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하대정맥 및 우심방의 혈전을 동반한 간세포암을 효과적으로 치료한 증례
이현정 ( Hyun Jung Lee ),임형준 ( Hyung Joon Yim ),정환훈 ( Hwan Hoon Chung ),이승화 ( Seung Hwa Lee ),김해림 ( Hae Rim Kim ),현종진 ( Jong Jin Hyun ),정성우 ( Sung Woo Jung ),구자설 ( Ja Seol Koo ),이상우 ( Sang Woo Lee ),최재현 대한간암학회 2012 대한간암학회지 Vol.12 No.2
In patients with advanced hepatocellular carcinoma (HCC), tumor thrombus in inferior vena cava (IVC) and right atrium (RA) are not uncommon findings and are usually associated with extremely poor outcome. Although aggressive surgical interventions such as extracorporeal circulation and tumor excision have been performed, the reported results were still unsatisfactory. Herein, we report the favorable result of combined treatment with radiation therapy and transarterial chemoembolization in a patient with advanced HCC with extensive tumor thrombus through the IVC into the RA. In conclusion, noninvasive combined modalities, such as transarterial chemoembolization and radiation therapy may sometimes provide effective palliation for patients with far advanced HCC with IVC/RA tumor thrombus and who are not candidates for alternative treatment options.
응급실에 내원한 두부외상환자의 2차 평가로써 초음파를 이용한 시각신경집 지름 측정은 유용한가?
이동욱 ( Dong Wook Lee ),이정원 ( Jung Won Lee ),박세훈 ( Sae Hoon Park ),박일성 ( Ihl Sung Park ),이현정 ( Hyun Jung Lee ),유병대 ( Byeong Dae Yoo ),문형준 ( Hyung Jun Moon ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.3
Purpose: Bedside ultrasonography is available in most emergency departments, and detecting the intracranial pressure is elevated is critical. Our objective is to evaluate the availability of bedside optic nerve ultrasound (ONUS) as a secondary survey for patients with head injuries in the emergency department (ED). Methods: From September, 2012, to March, 2013, we performed a prospective study of patients presenting to the ED after an accident. Patients with head injuries but without obvious ocular trauma or ocular disease were included. The ONUS was performed using a 3 to 12 MHz linear probe on closed eyelids after a primary survey. We analyzed the correlation between the brain computed tomography (CT) findings that suggested elevated intracranial pressure (ICP) and the Optic nerve sheath diameter (ONSD) measured by using ONUS. Results: A total of 81 patients were enrolled. Forty-seven had CT results consistent with elevated ICP, and their mean ONSD was 5.98±0.59 mm; the mean ONSD of patients who showed no signs of elevated ICP on CT was 4.63±0.21 mm. The sensitivity and the specificity for the ONSD, compared with elevated ICP, were 98.87% and 100%, respectively, when the cut-off value was set to 4.96 mm. The area under curve (AUC) was 0.997 in the receiver operating characteristic curve (ROC curve). Conclusion: An evaluation using ONUS is a simple noninvasive procedure and is a potentially useful tool as a secondary survey to identify an elevated ICP.
일개 대학병원에서 경험한 자리공 중독 환자의 임상적 특성
정동길 ( Dong Kil Jeong ),문형준 ( Hyung Jun Moon ),이정원 ( Jung Won Lee ),박세훈 ( Sae Hoon Park ),이현정 ( Hyung Jung Lee ),설승환 ( Seung Whan Seo ),김아름 ( Ah Reum Kim ),최재형 ( Jae Hyung Choi ),김재우 ( Jae Woo Kim ) 대한임상독성학회 2012 대한임상독성학회지 Vol.10 No.2
Purpose: Although Pokeweed intoxication is relatively less severe, thereis little data onthe clinical presentation ofPokeweed intoxication in Korea. This study examined the clinical aspectsto providebasic data for evaluating Pokeweed intoxication. Methods: A retrospective study by a chart review was performedon 19 patients who ingested Pokeweed and presented to anacademic emergency department with an annual census of 40,000 between March 2012 and May 2012. Results: Nineteen patients were identified. All patients wereintoxicated unintentionally. The most common symptoms were vomiting with diarrhea and abdominal pain. The onset time varied, but occurs 30 minutes to 5 hours post ingestion of Pokeweed. All patients were discharged without fatal complications. Conclusion: Compared to previous reports, mostpokeweed poisoning patients complain of gastrointestinalsymptoms. Supportive care is the mainstay of the management of pokeweed intoxication. All symptoms were resolved over a 24 to 48 hour period.
한국인의 원형탈모중과 남성형탈모중의 횡단절편 조직 소견
이현정(Hyun Jeong Lee),하석준(Seog Jun Ha),이주한(Joo Han Lee),김정철(Jung Chul Kim),김형옥(Hyung Ok Kim),김진우(Jin Wou Kim) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.5
N/A Background: The advantages of horizontal, over vertical, sectioning of scalp biopsies allow morphometric analysis of follicular structures. Objective: In this study, we performed the morphometric analysis of alopecia areata and androgenetic alopecia in Koreans using the horizontal sectioning method. Methods: Paird, 4-mm punch biopises were taken from the margin of alopecic patch from 21 alopecia areata patients or the frontal lesion of 13 androgenetic alopcia patients, and from clinically normal occipital scalp of all subjects. Results: The general histopathological features were consistent with the known descriptions, but the data on exact follicular counts showed striking differences compared with those from Caucasians. 1. In alopecia areata, numbers of vellus hairs (3.2 < 2.9) and follicular stellae (1.6±1.6) was increased significantly (p<0.05) compared with counts from normal occipital scalp (vellus hairs 1.1±1.3; follicular stellae 0.5±0.8). Anagen/telogen percent ratio was decreased in lesions (64.2%:35.8%) compared with normal occipital scalp (94.0%:5.7%). 2. In androgenetic alopecia, numbers of vellus hairs (4.1±3.7) and follicular stellae (4.4±3.4) was increased significantly (p<0.05) in the lesion compared with the normal occipital scalp (vellus hairs 1.1±1.3; follicular stellae 1.0±1.2). Mild decrease of anagen/telogen percent ratio was observed in lesions (86.5%:13.5%) compared with normal occipital scalp (93.5%:6.5%). Conclusion: Our results suggest that horizontal sectioning of scalp biopsies is a useful diagnostic method but differences in follicular counts should be considered in interpreting the morphometric data in Koreans.
CHP(Cyclo His-Pro) 함유 대두가수분해물을 이용한 코팅 쌀의 제조
이현정(Hyun Jung Lee),박혜인(Hyein Park),박유헌(Yooheon Park),서형주(Hyung Joo Suh) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.3
쌀의 기능성 소재화 및 새로운 용도 개발 연구의 일환으로, 제2형 당뇨환자의 혈당을 조절할 수 있는 인슐린 기능개선 소재로 알려져 있는 cyclo histidine-proline(CHP) 함유 대두가수분해물(SHC)을 쌀에 함유시켜 신규 기능성 쌀을 개발하고자 하였다. 이를 위해 흡수 및 분무 코팅에 의해 쌀의 가공 중 첨가 기능성 성분인 CHP 함유된 대두가수분해물의 소실을 억제하는 기능성 성분 강화 코팅 쌀의 제조공정을 검토하였다. 흡수 코팅법은 CHP 함유 대두가수분해물의 농도 증가에 따라 흡수저해가 일어나 흡수율이 낮게 나타나므로 적합하지 못하였다. 반면 methylcellulose 폴리머를 사용한 분무 코팅에 의하여 제조된 코팅 쌀은 다소의 균열 발생 및 미황색화가 관찰되었으나 외관 형태의 큰 변화는 관찰되지 않았다. 특히, 수화양상 및 수화속도가 원료 쌀에 비하여 높게 나타났으며, 코팅과정 중의 건조에 의한 호화 등은 관찰되지 않았다. 따라서 5%(w/v)의 CHP 함유 대두가수분해물을 함유한 1%(w/v) methylcellulose 폴리머를 보호제로 사용하여 분무 코팅한 후 건조하여 CHP 함유 대두가수분해물을 기능성 성분으로 하는 기능성 코팅 쌀을 제조하는 공정을 확립하였다. A method for coating rice with a novel substance, SHC [soybean hydrolysate with Cyclo Histidine-Proline (CHP)], was developed to produce functional rice for food production. The dip coating and spray coating method was tested to reduce the loss of functionality during the manufacturing of enriched rice. The dip coating method showed a very low absorption rate (0.079 min<SUP>-1</SUP>) of the functional substance compared to control (0.150 min<SUP>-1</SUP>), while the spray-coating method with protective coating materials [a methyl cellulose solution (l%, w/v) containing 5% (w/v) of the SHC] showed relatively adequate absorption characteristics. A light yellowish stain was observed in the rice samples processed by the spray-coating method (b value; surface1 0.69, flour 4.91) compared to raw rice (b value; surface 9.67, flour 4.86). The microscopic appearance of whole kernels and longitudinal sections revealed that cracks formed in all rice samples, regardless of the coating method. In conclusion, spray coating is a potential method for producing SHC-fortified rice with excellent physical characteristics.