Assessing the genotoxicity of oral zinc oxide nanoparticle administration in male rats using micronuclei and comet assay

Amal G. Ramadan(Amal G. Ramadan ),Ahmed A. M. Yassein(Ahmed A. M. Yassein ),Eissa A. Eissa(Eissa A. Eissa ),Gamal M. Hassan(Gamal M. Hassan ) 한국축산식품학회 2022 Food and Life Vol.2022 No.3

Zinc oxide nanoparticles (ZnO-NPs) are regularly utilized in the food and fertilizers industries. In our investigation, rats received oral administration of ZnO NPs with a particle size of 30±5 nm once daily at doses of 100, 200, 300, 400, and 600 mg/kg for ten weeks in order to assess the genotoxic effect. Impacts on hematological markers, genotoxic impact, and growth were investigated. The findings showed that ZnO-NPs significantly reduced body weight gain, red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit value (HCT), and platelet count (PLT), while increasing white blood cell (WBC), mean capsular volume (MCV), mean capsular hemoglobin (MCH), and mean capsular hemoglobin concentration (MCHC) in the treated rats. Our results for the comet assay and micronuclei test show a dosage-dependent increase in DNA fragmentation, which was supported by an increase in the percentage of DNA that is tailed, the length and intensity of DNA tails, and the tail moment, especially at the dose of 600 mg/kg. According to the findings, the frequency of micronucleated cells has increased.

Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis

Ahmed Abdel-Razik,Nasser Mousa,Dina Elhammady,Rania Elhelaly,Rasha Elzehery,Sherif Elbaz,Mohamed Eissa,Niveen El-Wakeel,Waleed Eldars 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.4

Background/Aims: The diagnosis of spontaneous bacterial peritonitis (SBP) is based on a polymorphonuclear leukocytes (PMNs) exceeding 250/μL in ascitic fluid. The aim of the study was to evaluate serum procalcitonin and ascitic fluid calprotectin as accurate diagnostic markers for detecting SBP. Methods: Seventy-nine patients with cirrhotic ascites were included. They were divided into a SBP group, including 52 patients, and a non-SBP group of 27 patients. Serum procalcitonin, ascitic calprotectin, and serum and ascitic levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL6) were measured using an enzyme-linked immunosorbent assay. Results: Serum procalcitonin and ascitic calprotectin were significantly higher in SBP patients than in non-SBP patients. Significant increases in both serum and ascitic levels of TNF-α and IL-6 were observed in SBP patients versus nonSBP patients. At a cutoff value of 0.94 ng/mL, serum procalcitonin had 94.3% sensitivity and 91.8% specificity for detecting SBP. In addition, at a cutoff value of 445 ng/mL, ascitic calprotectin had 95.4% sensitivity and 85.2% specificity for detecting SBP. Both were positively correlated with ascitic fluid proteins, PMN count, TNF-α, and IL-6. Conclusions: According to our findings, determination of serum procalcitonin levels and ascitic calprotectin appears to provide satisfactory diagnostic markers for the diagnosis of SBP.

Working Capital Management and Banks’ Performance: Evidence from India

Nabil Ahmed Mareai SENAN,Suhaib ANAGREH,Borhan Omar Ahmad AL-DALAIEN,Fatehi ALMUGARI,Amgad S,D,KHALED,Eissa A,AL-HOMAIDI 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6

The purpose of this study is to examine how Indian commercial banks’ performance can be improved by determinants of working capital management. This study uses both static models Generalised Moments Method (GMM) and pooled, fixed, and random-effects. The study is based on balanced panel data for 98 Indian banks from 2008 to 2018. Performance is defined by two indicators, namely, return on assets (ROA) and return on equity (ROE). While, working capital cycle, profit after tax, assets size, financial leverage, quick ratio, current ratio, return on capital employed, return on total assets, net profit margin, and monetary policy rate are used as independent variables. The results showed that net profit margin, profit after tax, monetary policy, and working capital cycle are the most important working capital factors that influence Indian commercial banks’ performance measured by (ROA). Moreover, among the working capital, the results showed that current ratio, assets size, net profit margin ratio, and return on capital employees have significant positive effects on (ROE). The article’s novelty and importance come from its recommendation that policymakers in emerging markets should motivate and enable managers and stakeholders to pay more attention to working capital by raising consumer awareness and increasing knowledge disclosure.

Exsolution-based Co/Ni bimetallic Catalysts for Dry Reforming of Methane

Dong Hyun Kim(김동현),Ahmed Al-Shahat Eissa(아흐메드 알사하트 이사),Kyubock Lee(이규복) 한국에너지기후변화학회 2021 한국에너지기후변화학회 학술대회 Vol.2021 No.11

Ni-based catalysts are widely used for dry reforming of methane (DRM), due to their high catalytic activity and low-cost. However, Ni-based catalysts suffer from deactivation, especially under long-term operating conditions, because of carbon deposition and catalyst sintering. As a result, the design of efficient noble-metal-free catalysts for the DRM still a great challenge. Incorporating another element with Ni has been reported to promote the catalytic activity and coke resistance of catalyst. In this study, we report a facile strategy for fabricating CoNi/MgAl₂O₄ catalyst by one-pot evaporation induced self-assembly combine with exsolution method. During the reduction process, the active metals were successfully exsolved on the catalyst surface, and it was confirmed that CoNi alloy was formed. Our results demonstrate that the formation of a stable exsolved CoNi alloy is an important factor for maintaining the catalyst durability under long-term DRM reaction conditions, and the catalytic activity varies greatly depending on the nickel content. At Co:Ni ratio of 1:4, the catalyst showed a surface area of 175 ㎡/g, and particles size of 12 - 14 nm. When applied for the DRM reaction at 800 ℃ and gas hourly space velocity of 36,000 h<SUP>-1</SUP>, it exhibited CO₂ and CH₄ conversions of 98 and 92%, respectively. After serving for the DRM reaction for 100 h, the catalyst displayed CO₂ and CH₄ conversions of 94 and 85%, respectively, indicating the excellent durability of the herein synthesized catalyst. In addition, a small amount of carbon (3.1%) was deposited on the catalyst’s surface after the long-term reaction test. The insights obtained from this study may have broad applications in developing highly stable CoNi bimetallic catalysts for methane reforming reactions.

Facile Synthesis of CoNi/MgAl₂O₄ Catalyst for Efficient Dry Reforming of Methane

Dong Hyun Kim(김동현),Ahmed Eissa Ahmed Al-Shahat(아흐메드이사),Jae Hwan Jung(정재환),Kyubock Lee(이규복) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7

Nickel-based catalysts have been widely used for catalyzing the dry reforming of methane (DRM), due to their high catalytic activity and low-cost. However, they suffer from the deactivation process as a result of the carbon deposition, especially under long-term operating condition. As a result, the design of highly active and durable Ni-based catalysts for the DRM still is a great challenge. In this study, we report a facile strategy for fabricating CoNi/MgAl₂O₄ catalyst by one-pot evaporation induced self-assembly (EISA) method. Our results demonstrated that the formation of nickel-cobalt alloy is an important factor for maintaining the catalyst’s durability under long-term DRM reaction conditions, and that catalytic activity varies greatly depending on the nickel content. At Co:Ni ratio of 1:4, the catalyst showed a surface area of 175 m²/g, and a particle size of 12 – 14 nm. When applied for the DRM reaction a 800℃, CH₄/CO₂ of 1.0, and gas hourly space velocity (GHSV) of 36,000 h-1, it exhibited CO₂ and CH₄conversion efficiencies of 98 and 92%, correspondingly. After 100 h, the catalyst performance maintained conversion efficiencies of 94 and 85% for CO₂ and CH₄, respectively, indicating the excellent durability of the herein synthesized catalyst. Moreover, a small quantity of carbon (3.1%) was observed on the catalyst’s surface after the long-term reaction test, indicating the high resistance for carbon deposition.

Synthesis and Anti-inflammatory Activity of Novel Pyridazine and Pyridazinone Derivatives as Non-ulcerogenic Agents

Makarem M. Saeed,Eman M. Ahmed,Nadia A. Khalil,Kholoud I. Eissa 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

Herein, we report the synthesis and pharmacological properties of several series of pyridazine and pyridazinone derivatives. All the synthesized compounds were tested, in vivo, for their anti-inflammatory and ulcerogenic properties against indomethacin, as a reference compound. Compounds 4a and 9d have shown a potent anti-inflammatory activity more than indomethacin with rapid onset of action and safe gastric profile. The latter compounds were then selected for further investigation. In the MTT assay in vitro, both compounds were identified as potent and selective COX-2 inhibitors.

Reduced Fertility and Fecundity among Patients with Bipolar I Disorder and Schizophrenia in Egypt

Hader Mansour,Kareem Kandil,Warda Fathi,Mai Elassy,Ibtihal Ibrahim,Hala Salah,Amal Yassin,Hanan Elsayed,Salwa Tobar,Hala El-Boraie,Ahmed Eissa,Mohamed Elhadidy,Nahed E. Ibrahim,Wafaa El-Bahaei,Vishwaj 대한신경정신의학회 2011 PSYCHIATRY INVESTIGATION Vol.8 No.3

Objective To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt. Methods BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables. Results Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37±0.9) and SZ patients (0.38±0.9) was significantly lower than for controls (1.04±1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1: 31.9% SZ: 27.8% control: 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8±1.57) was significantly higher than BP1 patients (1.14±1.31, p=0.02), but not significantly different from SZ patients (1.36±1.32, p=0.2). Conclusion Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability. Objective To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt. Methods BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables. Results Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37±0.9) and SZ patients (0.38±0.9) was significantly lower than for controls (1.04±1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1: 31.9% SZ: 27.8% control: 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8±1.57) was significantly higher than BP1 patients (1.14±1.31, p=0.02), but not significantly different from SZ patients (1.36±1.32, p=0.2). Conclusion Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability.