해양레저 안전장비 개발

구자영(Ja-Young Ku),임정빈(Jeong-Bin Yim),이재응(Je-Eung Lee),남택근(Taek-Keun Nam),정중식(Joong-Sik Jeong),박성현(Seong-Hyeon Park),양원재(Weon-Jae Yang),안영섭(Yeong-Sub Ahn) 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.1 No.-

이 논문에서는 안전한 해양레저 행위를 지원하기 위한 두 가지 개인 휴대용 전자장치 개발 내용을 기술한다. 하나는 조난자를 신속히 민-관-군 동시 다발적으로 수색하기 위한 선박용 9GHz 대역의 일반 레이더 전파에 응답하는 레이더 응답장치이다. 다른 하나는 조난자의 위치를 추적하고 식별할 수 있는 900MHz 스펙트럼 확산 주파수 홉핑 방식의 송수신기와 GPS를 이용한 해상 무선식별장치 개념의 전자장치이다. 해양경찰 함정을 이용한 해상에서의 다양한 현장실험을 통하여 두 가지 장비의 성능을 확인하였다. 그리고 향후 상용화 방안에 대해서 검토하였다. This paper describes two kinds of personal hand-held electronic devices to support marine leisure safety. The one is Radar response-type safety device triggering by the pulse signal from a commercial 9GHz-band Radar to provide quick search and rescue with combined civilian-government-military fleets. The other one is M-RFID(Marine Radio Frequency IDentification) based safety electronic device using 900MHz Tx/Rx with spread spectrum frequency hopping and GPS. Through the field tests at sea using Korea Coast Guard's warship the operating performances are verified. Further plan for practical use of each device was also discussed.

백서 Paraquat 두여에 의한 간과 폐 조직의 산화성 손상에서 Vitamin C와 Deferoxamine의 항산화 효과에 관한 연구

정연권,서길준,정중식,정성은,최국진,윤여규 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The toxicity of paraquat has been known to be caused by oxygen free radicals which leads to the lipid peroxidation and multiple organ failure. Although vitamin C has been known to be a potent antioxidant, recently there are numerous data which have shown that a low dose of vitamin C may act as a prooxidant due to the stimulation of the Fenton reaction with metal ions, which produces hydroxyl radicals. It has been reported that a deferoxamine in paraquat intoxication could reduce the production of the hydroxyl radicals by the inhibition of the Fenton reaction through the reduction of iron ion in tissue. The aim of this study was to evaluate the effect of the high and low dose of vitamin C and deferoxamine on lipid peroxidation and plasma TNF-α in paraquat intoxication. Methods: Female Sprague -Dawley rats were divided into seven groups: control group which was not given paraquat(20 mg/kg), P group which was given paraquat only, PVH group given paraquat and high dose of vitamin C(100 mg/kg), PVL group given paraquat and low dose of vitamin C(10 mg/kg), PVHD given paraquat, high dose of vitamine C and deferoxamine(100 mg/kg), PVLD given paraquat, low dose of vitamin C and deferoxamine, and PD given paraquat and deferoxamine. Animals were killed at 6 and 24 hours after treatment. Malondialdehyde(MDA), superoxide dismutase(SOD) and glutathione(GSH) contents, catalase activity, plasma TNF-α, and histologic changes in the lung and liver tissue were measured. Results: The lung histology in the PVH and PD or PVHD groups showed the significant decreases in the alveolar edema and interstitial thickness compared to the P group. The liver histololgy in the PVH and PVHD groups demonstrated marked differences in the central venous and sinusoidal dilatation compared to that of the P group. While the MDA levels of the lung and liver in the PVH and PD groups showed the significant reduction compared to that of the P group at 6 hours after treatment, all groups showed the significant changes compared to the P group at 24 hours. There was no significant change of the SOD levels of the lung and liver at 6 hours among all groups. At 24 hours, the SOD levels of the lung in PVH, PVL, and PVHD groups showed the significant increases compared to the P group. The increase of the SOD level in groups combined with deferoxamine, however, revealed a little reduction. The SOD level of the liver in PVH group only significantly increased compared to the P group at 24 hours. There was no significant change of the GSH level of the lung and liver among all groups at 6 hours. At 24 hours, the GSH level of the lung and liver were significantly increased in both PVH and PD group and PVH group, respectively, compared to the P group. Although the catalase activity of the lung was not significantly increased, that of liver was signiflcantly increased in both PVHD and PD groups compared to the P group at 6 hours. The catalase activities of the lung and liver were significantly increased in PVH, PD, and PVHD at 24 hours. The concentrations of the plasma TNF-α were slightly decreased at 6 hours and slightly increased at 24 hours compared to that of the P group, but they were not significant. Conclusion: This study showed that although the low dose of vitamin C had no effect, the high dose of vitamin C revealed a decrease of the MDA level and an increase of SOD, GSH, and catalase activity in the lung and liver tissues, and the effect of the high dose of vitamin C increased with time. The administration of the deferoxamine with or without high dose of vitamin C, however, significantly showed the inhibition of the lipid peroxidation and antioxidant effect and low dose vitamin C decreased the effect of deferoxamine. The effects of the vitamin C and deferoxamine on plasma TNP-α were not clearly shown.

Phalloides Syndrome의 임상적 고찰

김규석,임영운,정중식,신상도,표창해,이중의,서길준,정성은,윤여규,박정배,서강석,유은영,임용수 대한응급의학회 2000 대한응급의학회지 Vol.11 No.2

Background: To review the important features and treatment modalities of phalloides syndrome. Method: We perfomed a retrospective analysis of 16 patients with phalloides syndrome who visited the Emergency Center of Seoul National University Hospital, Uijongbu St. Mary's Hospital, Gachon Medical College Hospital, and Kyungpook National University Hospital from July 1st to August 31st, 1998. Mann-Whitney U test was used for statistical analysis(p<0.05). Results: 9 were male and 7 were female. The mean age was 54 years(men 46 years, women 65 years). Fourteen cases(88%) occurred in Kyungpook area. All cases of phalloides syndrome resulted from mistaking toxic mushrooms for edible mushrooms. The doses of ingestion of mushroom were not available because the patient could not remember the exact amounts. The identification of mushrooms in 4 cases was confirmed by mycologist, 6 cases by mushroom photoatlas, and remained 6 cases were not confirmed. The initial symptoms of mushroom poisoning were abdominal pain, nausea, and watery diarrhea. The time intervals from the ingestion of mushroom to the onset of symptom were from 6 to 13 hours(mean 11.3±2.68 hours). The laboratory data showed the increased GOT and GPT, prolonged prothrombin time, elevated serum creatinine level, and decreased platelet count. The initial management of phalloides mushroom poisoning was done conservatively, but the early specific treatments such as gastrointestinal decontamination, administration of activated charcoal, IV penicillin or silymarin were not perfomed in all cases. The mortality rate was 18.8%. There were significant differences in total bilirubin, prothrombin time, platelet count, and serum creatinine between survival and non-survival group(p<0.05) Conclusion: It is important to know the morphological differences between edible and toxic mushroom for prevention of phalloides syndrome. If the patient with acute gastroenteritis has a history of mushroom ingestion, the emergency physician should suspect phalloides syndrome and start early proper treatment. For the identification of mushroom it is desirable to contact a mycologist.

내독소혈증에서 성장호르몬의 항산화 효과

이창현,서길준,이중의,신상도,정중식,윤여규,고광휘 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.2

Background: Endotoxemia from a gram negative bacterial infection is a dangerous condition, which may progress to systemic inflammatory response syndrome (SIRS). Inflammatory cells activated by endotoxins generate oxidants and cytokines such as TNF-α, which in turn stimulate macrophages and neutrophils, and augmented inflammation makes systemic tissue injury deteriorate into multi-organ failure. This study is designed to evaluate the therapeutic antioxidant. Methods : Male Sprague-Dawley rats were divided into 3 groups: a control group, a group injected intraperitoneally with LPS (lipopolysaccharide), and a group injected intraperitoneally with LPS and growth hormone. Eight rats of each group were sacrified 24 hours and 48 hours after injection, and samples of blood, liver, and lung were obtained. Biochemical assays of the TNF-αlevel in the blood and of the malondialdehyde (MDA) level, the catalase activity, and the nitric oxide synthase (NOS) activity in liver and lung tissues were performed. Results: The serum TNF-αlevel, the tissue lipid peroxidation, and the tissue I-NOS activity were dramatically increased, and the tissue catalase activity was exhausted rapidly in sepsis. Growth hormone injection decreased the serum TNF-αlevel, the tissue lipid peroxidation, and the tissue I-NOS induction, and protected against catalase exhaustion. Conclusion: Growth hormone was proved to decrease TNF-αlevel and to have an antioxidant effect in septic condition. Clinical use of growth hormone in sepsis should be considered.