Increased Incidence of Carotid Artery Wall Changes and Associated Variables in Hemodialysis Patients without Symptomatic Cardiovascular Disease

Ahmet A. Kiykim,Ahmet Camsari,Serkan Kahraman,Mustafa Arici,Bulent Altun,Dilek Cicek,Yunus Erdem,Unal Yasavul,Cetin Turgan,Sali Caglar,Aytekin Oto 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.2

Cardiovascular disease (CVD) is still the major cause of the morbidity and mortality in hemodialysis (HD) patients. The characteristics of major arterial changes, atherosclerosis and related risk factors in HD patients remain unclear. We aimed to evaluate the atherosclerotic process in asymptomatic HD patients and healthy volunteers, and to determine the association between the risk factor(s) and the atherosclerotic process in these groups. 92 HD patients (female: 43, male: 49) and 62 age and sex matched healthy volunteers (female: 27, male: 35) were enrolled in this study. Diabetics, smokers, and patients with symptomatic CVD were excluded. The right and left carotid intima-media thicknesses (CIMTs) were measured and plaque structures were studied by B-mode ultrasound. The mean CIMT in patients and control group were 0.79±0.16 mm and 0.54±0.09mm, respectively. Mean CIMT in HD patients was thicker (p<0.001) and the presence ratio of plaque was higher in patients group (n=38, %61.2 vs n=9, %17.3) (p<0.001). Calcified type of plaque was more frequent in HD patients than control group. Age (r=0.48, p<0.001), left ventricular mass (r=0.42, p<0.05), and homocysteine (r=0.46, p<0.01), mean hematocrit (r=-0.36, p<0.05), plasma CRP (r=0.50, p<0.001), ESR (r=0.43, p<0.01) and albumin (r= -0.34, p<0.05) levels were correlated with the CIMT measurements and plaque presence, significantly. -CIMT as an atherosclerotic process indicator is thicker in asymptomatic HD patients than healthy subjects. We concluded that in addition to various classical risk factors, uremic environment may also contribute to acceleration of the atherosclerotic process.

The Association between Whole Blood Viscosity and Coronary Collateral Circulation in Patients with Chronic Total Occlusion

Mehmet Serkan Cetin,Elif Hande Ozcan Cetin,Kevser Gülcihan Balcı,Selahattin Aydin,Emek Ediboglu,Muhammed Fatih Bayraktar,Mustafa Mücahit Balcı,Orhan Maden,Ahmet Temizhan 대한심장학회 2016 Korean Circulation Journal Vol.46 No.6

Background and Objectives: Coronary collateral circulation (CCC) has been attributed as inborn bypass mechanisms supporting ischemic myocardium. Various factors have been postulated in CCC. Whole blood viscosity (WBV) has been an underappreciated entity despite close relationships between multiple cardiovascular diseases. WBV can be calculated with a validated equation from hematocrit and total plasma protein levels for a low and high shear rate. On the grounds, we aimed to evaluate the association between WBV and CCC in patients with chronic total occlusion. Subjects and Methods: A total of 371 patients diagnosed as having at least one major, chronic total occluded coronary artery were included. 197 patients with good CCC (Rentrop 2 and 3) composed the patient group. The poor collateral group consisted of 174 patients (Rentrop grade 0 and 1). Results: Patients with poor CCC had higher WBV values for a low-shear rate (LSR) (69.5±8.7 vs. 60.1±9.8, p<0.001) and high-shear rate (HSR) (17.0±2.0 vs. 16.4±1.8, p<0.001) than the good collateral group. Correlation analysis demonstrated a significant negative correlation between the grade of CCC and WBV for LSR (β=0.597, p<0.001) and HSR (β=0.494, p<0.001). WBV for LSR (β=0.476, p<0.001) and HSR (β=0.407, p<0.001) had a significant correlation with the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score. A multivariate analysis showed that the WBV for both shear rates were independent risk factors of poor CCC (WBV at LSR, OR: 1.362 CI 95%: 1.095-1.741 p<0.001 and WBV at HSR, 1.251 CI 95%: 1.180-1.347 p<0.001). Conclusion: WBV has been demonstrated as the overlooked predictor of poor coronary collateralization. WBV seemed to be associated with microvascular perfusion and angiogenesis process impairing CCC development

Dynamic modeling and analysis of a four-bar mechanism coupled with a CVT for obtaining variable input speeds

Ahmet Yildiz,Osman Kopmaz,Sevda Telli Cetin 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.3

This paper proposes a novel concept to obtain variable input speeds for a four-bar mechanism driven by an A.C. motor. In such a system,a continuously variable transmission (CVT) is proposed to use instead of an inverter-controlled motor. By this way, the speed variabilitywhich is crucial for obtaining different manufacturing and transportation processes can be provided by mechanically. Thus, moreefficient system can be achieved than classical motor controlled systems since the CVT allows electrical motor to run at its nominal pointin all conditions. For analyzing the dynamics of this new system, a theoretical model is established regarding that a half toroidal CVT isadded between the motor and the mechanism. The simulation results associated with the systems with and without a CVT are presentedby comparing to each other. The results indicate that the four-bar mechanism equipped with a CVT is feasible for the entire range ofpossible reduction ratios of the CVT.

FDG PET/CT and Conventional Imaging Methods in Cancer of Unknown Primary: an Approach to Overscanning

Neslihan Cetin Avci,Filiz Hatipoglu,Ahmet Alacacıoglu,Emine Ebru Bayar,Gonca Gul Bural 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.6

Purpose To compare the performance of fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomography(FDG PET/CT) with conventional imaging methods (CIM), including computed tomography (CT), magnetic resonanceimaging (MRI), and mammography (MMG) in cancer of unknown primary (CUP). Methods A total of 36 patients with CUP, who referred to our clinic for a FDG PET/CTscan, were enrolled in this study. Thirty ofthe patients were also examined through either diagnostic CT/MRI and/or MMG. The diagnostic performance of both methodsfor the primary cancer location was analyzed. The results of FDG PET/CT and CIM were compared based on the standardreference of the histopathology and/or clinical and laboratory follow-up. Results The primary cancer locations were detected in 24 patients (66.6%, 24/36) by FDG PET/CT, whereas CIM identified thelocations in 16 patients (53.3%, 16/30). Sensitivity, specificity, PPV, NPV, and accuracy rates of the detection of the primarytumor localizations were as follows: 83, 70, 89, 58, and 79% for FDG PET/CT; 70, 62, 84, 42, and 68% for CIM, respectively. There was no statistical significance between modalities regarding any of the categories in 30 patients. Conclusion FDG PET/CT detected the primary tumors of the patients with CUP more than CIM did. However, the differencebetween them was not found to be statistically significant. It may be considered that FDG PET/CT scan can be performed as afirst-line tool in the initial diagnosis of the patients with CUP and to add radiodiagnostic imaging in selective cases.We concludethat if the first-line examination of a CUP patient has been already performed by a CIM and the result was negative orinconclusive, FDG PET/CT can be considered to avoid unnecessary imaging procedures.

Preanesthetic Cardiopulmonary Bypass for Mechanical Mitral Valve Dysfunction

Ferit Çiçekçioğlu,Cetin Murat Songur,Emir Erol,Ahmet Kuddusi Irdem 대한흉부외과학회 2013 Journal of Chest Surgery (J Chest Surg) Vol.46 No.5

In Vitro Antimicrobial, Antioxidant, and Antispasmodic Activities and the Composition of the Essential Oil of Origanum acutidens (Hand.-Mazz.) Ietswaart

Ismihan Goze,Ahmet Alim,Senay Akkus Cetinus,Ali Cetin,Nedim Durmus,Ahmet Turan Atas,Nilufer Vural 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3

The radical scavenging, antimicrobial, and antispasmodic activities and the composition of Origanum acutidens (Hand.-Mazz.) Ietswaart (Order Labiatte) essential oil were evaluated in vitro. Gas chromatography/mass spectrometry analysis of the oil resulted in the identification of 20 compounds, representing 93.61% of the oil; carvacrol (65%) was the main component. The sample was also subjected to a screening for antioxidant activity by using the 1,1-diphenyl-2-picrylhydrazyl and β-carotene/linoleic acid assays. The essential oil exhibited strong antioxidant activity. Using the agar disk diffusion method, antimicrobial activities of the essential oils were determined for nine microorganisms; antimicrobial activity was shown against eight of them. O. acutidens oil exhibited spontaneous contractions in rat ileum at the 100% level at 0.1mg/mL level.

Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model

Mehmet Ozgür Avincsal,Seda Ozbal,Ahmet Omer Ikiz,Cetin Pekcetin,Enis Alpin Güneri 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.2

Objectives. Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation area by passing through the interstitium and capillary walls. To pass through these barriers, the in- flammatory cells degrade extracellular matrix proteins. Matrix metalloproteinases (MMPs) released by inflammatory cells mediate the degradation of these proteins. MMPs have synthetic inhibitors and doxycycline, a tetracycline anti- biotic, inhibits MMPs. This study investigated the efficiency of intranasal doxycycline in decreasing the symptoms and inflammatory cell infiltration in an animal model of AR. Methods. AR was created in female Wistar rats by repeated intranasal challenge with ovalbumin by intraperitoneal injection. For 15 days, topical intranasal doxycycline was administered one hour before ovalbumin administration. Following intranasal administration, nasal symptoms were scored and the nasal mucosae of all rats were evaluated histopatho- logically. To investigate tissue changes, hematoxyline-eosin and Alcian blue/periodic acid Schiff stains were used. As well, cilia loss, goblet cell changes, vascular congestion, vascular proliferation, inflammatory cell infiltration, eosinophil infiltration and the degree of hypertrophy in chondrocytes were evaluated with light microscopy. Results. Typical symptoms of AR were decreased by intranasal doxycycline administration. These effects were stable after repeated intranasal ovalbumin administration. Histological evaluation of doxycycline treated rats did not reveal typi- cal inflammatory changes associated with AR. Conclusion. MMPs may have crucial functions in AR and topical intranasal doxycycline, which decreases inflammatory cell infiltration, may offer an alternative therapy for AR.

Egg positive rate of Enterobius vermicularis and Taenia spp. by cellophane tape method in primary school children in Sivas, Turkey

Ali CELI·KSOZ,Mehmet ACIOZ,Serpil DE?ERL,Ahmet AL?M,Cetin AYGAN 대한기생충학열대의학회 2005 The Korean Journal of Parasitology Vol.43 No.2

A single horn endometrial carcinoma of a uterus bicornis unicollis

Cem Dane,Zeynep Tatar,Banu Dane,Murat Erqinbas,Ahmet Cetin 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.3

In this report, we describe a case of endometrial carcinoma arising in one horn of a bicornuate uterus. The diagnosis of this rare combination can be missed unless an unrecognized postmenopausal bleeding alerts the gynecologist to make a careful search for both endometrial cavities that may be curetted. Physicians should remember the possible existence of a separate uterine cavity when endometrial cancer is clinically suspected but histology fails to confirm the diagnosis. In this report, we describe a case of endometrial carcinoma arising in one horn of a bicornuate uterus. The diagnosis of this rare combination can be missed unless an unrecognized postmenopausal bleeding alerts the gynecologist to make a careful search for both endometrial cavities that may be curetted. Physicians should remember the possible existence of a separate uterine cavity when endometrial cancer is clinically suspected but histology fails to confirm the diagnosis.

Pretreatment Serum Albumin Level is an Independent Prognostic Factor in Patients with Stage IIIB Non-Small Cell Lung Cancer: A Study of the Turkish Descriptive Oncological Researches Group

Tanriverdi, Ozgur,Avci, Nilufer,Oktay, Esin,Kalemci, Serdar,Pilanci, Kezban Nur,Cokmert, Suna,Menekse, Serkan,Kocar, Muharrem,Sen, Cenk Ahmet,Akman, Tulay,Ordu, Cetin,Goksel, Gamze,Meydan, Nezih,Barut Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: Several prognostic factors have been studied in NSCLC, although it is unknown which is most useful. In this study, we aimed to investigate whether pre-treatment serum albumin level has prognostic value in patients with Stage IIIB NSCLC. Materials and Methods: This cross-sectional study included a total of 204 patients with Stage IIIB NSCLC who met the inclusion criteria. Pre-treatment serum albumin levels and demographic, clinical, and histological characteristics, as well as laboratory variables were recorded. A cut-off value was defined for serum albumin level and the patients were stratified into four groups on thios basis. Results: The majority of the patients was males and smokers, with a history of weight loss, and squamous histological type of lung cancer. The mean serum albumin level was $3.2{\pm}1.7g/dL$ (range, 2.11-4.36 g/dL). A cut-off value 3.11 g/dL was set and among the patients with a lower level, 68% had adenocarcinoma and 82% were smokers. The patients with low serum albumin levels had a lower response rate to e first-line chemotherapy with a shorter progression-free survival and overall survival. Multivariate analysis showed that low serum albumin level was an independent poor prognostic factor for NSCLC. Conclusions: This study results suggest that low serum albumin level is an independent poor prognostic factor in patients with Stage IIIB NSCLC, associated with reduction in the response rate to first-line therapy and survival rates.