there has been no study on the correlation of DAT levels between IPD patients with and without cognitive dysfunction. Thus, we evaluated the differences in regional DAT density in the brain of patients with IPD without dementia and those with dementia using FP-CIT positron emission tomography. We recruited 24 consecutive patients with IPD, including 7 with IPD without dementia and 17 with IPD with dementia, and 18 healthy controls. FP-CIT positron emission tomography scans were acquired 90 and 210 minutes after the FP-CIT injection. The DAT density did not differ in the caudate nucleus or the putamen between patients with IPD without dementia and those with dementia. However, the DAT density between the 2 groups with IPD demonstrated a significantly decreased density compared with that of healthy controls in the putamen. We cautiously suggest that there is no relationship between DAT density and cognitive severity because there were no significant differences in the DAT density between IPD with dementia and those without dementia.